scholarly journals Immunomodulatory effects of intraoperative dexmedetomidine on T helper 1, T helper 2, T helper 17 and regulatory T cells cytokine levels and their balance: a prospective, randomised, double-blind, dose-response clinical study

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Jae-Myeong Lee ◽  
Hyo-Jo Han ◽  
Won-Kyu Choi ◽  
Subin Yoo ◽  
Soojin Baek ◽  
...  
Keyword(s):  
T Cells ◽  
Clinical Study ◽  
Dose Response ◽  
T Helper ◽  
Immunomodulatory Effects ◽  
T Helper 1 ◽  
T Helper 17 ◽  
Double Blind ◽  
T Helper 2 ◽  
Cytokine Levels

scholarly journals FOXP3+ Regulatory T Cells and T Helper 1, T Helper 2, and T Helper 17 Cells in Human Early Pregnancy Decidua1

2010 ◽  
Vol 82 (4) ◽  
pp. 698-705 ◽  
Author(s):  
Jenny Mjösberg ◽  
Göran Berg ◽  
Maria C. Jenmalm ◽  
Jan Ernerudh
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Early Pregnancy ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 17 ◽  
T Helper 17 Cells ◽  
T Helper 2

scholarly journals OX40L–OX40 Signaling in Atopic Dermatitis

2021 ◽  
Vol 10 (12) ◽  
pp. 2578
Author(s):  
Masutaka Furue ◽  
Mihoko Furue
Keyword(s):  
T Cells ◽  
Atopic Dermatitis ◽  
Memory T Cells ◽  
Effector Memory ◽  
T Helper ◽  
T Helper 1 ◽  
Therapeutic Success ◽  
T Helper 2 ◽  
Promising Target ◽  
Antigen Presenting

OX40 is one of the co-stimulatory molecules expressed on T cells, and it is engaged by OX40L, primarily expressed on professional antigen-presenting cells such as dendritic cells. The OX40L–OX40 axis is involved in the sustained activation and expansion of effector T and effector memory T cells, but it is not active in naïve and resting memory T cells. Ligation of OX40 by OX40L accelerates both T helper 1 (Th1) and T helper 2 (Th2) effector cell differentiation. Recent therapeutic success in clinical trials highlights the importance of the OX40L–OX40 axis as a promising target for the treatment of atopic dermatitis.

scholarly journals CD4+T Cells: Differentiation and Functions

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Rishi Vishal Luckheeram ◽  
Rui Zhou ◽  
Asha Devi Verma ◽  
Bing Xia
Keyword(s):  
T Cells ◽  
Transcription Factors ◽  
T Cell ◽  
Cytokine Signaling ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 17 ◽  
Differentiated Cells ◽  
Follicular Helper ◽  
Follicular Helper T Cell

CD4+T cells are crucial in achieving a regulated effective immune response to pathogens. Naive CD4+T cells are activated after interaction with antigen-MHC complex and differentiate into specific subtypes depending mainly on the cytokine milieu of the microenvironment. Besides the classical T-helper 1 and T-helper 2, other subsets have been identified, including T-helper 17, regulatory T cell, follicular helper T cell, and T-helper 9, each with a characteristic cytokine profile. For a particular phenotype to be differentiated, a set of cytokine signaling pathways coupled with activation of lineage-specific transcription factors and epigenetic modifications at appropriate genes are required. The effector functions of these cells are mediated by the cytokines secreted by the differentiated cells. This paper will focus on the cytokine-signaling and the network of transcription factors responsible for the differentiation of naive CD4+T cells.

scholarly journals Ratios of T-helper 2 Cells to T-helper 1 Cells and Cytokine Levels in Patients with Hepatitis B

2017 ◽  
Vol 130 (15) ◽  
pp. 1810-1815 ◽  
Author(s):  
Ming-Hui Li ◽  
Dan Zhang ◽  
Lu Zhang ◽  
Xiao-Jing Qu ◽  
Yao Lu ◽  
...  
Keyword(s):  
Hepatitis B ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 2 ◽  
Cytokine Levels ◽  
T Helper 1 Cells

scholarly journals Arginine Enhances Induction of T Helper 1 and T Helper 2 Cytokine Synthesis by Peyer’s Patch αβ T Cells and Antigen-Specific Mucosal Immune Response

