scholarly journals Major depressive disorder and its association with adherence to antiretroviral therapy and quality of life: cross-sectional survey of people living with HIV/AIDS in Northwest Ethiopia

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Biksegn Asrat ◽  
Crick Lund ◽  
Fentie Ambaw ◽  
Emily Claire Garman ◽  
Marguerite Schneider

Abstract Background Major depression is believed to affect treatment adherence and overall quality of life (QoL) of people living with HIV/AIDS (PLWHA). Comorbid major depression contributes to a two-fold higher risk of mortality among PLWHA. Understanding the relationships of major depression, adherence to antiretroviral therapy (ART) and QoL is important to identify areas for intervention. The aim of this study is to examine relationship of major depressive disorder (MDD) and adherence to ART with QoL, and to investigate socio-demographic and clinical factors associated with MDD, adherence and QoL among PLWHA in Northwest Ethiopia. Method A cross-sectional study was conducted in the ART clinic of Felege-Hiwot referral hospital in Northwest Ethiopia from July to October 2019. Adult PLWHA were selected using a systematic random sampling technique. Data were collected using interview administered questionnaires and chart reviews. Mini International Neuropsychiatric Interview and WHOQOL-HIV-BREF-Eth instruments were used to measure MDD and QoL respectively. Adherence to ART was assessed using pill count data from patients’ adherence monitoring chart. Univariate and multivariate Poisson regressions were used to assess associations of socio-demographic and clinical factors with MDD and adherence to ART. A multivariate linear regression was used to examine the associations of both MDD and adherence with overall QoL. Result Of the total of 393 invited participants, 391 (99.5%) completed the interviews. MDD was negatively associated with overall QoL: participants with MDD had a lower QoL score of 0.17 points compared to those with no MDD. MDD was associated with reduced adherence to ART when functional disability was controlled (RR = 1.43; 95%CI = 1.05, 1.96; p = 0.025). However, there was no statistical association between adherence to ART and overall QoL. Functional disability was associated with both MDD (RR = 5.07; 95%CI = 3.27,7.86; p < 0.001) and overall QoL (β = 0.29; 95%CI = 0.21,0.36; p < 0.001). Conclusion The relationship between MDD and QoL indicates the need for feasible, acceptable and evidence-based mental health interventions to reduce depression and improve overall QoL of PLWHA. We recommend future studies investigate causal relationships of MDD, adherence to ART and QoL of PLWHA to better understand priority areas for intervention.

2021 ◽  
Vol 33 (3) ◽  
pp. 249-264
Author(s):  
Gert Scheerder ◽  
Sandra Van den Eynde ◽  
Patrick Reyntiens ◽  
Ria Koeck ◽  
Jessika Deblonde ◽  
...  

This cross-sectional survey explored the quality of life in 505 people living with HIV in Belgium. Several domains of quality of life were impaired: 26% had been diagnosed with depression and 43% had weak social support. HIV-related stigma is still widespread, with 49% believing most people with HIV are rejected and 65% having experienced discrimination due to HIV. The impact of HIV was limited on professional life, but 40% experienced a negative impact on life satisfaction and 41% a negative impact on sexual life. For several domains, people with a recent diagnosis of HIV and long-term survivors had significantly worse scores. This survey also uncovered strengths of people living with HIV, such as positive coping and HIV self-image. Expanding the scope of quality of life in people living with HIV may provide a more complete picture of relevant life domains that may be impacted by living with HIV, but this needs further validation.


2018 ◽  
Vol 71 (suppl 1) ◽  
pp. 513-522 ◽  
Author(s):  
Juliano de Souza Caliari ◽  
Lilian Andreia Fleck Reinato ◽  
Daiana Patrícia Marchetti Pio ◽  
Letícia Pimenta Lopes ◽  
Renata Karina Reis ◽  
...  

ABSTRACT Objective: To analyze factors related to the quality of life of elderly people living with HIV/AIDS. Method: A cross-sectional study was carried out with people aged 50 years or more in a specialized outpatient clinic. The data collection was by means of an interview. For the analysis of data and characterization of the sample, descriptive statistics and comparison tests were used. The project met the ethical requirements. Results: Participants were 81 users aged 50 to 75 years, mean age was 57.8 (± 6.1) years, 71.6% of whom were men. There was a statistically significant relationship with the quality of life, the following variables: gender, children, occupation, religion, diagnosis time, HIV exposure, adverse effects, treatment interruption, viral load counts, hospitalization, dependence for daily activities and use of drugs. Conclusion: The results suggest that the quality of life deficit is related not only to physical changes, but to the anguish and stigma related to HIV/AIDS.


10.3823/2627 ◽  
2020 ◽  
Vol 13 ◽  
Author(s):  
Maria Sandra Andrade ◽  
Clarissa Mourão Pinho ◽  
Aline Ferreira Targino Soares ◽  
Eduardo Tavares Gomes ◽  
Cynthia Angélica Ramos de Oliveira Dourado ◽  
...  

