scholarly journals Physical properties and biocompatibility of an injectable calcium-silicate-based root canal sealer: in vitro and in vivo study

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Eun-Su Lim ◽  
Young-Bae Park ◽  
Young-Sun Kwon ◽  
Won-Jun Shon ◽  
Kwang-Won Lee ◽  
...  
Keyword(s):  
Physical Properties ◽  
Root Canal ◽  
Calcium Silicate ◽  
In Vivo Study ◽  
Root Canal Sealer

scholarly journals Właściwości alkalizujące wybranych krzemianowo-wapniowych uszczelniaczy kanałowych. Badanie in vitro

2018 ◽  
Vol 64 (4) ◽  
Author(s):  
Przemysław Reszka ◽  
Łukasz Kucharski ◽  
Adam Klimowicz ◽  
Mariusz Lipski
Keyword(s):  
Root Canal ◽  
Calcium Silicate ◽  
In Vitro Study ◽  
Root Canal Sealer ◽  
Ph Values ◽  
Water Ph ◽  
Ah Plus ◽  
Ph Level ◽  
Root Canal Sealers

ABSTRACTIntroduction: The aim of this in vitro study was to assess the pH values of selected calcium-silicate root canal sealers in comparison with AH Plus resin-based root canal sealer.Materials and methods: Six root canal sealers were included in this study: BioRoot RCS (Septodont, France), GuttaFlow bioseal (Coltėne/Whaledent, Switzerland), MTA Fillapex (Angelus, Brazil), Total Fill BC Sealer (FKG, Switzerland), Well-Root ST (Vericom, Korea) and AH Plus (Dentsply, DeTrey, Germany). Materials samples (n = 6) were placed in dishes and immersed in 10 mL of distilled water (pH = 6.8). After 1, 3, 24, 48, 72, 168, 336 and 504 hrs, water pH was determined with a pH meter calibrated with a solution of known pH. Data were statistically analyzed using Student-t test (p < 0.05).Results: There were differences in the water pH between the materials tested. The highest water pHs were exhibited by Total Fill BC Sealer, Well-Root ST and BioRoot RCS (pH ~12), followed by GuttaFlow bioseal (pH ~10.5) and MTA Fillapex (pH ~9). The lowest pH was shown by AH Plus (pH ~8).Conclusions: All calcium-silicate root canal sealers studied are able to elevate the pH level, which could have biological and antimicrobial effects. The AH Plus root canal sealer has poor alkalizing properties.

Cytotoxicity and the Effect of Temperature on Physical Properties and Chemical Composition of a New Calcium Silicate–based Root Canal Sealer

2020 ◽  
Vol 46 (4) ◽  
pp. 531-538 ◽  
Author(s):  
Binwen Chen ◽  
Markus Haapasalo ◽  
Christophe Mobuchon ◽  
Xianyu Li ◽  
Jingzhi Ma ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Physical Properties ◽  
Root Canal ◽  
Calcium Silicate ◽  
Effect Of Temperature ◽  
Root Canal Sealer

scholarly journals Adding Two Antimicrobial Glasses to an Endodontic Sealer to Prevent Bacterial Root Canal Reinfection: An In Vivo Pilot Study in Dogs

Antibiotics ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1183
Author(s):  
Álvaro Zubizarreta-Macho ◽  
Cristina Rico-Romano ◽  
María Jesús Fernández-Aceñero ◽  
Jesús Mena-Álvarez ◽  
Belén Cabal ◽  
...  
Keyword(s):  
Glass Ceramic ◽  
Root Canal ◽  
Tissue Response ◽  
Control Group ◽  
Root Canal Sealer ◽  
Bacterial Reduction ◽  
Canal Systems ◽  
Histological Results

Current endodontic procedures continue to be unsuccessful for completely removing pathogens present inside the root canal system, which can lead to recurrent infections. In this study, we aimed to assess the antimicrobial capacity and tissue response of two inorganic bactericidal additives incorporated into a paste root canal sealer on contaminated root dentin in vivo. An experimental study was performed in 30 teeth of five Beagle dogs. After inducing microbiological contamination, root canal systems were treated by randomly incorporating one of two antimicrobial additives into a commercial epoxy-amine resin sealer (AH Plus), i.e., G3T glass-ceramic (n = 10) and ZnO-enriched glass (n = 10); 10 samples were randomized as a control group. After having sacrificed the animals, microbiological, radiological, and histological analyses were performed, which were complemented with an in vitro bactericidal test and characterization by field emission scanning electron microscopy. The tested groups demonstrated a non-significant microbiological reduction in the postmortem periapical index values between the control group and the bactericidal glass-ceramic group (p = 0.885), and between the control group and the ZnO-enriched glass group (p = 0.169). The histological results showed low values of inflammatory infiltrate, and a healing pattern characterized by fibrosis in 44.4% of the G3T glass-ceramic and 60.0% of ZnO-enriched glass. Bactericidal glassy additives incorporated in this root canal sealer are safe and effective in bacterial reduction.