1998 ◽  
Vol 62 (12) ◽  
pp. 2334-2340 ◽  
Author(s):  
Toshiya KOBAYASHI ◽  
Masafumi YAMAMOTO ◽  
Takachika HIROI ◽  
Jerry MCGHEE ◽  
Yasuyoshi TAKESHITA ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Mucosal Immune Response ◽  
Peyer’S Patch ◽  
T Helper ◽  
Peyer's Patch ◽  
T Helper 1 ◽  
T Helper 2 ◽  
Cytokine Synthesis ◽  
Αβ T Cells

Regulatory T Cells Suppress Development of Colitis, Blocking Differentiation of T-Helper 17 Into Alternative T-Helper 1 Cells

2011 ◽  
Vol 141 (3) ◽  
pp. 1014-1023 ◽  
Author(s):  
Tomohisa Sujino ◽  
Takanori Kanai ◽  
Yuichi Ono ◽  
Yohei Mikami ◽  
Atsushi Hayashi ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 17 ◽  
T Helper 1 Cells

scholarly journals Comparative Gamma Delta T Cell Immunology: A Focus on Mycobacterial Disease in Cattle

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Brandon L. Plattner ◽  
Jesse M. Hostetter
Keyword(s):  
T Cells ◽  
Host Response ◽  
Γδ T Cells ◽  
Mycobacterial Infection ◽  
T Helper ◽  
Gamma Delta ◽  
T Helper 1 ◽  
T Helper 2 ◽  
Gamma Delta T Cell ◽  
T Cell Immunology

A theme among many pathogenic mycobacterial species affecting both humans and animals is a prolonged asymptomatic or latent period that can last years to decades. The mechanisms that favor progression to active disease are not well understood. Pathogen containment is often associated with an effective cell-mediated or T-helper 1 immune profile. With certain pathogenic mycobacteria, such asMycobacterium aviumsubspeciesparatuberculosis, a shift to active clinical disease is associated with loss of T-helper 1 immunity and development of an ineffective humoral or T-helper 2 immune response. Recently γδ T cells have been shown to play a role early in mycobacterial infections and have been hypothesized to influence disease outcome. The purpose of this paper is to compare recent advancements in our understanding of γδ T cells in humans, cattle, and mice and to discuss roles of γδ T cells in host response to mycobacterial infection.

scholarly journals A Genetic Model Reveals Biological Features of Neonatal CD4 Helper Cells Undergone Homeostasis in Mice

2021 ◽  
Vol 9 ◽  
Author(s):  
Lei Lei ◽  
Xingzhe Zhang ◽  
Xiaofeng Yang ◽  
Yanhong Su ◽  
Haiyan Liu ◽  
...  
Keyword(s):  
T Cells ◽  
Genetic Model ◽  
Lineage Tracing ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 17 ◽  
Th2 Response ◽  
Adult Mice ◽  
Immune Balance ◽  
Adult Cells

CD4+ T cells are essential for regulating effective immune response to pathogens and immune balance. Recent studies have demonstrated the unique features of T cells in neonate mice, such as more sensitive to antigen response and preference toward T helper 2 (Th2) response and regulatory T cells (Tregs) differentiation. However, the biological characteristics of neonatal age-derived CD4+ T cells following homeostasis remain unclear. Here we utilized a lineage tracing model of TCRδCreERR26ZsGreen to mark neonatal- and adult-derived CD4+ T cells followed by a combination analysis of activation, proliferation, survival, and differentiation. Our results showed that neonatal CD4+ T cells had higher capacity of activation, proliferation, apoptosis, and differentiation toward Th2 and T helper 17 (Th17) lineages, accompanied by a reduced potential for T helper 1 (Th1), T helper 9 (Th9), and Treg lineages. In contrast, tracked neonatal CD4+ T cells exhibited similar characters of above-mentioned of tracked adult cells in adult mice. Therefore, our data support a natural requirement for CD4+ T cells to acquire fully-equipped functional potentials of adult cells.

Generation of Human T Helper 1 and T Helper 2 Subsets from Peripheral Blood-Derived Naive CD4+ T Cells

2003 ◽  
pp. 325-335
Author(s):  
Ellen M. Palmer ◽  
Roshanak Tolouei Semnani ◽  
Bradford L. McRae ◽  
Gijs A. van Seventer
Keyword(s):  
T Cells ◽  
Peripheral Blood ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 2
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