Does the combination of resistance training and a nutritional intervention have a synergic effect on muscle mass, strength, and physical function in older adults? A systematic review and meta-analysis

Abstract Background Health-promoting interventions are important for preventing frailty and sarcopenia in older adults. However, there is limited evidence that nutritional interventions yield additional effects when combined with resistance training. This systematic review and meta-analysis aimed to compare the effectiveness of nutritional interventions with resistance training and that of resistance training alone. Methods Randomized controlled trials published in peer-reviewed journals prior to July 2020 were retrieved from databases and other sources. The articles were screened according to the inclusion and exclusion criteria. The methodological quality of the included studies was assessed using Cochrane’s risk of bias tool 2. A meta-analysis was performed using the RevMan 5.4 program and STATA 16 program. Results A total of 22 studies were included in the meta-analysis. The results of the meta-analysis showed no significant differences between groups in muscle mass, muscle strength, or physical functional performance. In the subgroup analysis regarding the types of nutritional interventions, creatine showed significant effects on lean body mass (n = 4, MD 2.61, 95% CI 0.51 to 4.72). Regarding the other subgroup analyses, there were no significant differences in appendicular skeletal muscle mass (p = .43), hand grip strength (p = .73), knee extension strength (p = .09), chair stand test results (p = .31), or timed up-and-go test results (p = .31). In the meta-regression, moderators such as the mean age of subjects and duration of interventions were not associated with outcome variables. Conclusions This meta-analysis showed that nutritional interventions with resistance training have no additional effect on body composition, muscle strength, or physical function. Only creatine showed synergistic effects with resistance training on muscle mass. Trial registration CRD42021224843.

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Does the Combination of Resistance Training and A Nutritional Intervention Have A Synergic Effect on Muscle Mass, Strength, and Physical Function in Older Adults? A Systematic Review and Meta-Analysis

10.21203/rs.3.rs-596096/v1 ◽

2021 ◽

Author(s):

MoonKi Choi ◽

Hayeon Kim ◽

Juyeon Bae

Keyword(s):

Systematic Review ◽

Older Adults ◽

Resistance Training ◽

Physical Function ◽

Lean Body Mass ◽

Muscle Mass ◽

Meta Analysis ◽

Nutritional Intervention ◽

Test Results ◽

Nutritional Interventions

Abstract Background: Health-promoting interventions are important to prevent frailty and sarcopenia in older adults. However, there is limited evidence that nutritional interventions yield additional effects when combined with resistance training. This systematic review and meta-analysis aimed to compare the effectiveness of nutritional interventions with resistance training and that of resistance training only.Methods: Randomized controlled trials published in peer-reviewed journals prior to July 2020 were retrieved from databases and other sources. The articles were screened according to the inclusion and exclusion criteria. The methodological quality of the included studies was assessed using Cochrane’s risk of bias tool 2. A meta-analysis was performed using the RevMan 5.4 program.Results: A total of 26 studies were included in the meta-analysis. The results of the meta-analysis showed no significant differences between groups in lean body mass, appendicular skeletal muscle mass, hand grip strength, knee extension, chair stand test results, or the timed up-and-go test results. In the subgroup analysis regarding the types of nutritional interventions, creatine showed significant effects on lean body mass (n=3, MD 2.96, CI 0.76 to 5.16). Regarding the other subgroup analyses, there were no significant differences in the mean age or sex of the participants, type of nutritional intervention, or duration of intervention.Conclusions: This meta-analysis showed that the addition of nutritional interventions to resistance training has no additional effect on body composition, muscle strength, or physical function. Only creatine showed synergistic effects with resistance training on muscle mass.Trial RegistrationCRD42021224843

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Effects of vibration therapy on muscle mass, muscle strength and physical function in older adults with sarcopenia: a systematic review and meta-analysis

European Review of Aging and Physical Activity ◽

10.1186/s11556-020-00247-5 ◽

2020 ◽

Vol 17 (1) ◽

Author(s):

Shuang Wu ◽

Hong-Ting Ning ◽

Su-Mei Xiao ◽

Ming-Yue Hu ◽

Xin-Yin Wu ◽

...

Keyword(s):