In Vitro Osteogenic Potential of an Experimental Calcium Silicate–based Root Canal Sealer

2010 ◽  
Vol 36 (7) ◽  
pp. 1163-1169 ◽  
Author(s):  
Thomas E. Bryan ◽  
Khaled Khechen ◽  
Martha G. Brackett ◽  
Regina L.W. Messer ◽  
Ahmed El-Awady ◽  
...  
Keyword(s):  
Root Canal ◽  
Calcium Silicate ◽  
Osteogenic Potential ◽  
Root Canal Sealer

Ca–Si mesoporous nanoparticles with optimized Ag–Zn ratio inhibit the Enterococcus faecalis infection of teeth through dentinal tubule infiltration: An in vitro and in vivo study

2021 ◽  
Author(s):  
Qing Sun ◽  
Mengting Duan ◽  
Wei Fan ◽  
Bing Fan
Keyword(s):  
Enterococcus Faecalis ◽  
Successful Treatment ◽  
Root Canal ◽  
Necessary Conditions ◽  
In Vivo Study ◽  
Dentinal Tubule ◽  
Human Teeth ◽  
Mesoporous Nanoparticles

Enterococcus faecalis is the main cause of refractory root canal infections in human teeth. The control of root canal infection is one of the necessary conditions for successful treatment of...

Formulation and Evaluation of Atorvastatin Calcium-Poly-ε-Caprolactone Nanoparticles Loaded Ocular Inserts for Sustained Release and Antiinflammatory Efficacy

2020 ◽  
Vol 21 (15) ◽  
pp. 1688-1698
Author(s):  
Germeen N.S. Girgis
Keyword(s):  
Sustained Release ◽  
In Vitro Release ◽  
Pluronic F127 ◽  
In Vivo Study ◽  
Average Weight ◽  
Drug Release Profile ◽  
Atorvastatin Calcium ◽  
Anti Inflammatory

Purpose: The work was performed to investigate the feasibility of preparing ocular inserts loaded with Poly-ε-Caprolactone (PCL) nanoparticles as a sustained ocular delivery system. Methods: First, Atorvastatin Calcium-Poly-ε-Caprolactone (ATC-PCL) nanoparticles were prepared and characterized. Then, the optimized nanoparticles were loaded within inserts formulated with Methylcellulose (MC) and Polyvinyl Alcohol (PVA) by a solvent casting technique and evaluated physically, for in-vitro drug release profile. Finally, an in-vivo study was performed on the selected formulation to prove non-irritability and sustained ocular anti-inflammatory efficacy compared with free drug-loaded ocuserts. Results: The results revealed (ATC-PCL) nanoparticles prepared with 0.5% pluronic F127 were optimized with 181.72±3.6 nm particle size, 0.12±0.02 (PDI) analysis, -27.4± 0.69 mV zeta potential and 62.41%±4.7% entrapment efficiency. Nanoparticles loaded ocuserts manifested compatibility between drug and formulation polymers. Moreover, formulations complied with average weight 0.055±0.002 to 0.143±0.023 mg, and accepted pH. ATC-PCL nanoparticles loaded inserts prepared by 5% MC showed more sustained, prolonged in-vitro release over 24h. In-vivo study emphasized non-irritability, ocular anti-inflammatory effectiveness represented by smaller lid closure scores, and statistically significant lowering in PMN count after 3h. Conclusion: These findings proposed a possibly simple, new and affordable price technique to prepare promising (ATC-PCL) nanoparticles loaded inserts to achieve sustained release with prolonged antiinflammatory efficacy.

Quercetin improve ischemia/reperfusion‐induced cardiomyocyte apoptosis in vitro and in vivo study via SIRT1/PGC‐1α signaling

2019 ◽  
Vol 120 (6) ◽  
pp. 9747-9757 ◽  
Author(s):  
Jiayou Tang ◽  
Linhe Lu ◽  
Yang Liu ◽  
Jipeng Ma ◽  
Lifang Yang ◽  
...  
Keyword(s):  
Ischemia Reperfusion ◽  
Cardiomyocyte Apoptosis ◽  
In Vivo Study
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