A Study of the Effect of Short-Term Progesterone Treatment on Serum Calcium and Inorganic Phosphorus Concentration in the Rat

ABSTRACT Three patients with atypical, intermittent tetany of recent origin, hypocalcaemia, hypocalciuria and normal serum inorganic phosphorus concentration are described. Two patients were postoperative from thyroidectomy by more than 20 years and one had recently experienced metastatic malignant invasion of the thyroid area. A variety of studies showed that these patients were neither normal nor typically hypoparathyroid in the laboratory. Two hypotheses, each with some support are: 1. that the patients were not totally aparathyreotic, and 2. that, while aparathyreotic, they had adapted to the abnormal state by some mechanism operative in the absence of parathyroid hormone.

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Biological activity of 1,25-dihydroxyvitamin D2 and 24-epi-1,25-dihydroxyvitamin D2

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.1988.254.4.e402 ◽

1988 ◽

Vol 254 (4) ◽

pp. E402-E406

Author(s):

H. F. DeLuca ◽

R. R. Sicinski ◽

Y. Tanaka ◽

P. H. Stern ◽

C. M. Smith

Keyword(s):

Biological Activity ◽

Calcium Transport ◽

Inorganic Phosphorus ◽

Short Term ◽

Dihydroxyvitamin D3 ◽

Intestinal Calcium Transport ◽

Fetal Rat ◽

Bone Calcium ◽

Biological Effectiveness

The biological activity of 1,25-dihydroxyvitamin D2 [1,25(OH)2D2] and 24-epi-1,25-dihydroxyvitamin D2 [24-epi-1,25(OH)2D2] has been determined in vitamin D-deficient rats. The biological effectiveness of 1,25(OH)2D2 is equal to that reported previously for 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] (15) in intestinal calcium transport, mineralization of bone, mobilization of bone calcium, and elevation of plasma inorganic phosphorus of rachitic rats. However, 24-epi-1,25(OH)2D2 is at best one-half as active as 1,25(OH)2D2 in stimulating intestinal calcium transport and in the mineralization of rachitic bone. The 24-epi-1,25(OH)2D2 is one-third as active as 1,25(OH)2D3 in binding to the chick intestinal receptor for 1,25(OH)2D3. Thus receptor discrimination may account for the twofold difference in intestinal calcium transport activity. 24-Epi-1,25(OH)2D2 appeared inactive in in vivo mobilization of bone calcium or bone phosphorus. On the other hand, in fetal rat bone in culture, the epi compound was only five times less active than 1,25(OH)2D2 in inducing resorption. Short-term experiments on bone mineral mobilization in vivo show that the 24-epi-1,25(OH)2D2 does induce bone calcium mobilization but that its activity in this respect is short lived. It is suggested that 24-epi-1,25(OH)2D2 and, as a result, it shows preferential activity on intestine whose response to a single dose of 1,25(OH)2D2 remains for several days, whereas the short-lived bone system does not remain stimulated during the 24-h period between doses.

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Spatial and Seasonal Distribution and Transportation of Different Forms of Phosphorus in the Middle Reaches of the Yarlung Zangbo River

Water ◽

10.3390/w10121858 ◽

2018 ◽

Vol 10 (12) ◽

pp. 1858 ◽

Cited By ~ 4

Author(s):

Xiaolong Cheng ◽

Yanan Huang ◽

Xunchi Pu ◽

Ruidong An ◽

Wendian Huang ◽

...

Keyword(s):

Surface Sediments ◽

Organic Phosphorus ◽

Nutrient Status ◽

Inorganic Phosphorus ◽

Research Area ◽

Phosphorus Concentration ◽

Wet Season ◽

Overlying Water ◽

Total Phosphorus Concentration ◽

Yarlung Zangbo River

The Yarlung Zangbo River basin ecosystem is fragile. The distribution and transportation of phosphorus is of great significance for aquatic environmental protection and ecological security. The sequential extraction method and molybdenum antimony anti-spectrophotometry were used to measure the concentrations of different forms of phosphorus in the surface sediments from 15 sampling sites along the middle reaches of the Yarlung Zangbo River and its tributaries. The results show that the total phosphorus concentration in the surface sediments is 194.0~540.7 mg/kg, which is mainly composed of inorganic phosphorus. The concentrations of various phosphorus forms ranked as calcium-bound phosphorus (355.6 ± 86.0 mg/kg) > soluble phosphorus (15.9 ± 10.0 mg/kg) > iron-bound phosphorus (12.4 ± 12.3 mg/kg) > organic phosphorus (9.6 ± 6.1 mg/kg) > occluded phosphorus (9.2 ± 3.8 mg/kg) > aluminum-bound phosphorus (5.4 ± 2.3 mg/kg). On the whole, phosphorus concentration is greater in wet season than dry season. Regarding the spatial distribution characteristics, there are great disparities in the different forms of phosphorus in the middle reaches of the Yarlung Zangbo River. Comprehensive analysis shows that phosphorus of this area is mainly self-generated, and concentration of bioavailable phosphorus is small, demonstrating there will not be a large release. We also drew a “specific triangle” of the different forms of phosphorus concentrations in the research area and defined the “α” angle to determine the nutrient status of the overlying water quickly and effectively. Finally, phosphorus flux of the mainstream was estimated. This research may provide information on the phosphorus of Plateau Rivers.

