scholarly journals Association between dietary acid load and the risk of hypertension among adults from South China: result from nutrition and health survey (2015–2017)

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Shao-wei Chen ◽  
Gui-yuan Ji ◽  
Qi Jiang ◽  
Ping Wang ◽  
Rui Huang ◽  
...  
Keyword(s):  
Health Survey ◽  
South China ◽  
Southern China ◽  
Mainland China ◽  
Nutrition And Health ◽  
Cross Sectional ◽  
Dietary Acid Load ◽  
Related Data ◽  
Dietary Acid ◽  
Acid Load

Abstract Background Higher dietary acid load (DAL) was considered to be associated with an elevated risk of hypertension, while related data from mainland China remains scarce and incomplete. We aim to evaluate the association between DAL and the risk of hypertension among adults from South China. Methods We conducted a nutrition and health survey in Guangdong Province located in southern China from 2015 to 2017. A four-stage probability sampling method was utilized to select representative samples of citizens aged ≥18 years old. DAL was assessed by potential renal acid load (PRAL) and net endogenous acid production (NEAP). Participants were divided to 4 groups (Q1-Q4) according to the quartile points of PRAL or NEAP distributions. Generalized linear mixed effects models were applied to evaluate the association between DAL and the risk of hypertension. Results A total of 3501 individuals were eligible for this study and 45.9% was male participants. Hypertension rate was 30.7%. A higher PRAL was associated with higher prevalence rate of hypertension among the male (P-trend = 0.03). OR for Q2 was 1.34 (95%CI, 0.94–1.91), Q3 was 1.53 (95%CI = 1.08, 2.16) and Q4 was 1.51 (95%CI, 1.08–2.16) among the male. However, as for total participants, the female, the participants with ≤55 years or participants with > 55 years, the associations were lack of significance. With respect to association between NEAP and hypertension, non-significant results were identified. Conclusions The current study indicated male hypertension was associated with higher PRAL, while given to this study was cross-sectional design, further studies are warranted to verify the association.

scholarly journals The Serum Metabolome Identifies Biomarkers of Dietary Acid Load in 2 Studies of Adults with Chronic Kidney Disease

2019 ◽  
Vol 149 (4) ◽  
pp. 578-585 ◽  
Author(s):  
Casey M Rebholz ◽  
Aditya Surapaneni ◽  
Andrew S Levey ◽  
Mark J Sarnak ◽  
Lesley A Inker ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Fruits And Vegetables ◽  
Smoking Status ◽  
Cross Sectional ◽  
Dietary Acid Load ◽  
Nutrition Research ◽  
Net Endogenous Acid Production ◽  
Dietary Acid ◽  
Acid Load

ABSTRACT Background Dietary acid load is a clinically important aspect of the diet that reflects the balance between acid-producing foods, for example, meat and cheese, and base-producing foods, for example, fruits and vegetables. Methods We used metabolomics to identify blood biomarkers of dietary acid load in 2 independent studies of chronic kidney disease patients: the African American Study of Kidney Disease and Hypertension (AASK, n = 689) and the Modification of Diet in Renal Disease (MDRD, n = 356) study. Multivariable linear regression was used to assess the cross-sectional association between serum metabolites whose identity was known (outcome) and dietary acid load (exposure), estimated with net endogenous acid production (NEAP) based on 24-h urine urea nitrogen and potassium, and adjusted for age, sex, race, randomization group, measured glomerular filtration rate, log-transformed urine protein-to-creatinine ratio, history of cardiovascular disease, BMI, and smoking status. Results Out of the 757 known, nondrug metabolites identified in AASK, 26 were significantly associated with NEAP at the Bonferroni threshold for significance (P < 6.6 × 10−5). Twenty-three of the 26 metabolites were also identified in the MDRD study, and 13 of the 23 (57%) were significantly associated with NEAP (P < 2.2 × 10−3), including 5 amino acids (S-methylmethionine, indolepropionylglycine, indolepropionate, N-methylproline, N-δ-acetylornithine), 2 cofactors and vitamins (threonate, oxalate), 1 lipid (chiro-inositol), and 5 xenobiotics (methyl glucopyranoside, stachydrine, catechol sulfate, hippurate, and tartronate). Higher levels of all 13 replicated metabolites were associated with lower NEAP in both AASK and the MDRD study. Conclusion Metabolomic profiling of serum specimens from kidney disease patients in 2 study populations identified 13 replicated metabolites associated with dietary acid load. Additional studies are needed to validate these compounds in healthy populations. These 13 compounds may potentially be used as objective markers of dietary acid load in future nutrition research studies.

