scholarly journals Association between serotonin 2A receptor (HTR2A) genetic variations and risk of hypertension in a community-based cohort study

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Jung Ran Choi ◽  
Minhee Jeon ◽  
Sang Baek Koh
Keyword(s):  
Blood Pressure ◽  
Cross Sectional Study ◽  
Genetic Variations ◽  
Sectional Study ◽  
Community Based ◽  
Clinical Factor ◽  
Cross Sectional ◽  
Serotonin 2A Receptor ◽  
Baseline Systolic Blood Pressure ◽  
Serotonin 2A

Abstract Background Hypertension is one of the risk factors for obesity-related cardiovascular diseases. We investigated whether genetic variations in serotonin 2A receptor (HTR2A) were associated with hypertension. Methods We carried out a cross-sectional study in cohorts A (Ansan-Ansung cohort, N = 6039) and B (Wonju-Pyengchang cohort, N = 7524). Several genetic variants in HTR2A including rs7330636, rs9590999, rs2183057, and rs4942595 were selected and genotyped. Results In hypertensive participants in cohort A, the baseline systolic blood pressure and body mass index were 141.80 ± 17.20 mg/dL and 24.48 ± 4.75 kg/m2, respectively, which were higher than in those without hypertension (p < 0.001). rs4942595TC genotype was associated with hypertension in cohort A (OR = 0.739), after adjusting for variables. Subjects with rs4942578AA genotype had a decreased risk of hypertension after adjusting for clinical factor (OR = 0.735) in cohort B, and an elevated risk of hypertension in cohort A (OR = 1.562). The logistic regression analysis showed that participants with rs4941573TC genotype were 1.327 times more likely to have a higher blood pressure than those with TT genotype (95% CI 1.101–1.599) in cohort B. Whereas, the OR for developing hypertension in subjects with rs17069883CC genotype compared to those with AA genotype was 1.447 (95% CI 1.018–2.056; p for trend = 0.040) in cohort A. Conclusions HTR2A genetic variations were associated with hypertension risk in our study.

scholarly journals Heart rate variability and blood pressure among Japanese men and women: a community-based cross-sectional study

2014 ◽  
Vol 37 (8) ◽  
pp. 779-784 ◽  
Author(s):  
Hiromi Mori ◽  
Isao Saito ◽  
Eri Eguchi ◽  
Koutatsu Maruyama ◽  
Tadahiro Kato ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Community Based ◽  
Cross Sectional ◽  
Japanese Men ◽  
Men And Women

scholarly journals Relationship between obesity indices and hypertension among middle-aged and elderly populations in Taiwan: a community-based, cross-sectional study

BMJ Open ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. e031660 ◽  
Author(s):  
Yen-An Lin ◽  
Ying-Jen Chen ◽  
Yu-Chung Tsao ◽  
Wei-Chung Yeh ◽  
Wen-Cheng Li ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Logistic Regression ◽  
Cross Sectional Study ◽  
Multiple Logistic Regression ◽  
Sectional Study ◽  
Community Based ◽  
Cross Sectional ◽  
Elderly Populations ◽  
Obesity Indices ◽  
Northern Taiwan

ObjectiveObesity and hypertension (HTN) have become increasingly prevalent in Taiwan. People with obesity are more likely to have HTN. In this study, we evaluated several anthropometric measurements for the prediction of HTN in middle-aged and elderly populations in Taiwan.DesignCross-sectional observational study.SettingCommunity-based investigation in Guishan Township of northern Taiwan.ParticipantsA total of 396 people were recruited from a northern Taiwan community for a cross-sectional study. Anthropometrics and blood pressure were measured at the annual health exam. The obesity indices included body mass index (BMI), body fat (BF) percentage and waist circumference (WC).Outcome measuresStatistical analyses, including Pearson’s correlation, multiple logistic regression and the area under ROC curves (AUCs) between HTN and anthropometric measurements, were used in this study.ResultsOf the 396 people recruited, 200 had HTN. The age-adjusted Pearson’s coefficients of BMI, BF percentage and WC were 0.23 (p<0.001), 0.14 (p=0.01) and 0.26 (p<0.001), respectively. Multiple logistic regression of the HTN-related obesity indices showed that the ORs of BMI, BF percentage and WC were 1.15 (95% CI 1.08 to 1.23, p<0.001), 1.07 (95% CI 1.03 to 1.11, p<0.001) and 1.06 (95% CI 1.03 to 1.08, p<0.001), respectively. The AUCs of BMI, BF percentage and WC were 0.626 (95% CI 0.572 to 0.681, p<0.001), 0.556 (95% CI 0.500 to 0.613, p=0.052) and 0.640 (95% CI 0.586 to 0.694, p<0.001), respectively.ConclusionsWC is a more reliable predictor of HTN than BMI or BF percentage. The effect of abdominal fat distribution on blood pressure is greater than that of total BF amount.

