The Association of Dietary Acid Load with Resting Metabolic Rate and Metabolic Components in Overweight and Obese Women: A Cross Sectional Study

Abstract Background: Several epidemiologic studies have reported that dietary acid load is associated with metabolic profiles; however, to our knowledge, the relationship of this dietary pattern with resting metabolic rate (RMR) among obese and overweight females remains unreported. Therefore, this study aimed to evaluate the association of dietary acid load RMR and metabolic components among overweight and obese adult women.Methods: This cross-sectional study was conducted on 375 Iranian adults, aged 18–48 years. Dietary acid load indexes were calculated by using a validated 147-item semi-quantitative FFQ. Biochemical and anthropometric measures were assessed using standard methods. An impedance fat analyzer was used to obtain the body composition and an indirect calorimeter was used to assess the RMR. Result: It was observed that after correction for potential confounders, DBP and NEAP and PRAL scores were inversely associated (P<0.05). NEAP index was inversely associated with RMR (β= -0.25, 95% CI=-0.1.5 to 2.08, P=0.02), and positively associated with WC (β= 1.009, 95% CI=-1.43 to 3.45, P=0.05) and WHR (β= 0.01, 95% CI= -0.01 to0.04, P=0.03), such that subjects with higher scores in NEAP had lower RMR and higher WC and WHR. We also observed that DAL (β= -0.02, 95% CI= -0.08 to0.03, P=0.08) and PRAL (β= -0.037, 95% CI= -1.05 to 0.03 P=0.07) were marginally associated with RMR.Conclusion:The results of the present study suggested that higher dietary acid load scores may be negatively associated with lower RMR, while directly associated with greater WC, WHR, DBP, and HOMA-IR.

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The Association of Dietary Acid Load with Resting Metabolic Rate and Metabolic Components in Overweight and Obese Women: A Cross Sectional Study

10.21203/rs.3.rs-141018/v2 ◽

2021 ◽

Author(s):

Atieh Mirzababaei ◽

Farideh Shiraseb ◽

Leila Setayesh ◽

Atefeh Tavakoli ◽

Cain C. T. Clark Clark ◽

...

Keyword(s):

Metabolic Rate ◽

Resting Metabolic Rate ◽

Cross Sectional Study ◽

The Body ◽

Adult Women ◽

Sectional Study ◽

Cross Sectional ◽

Dietary Acid Load ◽

Dietary Acid ◽

Acid Load

Abstract Background: Several epidemiologic studies have reported that dietary acid load is associated with metabolic profiles; however, to our knowledge, the relationship of this dietary pattern with resting metabolic rate (RMR) among obese and overweight females remains unreported. Therefore, this study aimed to evaluate the association of dietary acid load RMR and metabolic components among overweight and obese adult women.Methods: This cross-sectional study was conducted on 375 Iranian adults, aged 18–48 years. Dietary acid load indexes were calculated by using a validated 147-item semi-quantitative FFQ. Biochemical and anthropometric measures were assessed using standard methods. An impedance fat analyzer was used to obtain the body composition and an indirect calorimeter was used to assess the RMR. Result: It was observed that after correction for potential confounders, DBP and NEAP and PRAL scores were inversely associated (P<0.05). NEAP index was inversely associated with RMR (β= -0.25, 95% CI=-0.1.5 to 2.08, P=0.02), and positively associated with WC (β= 1.009, 95% CI=-1.43 to 3.45, P=0.05) and WHR (β= 0.01, 95% CI= -0.01 to0.04, P=0.03), such that subjects with higher scores in NEAP had lower RMR and higher WC and WHR. We also observed that DAL (β= -0.02, 95% CI= -0.08 to0.03, P=0.08) and PRAL (β= -0.037, 95% CI= -1.05 to 0.03 P=0.07) were marginally associated with RMR.Conclusion:The results of the present study suggested that higher dietary acid load scores may be negatively associated with lower RMR, while directly associated with greater WC, WHR, DBP, and HOMA-IR.