scholarly journals The Association of Dietary Acid Load with Resting Metabolic Rate and Metabolic Components in Overweight and Obese Women: A Cross Sectional Study

2021 ◽  
Author(s):  
Atieh Mirzababaei ◽  
Farideh Shiraseb ◽  
Leila Setayesh ◽  
Atefeh Tavakoli ◽  
Cain C. T. Clark ◽  
...  
Keyword(s):  
Metabolic Rate ◽  
Resting Metabolic Rate ◽  
Cross Sectional Study ◽  
The Body ◽  
Adult Women ◽  
Sectional Study ◽  
Cross Sectional ◽  
Dietary Acid Load ◽  
Dietary Acid ◽  
Acid Load

Abstract Background: Several epidemiologic studies have reported that dietary acid load is associated with metabolic profiles; however, to our knowledge, the relationship of this dietary pattern with resting metabolic rate (RMR) among obese and overweight females remains unreported. Therefore, this study aimed to evaluate the association of dietary acid load RMR and metabolic components among overweight and obese adult women.Methods: This cross-sectional study was conducted on 375 Iranian adults, aged 18–48 years. Dietary acid load indexes were calculated by using a validated 147-item semi-quantitative FFQ. Biochemical and anthropometric measures were assessed using standard methods. An impedance fat analyzer was used to obtain the body composition and an indirect calorimeter was used to assess the RMR. Result: It was observed that after correction for potential confounders, DBP and NEAP and PRAL scores were inversely associated (P<0.05). NEAP index was inversely associated with RMR (β= -0.25, 95% CI=-0.1.5 to 2.08, P=0.02), and positively associated with WC (β= 1.009, 95% CI=-1.43 to 3.45, P=0.05) and WHR (β= 0.01, 95% CI= -0.01 to0.04, P=0.03), such that subjects with higher scores in NEAP had lower RMR and higher WC and WHR. We also observed that DAL (β= -0.02, 95% CI= -0.08 to0.03, P=0.08) and PRAL (β= -0.037, 95% CI= -1.05 to 0.03 P=0.07) were marginally associated with RMR.Conclusion:The results of the present study suggested that higher dietary acid load scores may be negatively associated with lower RMR, while directly associated with greater WC, WHR, DBP, and HOMA-IR.

scholarly journals The Association of Dietary Acid Load with Resting Metabolic Rate and Metabolic Components in Overweight and Obese Women: A Cross Sectional Study

2021 ◽  
Author(s):  
Atieh Mirzababaei ◽  
Farideh Shiraseb ◽  
Leila Setayesh ◽  
Atefeh Tavakoli ◽  
Cain C. T. Clark Clark ◽  
...  
Keyword(s):  
Metabolic Rate ◽  
Resting Metabolic Rate ◽  
Cross Sectional Study ◽  
The Body ◽  
Adult Women ◽  
Sectional Study ◽  
Cross Sectional ◽  
Dietary Acid Load ◽  
Dietary Acid ◽  
Acid Load

Abstract Background: Several epidemiologic studies have reported that dietary acid load is associated with metabolic profiles; however, to our knowledge, the relationship of this dietary pattern with resting metabolic rate (RMR) among obese and overweight females remains unreported. Therefore, this study aimed to evaluate the association of dietary acid load RMR and metabolic components among overweight and obese adult women.Methods: This cross-sectional study was conducted on 375 Iranian adults, aged 18–48 years. Dietary acid load indexes were calculated by using a validated 147-item semi-quantitative FFQ. Biochemical and anthropometric measures were assessed using standard methods. An impedance fat analyzer was used to obtain the body composition and an indirect calorimeter was used to assess the RMR. Result: It was observed that after correction for potential confounders, DBP and NEAP and PRAL scores were inversely associated (P<0.05). NEAP index was inversely associated with RMR (β= -0.25, 95% CI=-0.1.5 to 2.08, P=0.02), and positively associated with WC (β= 1.009, 95% CI=-1.43 to 3.45, P=0.05) and WHR (β= 0.01, 95% CI= -0.01 to0.04, P=0.03), such that subjects with higher scores in NEAP had lower RMR and higher WC and WHR. We also observed that DAL (β= -0.02, 95% CI= -0.08 to0.03, P=0.08) and PRAL (β= -0.037, 95% CI= -1.05 to 0.03 P=0.07) were marginally associated with RMR.Conclusion:The results of the present study suggested that higher dietary acid load scores may be negatively associated with lower RMR, while directly associated with greater WC, WHR, DBP, and HOMA-IR.

