Development of breast cancer mortality considering the implementation of mammography screening programs – a comparison of western European countries

To evaluate, by analysis of breast cancer mortality data from all the 26 Swedish counties for the years 1971 to 1990, whether the effect of the introduction of mammography screening in Sweden can be assessed by observation from existing mortality data. A Poisson regression model was used to study whether a decrease in breast cancer mortality among women aged 50–74 years was associated with the extent of mammography screening in different counties and periods. In regions where mammography screening had been introduced, breast cancer mortality tended to be decreased, on average, compared with regions with-'out screening. If a 10 year time lag between the start of screening and its full effect on mortality is assumed then the estimated reduction in breast cancer mortality associated with introduction of screening was 19% with a 95% confidence interval ranging from 3% to 37%. The results suggest that the effect of mammography screening may be studied using existing routine mortality data and appropriate statistical modelling. This way of assessing the outcome of the screening is valuable when continuously monitoring a screening programme that has become a public health routine.

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A magyarországi emlő- és méhnyakszűrés retrospektív vizsgálatának jellemzői a halálozási és megbetegedési adatok tükrében

Orvosi Hetilap ◽

10.1556/650.2019.31518 ◽

2019 ◽

Vol 160 (49) ◽

pp. 1948-1956

Author(s):

Attila Sárváry ◽

Pál Csaba Bálint ◽

Anikó Gyulai ◽

Zsigmond Kósa

Keyword(s):

Breast Cancer ◽

Cervical Cancer ◽

Cancer Mortality ◽

Breast Cancer Mortality ◽

Mortality And Morbidity ◽

Screening Programs ◽

In Situ Carcinoma ◽

Cervical Cancer Mortality ◽

Morbidity Data

Abstract: Introduction: The organized breast and cervical screening programs were implemented in the framework of public health program in Hungary in order to reduce breast cancer mortality by 30% and cervical cancer mortality by 60% in given age groups within 10 years by 2012. Aim: The aim of our study was to conduct a retrospective analysis of mortality and morbidity data and to evaluate the effectiveness of the implemented screening programs. Method: Descriptive statistical analysis was performed by age-standardized mortality and morbidity data between 1980 and 2015 with special regard to the period of 2002–2012. Results: Breast cancer mortality of women aged 45–64 reduced by 28.3%, the incidence reduced by 23.6% and the incidence of in situ carcinoma increased by 242% between 2002 and 2012. Cervical cancer mortality of women aged 25–64 years reduced by 25.5%, the incidence reduced by 21.2%, and the incidence of in situ carcinoma increased by 13.3% during 2002–2012. Conclusion: Although both breast cancer and cervical cancer mortality substantially decreased in Hungary, the decrease in cervical cancer did not reach the target value. Orv Hetil. 2019; 160(49): 1948–1956.

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Impact of Mammography Screening Rates on Breast Cancer Mortality in Nevada (NV), California (CA) and US: Implications for Health Care Policy

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2018.07.1203 ◽

2018 ◽

Vol 102 (3) ◽

pp. e409

Author(s):

P. Kumar ◽

C. Cross ◽

J. De Leon ◽

S. Moonie

Keyword(s):

Breast Cancer ◽

Health Care ◽

Cancer Mortality ◽

Mammography Screening ◽

Health Care Policy ◽

Breast Cancer Mortality ◽

Care Policy

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Worldwide Review and Meta-Analysis of Cohort Studies Measuring the Effect of Mammography Screening Programmes on Incidence-Based Breast Cancer Mortality

Cancers ◽

10.3390/cancers12040976 ◽

2020 ◽

Vol 12 (4) ◽

pp. 976

Author(s):

Amanda Dibden ◽

Judith Offman ◽

Stephen W. Duffy ◽

Rhian Gabe

Keyword(s):

Breast Cancer ◽

Cancer Screening ◽

Breast Cancer Screening ◽

Cancer Mortality ◽

Mammography Screening ◽

Meta Analysis ◽

Breast Cancer Mortality ◽

Substantial Reduction ◽

Healthcare Setting ◽

Actual Attendance

In 2012, the Euroscreen project published a review of incidence-based mortality evaluations of breast cancer screening programmes. In this paper, we update this review to October 2019 and expand its scope from Europe to worldwide. We carried out a systematic review of incidence-based mortality studies of breast cancer screening programmes, and a meta-analysis of the estimated effects of both invitation to screening and attendance at screening, with adjustment for self-selection bias, on incidence-based mortality from breast cancer. We found 27 valid studies. The results of the meta-analysis showed a significant 22% reduction in breast cancer mortality with invitation to screening, with a relative risk of 0.78 (95% CI 0.75–0.82), and a significant 33% reduction with actual attendance at screening (RR 0.67, 95% CI 0.61–0.75). Breast cancer screening in the routine healthcare setting continues to confer a substantial reduction in mortality from breast cancer.

