scholarly journals Clinical, Pathological and Molecular Characteristics of Chilean Patients with Early-, Intermediate- and Late-Onset Colorectal Cancer

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 631
Author(s):  
Karin Alvarez ◽  
Alessandra Cassana ◽  
Marjorie De La Fuente ◽  
Tamara Canales ◽  
Mario Abedrapo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Age Of Onset ◽  
Late Onset ◽  
Molecular Characteristics ◽  
Family History Of Cancer ◽  
Molecular Features ◽  
Age Of Diagnosis ◽  
History Of ◽  
History Of Cancer

Colorectal cancer (CRC) is the second most frequent neoplasm in Chile and its mortality rate is rising in all ages. However, studies characterizing CRC according to the age of onset are still lacking. This study aimed to identify clinical, pathological, and molecular features of CRC in Chilean patients according to the age of diagnosis: early- (≤50 years; EOCRC), intermediate- (51–69 years; IOCRC), and late-onset (≥70 years; LOCRC). The study included 426 CRC patients from Clinica Las Condes, between 2007 and 2019. A chi-square test was applied to explore associations between age of onset and clinicopathological characteristics. Body Mass Index (BMI) differences according to age of diagnosis was evaluated through t-test. Overall (OS) and cancer-specific survival (CSS) were estimated by the Kaplan–Meier method. We found significant differences between the age of onset, and gender, BMI, family history of cancer, TNM Classification of Malignant Tumors stage, OS, and CSS. EOCRC category was characterized by a family history of cancer, left-sided tumors with a more advanced stage of the disease but better survival at 10 years, and lower microsatellite instability (MSI), with predominant germline mutations. IOCRC has shown clinical similarities with the EOCRC and molecular similarities to the LOCRC, which agrees with other reports.

scholarly journals The Leptin Gene Family and Colorectal Cancer: Interaction with Smoking Behavior and Family History of Cancer

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e60777 ◽  
Author(s):  
Li Liu ◽  
Rong Zhong ◽  
Sheng Wei ◽  
Hao Xiang ◽  
Jigui Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Gene Family ◽  
Smoking Behavior ◽  
Family History Of Cancer ◽  
History Of ◽  
History Of Cancer

Race and Colorectal Cancer Screening Compliance Among Persons With a Family History of Cancer

2015 ◽  
Vol 110 ◽  
pp. S611-S612
Author(s):  
Adeyinka O. Laiyemo ◽  
Nicole Thompson ◽  
Carla Williams ◽  
Kolapo Idowu ◽  
Kathy P. Bull-Henry ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Family History ◽  
Colorectal Cancer Screening ◽  
Family History Of Cancer ◽  
History Of ◽  
History Of Cancer

A positive family history of cancer or lifestyle factors may not explain the high incidence of early-onset colorectal cancer in India

2014 ◽  
Vol 3 (5) ◽  
pp. 409-416
Author(s):  
Ratheesh Raman ◽  
Viswakalyan Kotapalli ◽  
Mohana Vamsy ◽  
Sujit C Patnaik ◽  
Mukta Srinivasulu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Early Onset ◽  
Positive Family History ◽  
Lifestyle Factors ◽  
Family History Of Cancer ◽  
High Incidence ◽  
History Of ◽  
Early Onset Colorectal Cancer ◽  
History Of Cancer

Practicum in assessing family history of cancer to inform colorectal cancer screening

2003 ◽  
Vol 124 (4) ◽  
pp. A647
Author(s):  
Marijayne Bushey ◽  
Ann Zauber ◽  
Sidney Winawer ◽  
Nathan Ellis ◽  
Emily Glogowski ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Family History ◽  
Colorectal Cancer Screening ◽  
Family History Of Cancer ◽  
History Of ◽  
History Of Cancer

scholarly journals Clinical Characteristic of Young Indonesian Colorectal Cancer Patients: A Preliminary Study

Medicinus ◽  
2018 ◽  
Vol 5 (3) ◽  
Author(s):  
Nata Pratama Lugito
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Young Patient ◽  
General Hospital ◽  
Clinical Characteristics ◽  
Young Patients ◽  
Old Patients ◽  
Family History Of Cancer ◽  
History Of ◽  
History Of Cancer

