Mapping psychosocial interventions in familial colorectal cancer: a rapid systematic review

Abstract Background Approximately 5% of colorectal cancer (CRC) cases are part of a well-defined inherited genetic syndrome and up to approximately 30% of these cases have a clinically defined familial basis. Psychosocial interventions in familial colorectal cancer address aspects mainly focused on affective, cognitive and behavioural outcomes. The present review aims to systematically map out the available psychosocial interventions for individuals with a family history of CRC and describe the current state of the research. Methods An extensive electronic search was conducted to investigate the literature published until June 2020. Inclusion criteria consisted of quantitative studies published in English that explored the impact of psychosocial interventions for familial CRC, clearly defined the psychosocial intervention offered and included participants with a family history of CRC. Results The analysis included 52 articles. Genetic counselling, educational interventions, psychological interventions and multimodal interventions were identified across the studies. In terms of diagnoses, Lynch Syndrome, Familial Adenomatous Polyposis, Familial Colorectal Cancer were the main conditions included in the studies. Affective, cognitive, behavioural aspects and quality of life emerged as the most frequently explored outcomes. The studies included individuals with both personal and familial history of CRC or family history alone. Conclusions Our rapid review provides an overview of the literature exploring the impact of psychosocial interventions for familial CRC. The psychosocial interventions identified had an overwhelmingly positive impact across all types of outcomes measured. Genetic counselling appeared to be most beneficial, and this is expected as it is purposively designed to address genetic conditions. Further quantitative analysis of primary empirical research is needed to determine the efficacy and effectiveness of psychosocial interventions as well as the mechanisms through which they exert their effect.

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Screeners vs. Non-screeners for Colorectal Cancer among People over 50 Years of Age: Factual and Psychological Discriminants

Journal of Gastrointestinal and Liver Diseases ◽

10.15403/jgld-2263 ◽

2020 ◽

Author(s):

Andrada Ciucă ◽

Ramona Moldovan ◽

Sebastian Pintea ◽

Dan Dumitrașcu ◽

Adriana Băban

Keyword(s):

Colorectal Cancer ◽

Family History ◽

Positive Family History ◽

Psychosocial Interventions ◽

The Elderly ◽

Roc Curve Analysis ◽

Convenience Sample ◽

Colonoscopy Screening ◽

History Of ◽

D Values

Background and Aims: Colorectal cancer (CRC) is the third most frequent form of cancer worldwide, and approximately one third of cases have a positive family history of CRC or associated cancers. Colonoscopy is one of the most effective methods of screening for CRC. Uptake of colonoscopy is suboptimal, and many countries lack a national screening programme. Our study aims at exploring and ranking several factual and psychological variables according to their accuracy in discriminating between screeners and non-screeners for CRC in a convenience sample of people over 50 years of age. Methods: The study included 103 individuals aged over 50 years, recruited from day centres for the elderly. We explored socio-demographic variables, frequency of colonoscopy, previous recommendations for screening, health literacy and family history of cancer. Receiver operating characteristic (ROC) analysis was used to establish the discriminative value for each variable between the positive and negative decision for colonoscopy screening. Areas under the curve (AUC) and their equivalent Cohen‘s d values were calculated. Results: Almost a quarter (25.75%) of participants reported previous colonoscopy screening. ROC curve analysis shows that colonoscopy uptake is best discriminated by perceived benefits of screening (AUC=0.71, d=0.78, p<0.001), previous recommendations for screening (AUC=0.68, d=0.69, p<0.001) and previous recommendations for preventive measures (AUC=0.67, d=0.64, p<0.001). Conclusions: Recommendations from healthcare professionals lead to improved colonoscopy uptake when emphasising the benefits of screening. Results can further inform psychosocial interventions by bringing empirical evidence to emphasize screening benefits and explicit recommendations for individuals at risk for CRC cancer.

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The impact of genetic counselling on risk perception and mental health in women with a family history of breast cancer

British Journal of Cancer ◽

10.1038/sj.bjc.6690139 ◽

1999 ◽

Vol 79 (5-6) ◽

pp. 868-874 ◽

Cited By ~ 180

Author(s):

M Watson ◽

S Lloyd ◽

J Davidson ◽

L Meyer ◽

R Eeles ◽

...

Keyword(s):

Breast Cancer ◽

Mental Health ◽

Risk Perception ◽

Family History ◽

Genetic Counselling ◽

History Of ◽

The Impact

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The impact of genetic counselling on risk perception in women with a family history of breast cancer

British Journal of Cancer ◽

10.1038/bjc.1994.423 ◽

1994 ◽

Vol 70 (5) ◽

pp. 934-938 ◽

Cited By ~ 122

Author(s):

DGR Evans ◽

V Blair ◽

R Greenhalgh ◽

P Hopwood ◽

A Howell

Keyword(s):

Breast Cancer ◽

Risk Perception ◽

Family History ◽

Genetic Counselling ◽

History Of ◽

The Impact

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174 The Impact of Family History of Colorectal Cancer on Colorectal Cancer Screening: Evidence of Variation Between Racial/Ethnic Groups

Gastroenterology ◽

10.1016/s0016-5085(13)60145-6 ◽

2013 ◽

Vol 144 (5) ◽

pp. S-41

Author(s):

Molly Perencevich ◽

Rohit P. Ojha ◽

Ewout W. Steyerberg ◽

Sapna Syngal

Keyword(s):