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The Association of Dietary Acid Load with Resting Metabolic Rate and Metabolic Components in Overweight and Obese Women: A Cross Sectional Study

Clinical Nutrition ESPEN ◽

10.1016/j.clnesp.2021.11.033 ◽

2021 ◽

Author(s):

Atieh Mirzababaei ◽

Farideh Shiraseb ◽

Leila Setayesh ◽

Atefeh Tavakoli ◽

Elnaz Daneshzad ◽

...

Keyword(s):

Metabolic Rate ◽

Resting Metabolic Rate ◽

Cross Sectional Study ◽

Obese Women ◽

Sectional Study ◽

Cross Sectional ◽

Dietary Acid Load ◽

Dietary Acid ◽

Acid Load

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The Association of Dietary Acid Load with Resting Metabolic Rate and Metabolic Components in Overweight and Obese Women: A Cross Sectional Study

10.21203/rs.3.rs-145354/v1 ◽

2021 ◽

Author(s):

Atieh Mirzababaei ◽

Farideh Shiraseb ◽

Leila Setayesh ◽

Atefeh Tavakoli ◽

Cain C. T. Clark Clark ◽

...

Keyword(s):

Metabolic Rate ◽

Resting Metabolic Rate ◽

Cross Sectional Study ◽

The Body ◽

Adult Women ◽

Sectional Study ◽

Cross Sectional ◽

Dietary Acid Load ◽

Dietary Acid ◽

Acid Load

Abstract Background: Several epidemiologic studies have reported that dietary acid load is associated with metabolic profiles; however, to our knowledge, the relationship of this dietary pattern with resting metabolic rate (RMR) among obese and overweight females remains unreported. Therefore, this study aimed to evaluate the association of dietary acid load RMR and metabolic components among overweight and obese adult women.Methods: This cross-sectional study was conducted on 375 Iranian adults, aged 18–48 years. Dietary acid load indexes were calculated by using a validated 147-item semi-quantitative FFQ. Biochemical and anthropometric measures were assessed using standard methods. An impedance fat analyzer was used to obtain the body composition and an indirect calorimeter was used to assess the RMR. Result: It was observed that after correction for potential confounders, DBP and NEAP and PRAL scores were inversely associated (P<0.05). NEAP index was inversely associated with RMR (β= -0.25, 95% CI=-0.1.5 to 2.08, P=0.02), and positively associated with WC (β= 1.009, 95% CI=-1.43 to 3.45, P=0.05) and WHR (β= 0.01, 95% CI= -0.01 to0.04, P=0.03), such that subjects with higher scores in NEAP had lower RMR and higher WC and WHR. We also observed that DAL (β= -0.02, 95% CI= -0.08 to0.03, P=0.08) and PRAL (β= -0.037, 95% CI= -1.05 to 0.03 P=0.07) were marginally associated with RMR.Conclusion:The results of the present study suggested that higher dietary acid load scores may be negatively associated with lower RMR, while directly associated with greater WC, WHR, DBP, and HOMA-IR.

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Nutrient pattern of unsaturated fatty acids and vitamin E increase resting metabolic rate of overweight and obese women

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000664 ◽

2020 ◽

pp. 1-9

Author(s):

Habib Yarizadeh ◽

Leila Setayesh ◽

Caroline Roberts ◽

Mir Saeed Yekaninejad ◽

Khadijeh Mirzaei

Keyword(s):