scholarly journals The Association of Dietary Acid Load with Resting Metabolic Rate and Metabolic Components in Overweight and Obese Women: A Cross Sectional Study

2021 ◽  
Author(s):  
Atieh Mirzababaei ◽  
Farideh Shiraseb ◽  
Leila Setayesh ◽  
Atefeh Tavakoli ◽  
Cain C. T. Clark Clark ◽  
...  
Keyword(s):  
Metabolic Rate ◽  
Resting Metabolic Rate ◽  
Cross Sectional Study ◽  
The Body ◽  
Adult Women ◽  
Sectional Study ◽  
Cross Sectional ◽  
Dietary Acid Load ◽  
Dietary Acid ◽  
Acid Load

Abstract Background: Several epidemiologic studies have reported that dietary acid load is associated with metabolic profiles; however, to our knowledge, the relationship of this dietary pattern with resting metabolic rate (RMR) among obese and overweight females remains unreported. Therefore, this study aimed to evaluate the association of dietary acid load RMR and metabolic components among overweight and obese adult women.Methods: This cross-sectional study was conducted on 375 Iranian adults, aged 18–48 years. Dietary acid load indexes were calculated by using a validated 147-item semi-quantitative FFQ. Biochemical and anthropometric measures were assessed using standard methods. An impedance fat analyzer was used to obtain the body composition and an indirect calorimeter was used to assess the RMR. Result: It was observed that after correction for potential confounders, DBP and NEAP and PRAL scores were inversely associated (P<0.05). NEAP index was inversely associated with RMR (β= -0.25, 95% CI=-0.1.5 to 2.08, P=0.02), and positively associated with WC (β= 1.009, 95% CI=-1.43 to 3.45, P=0.05) and WHR (β= 0.01, 95% CI= -0.01 to0.04, P=0.03), such that subjects with higher scores in NEAP had lower RMR and higher WC and WHR. We also observed that DAL (β= -0.02, 95% CI= -0.08 to0.03, P=0.08) and PRAL (β= -0.037, 95% CI= -1.05 to 0.03 P=0.07) were marginally associated with RMR.Conclusion:The results of the present study suggested that higher dietary acid load scores may be negatively associated with lower RMR, while directly associated with greater WC, WHR, DBP, and HOMA-IR.

High dietary acid load score is not associated with the risk of metabolic syndrome in Iranian adults

2020 ◽  
pp. 1-12
Author(s):  
Noushin Mohammadifard ◽  
Golgis Karimi ◽  
Alireza Khosravi ◽  
Nizal Sarrafzadegan ◽  
Mahnaz Jozan ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Blood Sugar ◽  
Cross Sectional Study ◽  
Dietary Intakes ◽  
Cross Sectional ◽  
Dietary Acid Load ◽  
Net Endogenous Acid Production ◽  
Increased Risk ◽  
Dietary Acid ◽  
Acid Load

Abstract. Background and objective: The association between dietary acid load and metabolic syndrome (MetS) risk is not well-known. Therefore, we aimed to investigate the relationship between dietary acid load and the risk of MetS among Iranian adults. Methods: This cross-sectional study was carried out on 1430 Iranian adults. Dietary intakes were assessed using a validated food frequency questionnaire. Dietary acid load was estimated using potential renal acid load (PRAL) and net endogenous acid production (NEAP). MetS was defined according to the ATP-III criteria. The risk of MetS and its components was explored using logistic regression test. Results: Totally, 205 individuals were identified to have MetS. No significant association for MetS was found across the quartiles of PRAL and NEAP either in the crude model [Q4 PRAL: OR (95% CI): 0.94 (0.67–1.32), and NEAP: OR (95% CI): 0.88 (0.63–1.25)] or fully-adjusted model [Q4 PRAL: OR (95% CI): 0.90 (0.61–1.33), and NEAP: OR (95% CI): 1.05 (0.70–1.57)]. Amongst the components of MetS, higher scores of NEAP was associated with an increased risk of impaired blood sugar after adjustment for potential confounders [OR (95% CI): 1.35 (0.93–1.96)]. No significant association was found for other components either with PRAL or with NEAP. Conclusion: Our findings suggest no association between dietary acid load and MetS risk in Iranian adults. However, higher dietary acid load, measured by NEAP, but not PRAL, was associated with increased risk of impaired fasting blood sugar. Longitudinal studies are warranted to explore whether a diet low in potential acid load could reduce MetS risk.

