Toward computational modelling on immune system function

AbstractThe 2nd Computational Methods for the Immune System function Workshop has been held in Madrid in conjunction with the IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2018) in Madrid, Spain, from December 3 to 6, 2018. The workshop has been obtained 100% more submissions in respect to the first edition, highlighting a growing interest for the treated topics. The best papers (9) have been selected for extension in this special issue, with themes about immune system and disease simulation, computer-aided design of novel candidate vaccines, methods for the analysis of immune system involved diseases based on statistical methods, meta-heuristics and game theory, and modelling strategies for improving the simulation of the immune system dynamics.

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Toward computational modelling on immune system function

BMC Bioinformatics ◽

10.1186/s12859-020-03897-5 ◽

2020 ◽

Vol 21 (S17) ◽

Author(s):

Francesco Pappalardo ◽

Giulia Russo ◽

Pedro A. Reche

Keyword(s):

Immune System ◽

Brain Injuries ◽

Computational Modelling ◽

System Function ◽

T Cell Epitopes ◽

Immune System Function ◽

In Silico Modeling ◽

International Conference On Bioinformatics ◽

Full Day

AbstractThe 3rd edition of the computational methods for the immune system function workshop has been held in San Diego, CA, in conjunction with the IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2019) from November 18 to 21, 2019. The workshop has continued its growing tendency, with a total of 18 accepted papers that have been presented in a full day workshop. Among these, the best 10 papers have been selected and extended for presentation in this special issue. The covered topics range from computer-aided identification of T cell epitopes to the prediction of heart rate variability to prevent brain injuries, from In Silico modeling of Tuberculosis and generation of digital patients to machine learning applied to predict type-2 diabetes risk.

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EFFECT OF PETTING A DOG ON IMMUNE SYSTEM FUNCTION

Psychological Reports ◽

10.2466/pr0.95.7.1087-1091 ◽

2004 ◽

Vol 95 (7) ◽

pp. 1087 ◽

Cited By ~ 14

Author(s):

CARL J. CHARNETSKI

Keyword(s):

Immune System ◽

System Function ◽

Immune System Function

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Advances in Engineering Graphics: Improvements and New Proposals

Symmetry ◽

10.3390/sym13050827 ◽

2021 ◽

Vol 13 (5) ◽

pp. 827

Author(s):

José Ignacio Rojas-Sola

Keyword(s):

Computer Animation ◽

Computer Aided Design ◽

Geometric Modeling ◽

Correct Interpretation ◽

Special Issue ◽

Engineering Graphics ◽

Communication Techniques ◽

Graphic Communication ◽

Graphic Language ◽

Aided Design

The study of graphic communication techniques that engineers, architects, and designers use to express ideas and concepts, or the graphic expression applied to the design process, is becoming increasingly important. The correct interpretation of graphic language allows the development of skills in the training of an engineer or architect. For this reason, research on this topic is especially valuable in finding improvements or new proposals that help toward a better understanding of those techniques. This Special Issue shows the reader some examples of different disciplines available, such as engineering graphics, industrial design, geometric modeling, computer-aided design, descriptive geometry, architectural graphics and computer animation.

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Effects of Long-Term Supplementation of Bovine Colostrum on the Immune System in Young Female Basketball Players. Randomized Trial

Nutrients ◽

10.3390/nu13010118 ◽

2020 ◽

Vol 13 (1) ◽

pp. 118

Author(s):

Anna Skarpańska-Stejnborn ◽

Mirosława Cieślicka ◽

Hanna Dziewiecka ◽

Sławomir Kujawski ◽

Anita Marcinkiewicz ◽

...

Keyword(s):

Immune System ◽

Physical Exercise ◽

Exercise Program ◽

Bovine Colostrum ◽

Control Group ◽

System Function ◽

Basketball Players ◽

Immune System Function ◽

Experimental Group

An intensive physical exercise program could lead to a decrease in immune system function. Effects of long-term supplementation of bovine colostrum on the response of immune function on physical exercise test in athletes were examined. Twenty-seven elite female basketball players (age 16–19) were randomly assigned to either an experimental group or a control group. Eventually, n = 11 athletes completed intervention in the experimental group (3.2 g bovine colostrum orally twice a day for 24 weeks), while n = 9 athletes in the control group were given a placebo. Before the supplementation, after 3 and 6 months, subjects performed the physical exercise stress test. Before, just after, and 3 h after physical exercise testing, blood was drawn and immune system indicators were examined. Plasma interleukin (IL)-1alpha, IL-2, IL-10, IL-13, tumor necrosis factor (TNF) alpha, creatine kinase (CK MM), immunoglobulin G (IgG), insulin-like growth factor 1 (IGF1), and WBC, lymphocyte (LYM), monocyte (MON), and granulocyte (GRA) were measured. A statistically significant change in IL-10 in response to the exercise program during the supplementation period in both groups was observed (p = 0.01). However, the results of the rest of the comparisons were statistically insignificant (p > 0.05). Contrary to our initial hypothesis, there were no significant effects of bovine supplementation on the dynamics of immune system function indicators.

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Physical exercise and immune system function in cancer survivors

Cancer ◽

10.1002/cncr.10244 ◽

2002 ◽

Vol 94 (2) ◽

pp. 539-551 ◽

Cited By ~ 91

Author(s):

Adrian S. Fairey ◽

Kerry S. Courneya ◽

Catherine J. Field ◽

John R. Mackey

Keyword(s):

Immune System ◽

Physical Exercise ◽

Cancer Survivors ◽

System Function ◽

Immune System Function

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In utero cell transfer between porcine littermates

Reproduction Fertility and Development ◽

10.1071/rd10165 ◽

2011 ◽

Vol 23 (2) ◽

pp. 297 ◽

Cited By ~ 13

Author(s):

Andrea McConico ◽

Kim Butters ◽

Karen Lien ◽

Bruce Knudsen ◽

Xiaosheng Wu ◽

...

Keyword(s):

Immune System ◽

Cord Blood ◽

Normal Pregnancy ◽

Human Cells ◽

Cell Transfer ◽

System Function ◽

Human Cord Blood ◽

Immune System Function ◽

Vascular Connections

Trafficking of cells between mother and fetus during the course of normal pregnancy is well documented. Similarly, cells are known to travel between twins that share either a placenta (i.e. monozygotic) or associated chorion (i.e. monochorionic). Transferred cells are thought to be channelled via the vessels of the placenta or vascular connections established via the chorion and the long-term presence of these cells (i.e. microchimerism) can have important consequences for immune system function and reparative capacity of the host. Whether cells can be transferred between twins with separate placentas and separate chorions (i.e. no vascular connections between placentas) has not been investigated nor have the biological consequences of such a transfer. In the present study, we tested the possibility of this type of cell transfer by injecting human cord blood-derived cells into a portion of the littermates of swine and probing for human cells in the blood and tissues of unmanipulated littermates. Human cells were detected in the blood of 78% of unmanipulated littermates. Human cells were also detected in various tissues of the unmanipulated littermates, including kidney (56%), spleen (33%), thymus (11%) and heart (22%). Human cells were maintained in the blood until the piglets were sacrificed (8 months after birth), suggesting the establishment of long-term microchimerism. Our findings show that the transfer of cells between fetuses with separate placentas and separate chorions is significant and thus such twins may be subject to the same consequences of microchimerism as monozygotic or monochorionic counterparts.

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