Purposes: Evaluate the quality of life and the associated factors in people living with HIV. Methods: This is a cross-sectional study with a quantitative approach and random sample selection, carried out in two Specialized Assistance Services, with 356 people living with HIV. The comparison between the domain scores was performed using the student t test, ANOVA and Pearson’s correlation. Multiple linear regression was used to assess the contribution of variables to the outcome quality of life using the stepwise method. Results: The domains that showed the best results in averages were Psychological (17.0), Social Relations (14.9) and Level of Independence (14.0). The domain that had the greatest determination was the Psychological (R² = 0.49), followed by Social Relations (R² = 0.434), the lowest determination was the Spirituality domain (R² = 0.270). No domain had a score considered high. Conclusion: The quality of life presented unsatisfactory results, especially in the Physical, Environment and Spirituality domains. The need to formulate strategies aimed at coping with HIV and increasing the quality of life of people living with HIV is evident.


Author(s):  
Grishma T. Dixit ◽  
Nilesh Thakor ◽  
Mihir Goswami ◽  
P. B. Verma

Background: Human Immunodeficiency Virus is the biggest threat to the mankind today from their health perspective. To know the perception of health status and quality of life of people living with HIV/AIDS.Methods: This cross sectional study was undertaken during March 2015 to April 2016 at Patan city. After taking permission from NGO and Gujarat State AIDS Control Society (GSACS) total 100 purposively selected People living with HIV (PLHIV) attached to the NGO of Patan city were interviewed using predesigned semi-structured performa. Written informed consent was taken from all PLHIV. Ethical approval was obtained from institutional ethical committee for human research. Data safety and confidentiality was also given due consideration. Data were statistically analyzed using SPSS software (trial version). Results: Age of study population ranges from 18 to 68 years. Mean age of study population is 34.21 + 9.1 years. Maximum number of PLHIV, 51 % are in the age group of 31-40 years age group. Out of total, 76 have perception of being healthy .Out of total, 61 % PLHIV have faced stigma. Out of total,92% were enjoying life, 74% perceived good quality of life, 95% perceived safe in life, 96% perceived satisfaction with health services, 84% perceived  satisfaction with their day to day work capability and only 8% perceived fear about their future life. Conclusions: Positive attitude towards life and health was observed in People Living with HIV. 


2014 ◽  
Vol 22 (6) ◽  
pp. 994-1000 ◽  
Author(s):  
Ana Cristina de Oliveira e Silva ◽  
Renata Karina Reis ◽  
Jordana Almeida Nogueira ◽  
Elucir Gir

OBJECTIVES: to assess the quality of life of people living with HIV/AIDS and verify its association with clinical characteristics and treatment adherence.METHOD: cross-sectional study conducted in a hospital in the state of Paraíba, Brazil. A questionnaire was used to collect socio-demographic and clinical data. The quality of life scale proposed by the World Health Organization and a questionnaire to measure treatment adherence were used.RESULTS: of the 314 interviewees, 190 (60.5%) were male, aged 43 years on average, 121 (38.5%) had attended up to five years of schooling, 108 (34.4%) received up to two times the minimum wage, and 112 (35.7%) were on sick leave. In regard to clinical variables, individuals with an undetectable viral load scored higher in all the domains concerning quality of life, with statistically significant differences in three domains. Regarding treatment adherence, 235 (73.8%) presented poor adherence and those who strictly adhered to treatment obtained better scores in quality of life. The results show that quality of life is better among individuals adherent to ART. Supporting people to adhere to the antiretroviral treatment should be a persistent task of healthcare workers and other people participating in the treatment, such as family members and friends.


2017 ◽  
Vol 70 (5) ◽  
pp. 1004-1010 ◽  
Author(s):  
Francisco Braz Milanez Oliveira ◽  
Artur Acelino Francisco Luz Nunes Queiroz ◽  
Álvaro Francisco Lopes de Sousa ◽  
Maria Eliete Batista Moura ◽  
Renata Karina Reis

ABSTRACT Objective: To analyze whether sexual orientation affects the quality of life of people living with HIV/Aids (PLWHA). Method: A cross-sectional analytical study was carried out with 146 PLWHA in Teresina, capital city of the state of Piauí, in 2013, by means of the WHOQOL-HIV-bref. Descriptive analysis and multiple linear regression were used for data analysis. Results: There was a prevalence of men (63.7%), non-heterosexual (57.0%), aged between 19 and 39 years (89%). Of the total, 75.5% mentioned presence of negative feelings, such as fear and anxiety, and 38% reported have suffered stigma. With regard to the dimensions investigated, the most affected were “environment” and “level of independence”. Non-heterosexual orientation was negatively associated with quality of life in almost all dimensions. Conclusion: Living with HIV/Aids and having a non-heterosexual orientation have a negative impact on quality of life.


2019 ◽  
Vol 8 (3) ◽  
pp. 369-382 ◽  
Author(s):  
María J. Fuster-RuizdeApodaca ◽  
Nuria Sánchez-Vega ◽  
María J. Galindo ◽  
Ignacio Marín-Jimenez ◽  
Javier de Toro ◽  
...  

SpringerPlus ◽  
2014 ◽  
Vol 3 (1) ◽  
Author(s):  
Fidèle Bakiono ◽  
Laurent Ouédraogo ◽  
Mahamoudou Sanou ◽  
Sékou Samadoulougou ◽  
Patrice Wendpouiré Laurent Guiguemdé ◽  
...  

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