scholarly journals Risk of mini-mental state examination (MMSE) decline in the elderly with type 2 diabetes: a Chinese community-based cohort study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Lei Zhao ◽  
Chao Han ◽  
Zheng Zheng ◽  
Shuang Ling Xiu ◽  
Piu Chan

Background: The oral administration of Astaxanthin may decrease depression symptoms and improved cognitive function through its beneficial effects on inflammation, and oxidative stress. Objective: This study was designed to assess whether Astaxanthin supplementation can reduce symptoms of depression and increase MMSE score in patients with Type 2 Diabetes Mellitus. Methods: This randomized, double-blind, placebo-controlled clinical trial was performed in 44 patients between 30 and 60 y of age with a diagnosis of type 2 diabetes. Patients were randomly assigned to receive either a single capsule of 8 mg of Astaxanthin /day (n = 22) or placebo (n = 22) for 8 wk. The primary [Beck Depression Inventory (BDI), which examines depressive symptoms] and secondary (Mini-Mental State Examination (MSSE) score, which evaluates cognitive function) outcomes were assessed. Results: After 8 week of intervention, Mini-Mental State Examination baseline score was significantly improved only in the group treated with Astaxanthin, during study (p < 0.01). But no significant reduction in the Beck Depression Inventory (BDI) was observed in both group. Conclusion: Overall, Astaxanthin supplementation of patients with diabetes for 8 weeks had beneficial effects on the MMSE score. Key words: Astaxanthin, Cognitive function Depression


2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Sharon Gondodiputro ◽  
Dahlia Santika Hutasoit ◽  
Lina Rahmiati

Prevalence of chronic diseases and disability will increase at the advancing age. In the future, the need for the caregiver will increase. Only few studies about the expectations of the elderly towards the sociodemographics status of the caregiver found. Unfulfilled expectations of the elderly towards their caregivers may cause both health and non-health issues. The purpose of this study was to explore the elderly expectations of the caregiver’s sociodemographic preferences. A qualitative study was carried out to 7 elderly aged 64–77 years old from July to August 2018 in Bandung city. These elderly selected from 7 integrated care posts (pos pembinaan terpadu/posbindu) that met the inclusion criteria: aged 60 years old and above; male or female; capable of communicating adeptly, and no dementia by undergoing the mini-mental state examination (MMSE). A one-on-one interview was conducted at the residence of the elderly using an interview guide consisted of several opened questions related to the caregiver’s sociodemographic preferences. A content analysis was carried out. This study discovered that the elderly preferred their family members or relatives whom they can trust to become their caregivers (their children and grandchildren). Most of these elderly also preferred daughters who live with them and has a decent income. If the family members could not become their caregiver then their neighbor or a community volunteer/cadre, they knew well, and trust to be their caregiver. It concluded that the elderly prefer their daughters who live with them and has a decent income to be their caregivers. EKSPEKTASI USIA LANJUT TERHADAP STATUS SOSIODEMOGRAFI CAREGIVER: SUATU PENDEKATAN KUALITATIFPrevalensi penyakit kronis dan disablilitas akan meningkat dengan pertambahan usia. Hal ini berdampak pada kebutuhan terhadap caregiver akan meningkat pula. Penelitian tentang ekspektasi usia lanjut terhadap status sosiodemografi caregiver belum banyak dilakukan. Ekspektasi usia lanjut merupakan faktor penting karena bila ekspektasi tersebut tidak terpenuhi maka akan berisiko timbul masalah kesehatan dan nonkesehatan. Tujuan penelitian ini mengeksplorasi ekspektasi usia lanjut terhadap status sosiodemografi caregiver. Studi kualitatif dilakukan terhadap 7 orang usia lanjut berusia 64–77 tahun pada Juli hingga Agustus 2018 di Kota Bandung. Para usia lanjut berasal dari 7 pos pembinaan terpadu (posbindu) yang memenuhi kriteria inklusi, yaitu usia ≥60 tahun, laki-laki atau perempuan, dapat berkomunikasi dengan baik, dan tidak demensia dengan dilakukan mini-mental state examination (MMSE). Wawancara dilakukan di kediaman informan masing-masing menggunakan panduan wawancara terkait pertanyaan dengan preferensi sosiodemografi caregiver. Analisis konten dilakukan. Studi ini menemukan bahwa usia lanjut lebih memilih anggota keluarga mereka yang dapat dipercaya untuk menjadi caregiver terutama anak dan cucu. Anak perempuan yang tinggal bersama usia lanjut dan memiliki penghasilan layak menjadi pilihan utama. Jika anggota keluarga tidak dapat menjadi caregiver maka tetangga atau kader yang mereka kenal baik dan dipercaya menjadi pilihan. Simpulan, pilihan utama caregiver bagi usia lanjut, yaitu anak perempuan mereka yang tinggal bersama dan memiliki penghasilan layak.


2019 ◽  
Vol 44 (5) ◽  
pp. 1115-1127 ◽  
Author(s):  
Youlu Zhao ◽  
Yuhui Zhang ◽  
Zhikai Yang ◽  
Jinwei Wang ◽  
Zuying Xiong ◽  
...  

Background: Patients with chronic kidney disease experience a high burden of sleep disorders, and there are associations between sleep disorders and cognitive impairment. Objectives: Based on our previous cross-sectional survey on cognitive impairment in peritoneal dialysis, we further explored the relationship between sleep disorders and cognitive impairment, and predictors for declining cognitive function. Method: We conducted a multicenter prospective cohort study enrolling 458 clinically stable patients on peritoneal dialysis who were then followed up for 2 years.Demographic data, comorbidities, depression, and biochemistry data were collected at baseline. Sleep disorders including insomnia, restless legs syndrome, sleep apnea syndrome, excessive daytime sleepiness, possible narcolepsy, sleep walking and nightmares, and possible rapid eye movement behavior disorders were assessed using a panel of specific sleep questionnaires at baseline and in a second survey. Global cognitive function was measured at baseline and in a second survey, using the Modified Mini-Mental State Examination. Specific cognitive domains were evaluated using Trail-Making Test Forms A and B for executive function, and subtests of the Battery for the Assessment of Neuropsychological Status were used to asses immediate and delayed memory, visuospatial skills, and language ability. Results: Sleep disorders were common among peritoneal dialysis patients. The prevalence of cognitive impairment evaluated by the Modified Mini-Mental State Examination (3MS) increased from 19.8 to 23.9%. Possible narcolepsy was associated with decreased Modified Mini-Mental State Examination scores at baseline. During follow-up, sleepwalking and nightmares were associated with higher risks of declined delayed memory in the longitudinal study. Conclusions: Possible narcolepsy was associated with general cognitive dysfunction, and sleep walking and nightmares were risk factors for impaired delayed memory.


BMJ ◽  
2020 ◽  
pp. l6775
Author(s):  
Rob Cook ◽  
Peter Davidson ◽  
Rosie Martin

The study Dambha-Miller H, Day AJ, Strelitz J, et al. Behaviour change, weight loss and remission of Type 2 diabetes: a community-based prospective cohort study. Diabet Med 2019. doi: 10.1111/dme.14122 . This project was funded by the NIHR Health Technology Assessment Programme (project number 08/116/300) as well as the Wellcome Trust (grant number: G061895), the Epidemiology Unit programme (MC_UU_12015/4), and the National Health Service R&D support funding. To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000841/weight-loss-after-type-2-diabetes-diagnosis-boosts-chance-of-remission


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