scholarly journals Can minimally invasive puncture and drainage for hypertensive spontaneous Basal Ganglia intracerebral hemorrhage improve patient outcome: a prospective non-randomized comparative study

2014 ◽  
Vol 1 (1) ◽  
pp. 10 ◽  
Author(s):  
Guo-Qiang Wang ◽  
Shi-Qiang Li ◽  
Yong-Hua Huang ◽  
Wei-Wei Zhang ◽  
Wen-Wei Ruan ◽  
...  
Keyword(s):  
Patient Outcome ◽  
Basal Ganglia ◽  
Minimally Invasive ◽  
Intracerebral Hemorrhage ◽  
Comparative Study ◽  
Improve Patient Outcome ◽  
Improve Patient

scholarly journals Role of a Checklist to Improve Patient Safety in Interventional Radiology

2019 ◽  
Vol 03 (03) ◽  
pp. 157-161
Author(s):  
Soumil Singhal ◽  
Mangerira Chinnappa Uthappa
Keyword(s):  
Patient Outcome ◽  
Interventional Radiology ◽  
Patient Satisfaction ◽  
Minimally Invasive ◽  
Improve Patient Outcome ◽  
Aviation Industry ◽  
Minimal Risk ◽  
Complication Rates ◽  
Image Guided ◽  
Improve Patient

AbstractA checklist can be defined as a comprehensive formal list of essential actions to be taken in a specific fashion. This concept has been extended from the aviation industry to health care to improve patient outcome and patient satisfaction with a significant reduction in complication rates. This review article aims to assess the importance and benefits associated with the use of a well-formulated checklist while performing the various minimally invasive image-guided procedures. Various databases including PubMed, Medline, Scopus, and Cochrane were searched for using various keywords including “Checklist,” “Radiology,” “Interventional Radiology,” “Image-Guided Procedure,” and “minimally invasive procedure.” The use of a checklist is the way ahead especially when patients today require minimal risk but demand high-quality care. Implementation of such an easy-to-perform tailor-made mechanism can significantly improve patient outcome and patient satisfaction.

Targeting Bcl-2 Family Proteins in Adult T-Cell Leukemia/Lymphoma: In Vitro and In Vivo Effects of a Novel Bcl-2 Family Inhibitor ABT-737.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 1685-1685
Author(s):  
Kenji Ishitsuka ◽  
Chie Ishikawa ◽  
Fusanori Yotsumoto ◽  
Hiroo Katsuya ◽  
Naoko Kunami ◽  
...  
Keyword(s):  
Patient Outcome ◽  
T Cell ◽  
Conflicts Of Interest ◽  
Interleukin 2 ◽  
Chemotherapeutic Agents ◽  
Improve Patient Outcome ◽  
Type I ◽  
Induced Apoptosis ◽  
Improve Patient

Abstract Abstract 1685 Poster Board I-711 Adult T-cell lymphoma/leukemia (ATLL) is a T-cell malignancy caused by human T-lymphotrophic virus type I (HTLV-I), and its therapeutic outcome is still remains very poor. Therefore, novel therapeutic strategies are needed to improve patient outcome. In this study, we elucidated the therapeutic potential to target anti-apoptotic Bcl-2 family proteins for the treatment of ATLL by using ABT-737 (Abbott Laboratories, Abbott Park, IL, USA), a small molecule inhibitor of Bcl-2, Bcl-XL and Bcl-w. We first validated the rationale of this study by assessing the expression of Bcl-2 family proteins among 25 lymph-node specimens derived from ATLL patients by using immunohistochemistory. Both or either of Bcl-2 and Bcl-XL proteins was highly expressed in 80% of specimens. We next examined the cytotoxicity of ABT-737 against ATLL cell lines. ABT-737 significantly inhibited growth of MT-1, MT-2 and HuT 102 cells with a concentration of 50 percent inhibition (IC50) at 72 h of 2.4, 0.23 and 0.008μM, respectively. We then elucidated the mechanism of growth inhibition induced by ABT-737 using MT-1 and MT-2 cells. ABT-737 induced apoptosis in MT-1, MT-2 cells with cleavage of caspase 9, 3 and PARP. ABT-737 also induced apoptosis in fresh tumor cells derived from patients with ATLL. We next elucidated the potential of ABT-737 to enhance the cytotoxicity induced by conventional chemotherapeutic agents. The interaction between them was evaluated using the Chou-Talalay method by determining the combination index. ABT-737 synergistically enhanced the cytotoxicity and apoptosis induced by either of doxorubicin, vincristine or etoposide, which is a current key drug to treat ATLL. Most importantly, ABT-737 significantly inhibited tumor growth of in vivo ATLL model using SCID mice inoculated by HuT 102 cells subcutaneously. The mean tumor volume, weight and serum level of soluble interleukin-2 receptor á of ABT-737 (100mg/kg/day)-treated mice were significantly lower than those of vehicle-treated mice after treatment for 21 days. Moreover, massive induction of apoptosis in tumors treated by ABT-737 was observed by immunofluorescent TUNEL assay. These results suggest that ABT-737 used either alone or in combination with conventional cytotoxic drugs, represents a promising novel targeted approach to overcome drug resistance and improve patient outcome in ATLL. Disclosures No relevant conflicts of interest to declare.

