Generation of Human T Helper 1 and T Helper 2 Subsets from Peripheral Blood-Derived Naive CD4+ T Cells

2003 ◽  
pp. 325-335
Author(s):  
Ellen M. Palmer ◽  
Roshanak Tolouei Semnani ◽  
Bradford L. McRae ◽  
Gijs A. van Seventer
Keyword(s):  
T Cells ◽  
Peripheral Blood ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 2

scholarly journals OX40L–OX40 Signaling in Atopic Dermatitis

2021 ◽  
Vol 10 (12) ◽  
pp. 2578
Author(s):  
Masutaka Furue ◽  
Mihoko Furue
Keyword(s):  
T Cells ◽  
Atopic Dermatitis ◽  
Memory T Cells ◽  
Effector Memory ◽  
T Helper ◽  
T Helper 1 ◽  
Therapeutic Success ◽  
T Helper 2 ◽  
Promising Target ◽  
Antigen Presenting

OX40 is one of the co-stimulatory molecules expressed on T cells, and it is engaged by OX40L, primarily expressed on professional antigen-presenting cells such as dendritic cells. The OX40L–OX40 axis is involved in the sustained activation and expansion of effector T and effector memory T cells, but it is not active in naïve and resting memory T cells. Ligation of OX40 by OX40L accelerates both T helper 1 (Th1) and T helper 2 (Th2) effector cell differentiation. Recent therapeutic success in clinical trials highlights the importance of the OX40L–OX40 axis as a promising target for the treatment of atopic dermatitis.

scholarly journals FOXP3+ Regulatory T Cells and T Helper 1, T Helper 2, and T Helper 17 Cells in Human Early Pregnancy Decidua1

2010 ◽  
Vol 82 (4) ◽  
pp. 698-705 ◽  
Author(s):  
Jenny Mjösberg ◽  
Göran Berg ◽  
Maria C. Jenmalm ◽  
Jan Ernerudh
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Early Pregnancy ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 17 ◽  
T Helper 17 Cells ◽  
T Helper 2

scholarly journals Arginine Enhances Induction of T Helper 1 and T Helper 2 Cytokine Synthesis by Peyer’s Patch αβ T Cells and Antigen-Specific Mucosal Immune Response

1998 ◽  
Vol 62 (12) ◽  
pp. 2334-2340 ◽  
Author(s):  
Toshiya KOBAYASHI ◽  
Masafumi YAMAMOTO ◽  
Takachika HIROI ◽  
Jerry MCGHEE ◽  
Yasuyoshi TAKESHITA ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Mucosal Immune Response ◽  
Peyer’S Patch ◽  
T Helper ◽  
Peyer's Patch ◽  
T Helper 1 ◽  
T Helper 2 ◽  
Cytokine Synthesis ◽  
Αβ T Cells

Severe immune-related adverse events in anti-PD-1-treated patients are clustered into distinct subtypes by peripheral blood T-cell profiles.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 2564-2564
Author(s):  
Kyung Hwan Kim ◽  
Jinhyun Cho ◽  
Joon Young Hur ◽  
Bo Mi Ku ◽  
Jiae Koh ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Adverse Events ◽  
Peripheral Blood ◽  
Clinical Manifestations ◽  
T Helper ◽  
T Helper 1 ◽  
Ki 67 ◽  
Epithelial Tumor ◽  
Color Flow

2564 Background: Although anti-programmed death-1 (PD-1) treatment has shown remarkable anti-tumor efficacy, immune-related adverse events (irAEs) develop with heterogeneous clinical manifestations. Immunological understanding of irAEs is currently limited. In the present study, we analyzed peripheral blood T cells obtained from cancer patients who received anti-PD-1 treatment to determine the immunological characteristics of severe irAEs. Methods: This study included 31 patients with refractorythymic epithelial tumor (TET) who were enrolled in a phase II trial of pembrolizumab (NCT02607631) and 60 patients with metastatic non-small cell lung cancer (NSCLC) who received pembrolizumab or nivolumab. T-cell profiling was performed by multi-color flow cytometry using peripheral blood obtained immediately before treatment and 7 days after the first dose of anti-PD-1 antibodies. Results: Severe irAEs (≥ grade 3) occurred in 7 TET patients (22.6%) and 6 NSCLC patients (10.0%). Patients with severe irAEs exhibited a significantly lower fold increase in the frequency of effector regulatory T (eTreg) cells after anti-PD-1 treatment, higher ratio of T helper-17 (Th17) and T helper-1 cells at baseline, and higher percentage of Ki-67+cells among PD-1+CD8+T cells post-treatment. In clustering analysis, patients with severe irAEs were grouped into four distinct subtypes: Th17-related, TNF-related,Treg-related, and CD8-related. Conclusions: Severe irAEs after anti-PD-1 treatment were clustered into four immunological subtypes, indicating that development of severe irAEs is not attributed to a single mechanism. Further investigations in larger cohorts are needed to validate our current findings.

scholarly journals Comparative Gamma Delta T Cell Immunology: A Focus on Mycobacterial Disease in Cattle

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Brandon L. Plattner ◽  
Jesse M. Hostetter
Keyword(s):  
T Cells ◽  
Host Response ◽  
Γδ T Cells ◽  
Mycobacterial Infection ◽  
T Helper ◽  
Gamma Delta ◽  
T Helper 1 ◽  
T Helper 2 ◽  
Gamma Delta T Cell ◽  
T Cell Immunology

A theme among many pathogenic mycobacterial species affecting both humans and animals is a prolonged asymptomatic or latent period that can last years to decades. The mechanisms that favor progression to active disease are not well understood. Pathogen containment is often associated with an effective cell-mediated or T-helper 1 immune profile. With certain pathogenic mycobacteria, such asMycobacterium aviumsubspeciesparatuberculosis, a shift to active clinical disease is associated with loss of T-helper 1 immunity and development of an ineffective humoral or T-helper 2 immune response. Recently γδ T cells have been shown to play a role early in mycobacterial infections and have been hypothesized to influence disease outcome. The purpose of this paper is to compare recent advancements in our understanding of γδ T cells in humans, cattle, and mice and to discuss roles of γδ T cells in host response to mycobacterial infection.

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