<p>Introduction: Colorectal cancer (CRC) is generally a disease of persons aged above 40 year-old. Controversies still exist regarding clinical characteristics of CRC in young persons. The aim of this study is to know the clinical characteristics of young CRC patients in Siloam General Hospital, Karawaci, Banten.</p><p>Material And Methods: A total of 14 patients with diagnosis of CRC from December 2013 to January 2014 in Siloam General Hospital, Karawaci, Banten were studied cross – sectionally.  The symptoms and signs, family history of cancer, diabetes, location of mass were collected and evaluated.</p><p>Results: There were 5 (35.7%) cases of CRC patients aged below 40 year-old (young patients) and 9 (64.3%) above 40 years-old (old patients). The most common symptom was constipation followed by bloody diarrhea i.e. 57.1% and 42.9% consecutively. Constipation occurred in 2 and 6 young and old patients consecutively and in 3 and 3 young and old patients consecutively. In young patients, 2 (14.2%) had a history of cancer in the family compared to none in the old patients. According to the location of tumor in the colon 4 (28.5%) were in ascending colon with 2 and 2 in young and old patients consecutively, 3 (21.7%) were in descending colon with 2 and 1 in young and old patients consecutively, 8 (57.1%) were in rectum with 2 and 6 in young and old patients consecutively. One young patient had diabetes, and one other young patient had positive <em>Clostridium difficile</em> antigen and toxin.</p><p>Conclusion: Approximately 35.7% cases CRC patient in our hospital was of young patients. Two patients were having family history of cancer. The location of mass was not specific for young CRC patients.</p><strong><em>Key words: colorectal cancer, young patients</em></strong>

Risk factors for early-onset colorectal cancer in China.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 10542-10542
Author(s):  
Zhe Pan ◽  
Junfeng Huang ◽  
Mingkai Huang ◽  
Zhiyuan Yao ◽  
Jiongqiang Huang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Cohort Study ◽  
Family History ◽  
Early Onset ◽  
Cancer Site ◽  
Family History Of Cancer ◽  
History Of ◽  
Early Onset Colorectal Cancer ◽  
History Of Cancer

10542 Background: The incidence of colorectal cancer among persons aged < 50 years (early-onset colorectal cancer, EOCRC) has increased since the early 1990s. However, the risk factors contributing to this trend remain largely unknown. Methods: We conducted a retrospective study of participants who were aged < 50 years and without a previous cancer history, using the China Kadoorie Biobank cohort study. We analyzed data related to demographics, lifestyle habits, family history, and comorbidities of EOCRC cases with participants without colorectal cancer in this age group (controls). Univariate and multivariate-adjusted cox regression models were used to estimate the associations with risk factors. Results: We identified 225 EOCRC cases and 88842 controls that include the final analyses. Of the 225 EOCRC patients, 105 (46.7%) were colon cancers and 120 (53.3%) were rectum cancers. EOCRC cases were older, have more intake of fish and eggs, have higher BMIs, diabetes, and family history of cancer compared with controls (P < 0.05). After adjustment for potential confounding factors, increasing age (HR 2.18, 95%CI 2.05-2.31), BMI (HR 1.06, 95%CI 1.01-1.11), family history of cancer (HR 1.41, 95%CI 1.00-1.98), and more intake of fish (HR 1.54, 95%CI 1.09-2.19) were significantly associated with a higher risk of EOCRC. In sensitivity analyses stratified by cancer site (colon and rectum), the results remained consistent. Conclusions: Based on the large Chinese cohort study, we found increasing age, higher BMI or obesity, family history of cancer, and more intake of fish were independent risk factors for EOCRC. Further studies are needed to identify factors that cause the increasing incidence of EOCRC in China and other countries, and explore the potential mechanism behind.[Table: see text]

scholarly journals Risk of Colorectal Cancer for Carriers of Mutations in MUTYH, With and Without a Family History of Cancer

2014 ◽  
Vol 146 (5) ◽  
pp. 1208-1211.e5 ◽  
Author(s):  
Aung Ko Win ◽  
James G. Dowty ◽  
Sean P. Cleary ◽  
Hyeja Kim ◽  
Daniel D. Buchanan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Family History Of Cancer ◽  
History Of ◽  
History Of Cancer
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