scholarly journals Distribution of risks and Factors Associated with Unscreened Hypertension among Adults Living in Rural of Dano District, West Shewa, Oromia, Ethiopia, 2020: Community-based cross-sectional study

2021 ◽  
Author(s):  
Firaol Regea
Keyword(s):  
Blood Pressure ◽  
Associated Factors ◽  
Statistical Significance ◽  
Cross Sectional Study ◽  
P Value ◽  
Multivariable Logistic Regression Analysis ◽  
Sectional Study ◽  
Community Based ◽  
Cross Sectional ◽  
Measuring Device

Abstract Background: Hypertension affects more than one quarter of adults worldwide and one in three peoples in developing countries. Although Hypertension is known to be a silent medical condition, there is limited information on the prevalence of unscreened hypertension and associated factors among rural dwellers in Ethiopia in general and Dano district in particular. Objective: To assess the prevalence of Unscreened hypertension and associated factors among adults living in the rural area of Dano district, West Shewa, Oromia, Ethiopia 2020.Methods and materials - A community-based cross-sectional study was employed. A multi-stage sampling technique was used to select 605 Adults from the rural community of Dano District from May 23 -July 5, 2020. Data were collected by trained BSc nurses and Public health officers. Standardized WHO STEPS survey tool was used to collect socio-demographic and behavioral characteristics of the participants. Standardized digital blood pressure device was used to measure Blood pressure. The mean score of three blood measurements was used to classify hypertension after intra-class correlation was tested. GmateTM blood glucose measuring device was used to measure blood sugar. Multivariable logistic regression analysis was done to identify factors independently associated with unscreened hypertension. Adjusted Odds Ratio with 95% CI was estimated to measure the strength of association. The level of statistical significance was declared at p-value < 0.05. The results presented by tables and figures. Result: The prevalence of Unscreened Hypertension was 14.6%, (95% CI: 11.95%, 17.4%). Being in age of 19-33 years[(AOR: 2.5,95%CI:( 1,6)], having family history of hypertension [AOR=3.1,95%CI:(1.23,7.77)],having other chronic disease [AOR=0.28,95%CI:(0.11, 0.72)], Participants’ health-seeking behaviour to hypertension[AOR=3.3,95%CI:(1.6,6.5)] and participants knowledge about hypertension[AOR=2.3,95%CI:(1.2,4.5)]were independently associated with unscreened Hypertension.Conclusion - The evidence from this study shows unscreened hypertension is prevalent among adults in the study area. Therefore, opportunistic screening of adults regardless of their age and health status is important.

Magnitude of metabolic syndrome and its components among adult residents of Mekelle city, Northern Ethiopia, community-based cross-sectional study.

