scholarly journals Predictors of acute cardiovascular events following acute exacerbation period for patients with COPD: a nested case–control study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Wei-ping Hu ◽  
Tsokyi Lhamo ◽  
Feng-ying Zhang ◽  
Jing-qing Hang ◽  
Yi-hui Zuo ◽  
...  
Keyword(s):  
Acute Exacerbation ◽  
Cardiovascular Events ◽  
Case Control Study ◽  
Case Control ◽  
Left Ventricular ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Coronary Syndrome ◽  
Nested Case Control ◽  
Control Study

Abstract Background It has been noted that there is an increase in the incidence of acute cardiovascular events (CVEs) in patients with chronic obstructive pulmonary disease (COPD) during an acute exacerbation (AE), thereby causing increased inpatient mortality. Thus, we have tried to identify predictors of acute CVEs in patients with AECOPD via a nested case–control study. Methods A total of 496 cases hospitalized for AECOPD were included in this study, and followed-up for up to 6 months after discharge. Acute CVEs in the AE period were defined as a new or worsening acute coronary syndrome (ACS), arrhythmia, or left ventricular disfunction (LVD). Predictors of CVEs were selected from several variables, including baseline characteristics and treatments in the stable period as well as symptoms, laboratory tests, complications and treatments in the AE period. Results Thirty cases (6.05%) had acute CVEs, namely 2 had ACS, 13 had LVD and 19 experienced some form of arrhythmia. Four deaths were observed in the CVE group, with significantly increased death risk compared with the non-CVE group (P = 0.001, OR = 5.81). Moreover, patients who had CVEs were more prone to have re-exacerbation within 3 months. Multivariate analysis showed that previous LVD history (P = 0.004, OR = 5.06), 20% increase in heart rate (HR) (P = 0.003, OR = 10.19), electrolyte disturbance (P = 0.01, OR = 4.24) and diuretics (P = 0.002, OR = 6.37) were independent predictors of CVEs. In addition, usage of theophylline, fluoroquinolone and inhaled beta agonists in the AE period were not statistically associated with acute CVEs. Conclusions Our preliminary study indicates that patients hospitalized for AECOPD with previous LVD history or increased HR need close observation and diuretics should be cautiously used with regular electrolyte monitoring. These findings need to be confirmed in a large cohort.

scholarly journals Predictors of acute cardiovascular events following acute exacerbation period for patients with COPD: a nested case-control study

2020 ◽  
Author(s):  
Weiping Hu ◽  
Tsokyi Lhamo ◽  
Feng-ying Zhang ◽  
Jing-qing Hang ◽  
Yi-hui Zuo ◽  
...  
Keyword(s):  
Acute Exacerbation ◽  
Cardiovascular Events ◽  
Case Control Study ◽  
Case Control ◽  
Left Ventricular ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Coronary Syndrome ◽  
Nested Case Control ◽  
Control Study

Abstract BackgroundFor patients with chronic obstructive pulmonary disease (COPD), the incidence of acute cardiovascular events (CVEs) increases during acute exacerbation (AE) period, causing increased inpatient mortality. Thus, we try to identify predictors of acute CVEs in patients with AECOPD via a nested case-control study.MethodsA total of 496 cases hospitalized for AECOPD were included into analysis, and followed-up for 6 months after discharge. Acute CVEs in the AE period were defined as the new or worsening acute coronary syndrome (ACS), arrhythmia, left ventricular disfunction (LVD). Predictors were selected from several variables, including baseline characteristics and treatments in the stable period as well as symptoms, laboratory tests, complications and treatments in the AE period.ResultsThirty cases (6.05%) had acute CVEs, including 2 with ACS, 13 with LVD and 19 with arrhythmia. Four deaths were observed in the CVE group, with significantly increased death risk compared with the non-CVE group (P=0.001, OR=5.81). Moreover, patients who have had CVEs were vulnerable to have re-exacerbation within 3 months. Multivariate analysis showed that previous LVD history (P=0.004, OR=5.06), 20% increase in heart rate (HR) (P=0.003, OR= 10.19), electrolyte disturbance (P=0.01, OR= 4.24) and diuretics (P=0.002, OR = 6.37) were independent predictors. In addition, usage of theophylline, fluoroquinolone and inhaled beta agonists in the AE period were not statistically associated with acute CVEs.ConclusionsOur study preliminarily indicated that patients hospitalized for AECOPD with previous LVD history or increased HR need close observation and diuretics should be cautiously used with electrolyte monitoring. These findings needs to be confirmed in a large cohort.