Vitamin E ◽

Metabolic Rate ◽

Unsaturated Fatty Acids ◽

Resting Metabolic Rate ◽

Blood Parameters ◽

Cross Sectional Study ◽

Obese Women ◽

Cross Sectional ◽

Dietary Nutrients ◽

Nutrient Patterns

Abstract. Objectives: Obesity plays an important role in the development of chronic diseases including cardiovascular disease and diabetes. A low resting metabolic rate (RMR) for a given body size and composition is a risk factor for obesity, however, there is limited evidence available regarding the association of nutrient patterns and RMR. The aim of this study was to determine the association of nutrient patterns and RMR in overweight and obese women. Study design: This cross-sectional study was conducted on 360 women who were overweight or obese. Method: Dietary intake was assessed using a semi-quantitative standard food frequency questionnaire (FFQ). Nutrient patterns were also extracted by principal components analysis (PCA). All participants were evaluated for their body composition, RMR, and blood parameters. Result: Three nutrient patterns explaining 64% of the variance in dietary nutrients consumption were identified as B-complex-mineral, antioxidant, and unsaturated fatty acid and vitamin E (USFA-vit E) respectively. Participants were categorized into two groups based on the nutrient patterns. High scores of USFA-vit E pattern was significantly associated with the increase of RMR (β = 0.13, 95% CI = 0.79 to 68.16, p = 0.04). No significant associations were found among B-complex-mineral pattern (β = −0.00, 95% CI = −49.67 to 46.03, p = 0.94) and antioxidant pattern (β = 0.03, 95% CI −41.42 to 22.59, p = 0.56) with RMR. Conclusion: Our results suggested that the “USFA-vit E” pattern (such as PUFA, oleic, linoleic, vit.E, α-tocopherol and EPA) was associated with increased RMR.

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Variants of the Cry 1 Gene May Influence the Effect of Fat Intake on Resting Metabolic Rate In Overweight and Obese Women: A Cross-sectional Study

10.21203/rs.3.rs-304833/v1 ◽

2021 ◽

Author(s):

Atieh Mirzababaei ◽

Elnaz Daneshzad ◽

Farideh Shiraseb ◽

Sanaz Pourreza ◽

Leila Setayesh ◽

...

Keyword(s):

Dietary Intake ◽

Metabolic Rate ◽

Resting Metabolic Rate ◽

Cross Sectional Study ◽

Overweight And Obesity ◽

Allele Carrier ◽

Fat Intake ◽

Obese Women ◽

Sectional Study ◽

Cross Sectional

Abstract Background: Previous studies have shown that the minor allele (C allele) for Cry 1 rs2287161, may be associated with increased risk of cardiovascular diseases (CVDs). Low resting metabolic rate (RMR) caused by the diet has been shown to have, potentially, unfavorable effects on obesity. This study sought to investigate the interactions between the Cry 1 Gene and fat intake on RMR in overweight and obese women.Methods: This comparative cross-sectional study was conducted on 377 Iranian women with overweight and obesity. A food frequency questionnaire (FFQ), with 147 items, was used to assess dietary intake. Individuals were categorized into two groups based on the rs2287161 genotype. Body composition, dietary intake, and RMR were assessed for all participants.Results: There was a significant difference between genotypes for FBS (P=0.04), fat free mass (FFM) (P=0.0009), RMR per FFM (P =0.05), RMR per body mass index (BMI) (P=0.02), and RMR deviation (P=0.01). Our findings also showed significant interactions between total fat and C allele carrier group on RMR per kg, RMR per body surface area (BSA), RMR per FFM, and RMR deviation (P for interaction <0.1), in addition to a significant interaction between CC+CG group genotype and PUFA intake on RMR per BMI (P for interaction =0.009) and RMR per kg (P for interaction=0.02) and RMR per BSA (P=0.07), compared to the GG group, after control for confounder factors.Conclusion: These results highlight that dietary compositions, gene variants, and their interaction, should be acutely considered in lower RMR.

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High dietary acid load score is not associated with the risk of metabolic syndrome in Iranian adults

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000626 ◽

2020 ◽

pp. 1-12

Author(s):

Noushin Mohammadifard ◽

Golgis Karimi ◽

Alireza Khosravi ◽

Nizal Sarrafzadegan ◽

Mahnaz Jozan ◽

...

