scholarly journals A rare case of adult herpes simplex encephalitis complicated with rhabdomyolysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Qinwei Yu ◽  
Chao Han ◽  
Lei Pei ◽  
Jinsha Huang ◽  
Yan Xu ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Herpes Simplex ◽  
Rare Case ◽  
Viral Encephalitis ◽  
Creatine Phosphokinase ◽  
Herpes Simplex Encephalitis ◽  
Careful Analysis ◽  
Case Presentation ◽  
Blood Examination ◽  
Simplex Virus

Abstract Background Compelling evidence indicates that status epilepticus is a prevalent cause of rhabdomyolysis. However, cases of rhabdomyolysis induced by a single seizure accompanied by viral encephalitis are rarely reported. Herein, we present a case of adult Herpes Simplex Encephalitis complicated with rhabdomyolysis. Case presentation A 32-year-old male was patient presented with fever accompanied by episodes of convulsions, myalgia, and oliguria, which exacerbated the delirium. Routine blood examination showed impaired kidney function and elevated myoglobin (Mb) and creatine phosphokinase (CK) levels. MRI scanning revealed a damaged frontotemporal lobe and limbic system. In addition, herpes simplex virus (HSV) pathogen was identified in the cerebrospinal fluid thus indicating HSV infection. Therefore, a diagnosis of rhabdomyolysis triggered by HSV infection accompanied by epilepsy was made. Notably, the patient recovered well after early intervention and treatment. Conclusion The case presented here calls for careful analysis of rhabdomyolysis cases with unknown causes, minor seizures, and without status epilepticus. This case also indicates that HSV virus infection might contribute to the rhabdomyolysis.

scholarly journals Herpes simplex reactivation following neurosurgery: case report and review of the literature

2019 ◽  
Vol 47 (2) ◽  
pp. E9 ◽  
Author(s):  
Diane C. McLaughlin ◽  
Rebecca L. Achey ◽  
Robert Geertman ◽  
Jonah Grossman
Keyword(s):  
Herpes Simplex ◽  
Antiviral Therapy ◽  
Viral Encephalitis ◽  
Herpes Simplex Encephalitis ◽  
Viral Reactivation ◽  
High Dose ◽  
Chain Reaction ◽  
Polymerase Chain ◽  
Direct Nerve ◽  
Simplex Virus

Herpes simplex encephalitis is a common viral encephalitis associated with significant morbidity and mortality if not diagnosed and treated early. Neurosurgery may be an impetus for viral reactivation, either from direct nerve manipulation or high-dose steroids often administered during cases. The authors present the 40th known case of herpes simplex virus (HSV) encephalitis following neurosurgical intervention and review the previously reported cases. In their review, the authors observed positive HSV polymerase chain reaction (PCR), which had initially been negative in several cases. In cases in which there is high suspicion of HSV, it may be prudent to continue antiviral therapy and retest CSF for HSV PCR. Antiviral therapy significantly reduces mortality associated with HSV encephalitis.

scholarly journals Silencing Status Epilepticus-Induced BDNF Expression with Herpes Simplex Virus Type-1 Based Amplicon Vectors

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0150995 ◽  
Author(s):  
Chiara Falcicchia ◽  
Pascal Trempat ◽  
Anna Binaschi ◽  
Coline Perrier-Biollay ◽  
Paolo Roncon ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Status Epilepticus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Bdnf Expression ◽  
Simplex Virus

scholarly journals Extensive Epidermal Skin Loss Secondary to HSV Type One: Neonatal Management Challenges

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Rebecca J Calthorpe ◽  
Emma Spencer ◽  
Jane C Ravenscroft ◽  
Ting S Tang ◽  
Anna E Martinez ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Epidermolysis Bullosa ◽  
Herpes Simplex Virus Type ◽  
Rare Case ◽  
Preterm Neonate ◽  
Skin Loss ◽  
Simplex Virus ◽  
Aplasia Cutis

We describe a rare case of a preterm neonate presenting at birth with extensive epidermal skin loss of over 90% due to disseminated herpes simplex virus type one infection. Differential diagnosis included aplasia cutis and epidermolysis bullosa. Serum PCR and mouth swabs confirmed HSV type one, and the patient required three weeks of treatment with intravenous aciclovir, followed by oral aciclovir. We describe the management challenges and give practical solutions applicable to the care of a neonate presenting with widespread skin loss due to any aetiology.