scholarly journals Predictors of acute cardiovascular events following acute exacerbation period for patients with COPD: a nested case-control study

2020 ◽  
Author(s):  
Weiping Hu ◽  
Tsokyi Lhamo ◽  
Feng-ying Zhang ◽  
Jing-qing Hang ◽  
Yi-hui Zuo ◽  
...  
Keyword(s):  
Acute Exacerbation ◽  
Cardiovascular Events ◽  
Case Control Study ◽  
Case Control ◽  
Left Ventricular ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Coronary Syndrome ◽  
Nested Case Control ◽  
Control Study

Abstract Background It has been noted that there is an increase in the incidence of acute cardiovascular events (CVEs) in patients with chronic obstructive pulmonary disease (COPD) during an acute exacerbation (AE) , thereby causing increased inpatient mortality. Thus, we have tried to identify predictors of acute CVEs in patients with AECOPD via a nested case-control study.Methods A total of 496 cases hospitalized for AECOPD were included in this study, and followed-up for up to 6 months after discharge. Acute CVEs in the AE period were defined as a new or worsening acute coronary syndrome (ACS), arrhythmia, left ventricular disfunction (LVD). Predictors of CVEs were selected from several variables, including baseline characteristics and treatments in the stable period as well as symptoms, laboratory tests, complications and treatments in the AE period. Results Thirty cases (6.05%) had acute CVEs, namely 2 had ACS, 13 had LVD and 19 experienced some form of arrhythmia. Four deaths were observed in the CVE group, with significantly increased death risk compared with the non-CVE group (P=0.001, OR=5.81). Moreover, patients who had CVEs were more prone to have re-exacerbation within 3 months. Multivariate analysis showed that previous LVD history (P=0.004, OR=5.06), 20% increase in heart rate (HR) (P=0.003, OR= 10.19), electrolyte disturbance (P=0.01, OR= 4.24) and diuretics (P=0.002, OR = 6.37) were independent predictors of CVEs. In addition, usage of theophylline, fluoroquinolone and inhaled beta agonists in the AE period were not statistically associated with acute CVEs. Conclusions Our preliminary study indicates that patients hospitalized for AECOPD with previous LVD history or increased HR need close observation and diuretics should be cautiously used with regular electrolyte monitoring. These findings need to be confirmed in a large cohort.

scholarly journals Risk factors of acute cardiovascular events following acute exacerbation period for patients with COPD: a nested case-control study

2020 ◽  
Author(s):  
Weiping Hu ◽  
Tsokyi Lhamo ◽  
Feng-ying Zhang ◽  
Jing-qing Hang ◽  
Yi-hui Zuo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Exacerbation ◽  
Cardiovascular Events ◽  
Case Control Study ◽  
Case Control ◽  
Left Ventricular ◽  
Chronic Obstructive ◽  
Coronary Syndrome ◽  
Nested Case Control ◽  
Control Study

Abstract Background For patients with chronic obstructive pulmonary disease (COPD), the incidence of acute cardiovascular events (CVEs) increases during acute exacerbation (AE) period, causing increased inpatient mortality. Thus, we try to identify risk factors of acute CVEs in patients with AECOPD via a nested case-control study.Methods A total of 496 cases hospitalized for AECOPD were included into analysis, and followed-up for 6 months after discharge. Acute CVEs in the AE period were defined as the new or worsening acute coronary syndrome (ACS), arrhythmia, left ventricular disfunction (LVD). Risk factors were selected from several variables, including baseline characteristics and treatments in the stable period as well as symptoms, laboratory tests, complications and treatments in the AE period. Results Thirty cases (6.05%) had acute CVEs, including 2 with ACS, 13 with LVD, 19 with arrhythmia, and 4 deaths, with significantly increased mortality risk (P=0.001, OR=5.81). Moreover, patients who have had CVEs were inclined to have re-exacerbation within 3 months. Multivariate analysis showed that previous LVD history (P=0.004, OR=5.06), 20% increase in heart rate (HR) (P=0.003, OR= 10.19), electrolyte disturbance (P=0.01, OR= 4.24) and diuretics (P=0.002, OR = 6.37) were independent risk factors. In addition, usage of theophylline, fluoroquinolone and inhaled beta agonists in the AE period were not statistically associated with acute CVEs. Conclusions Our study preliminarily indicated that patients hospitalized for AECOPD with previous LVD history or increased HR need close observation and diuretics should be cautiously used with electrolyte monitoring. These findings needs to be confirmed in a large cohort.