2020 ◽  
Author(s):  
Gebremedhin Gebreegziabiher Gebrehiwot ◽  
Tefera Belachew ◽  
Kibrti Mehari ◽  
Dessalegn Tamiru
Keyword(s):  
Public Health ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Cross Sectional Study ◽  
Blood Cholesterol ◽  
Sectional Study ◽  
Community Based ◽  
Cross Sectional ◽  
Mekelle City

Abstract Background: Metabolic Syndrome is becoming a big public health problem in developing countries like Ethiopia. The risk of dying from NCDs in low and lower-middle-income countries is almost two times that in high-income countries. NCDs account for 42% of deaths in Ethiopia. The trend of deaths due to NCD is increasing over time in Ethiopia. The objective of this study was to assess the magnitude of metabolic syndrome and its components among adult residents of Mekelle city.Method: a community-based cross-sectional study was conducted from July to September 2019 among adults aged 20 years and above in Mekelle city. Around 266 study participants were selected using a simple random sampling technique. Sociodemographic, lifestyle, anthropometric measurements, and blood biochemical tests were performed using WHO stepwise technique. Blood glucose and lipid profiles were determined after overnight fasting. The classification of metabolic syndrome was based on the international diabetic federation criteria. Descriptive statistics and logistic regression analysis were done using SPSS version 24.Result: the prevalence of Metabolic syndrome was 21.8%. Elevated waist circumference was the most prevalent metabolic syndrome component followed by hypertriglyceridemia, with a prevalence of 41.7% and 38.0% respectively. The prevalence of the remaining three components of MetS were also 33.8%, 32.7%, 21.4%, and 14.3% for systolic blood pressure, diastolic blood pressure, fasting blood glucose, and lower high-density lipoprotein cholesterol respectively. Age of 40 years and above, the highest rank of monthly income, blood cholesterol greater than 200mg/dl, waist to height ratio greater than 0.55, and walking at least 10 minutes daily were identified as significant predictors of metabolic syndrome.Conclusion : Adult residents of Mekelle city have a high magnitude of Metabolic syndrome and its components which may aggravate the risk of developing cardiovascular disease. This result emphasizes an urgent need for a public health strategy for preventive, early detection, and management of metabolic syndrome, and its individual components.

scholarly journals Uncovering the high burden of hypertension and its predictors among adult population in Hosanna town, southern Ethiopia: a community-based cross-sectional study

BMJ Open ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. e035823
Author(s):  
Nebiyu Dereje ◽  
Alemu Earsido ◽  
Layla Temam ◽  
Ashenafi Abebe
Keyword(s):  
Blood Pressure ◽  
Adult Population ◽  
Public Health Problem ◽  
Cross Sectional Study ◽  
Southern Ethiopia ◽  
Binary Logistic Regression Analysis ◽  
Sectional Study ◽  
Community Based ◽  
Cross Sectional ◽  
Undiagnosed Hypertension

ObjectiveHypertension is a global public health problem, with its burden increasing particularly in developing countries. However, it has not yet received due attention in Ethiopia. The aim of this study was to determine the prevalence and associated factors of hypertension among adult population in Hosanna town, southern Ethiopia.DesignCommunity-based cross-sectional study.SettingHosanna town, southern Ethiopia.ParticipantsAdult population aged ≥18 years (n=634) were recruited by a multistage stratified sampling technique.Outcome measuresA face-to-face interview using structured questionnaire was carried out by trained nurses. Anthropometry and blood pressure were measured following standard procedures. Hypertension status was defined as systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg in two separate measurements or reported use of prescribed antihypertensive drugs for raised blood pressure. Factors associated with hypertension were identified by multivariable binary logistic regression analysis.ResultsThe overall prevalence of hypertension was found to be 17.2% (19.3% and 14.2% among men and women, respectively). About 40% were unaware that they were hypertensive prior to the study. Older age ≥35 years (adjusted OR=3.9, 95% CI: 1.4 to 10.8), alcohol use (adjusted OR=3.4, 95% CI: 1.4 to 8.3), consumption of saturated oil (adjusted OR=6.5, 95% CI: 1.5 to 17.5) and unspecified different types of oil (adjusted OR=8.2, 95% CI: 1.9 to 25.1) and overweight/obesity (adjusted OR=2.9, 95% CI: 1.9 to 4.6) were found to be independently associated with hypertension.ConclusionsThe prevalence of both diagnosed and undiagnosed hypertension is alarmingly high in the town. These findings underscore the need to design health information provision systems on the risk factors of hypertension and promote good health practices. Blood pressure screening programmes at community levels to identify and treat undiagnosed hypertension should be considered.

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