scholarly journals A Rare Case of Herpes Simplex Virus-2 Hepatitis with Negative Serology

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Mohanad Soliman ◽  
Olalekan Akanbi ◽  
Ihab Almagdub ◽  
Kishore Karri ◽  
Pradeep Yarra ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
High Risk ◽  
Liver Failure ◽  
Complete Resolution ◽  
Rare Case ◽  
High Risk Population ◽  
Pregnant Teenager ◽  
Simplex Virus ◽  
Herpes Simplex Virus 2

Herpes simplex virus-2 (HSV2) hepatitis represents a rare but serious complication of HSV2 infection that can progress to acute liver failure (ALF). We describe a case of a pregnant teenager who presented with four days of fever, headache, malaise, nausea, and vomiting. She was initially misdiagnosed with sepsis of unclear source and treated with broad-spectrum antibiotics. Empiric acyclovir was started one week into her hospitalization despite negative serologies while awaiting HSV2 PCR leading to complete resolution of symptoms. Given its high mortality and nonspecific presentation, clinicians should consider HSV hepatitis in all patients with acute hepatitis especially in high-risk population.

Herpes simplex encephalitis: an autopsy case with isolation of type 1 herpes simplex virus

1977 ◽  
Vol 40 (1) ◽  
pp. 91-93 ◽  
Author(s):  
Shozo Miyake ◽  
Shigeru Yasuraoka ◽  
Yasuyoshi Kiryu ◽  
Eijiro Satoyoshi ◽  
Takeshi Kurata ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Herpes Simplex Encephalitis ◽  
Autopsy Case ◽  
Simplex Virus

Chronic granulomatous herpes encephalitis: a rare entity posing a diagnostic challenge

2011 ◽  
Vol 8 (4) ◽  
pp. 402-406 ◽  
Author(s):  
Matthew A. Adamo ◽  
Lisa Abraham ◽  
Ian F. Pollack
Keyword(s):  
Herpes Simplex ◽  
Herpes Simplex Encephalitis ◽  
Disease Process ◽  
Toll Like Receptor ◽  
Herpes Encephalitis ◽  
Diagnostic Challenge ◽  
Intractable Seizures ◽  
History Of ◽  
Simplex Virus ◽  
Chronic Disease State

Herpesviruses can cause an acute, subacute, or chronic disease state in both immunocompetent and immunocompromised individuals. Herpes simplex virus (HSV) encephalitis is most often an acute monophasic disease process. Rarely, however, it may progress to a chronic state, and more rarely still to a granulomatous encephalitis. Prior studies have suggested that antiviral immunity with Toll-like receptors determines susceptibility to herpesviruses. The authors report the case of a 14-year-old girl with a remote history of treated HSV encephalitis, who had intractable seizures and worsening MR imaging changes that were concerning for either a neoplastic or an inflammatory process. She was found to have granulomatous herpes simplex encephalitis and had a low cytokine response to Toll-like receptor 3 stimulation.

scholarly journals Co-infection of Hepatitis A and Herpes Simplex Virus: A Case Report

2020 ◽  
Vol 6 (7) ◽  
pp. 158-162
Author(s):  
S. Akhunbaev ◽  
A. Kutmanova ◽  
A. Gupta
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Fatty Liver Disease ◽  
Rare Case ◽  
Hepatitis A ◽  
Early Stage ◽  
Alcoholic Fatty Liver ◽  
Intravenous Drugs ◽  
Simplex Virus ◽  
Alcoholic Fatty Liver Disease

Hepatitis A is a self-limiting disease where fulminant hepatitis and death occur in a small proportion of patients. Fulminant hepatic failure is more common in patients with underlying liver diseases, such as chronic hepatitis B and C, co-infection with more than one genotype of hepatitis A at the same time, non-alcoholic fatty liver disease or alcoholic steatohepatitis, in advanced age and with dependence on intravenous drugs. We present a case of infection of hepatitis A and herpes simplex virus that lead to acute liver failure. In this rare case, the importance of attention to the first manifestations of the disease in diagnosing severe cases of hepatitis A in adults is emphasized. At the same time, HSV hepatitis can also be the cause of fulminant hepatic insufficiency. Therefore, patients with severe hepatitis A need an early examination for HSV infection, and empirical treatment with acyclovir should begin at early stage.

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