Colorectal Cancer ◽

Cancer Screening ◽

Family History ◽

Ethnic Groups ◽

Colorectal Cancer Screening ◽

History Of ◽

The Impact ◽

Racial Ethnic

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The impact of risk perception on emotional distress in individuals with a family history of cancer

Cognition Brain Behavior An Interdisciplinary Journal ◽

10.24193/cbb.2021.25.11 ◽

2021 ◽

Vol 25 (3) ◽

pp. 221-231

Author(s):

Andrada Ciucă ◽

Ramona Moldovan ◽

Sebastian Pintea ◽

Adriana Băban

Keyword(s):

Risk Perception ◽

Family History ◽

Emotional Distress ◽

Perceived Risk ◽

Psychosocial Interventions ◽

Cross Sectional ◽

Family History Of Cancer ◽

History Of ◽

The Impact ◽

History Of Cancer

Purpose: Understanding the factors impacting individuals’ emotional distress in the context of a family history of cancer is key in designing and implementing psychosocial interventions. Our study investigated the extent to which having a family history of cancer is associated with emotional distress and whether the perceived risk to develop colorectal cancer (CRC) plays any role in this equation. Methods: This cross-sectional study included 253 individuals from the general population who volunteered to take part in this study. We assessed their family history of cancer and perceived risk for developing CRC, and assessed the emotional distress. Findings: Individuals with a family history of cancer have higher levels of emotional distress compared to individuals without a family history, t(251)=-10.16, p<.001. Our data show that risk perception to develop CRC moderates the relationship between the family history of cancer and emotional distress (β=0.38, CI=(1.68, 5.92), r2=0.24, p<.001, d=0.25). Conclusion: This study was aimed at corroborating the role family history of cancer and risk perception have in explaining the emotional distress associated with cancer. Our results contribute to a clearer understanding of the impact family history of cancer has on emotional distress and show that risk perception is key in this relationship.

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Colorectal Cancer in the Royal Navy – an opportunity to intervene?

Journal of The Royal Naval Medical Service ◽

10.1136/jrnms-81-16 ◽

1995 ◽

Vol 81 (1) ◽

pp. 16-26

Author(s):

N P J Cripps ◽

L B Cannon

Keyword(s):

Colorectal Cancer ◽

Family History ◽

Early Detection ◽

Disease Incidence ◽

Occult Blood ◽

Population Based ◽

Colorectal Adenomas ◽

Royal Navy ◽

History Of ◽

The Impact

AbstractColorectal cancer is uncommon in Royal Naval personnel; an average of two cases are diagnosed annually, often with disease advanced at presentation. During the next five years, IO serving individuals arelikely to present with colorectal cancer and many, ifnot all of these, already harbour premalignantadenomas or asymptomatic colonic malignancy.Currently over 2,000 servicemen are estimated tocarry undiagnosed colorectal adenomas..Requests for hospital appointments for those reporting a family history of colorectal cancer and who request screening are increasing in frequency. An understanding of the personal implications of a familyhistory of colorectal cancer and a basis for the management of these individuals will be provided.This paper considers ways in which the impact of colorectal cancer on the Royal Navy and its pensioners could be altered. Evidence derived from population based and family hi story based colorectal cancer screening studies are organised into a protocol by which the Royal Navy might be examined. The effect of a family history of colorectal cancer on disease incidence and the percentage of positives resulting from faecal occult blood testing are applied to the ageprofile of the Royal Navy. These show that amaximum of 56 flexible sigmoidoscopies and 90colonoscopies would be needed in the first year of aprogramme to attempt the early detection of neoplasia.This paper is aimed at gaining feedback from primary and secondary care practitioners so that the possibility of introducing a programme for the early detection of colorectal cancer in the Royal Navy canbe considered.

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Clinical, Pathological and Molecular Characteristics of Chilean Patients with Early-, Intermediate- and Late-Onset Colorectal Cancer

Cells ◽

10.3390/cells10030631 ◽

2021 ◽

Vol 10 (3) ◽

pp. 631

Author(s):

Karin Alvarez ◽

Alessandra Cassana ◽

Marjorie De La Fuente ◽

Tamara Canales ◽

Mario Abedrapo ◽

...

Keyword(s):

Colorectal Cancer ◽

Family History ◽

Age Of Onset ◽

Late Onset ◽

Molecular Characteristics ◽

Family History Of Cancer ◽

Molecular Features ◽

Age Of Diagnosis ◽

History Of ◽

History Of Cancer

Colorectal cancer (CRC) is the second most frequent neoplasm in Chile and its mortality rate is rising in all ages. However, studies characterizing CRC according to the age of onset are still lacking. This study aimed to identify clinical, pathological, and molecular features of CRC in Chilean patients according to the age of diagnosis: early- (≤50 years; EOCRC), intermediate- (51–69 years; IOCRC), and late-onset (≥70 years; LOCRC). The study included 426 CRC patients from Clinica Las Condes, between 2007 and 2019. A chi-square test was applied to explore associations between age of onset and clinicopathological characteristics. Body Mass Index (BMI) differences according to age of diagnosis was evaluated through t-test. Overall (OS) and cancer-specific survival (CSS) were estimated by the Kaplan–Meier method. We found significant differences between the age of onset, and gender, BMI, family history of cancer, TNM Classification of Malignant Tumors stage, OS, and CSS. EOCRC category was characterized by a family history of cancer, left-sided tumors with a more advanced stage of the disease but better survival at 10 years, and lower microsatellite instability (MSI), with predominant germline mutations. IOCRC has shown clinical similarities with the EOCRC and molecular similarities to the LOCRC, which agrees with other reports.

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