Keyword(s):

Metabolic Syndrome ◽

Blood Sugar ◽

Cross Sectional Study ◽

Dietary Intakes ◽

Cross Sectional ◽

Dietary Acid Load ◽

Net Endogenous Acid Production ◽

Increased Risk ◽

Dietary Acid ◽

Acid Load

Abstract. Background and objective: The association between dietary acid load and metabolic syndrome (MetS) risk is not well-known. Therefore, we aimed to investigate the relationship between dietary acid load and the risk of MetS among Iranian adults. Methods: This cross-sectional study was carried out on 1430 Iranian adults. Dietary intakes were assessed using a validated food frequency questionnaire. Dietary acid load was estimated using potential renal acid load (PRAL) and net endogenous acid production (NEAP). MetS was defined according to the ATP-III criteria. The risk of MetS and its components was explored using logistic regression test. Results: Totally, 205 individuals were identified to have MetS. No significant association for MetS was found across the quartiles of PRAL and NEAP either in the crude model [Q4 PRAL: OR (95% CI): 0.94 (0.67–1.32), and NEAP: OR (95% CI): 0.88 (0.63–1.25)] or fully-adjusted model [Q4 PRAL: OR (95% CI): 0.90 (0.61–1.33), and NEAP: OR (95% CI): 1.05 (0.70–1.57)]. Amongst the components of MetS, higher scores of NEAP was associated with an increased risk of impaired blood sugar after adjustment for potential confounders [OR (95% CI): 1.35 (0.93–1.96)]. No significant association was found for other components either with PRAL or with NEAP. Conclusion: Our findings suggest no association between dietary acid load and MetS risk in Iranian adults. However, higher dietary acid load, measured by NEAP, but not PRAL, was associated with increased risk of impaired fasting blood sugar. Longitudinal studies are warranted to explore whether a diet low in potential acid load could reduce MetS risk.

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The relationship between modified Nordic diet and resting metabolic rate among overweight and obese women in Tehran, Iran: a cross sectional study

International Journal of Clinical Practice ◽

10.1111/ijcp.14946 ◽

2021 ◽

Author(s):

Ghazaleh Khalili ◽

Atieh Mirzababaei ◽

Farideh Shiraseb ◽

Khadijeh Mirzaei

Keyword(s):

Metabolic Rate ◽

Resting Metabolic Rate ◽

Cross Sectional Study ◽

Obese Women ◽

Sectional Study ◽

Cross Sectional ◽

Nordic Diet ◽

The Relationship

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The Association Between Deficiency of Nutrient Intake on Resting Metabolic Rate in Overweight and Obese Women: A Cross-Sectional Study

10.21203/rs.3.rs-65422/v1 ◽

2020 ◽

Author(s):

Seyedeh Forough Sajjadi ◽

Atieh Mirzababaei ◽

Afsoun Abdollahi ◽

Farideh Shiraseb ◽

Khadijeh Mirzaei

Keyword(s):

Vitamin C ◽

Dietary Intake ◽

Metabolic Rate ◽

Resting Metabolic Rate ◽

Cross Sectional Study ◽

Fat Free Mass ◽

Health Concern ◽

Obese Women ◽

Sectional Study ◽

Cross Sectional

Abstract Background: The double burden of malnutrition is an emerging public health concern nowadays which a correlation with Obesity. The aim of this study was to examine the relationship between resting metabolic rate (RMR) and dietary intake of zinc, vitamin C, and riboflavin based on Nutrient Adequacy Ratios (NAR) in overweight and obese women.Methods: We enrolled 293 overweight and obese women in this cross-sectional study. BMI, body fat mass, fat-free mass, insulin level were assessed. RMR was measured using indirect calorimetry. NAR was measured by calculating the ratio of daily individual intakes to the standard recommended amounts.Results: the RMR/FFM showed a significant association with riboflavin (β=1.59; 95% CI: 1.04-23.26, P=0.04) and zinc (β=0.78; 95% CI: 1.04-4.61, P=0.03) in the crude model. Moreover, differences in vitamin C and RMR/FFM was marginal significant (β=0.75; 95% CI: 0.95-4.77, P=0.06). After adjust for confounders the riboflavin association change to marginal significance (β=1.52; 95% CI: 0.91-23.04, P=0.06). After controlling for potential confounders, the associations change between zinc and RMR/FFM (β=0.66; 95% CI: 0.78-4.86, P=0.15) and between RMR/FFM and vitamin C (β=0.48; 95% CI: 0.66-3.96, P=0.28).Conclusion: Our study showed a significant association between dietary intake of zinc, riboflavin, and vitamin C and change in RMR/FFM in overweight and obese women.

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