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Influence of Progesterone-Treatment Length and eCG Administration on Appearance of Estrus Behavior, Ovulatory Success and Fertility in Sheep

Animals ◽

10.3390/ani9010009 ◽

2018 ◽

Vol 9 (1) ◽

pp. 9 ◽

Cited By ~ 7

Author(s):

Paula Martinez-Ros ◽

Alejandro Rios-Abellan ◽

Antonio Gonzalez-Bulnes

Keyword(s):

Drug Release ◽

Chorionic Gonadotrophin ◽

Ovulation Rate ◽

The Other ◽

Short Term ◽

Treatment Length ◽

Progesterone Secretion ◽

Progesterone Treatment ◽

Estrus Behavior

The present study characterizes, for sheep, the occurrence and timing of the onset of estrus behavior and ovulation and the yields obtained (ovulation rate, progesterone secretion, and fertility) after Controlled Internal Drug Release (CIDR) insertion for five, six, seven, or fourteen days, with or without equine chorionic gonadotrophin (eCG) in ewes of the Segureña meat breed. All the treatments showed above 80% of females displaying estrus, but the onset of estrus was earlier and more synchronized when using eCG and, among groups with eCG, onset of estrus was earlier in the sheep treated for 14 days than in the short-term treatments (p < 0.05 for all). Administration of eCG after either short- or long-term treatments assured the occurrence of fertile ovulations in all the animals. Conversely, ovulatory success without eCG was found to be dependent on treatment length, with a high percentage of animals ovulating after five days of treatment (83.3%) and very low percentages after treatment for six or seven days (40% and 20%, respectively). Ovulation rate and progesterone secretion were similar among animals ovulating, but ovulation failures predetermined the fertility yields obtained in response to the treatments. Hence, the best results were found after treatment for 14 days plus eCG, and for 5 days without eCG (83.3 for both, p < 0.05 when compared to the other groups with different treatment lengths and with or without eCG).

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SERUM CALCIUM, INORGANIC PHOSPHORUS AND PHOSPHATASE ACTIVITY, ETC

The Journal of Nervous and Mental Disease ◽

10.1097/00005053-193702000-00016 ◽

1937 ◽

Vol 85 (2) ◽

pp. 211

Author(s):

&NA;

Keyword(s):

Phosphatase Activity ◽

Serum Calcium ◽

Inorganic Phosphorus

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INFLUENCE OF GONADAL HORMONES ON THE ACTION OF CALCITONIN IN THE RAT

Acta Endocrinologica ◽

10.1530/acta.0.0680585 ◽

1971 ◽

Vol 68 (3) ◽

pp. 585-596 ◽

Cited By ~ 3

Author(s):

O. Helmer Serensen ◽

Inge Hindberg

Keyword(s):

Serum Calcium ◽

Thyroid Tissue ◽

Gonadal Hormones ◽

Term Treatment ◽

Female Rats ◽

Short Term ◽

Oestrogen Treatment ◽

Male And Female Rats ◽

Long Term Treatment

ABSTRACT The influence of short-term and long-term treatment with gonadal hormones on the response to calcitonin was investigated in the rat. Oestrogen-treatment, short-term as well as long-term, resulted in a reduced responsiveness to calcitonin. Long-term treatment with androgens enhanced the hypocalcaemic effect of calcitonin in castrated rats of either sex, but reduced the effect in intact animals. No sex differences could be registered in the sensitivity to calcitonin, when intact animals were compared according to age, while marked differences were observed, when the animals were compared according to weight. There was a linear decrease in the response to calcitonin with increasing age in rats of both sexes. An intraperitoneal calcium load was followed by an acute rise in the serum calcium levels. The adult animals counteracted the hypercalcaemia more slowly than the young ones. Significant differences also occurred between male and female rats, the rise in the serum calcium concentration being much more pronounced in the latter group. The hypocalcaemic activity of thyroid tissue from rats of both sexes and of various ages showed considerable variations, but no differences correlated to age or sex.

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Short-Term Omeprazole Use Does Not Affect Serum Calcium Concentrations and Bone Density in Horses

Journal of Equine Veterinary Science ◽

10.1016/j.jevs.2015.07.003 ◽

2015 ◽

Vol 35 (9) ◽

pp. 714-723 ◽

Cited By ~ 5

Author(s):

Stephanie S. Caston ◽

Douglas C. Fredericks ◽

Kevin D. Kersh ◽

Chong Wang

Keyword(s):

Bone Density ◽

Serum Calcium ◽

Short Term

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