Systematic Review ◽

Older Adults ◽

Muscle Strength ◽

Physical Function ◽

Muscle Mass ◽

Meta Analysis ◽

Whole Body Vibration ◽

Whole Body ◽

Local Vibration ◽

Vibration Therapy

Abstract Background Sarcopenia, a progressive loss of muscle mass and function with advancing age, is a prevalent condition among older adults. As most older people are too frail to do intensive exercise and vibration therapy has low risk and ease of participation, it may be more readily accepted by elderly individuals. However, it remains unclear whether vibration therapy would be effective among older adults with sarcopenia. This systematic review and meta-analysis examined the effect of vibration therapy including local vibration therapy and whole-body vibration therapy, for enhancing muscle mass, muscle strength and physical function in older people with sarcopenia. Methods A systematic literature search was conducted in March 2019 in the following 5 electronic databases: PubMed, CINAHL, Embase, PEDro, and the Cochrane Central Register of Controlled Trials, with no restriction of language or the year of publication. Randomized controlled trials and quasi-experimental studies examining effects of vibration therapy on muscle mass, muscle strength or physical function in older adults with sarcopenia were included in this systematic review. Two reviewers independently assessed the methodological quality of the selected studies. Results Of the 1972 identified studies, seven publications from six studies involving 223 participants were included in this systematic review. Five of them conducted whole-body vibration therapy, while two conducted local vibration therapy. A meta-analysis of randomized controlled studies indicated that muscle strength significantly increased after whole-body vibration therapy (SMD 0.69, 95% CI 0.28 to 1.11, I2 = 0%, P = 0.001) and local vibration therapy (SMD 3.78, 95% CI 2.29 to 5.28, P < 0.001). Physical performance measured by the sit-to-stand test and the timed-up-and-go test were significantly improved after the intervention (SMD -0.79, 95% CI − 1.21 to − 0.37, I2 = 0%, P < 0.001) and SMD -0.83, 95% CI − 1.56 to − 0.11, I2 = 64%, P = 0.02, respectively). Conclusion Vibration therapy could be a prospective strategy for improving muscle strength and physical performance in older adults with sarcopenia. However, due to the limited number of the included studies, caution is needed when interpreting these results. More well-designed, large sample size studies should be conducted to further explore and validate the benefits of vibration therapy for this population.

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Effectiveness of resistance training on muscle strength and physical function in people with Parkinson’s disease: a systematic review and meta-analysis

Clinical Rehabilitation ◽

10.1177/0269215515570381 ◽

2015 ◽

Vol 30 (1) ◽

pp. 11-23 ◽

Cited By ~ 35

Author(s):

Chloe Lau Ha Chung ◽

Shamala Thilarajah ◽

Dawn Tan

Keyword(s):

Systematic Review ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Resistance Training ◽

Muscle Strength ◽

Physical Function ◽

Meta Analysis

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Resistance Training with Blood Flow Restriction Compared to Traditional Resistance Training on Strength and Muscle Mass in Non-Active Older Adults: A Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph182111441 ◽

2021 ◽

Vol 18 (21) ◽

pp. 11441

Author(s):

Darío Rodrigo-Mallorca ◽

Andrés Felipe Loaiza-Betancur ◽

Pablo Monteagudo ◽

Cristina Blasco-Lafarga ◽

Iván Chulvi-Medrano

Keyword(s):

Systematic Review ◽

Older Adults ◽

Blood Flow ◽

Resistance Training ◽

Muscle Mass ◽

High Intensity ◽

Meta Analysis ◽

Small Sample ◽

Blood Flow Restriction ◽

Flow Restriction

Low-intensity training with blood flow restriction (LI-BFR) has been suggested as an alternative to high-intensity resistance training for the improvement of strength and muscle mass, becoming advisable for individuals who cannot assume such a load. The systematic review aimed to determine the effectiveness of the LI-BFR compared to dynamic high-intensity resistance training on strength and muscle mass in non-active older adults. A systematic review was conducted according to the Cochrane Handbook and reportedly followed the PRISMA statement. MEDLINE, EMBASE, Web of Science Core Collection, and Scopus databases were searched between September and October 2020. Two reviewers independently selected the studies, extracted data, assessed the risk of bias and the quality of evidence using the GRADE approach. Twelve studies were included in the qualitative synthesis. Meta-analysis pointed out significant differences in maximal voluntary contraction (MVC): SMD 0.61, 95% CI [0.10, 1.11], p = 0.02, I2 71% p < 0.0001; but not in the repetition maximum (RM): SMD 0.07, 95% CI [−0.25, 0.40], p = 0.66, I2 0% p < 0.53; neither in the muscle mass: SMD 0.62, 95% CI [−0.09, 1.34], p = 0.09, I2 59% p = 0.05. Despite important limitations such as scarce literature regarding LI-BFR in older adults, the small sample size in most studies, the still differences in methodology and poor quality in many of them, this systematic review and meta-analysis revealed a positive benefit in non-active older adults. LI- BFR may induce increased muscular strength and muscle mass, at least at a similar extent to that in the traditional high-intensity resistance training.

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The effects of resistance training with blood flow restriction on muscle strength, muscle hypertrophy and functionality in patients with osteoarthritis and rheumatoid arthritis: A systematic review with meta-analysis

PLoS ONE ◽

10.1371/journal.pone.0259574 ◽

2021 ◽

Vol 16 (11) ◽

pp. e0259574

Author(s):

Leonardo Peterson dos Santos ◽

Rafaela Cavalheiro do Espírito Santo ◽

Thiago Rozales Ramis ◽

Juliana Katarina Schoer Portes ◽

Rafael Mendonça da Silva Chakr ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Systematic Review ◽

