scholarly journals Correlation between the HIF-1α/Notch signaling pathway and Modic changes in nucleus pulposus cells isolated from patients with low back pain

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Zekang Xiong ◽  
Jun Ding ◽  
Jinge Zhou ◽  
Sheng Yao ◽  
Jin Zheng ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Nucleus Pulposus ◽  
Notch Signaling Pathway ◽  
Modic Changes ◽  
Low Back ◽  
Nucleus Pulposus Cells

scholarly journals Interaction Between HIF-1α and Notch Signaling Pathways in Nucleus Pulposus Cells of Patients with Modic Changes

2020 ◽  
Author(s):  
Zekang Xiong ◽  
Xiaodong Guo ◽  
Jin Zheng ◽  
Jun Ding ◽  
Jinge Zhou ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Signaling Pathways ◽  
Signaling Pathway ◽  
Nucleus Pulposus ◽  
Notch Pathway ◽  
Notch Signaling Pathway ◽  
Modic Changes ◽  
Nucleus Pulposus Cells ◽  
Tissue Samples ◽  
Promising Target

Abstract Background The HIF-1α/Notch signaling pathway has been shown to regulate proliferation, apoptosis, and metabolism in the intervertebral disc (IVD). The NP is an important structure adjacent to the disc. However, the roles of HIF1α and Notch signaling pathways in NP cells of patients with different Modic changes (MCs) are unclear. The purpose of this research was to assess the expression and association of HIF-1α and components of the Notch pathway in nucleus pulposus (NP) tissue of patients with various MCs. Methods Eighty-five surgical NP tissue samples were obtained from patients undergoing microdiscectomy procedures for the treatment of low back and root pain caused by prolapse of the IVD. The NP tissues were divided into four groups based on the adjacent endplate degeneration: MC I, II, III, and negative MC groups. The expression of HIF-1α and Notch-related components were measured and compared. Results The expression of HIF-1α, Notch1, and Notch2 were gradually increased in the MC I and MC II groups compared with that of the negative MC group. Meanwhile, HIF-1α and Notch-related components were rarely detected in MC III group. Conclusions The expression of HIF-1α/Notch is increased in the NP cells of patients with MC I and MC II. Application of the association between HIF-1α/Notch signaling pathway could be promising target for clinical diagnosis and treatment of disc degeneration in MC patients.

Therapeutic effects of naringin on degenerative human nucleus pulposus cells for discogenic low back pain

2016 ◽  
Vol 16 (10) ◽  
pp. 1231-1237 ◽  
Author(s):  
Nianhu Li ◽  
Camden Whitaker ◽  
Zhanwang Xu ◽  
Michael Heggeness ◽  
Shang-You Yang
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Nucleus Pulposus ◽  
Therapeutic Effects ◽  
Low Back ◽  
Nucleus Pulposus Cells ◽  
Discogenic Low Back Pain

BMP9 Promotes the Extracellular Matrix of Nucleus Pulposus Cells via Inhibition of the Notch Signaling Pathway

2019 ◽  
Vol 38 (4) ◽  
pp. 358-366
Author(s):  
Xiang Zhang ◽  
Bo Qiao ◽  
Zhenming Hu ◽  
Weidong Ni ◽  
Shuquan Guo ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Nucleus Pulposus ◽  
Notch Signaling Pathway ◽  
Nucleus Pulposus Cells

scholarly journals Apparent diffusion in nucleus pulposus is associated with pain and mobility improvements after spinal mobilization for acute low back pain

2017 ◽  
Author(s):  
Paul Thiry ◽  
Francois Reumont ◽  
Jean-Michel Brismée ◽  
Frédéric Dierick
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Nucleus Pulposus ◽  
Pain Perception ◽  
Random Motion ◽  
Nociceptive Response ◽  
Low Back ◽  
Acute Low Back Pain ◽  
Flexion Extension ◽  
Apparent Diffusion

ABSTRACTPain perception, trunk mobility in flexion, extension, and lateral flexion, and apparent diffusion coefficient (ADC) within nucleus pulposus of all lumbar discs were collected before and after posterior-to-anterior mobilization in 16 adults with acute low back pain. ADC was computed from diffusion maps and 3 specific portions of the nucleus pulposus were investigated: anterior (ADCant), middle (ADCmid), and posterior (ADCpost), and their mean as ADCall, a summary measure of ADC within nucleus pulposus. Pain ratings were significantly reduced after mobilization, and mobility of the trunk was significantly increased. Concomitantly, a significant increase in ADCall values was observed. The greatest ADCall changes were observed at the L3-L4 and L4-L5 levels and were mainly explained by changes in ADCant and ADCpost. The simultaneous reduction in pain and increase of water diffusion within nucleus pulposus has has been previously observed in subjects with chronic conditions and exists in the acute phase of the disease. Since the largest changes in ADC were observed at the periphery of the nucleus pulposus, and taken together with pain decrease, our results suggest that increased peripheral random motion of water molecules is implicated in the modulation of the intervertebral disc nociceptive response.

scholarly journals The effect of infliximab in patients with chronic low back pain and Modic changes (the BackToBasic study): study protocol of a randomized, double blind, placebo-controlled, multicenter trial

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Elisabeth Gjefsen ◽  
Lars Christian Haugli Bråten ◽  
Guro Løvik Goll ◽  
Monica Wigemyr ◽  
Nils Bolstad ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Treatment Strategy ◽  
Treatment Options ◽  
Modic Changes ◽  
Low Back ◽  
Double Blind ◽  
Link Type

Abstract Background Low back pain is common and a significant number of patients experience chronic low back pain. Current treatment options offer small to moderate effects. Patients with vertebral bone marrow lesions visualized as Modic changes on magnetic resonance imaging may represent a subgroup within the low back pain population. There is evidence for inflammatory mediators being involved in development of Modic changes; hence, suppression of inflammation could be a treatment strategy for these patients. This study examines the effect of anti-inflammatory treatment with the TNF-α inhibitor infliximab in patients with chronic low back pain and Modic changes. Methods/design The BackToBasic trial is a multicenter, double blind, randomized controlled trial conducted at six hospitals in Norway, comparing intravenous infusions with infliximab with placebo. One hundred twenty-six patients aged 18–65 with chronic low back pain and type 1 Modic changes will be recruited from secondary care outpatients’ clinics. The primary outcome is back pain-specific disability at day 154 (5 months). The study is designed to detect a difference in change of 10 (SD 18) in the Oswestry Disability Index at day 154/ 5 months. The study also aims to refine MRI-assessment, investigate safety and cost-effectiveness and explore the underlying biological mechanisms of Modic changes. Discussion Finding treatments that target underlying mechanisms could pose new treatment options for patients with low back pain. Suppression of inflammation could be a treatment strategy for patients with low back pain and Modic changes. This paper presents the design of the BackToBasic study, where we will assess the effect of an anti-inflammatory treatment versus placebo in patients with chronic low back pain and type 1 Modic changes. The study is registered at ClinicalTrials.gov under the identifier NCT03704363. The EudraCT Number: 2017–004861-29.

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