scholarly journals Association of estimated dietary acid load with albuminuria in Japanese adults: a cross-sectional study

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Keiko Kabasawa ◽  
Michihiro Hosojima ◽  
Ribeka Takachi ◽  
Kazutoshi Nakamura ◽  
Yumi Ito ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Dietary Acid Load ◽  
Japanese Adults ◽  
Dietary Acid ◽  
Acid Load

scholarly journals The association between dietary acid load and muscle strength among Iranian adults

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Saba Mohammadpour ◽  
Farhang Djafari ◽  
Samira Davarzani ◽  
Kurosh Djafarian ◽  
Cain C. T. Clark ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Dietary Acid Load ◽  
Left Hand ◽  
Linear Relationships ◽  
Net Endogenous Acid Production ◽  
Dietary Acid ◽  
Acid Load ◽  
Load Indices

Abstract Objective There is limited evidence regarding the association between dietary acid load and muscle strength. Thus, in this study, we investigated the association between dietary acid–base load indices and muscle strength among Iranian adults. Results This cross-sectional study was conducted on 270 Iranian adults, aged 18–70 year. Dietary acid load indexes, were calculated by using a validated 168-item semi-quantitative food frequency questionnaire (FFQ). Muscle strength was measured by a digital handgrip dynamometer. There was a significant increase in mean muscle strength of left-hand (MSL), muscle strength of right-hand (MSR) and the mean of the MSL and MSR (MMS) across tertiles of Potential Renal Acid Load (PRAL), Net Endogenous Acid Production (NEAP), and Dietary Acid Load (DAL). Significant linear relationships between PRAL and; MSL (β = 0.24, p < 0.001), MSR (β = 0.23, p < 0.001) and MMS (β = 0.24, p < 0.001), between NEAP and MSL (β = 0.21, p < 0.001), MSR (β = 0.19, p = 0.002), and MMS (β = 0.20, p = 0.001) and between DAL and MSL (β = 0.25, p < 0.001), MSR (β = 0.23, p < 0.001) and MMS (β = 0.24, p < 0.001), were attenuated after controlling for potential confounders. However, the nonlinear relationship between dietary acid load indicators and muscle strength were significant (p < 0.001 for all).

scholarly journals The Association of Dietary Acid Load with Resting Metabolic Rate and Metabolic Components in Overweight and Obese Women: A Cross Sectional Study

2021 ◽  
Author(s):  
Atieh Mirzababaei ◽  
Farideh Shiraseb ◽  
Leila Setayesh ◽  
Atefeh Tavakoli ◽  
Cain C. T. Clark ◽  
...  
Keyword(s):  
Metabolic Rate ◽  
Resting Metabolic Rate ◽  
Cross Sectional Study ◽  
Epidemiologic Studies ◽  
Adult Women ◽  
Obese Women ◽  
Cross Sectional ◽  
Dietary Acid Load ◽  
Dietary Acid ◽  
Acid Load

Abstract Objective: Several epidemiologic studies have reported that dietary acid load is associated with metabolic profiles; however, to our knowledge, the relationship of this dietary pattern with resting metabolic rate (RMR) among obese and overweight females remains unreported. Therefore, this study aimed to evaluate the association of dietary acid load RMR and metabolic components among overweight and obese adult women.Results: It was observed that after correction for potential confounders, DBP and NEAP and PRAL scores were inversely associated (P<0.05). NEAP index was inversely associated with RMR (β= -0.25, 95% CI=-0.1.5 to 2.08, P=0.02), and positively associated with WC (β= 1.009, 95% CI=-1.43 to 3.45, P=0.05) and WHR (β= 0.01, 95% CI= -0.01 to0.04, P=0.03), such that subjects with higher scores in NEAP had lower RMR and higher WC and WHR. We also observed that DAL (β= -0.02, 95% CI= -0.08 to0.03, P=0.08) and PRAL (β= -0.037, 95% CI= -1.05 to 0.03 P=0.07) were marginally associated with RMR.

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