scholarly journals Chronic Obstructive Pulmonary Disease and Incidence of Hip Fracture: A Nested Case–Control Study in the EpiChron Cohort

2020 ◽  
Vol Volume 15 ◽  
pp. 2799-2806
Author(s):  
Jesús Díez-Manglano ◽  
María Berges Vidal ◽  
Lucía Martínez Barredo ◽  
Beatriz Poblador-Plou ◽  
Antonio Gimeno-Miguel ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Hip Fracture ◽  
Pulmonary Disease ◽  
Case Control Study ◽  
Case Control ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Nested Case Control ◽  
Control Study

scholarly journals Major comorbidities lead to the risk of adverse cardiovascular events in chronic obstructive pulmonary disease patients using inhaled long-acting bronchodilators: a case-control study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Yen-Fu Chen ◽  
Yi-Ching Cheng ◽  
Chien-Hong Chou ◽  
Chung-Yu Chen ◽  
Chong-Jen Yu
Keyword(s):  
Cardiovascular Events ◽  
Case Control Study ◽  
Case Control ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
History Of ◽  
Long Acting ◽  
Control Study ◽  
Related Mortality

Abstract Background While inhaled bronchodilators reduce symptoms and acute exacerbations of chronic obstructive pulmonary disease (COPD), their use is associated with increased cardiovascular events in some studies. This study investigates the risk of adverse events associated with the use of inhaled bronchodilators in COPD patients with multimorbidity. Methods A case-control study was conducted between January 2015 and December 2017, and patients with spirometry-confirmed diagnosis of COPD (N = 1565) using inhaled long-acting bronchodilators were enrolled. Medical records were reviewed and clinical data, including age, gender, smoking status, major comorbidities, lung function stage, history of exacerbations, bronchodilator regimens, and treatment duration were analyzed. Major adverse cardiovascular events occurring during long-acting bronchodilator use were recorded. Results The most common comorbidities were cardiovascular disease (CVD) (53.6%) and chronic kidney disease (CKD) (25.8%). We observed that CVD (odds ratio [OR], 5.77), CKD (OR, 2.02) and history of frequent exacerbations (OR, 2.37) were independent risk factors for cardiovascular events, regardless of the type of bronchodilators use. Moreover, COPD patients with both CKD and CVD had higher risk (6.32-fold) of adverse cardiovascular effects than those with neither comorbidity. Eighty-seven of 1565 (5.56%) COPD patients died during this study period. Of them, 21.8% (19/87) were cardiovascular-related and 73.6% (64/87) patients were respiratory-related mortality. Among COPD patients using long-acting bronchodilators, CKD was the only risk factor to predict cardiovascular events and cardiovascular-related mortality (OR, 4.87; 95% confidence interval [CI], 1.75–13.55]. Conclusions COPD patients had higher risk of cardiovascular events were associated with their CVD and/or CKD comorbidities and history of frequent exacerbations, rather than associated with their use of inhaled bronchodilators.

Relationship between glycemic control and chronic obstructive pulmonary disease in patients with type 2 diabetes: A nested case-control study

2020 ◽  
Vol 14 (6) ◽  
pp. 729-735
Author(s):  
Tasmania del Pino-Sedeño ◽  
Beatriz González de León ◽  
Elías Fernando Pérez Martín ◽  
Anna María Martín Gandolfo ◽  
Marcos Estupiñán Ramírez ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Chronic Obstructive Pulmonary Disease ◽  
Glycemic Control ◽  
Case Control Study ◽  
Case Control ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Nested Case Control ◽  
Control Study
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