scholarly journals Comparative Gamma Delta T Cell Immunology: A Focus on Mycobacterial Disease in Cattle

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Brandon L. Plattner ◽  
Jesse M. Hostetter

A theme among many pathogenic mycobacterial species affecting both humans and animals is a prolonged asymptomatic or latent period that can last years to decades. The mechanisms that favor progression to active disease are not well understood. Pathogen containment is often associated with an effective cell-mediated or T-helper 1 immune profile. With certain pathogenic mycobacteria, such asMycobacterium aviumsubspeciesparatuberculosis, a shift to active clinical disease is associated with loss of T-helper 1 immunity and development of an ineffective humoral or T-helper 2 immune response. Recently γδ T cells have been shown to play a role early in mycobacterial infections and have been hypothesized to influence disease outcome. The purpose of this paper is to compare recent advancements in our understanding of γδ T cells in humans, cattle, and mice and to discuss roles of γδ T cells in host response to mycobacterial infection.

2021 ◽  
Vol 10 (12) ◽  
pp. 2578
Author(s):  
Masutaka Furue ◽  
Mihoko Furue

OX40 is one of the co-stimulatory molecules expressed on T cells, and it is engaged by OX40L, primarily expressed on professional antigen-presenting cells such as dendritic cells. The OX40L–OX40 axis is involved in the sustained activation and expansion of effector T and effector memory T cells, but it is not active in naïve and resting memory T cells. Ligation of OX40 by OX40L accelerates both T helper 1 (Th1) and T helper 2 (Th2) effector cell differentiation. Recent therapeutic success in clinical trials highlights the importance of the OX40L–OX40 axis as a promising target for the treatment of atopic dermatitis.


2010 ◽  
Vol 82 (4) ◽  
pp. 698-705 ◽  
Author(s):  
Jenny Mjösberg ◽  
Göran Berg ◽  
Maria C. Jenmalm ◽  
Jan Ernerudh

1998 ◽  
Vol 62 (12) ◽  
pp. 2334-2340 ◽  
Author(s):  
Toshiya KOBAYASHI ◽  
Masafumi YAMAMOTO ◽  
Takachika HIROI ◽  
Jerry MCGHEE ◽  
Yasuyoshi TAKESHITA ◽  
...  

2003 ◽  
pp. 325-335
Author(s):  
Ellen M. Palmer ◽  
Roshanak Tolouei Semnani ◽  
Bradford L. McRae ◽  
Gijs A. van Seventer

Animals ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3594
Author(s):  
Petr Slama ◽  
Terezie Zavadilova ◽  
Ales Pavlik ◽  
Pavel Horky ◽  
Sylvie Skalickova ◽  
...  

In this study, we focused analyzing γδ T cells during bovine mammary gland inflammation induced by Streptococcus uberis. A mammary gland cell suspension was obtained using lavage 24, 48, 72, and 168 h after intramammary-induced infection. The proportion of lymphocytes increased during the entire week in which inflammation was present. The γδ T cells were also elevated during inflammation, reaching their peak at 72 h following induced inflammation. The percentage of apoptotic lymphocytes continually increased, with the highest proportion occurring 168 h after S. uberis infection. The results show that γδ T cells may be involved in the resolution of inflammation in bovine mammary glands, with the apoptosis of those cells potentially playing an important role.


Cytokine ◽  
2009 ◽  
Vol 48 (1-2) ◽  
pp. 118
Author(s):  
Laura Pontecorvo ◽  
Eugenio Stabile ◽  
Leopoldo Laricchia-Robbio ◽  
Giuseppe Rosano ◽  
Andrea la Sala

2019 ◽  
Vol 10 ◽  
Author(s):  
Perrine Bohner ◽  
Mathieu F. Chevalier ◽  
Valérie Cesson ◽  
Sonia-Christina Rodrigues-Dias ◽  
Florence Dartiguenave ◽  
...  

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