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Race-Specific Impact of Natural History, Mammography Screening, and Adjuvant Treatment on Breast Cancer Mortality Rates in the United States

Breast Diseases A Year Book Quarterly ◽

10.1016/j.breastdis.2011.10.028 ◽

2011 ◽

Vol 22 (4) ◽

pp. 362-364

Author(s):

K.A. Dookeran

Keyword(s):

Breast Cancer ◽

United States ◽

Natural History ◽

Adjuvant Treatment ◽

Cancer Mortality ◽

Mammography Screening ◽

Breast Cancer Mortality ◽

The United States ◽

Mortality Rates ◽

Specific Impact

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Chapter IV. Reduced breast-cancer mortality with mammography screening-an assessment of currently available data

International Journal of Cancer ◽

10.1002/ijc.2910460711 ◽

1990 ◽

Vol 46 (S5) ◽

pp. 76-84 ◽

Cited By ~ 42

Author(s):

Lars E. Rutqvist ◽

Anthony B. Miller ◽

Ingvar Andersson ◽

Matti Hakama ◽

Timo Hakulinen ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Mortality ◽

Mammography Screening ◽

Breast Cancer Mortality

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Realisation of mammography screening in Khanty-Mansiysk Autonomous State – Yugra

Tumors of female reproductive system ◽

10.17650/1994-4098-2020-16-3-32-36 ◽

2021 ◽

Vol 16 (3) ◽

pp. 32-36

Author(s):

Ju. A. Belaya ◽

N. A. Zakharova ◽

A. R. Brentnall

Keyword(s):

Breast Cancer ◽

Cancer Mortality ◽

Mammography Screening ◽

Breast Cancer Mortality ◽

Target Population ◽

Mammographic Screening ◽

Detection Sensitivity ◽

Mortality And Morbidity ◽

Screening Performance ◽

State Region

Objective: to perform a retrospective analysis of the quality of mammography screening in Khanty-Mansiysk State Region – Yugra from its beginning to 2018 inclusive.Materials and methods. During this investigation a throughout analysis of epidemiological indicators (breast cancer mortality and morbidity), quality indicators (coverage of the target population, cancer detection in general and early detection, sensitivity and morbidity) and mammographic screening performance indicators (projected and observed morbidity and mortality) was carried out.Results and conclusions. During this period, 572,348 women were screened, 9.7 % of whom were recommended for further screening. The coverage of the target population for one round was 33 %. Screening test sensitivity for the specified period was 80 %. The observed number of women with newly detected breast cancer cases of stage I in 2018 made 42 % (53 cases) higher in comparison with expected numbers, and in stage T2+ it made 21 % (62 cases) less. The observed number of deaths in 2018 was 23.7 % lower than expected. The above-mentioned demonstrates once again that mammography screening in Khanty-Mansiysk State Region – Yugra has led to the improvement of early diagnosis of breast cancer. This, in turn, leads to a steady decline in breast cancer mortality among women over 40 years of age.

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Breast cancer mortality and screening mammography in New Zealand: Incidence-based and aggregate analyses

Journal of Medical Screening ◽

10.1177/0969141318776039 ◽

2018 ◽

Vol 26 (1) ◽

pp. 35-43 ◽

Cited By ~ 1

Author(s):

Richard Taylor ◽

Marli Gregory ◽

Kerry Sexton ◽

Jessica Wharton ◽

Nisha Sharma ◽

...

Keyword(s):

Breast Cancer ◽

New Zealand ◽

Cancer Mortality ◽

Mammography Screening ◽

Breast Cancer Mortality ◽

Primary Treatment ◽

Screening Mammography ◽

Randomized Controlled ◽

Before And After ◽

Incident Cases

Objective To investigate trends in breast cancer mortality in New Zealand women, to corroborate or negate a causal association with service screening mammography. Method Cumulated mortality rates from breast cancer deaths individually linked to incident cases diagnosed before and after screening commencement were compared, in women aged 50–64 (from 2001) and aged 45–49 and 65–69 (from 2006). Trends and differences in aggregate invasive breast cancer mortality (1975–2013) were assessed in relation to introduction of mammography screening targeting women aged 50–64 and 45–69. Joinpoint analysis was also undertaken. Results The reduction in incidence-based cumulated breast cancer mortality before and after the introduction of screening was −15% (p = 0.006) for women aged 45–69, and 17% (p = 0.005) for those aged 50–64. Aggregate mortality declined by −34% (2005–13 compared with 1992–98) in the age group 50–64, and by –28% among women aged 45–49 and –25% among women aged 65–74. For women aged 50–64 the 2-joinpoint model shows a 1990 turning point, from prior rising mortality to a mean −1.8% decline per annum, coinciding with improvements in primary treatment of breast cancer; and a steepening of the decline (−3.0% p.a.) from the late 1990s, coinciding with the introduction of service mammography screening. Conclusion Breast cancer mortality declines occurring since the advent of screening mammography in New Zealand are consistent with other incidence-based and aggregate studies of screening mammography in populations, individual-based cohort studies, and randomized controlled trials.

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