Blood Flow ◽

Resistance Training ◽

Muscle Strength ◽

Muscle Mass ◽

Meta Analysis ◽

Blood Flow Restriction ◽

Flow Restriction ◽

Low Intensity

Introduction Rheumatoid arthritis(RA) and osteoarthritis(OA) patients showed systemic manifestations that may lead to a reduction in muscle strength, muscle mass and, consequently, to a reduction in functionality. On the other hand, moderate intensity resistance training(MIRT) and high intensity resistance training(HIRT) are able to improve muscle strength and muscle mass in RA and OA without affecting the disease course. However, due to the articular manifestations caused by these diseases, these patients may present intolerance to MIRT or HIRT. Thus, the low intensity resistance training combined with blood flow restriction(LIRTBFR) may be a new training strategy for these populations. Objective To perform a systematic review with meta-analysis to verify the effects of LIRTBFR on muscle strength, muscle mass and functionality in RA and OA patients. Materials and methods A systematic review with meta-analysis of randomized clinical trials(RCTs), published in English, between 1957–2021, was conducted using MEDLINE(PubMed), Embase and Cochrane Library. The methodological quality was assessed using Physiotherapy Evidence Database scale. The risk of bias was assessed using RoB2.0. Mean difference(MD) or standardized mean difference(SMD) and 95% confidence intervals(CI) were pooled using a random-effects model. A P<0.05 was considered statistically significant. Results Five RCTs were included. We found no significant differences in the effects between LIRTBFR, MIRT and HIRT on muscle strength, which was assessed by tests of quadriceps strength(SMD = -0.01[-0.57, 0.54], P = 0.96; I² = 58%) and functionality measured by tests with patterns similar to walking(SMD = -0.04[-0.39, 0.31], P = 0.82; I² = 0%). Compared to HIRT, muscle mass gain after LIRTBFR was reported to be similar. When comparing LIRTBFR with low intensity resistance training without blood flow restriction(LIRT), the effect LIRTBFR was reported to be higher on muscle strength, which was evaluated by the knee extension test. Conclusion LIRTBFR appears to be a promising strategy for gains in muscle strength, muscle mass and functionality in a predominant sample of RA and OA women.

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Exercise Programs for Muscle Mass, Muscle Strength and Physical Performance in Older Adults with Sarcopenia: A Systematic Review and Meta-Analysis

Aging and Disease ◽

10.14336/ad.2019.1012 ◽

2020 ◽

Vol 11 (4) ◽

pp. 863

Author(s):

Wangxiao Bao ◽

Yun Sun ◽

Tianfang Zhang ◽

Liliang Zou ◽

Xiaohong Wu ◽

...

Keyword(s):

Systematic Review ◽

Older Adults ◽

Muscle Strength ◽

Muscle Mass ◽

Physical Performance ◽

Meta Analysis ◽

Exercise Programs

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The Impact of Dairy Protein Intake on Muscle Mass, Muscle Strength, and Physical Performance in Middle-Aged to Older Adults with or without Existing Sarcopenia: A Systematic Review and Meta-Analysis

Advances in Nutrition ◽

10.1093/advances/nmy065 ◽

2019 ◽

Vol 10 (1) ◽

pp. 59-69 ◽

Cited By ~ 25

Author(s):

Nivine I Hanach ◽

Fiona McCullough ◽

Amanda Avery

Keyword(s):

Systematic Review ◽

Older Adults ◽

Muscle Strength ◽

Muscle Mass ◽

Physical Performance ◽

Protein Intake ◽

Meta Analysis ◽

Middle Aged ◽

Dairy Protein ◽

The Impact

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Nutritional interventions for the management of frailty in older adults: systematic review and meta-analysis of randomized clinical trials

Nutrition Reviews ◽

10.1093/nutrit/nuaa101 ◽

2020 ◽

Author(s):

Mariana B de Moraes ◽

Christina Avgerinou ◽

Fernanda B Fukushima ◽

Edison I O Vidal

Keyword(s):

Systematic Review ◽

Older Adults ◽

Muscle Strength ◽

Older People ◽

Meta Analysis ◽

Nutritional Supplements ◽

Cochrane Central Register ◽

Nutritional Education ◽

Nutritional Interventions ◽

Meta Analyses

Abstract Context Although nutrition is considered an important intervention for the management of frailty, the actual effectiveness of interventions addressing nutrition in frail older people remains unclear. Objective The aim for this systematic review was to appraise the evidence regarding the effectiveness of nutritional interventions for the management of frailty in older adults. Data Extraction We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature, Cochrane Central Register of Controlled Trials, Web of Science, and Latin American and Caribbean Health Sciences Literature databases were searched from January 2001 to November 2019. Two independent reviewers extracted relevant data. From 2370 initial records, 19 publications presenting data from 17 studies (1564 individuals; follow-up: 7–96 weeks) were included. Data Analysis None of the Bayesian random-effects meta-analyses comparing nutritional supplements with placebo regarding mortality, body mass index, weight, frailty status, muscle strength, gait speed, body composition, and cognitive function showed statistically significant differences. The same applies to a single meta-analysis comparing nutritional education with general health advice regarding muscle strength. Conclusion Our results suggest, mostly with low to very low degrees of certainty, that nutritional supplements or nutritional education delivered in isolation may not be effective for the management of frailty in older people. Review registration number CRD42018111510 (PROSPERO).

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