scholarly journals Agent-mediated spatial storage effect in heterogeneous habitat stabilizes competitive mouse lemur coexistence in Menabe Central, Western Madagascar

BMC Ecology ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Livia Schäffler ◽  
Joachim Saborowski ◽  
Peter M Kappeler
BMC Genomics ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Umit Akkose ◽  
Veysel Ogulcan Kaya ◽  
Laura Lindsey-Boltz ◽  
Zeynep Karagoz ◽  
Adam D. Brown ◽  
...  

Abstract Background Nucleotide excision repair is the primary DNA repair mechanism that removes bulky DNA adducts such as UV-induced pyrimidine dimers. Correspondingly, genome-wide mapping of nucleotide excision repair with eXcision Repair sequencing (XR-seq), provides comprehensive profiling of DNA damage repair. A number of XR-seq experiments at a variety of conditions for different damage types revealed heterogenous repair in the human genome. Although human repair profiles were extensively studied, how repair maps vary between primates is yet to be investigated. Here, we characterized the genome-wide UV-induced damage repair in gray mouse lemur, Microcebus murinus, in comparison to human. Results We derived fibroblast cell lines from mouse lemur, exposed them to UV irradiation, and analyzed the repair events genome-wide using the XR-seq protocol. Mouse lemur repair profiles were analyzed in comparison to the equivalent human fibroblast datasets. We found that overall UV sensitivity, repair efficiency, and transcription-coupled repair levels differ between the two primates. Despite this, comparative analysis of human and mouse lemur fibroblasts revealed that genome-wide repair profiles of the homologous regions are highly correlated, and this correlation is stronger for highly expressed genes. With the inclusion of an additional XR-seq sample derived from another human cell line in the analysis, we found that fibroblasts of the two primates repair UV-induced DNA lesions in a more similar pattern than two distinct human cell lines do. Conclusion Our results suggest that mouse lemurs and humans, and possibly primates in general, share a homologous repair mechanism as well as genomic variance distribution, albeit with their variable repair efficiency. This result also emphasizes the deep homologies of individual tissue types across the eukaryotic phylogeny.


NeuroImage ◽  
2021 ◽  
Vol 226 ◽  
pp. 117589
Author(s):  
Clément M. Garin ◽  
Nachiket A. Nadkarni ◽  
Brigitte Landeau ◽  
Gaël Chételat ◽  
Jean-Luc Picq ◽  
...  
Keyword(s):  

1998 ◽  
Vol 66 (3) ◽  
pp. 355-358 ◽  
Author(s):  
J. Buey ◽  
L. Díez ◽  
P. Espinet ◽  
H.-S. Kitzerow ◽  
J.A. Miguel

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mikio Fukuhara ◽  
Tomoyuki Kuroda ◽  
Fumihiko Hasegawa ◽  
Toshiyuki Hashida ◽  
Mitsuhiro Takeda ◽  
...  

AbstractIn this study, the electric storage effect of AlO6 clusters in amorphous alumina (AAO) supercapacitors was investigated in terms of cluster morphologies under electron-beam irradiation. Based on first-principles density functional calculation, the optimised structure of AlO6 clusters around an O-vacancy is characterised by a large vacant space created by the absence of an O atom and its neighbouring Al atom. The localised electrons present near the two-atomic vacancies induce positive charges on the inside of the insulating oxide surface, ensuring the adsorption of many electrons on the surface. Electron-beam irradiation (adsorption) from 100 to 180 keV causes the lengths of the Al–O bonds of the cluster to shrink, but then return to the original length with decreasing voltage energy, indicating a rocking-chair-type charge-breathing effect accompanied by a volume expansion of approximately 4%. The I–V and I–R characteristics depicted Coulomb blockade for the switching effect of both the negative and positive potentials. The Ragone plot of the AAO supercapacitor is located at capability area of the second cell.


2021 ◽  
Author(s):  
Blandine Chazarin ◽  
Margaux Benhaim-Delarbre ◽  
Charlotte Brun ◽  
Aude Anzeraey ◽  
Fabrice Bertile ◽  
...  

Grey mouse lemurs (Microcebus murinus) are a primate species exhibiting strong physiological seasonality in response to environmental energetic constraint. They notably store large amounts of lipids during early winter (EW), which are thereafter mobilized during late winter (LW), when food availability is low. In addition, they develop glucose intolerance in LW only. To decipher how the hepatic mechanisms may support such metabolic flexibility, we analyzed the liver proteome of adult captive male mouse lemurs, which seasonal regulations of metabolism and reproduction are comparable to their wild counterparts, during the phases of either constitution or use of fat reserves. We highlight profound changes that reflect fat accretion in EW at the whole-body level, however, without triggering an ectopic storage of fat in the liver. Moreover, molecular regulations would be in line with the lowering of liver glucose utilization in LW, and thus with reduced tolerance to glucose. However, no major regulation was seen in insulin signaling/resistance pathways, which suggests that glucose intolerance does not reach a pathological stage. Finally, fat mobilization in LW appeared possibly linked to reactivation of the reproductive system and enhanced liver detoxification may reflect an anticipation to return to summer levels of food intake. Altogether, these results show that the physiology of mouse lemurs during winter relies on solid molecular foundations in liver processes to adapt fuel partitioning while avoiding reaching a pathological state despite large lipid fluxes. This work emphasizes how the mouse lemur is of primary interest for identifying molecular mechanisms relevant to biomedical field.


2021 ◽  
Vol 15 (1) ◽  
pp. 105-111
Author(s):  
Xiaolong Zhang ◽  
Hong Yu ◽  
Lin Chen ◽  
Chuntang Mao ◽  
Yuanbing Wang ◽  
...  

The distribution of the bark procyanidin contents in 26 populations of Pinus yunnanensis and 8 populations of P. kesiya var. langbianensis and 5 populations of P. densata was determined. The results indicated that genetic and environmental factors commonly affected the procyanidin content in the populations of P. yunnanensis and related species. The procyanidin contents in the three related species followed the order of P. densata (54.72 mg/g) > P. kesiya (43.86 mg/g) > P. yunnanensis (37.95 mg/g). Furthermore, the procyanidin content in P. yunnanensis and related species had high variability. The procyanidin contents in the three related species showed that the procyanidin contents of P. densata distributed in northwest Yunnan and P. kesiya distributed in southern Yunnan were high, the procyanidin content of the population with introgression and hybridization or a heterogeneous habitat was also high, and that of P. yunnanensis distributed in central Yunnan was low. The quadratic regression model of procyanidin content and latitude was Y = 1329.06 -100.52* Latitude +1.95 * Latitude2.


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