scholarly journals Hyperplastic Cardiac Sarcoma Recurrence

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Masood A. Shariff ◽  
Juan A. Abreu ◽  
Farida Durrani ◽  
Eddie Daniele ◽  
Kimberly C. Bowman ◽  
...  
Keyword(s):  
Patient Outcome ◽  
Median Survival ◽  
Multidisciplinary Approach ◽  
Multidisciplinary Care ◽  
Improve Patient Outcome ◽  
Rare Tumors ◽  
Improve Patient

Primary cardiac sarcomas are rare tumors with a median survival of 6–12 months. Data suggest that an aggressive multidisciplinary approach may improve patient outcome. We present the case of a male who underwent resection of cardiac sarcoma three times from the age of 32 to 34. This report discusses the malignant nature of cardiac sarcoma and the importance of postoperative multidisciplinary care.

Minimally invasive endoscopic hematoma evacuation vs best medical management for spontaneous basal-ganglia intracerebral hemorrhage

2019 ◽  
Vol 11 (6) ◽  
pp. 579-583 ◽  
Author(s):  
Nitin Goyal ◽  
Georgios Tsivgoulis ◽  
Konark Malhotra ◽  
Aristeidis H Katsanos ◽  
Abhi Pandhi ◽  
...  
Keyword(s):  
Basal Ganglia ◽  
Minimally Invasive ◽  
Intracerebral Hemorrhage ◽  
Hospital Mortality ◽  
Medical Management ◽  
Intervention Group ◽  
Stroke Severity ◽  
Hematoma Evacuation ◽  
Discharge Disposition ◽  
Relative Safety

BackgroundWe conducted a case-control study to assess the relative safety and efficacy of minimally invasive endoscopic surgery (MIS) for clot evacuation in patients with basal-ganglia intracerebral hemorrhage (ICH).MethodsWe evaluated consecutive patients with acute basal-ganglia ICH at a single center over a 42-month period. Patients received either best medical management according to established guidelines (controls) or MIS (cases). The following outcomes were compared before and after propensity-score matching (PSM): in-hospital mortality; discharge National Institutes of Health Stroke Scale score; discharge disposition; and modified Rankin Scale scores at discharge and at 3 months.ResultsAmong 224 ICH patients, 19 (8.5%) underwent MIS (mean age, 50.9±10.9; 26.3% female, median ICH volume, 40 (IQR, 25–51)). The interventional cohort was younger with higher ICH volume and stroke severity compared with the medically managed cohort. After PSM, 18 MIS patients were matched to 54 medically managed individuals. The two cohorts did not differ in any of the baseline characteristics. The median ICH volume at 24 hours was lower in the intervention group (40 cm3 (IQR, 25–50) vs 15 cm3 (IQR, 5–20); P<0.001). The two cohorts did not differ in any of the pre-specified outcomes measures except for in-hospital mortality, which was lower in the interventional cohort (28% vs 56%; P=0.041).ConclusionsMinimally invasive endoscopic hematoma evacuation was associated with lower rates of in-hospital mortality in patients with spontaneous basal-ganglia ICH. These findings support a randomized controlled trial of MIS versus medical management for ICH.

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