The effect of periodontal therapy on glycemic control and fasting plasma glucose level in type 2 diabetic patients: systematic review and meta-analysis

Background. The aim of this study was to assess target diabetic goal achievements and to explore variables associated with them. Methods. A cross-sectional study was conducted between December 2015 and April 2016 on 188 type 2 diabetic patients attending Ayder Referral Hospital’s outpatient diabetic clinic. Glycemic control was assessed using fasting plasma glucose values and total cholesterol and triglyceride were used to evaluate lipid profiles. Bivariate and multivariate logistic regression analyses were done to identify factors associated with poor glycemic control, hypertension, and dyslipidemia. Result. Mean duration of diabetes was 6.5 years. Combined glycemic, lipid, and blood pressure targets were achieved only in 8.5% of the participants. More males achieved combined targets than females. Separately, while above two-thirds of the patients had poor glycemic control (67%), more than half of the participants have had poor lipid (58.5%) and blood pressure (52.1%) control. A significant portion of the patients (68.1%) had also comorbidities other than hyperglycemia. In bivariate and multivariate analyses, longer duration of diabetes disease (AOR: 3.4; P=0.013) and marked month to month fasting plasma glucose (FPG) variability as measured by large standard deviation (AOR: 2.5; P=0.023) were significantly associated with overall poor mean FPG results. Female sex was also significantly associated with dyslipidemia (AOR: 1.9; P=0.049). Conclusion. The study showed that achievements of combined diabetic goals are generally poor.

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Body Mass Index, Fasting Plasma Glucose Levels, and C-peptide Levels as Predictors of the Future Insulin Use in Japanese Type 2 Diabetic Patients

Endocrine Journal ◽

10.1507/endocrj.k09e-279 ◽

2010 ◽

Vol 57 (3) ◽

pp. 237-244 ◽

Cited By ~ 27

Author(s):

Atsushi GOTO ◽

Maki TAKAICHI ◽

Miyako KISHIMOTO ◽

Yoshihiko TAKAHASHI ◽

Hiroshi KAJIO ◽

...

Keyword(s):

Body Mass Index ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

C Peptide ◽

Glucose Levels ◽

Insulin Use ◽

Type 2 Diabetic

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Intensive glycemic control has no impact on the risk of heart failure in type 2 diabetic patients: Evidence from a 37,229 patient meta-analysis

Yearbook of Endocrinology ◽

10.1016/j.yend.2012.04.015 ◽

2012 ◽

Vol 2012 ◽

pp. 3-4

Author(s):

E. Oetjen

Keyword(s):

Heart Failure ◽

Glycemic Control ◽

Meta Analysis ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Intensive Glycemic Control ◽

Type 2 Diabetic

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Reno-protective effects of renin–angiotensin system blockade in type 2 diabetic patients: a systematic review and network meta-analysis

Diabetologia ◽

10.1007/s00125-011-2398-8 ◽

2011 ◽

Vol 55 (3) ◽

pp. 566-578 ◽

Cited By ~ 79

Author(s):

P. Vejakama ◽

A. Thakkinstian ◽

D. Lertrattananon ◽

A. Ingsathit ◽

C. Ngarmukos ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Renin Angiotensin System ◽

Diabetic Patients ◽

Protective Effects ◽

Type 2 Diabetic Patients ◽

Angiotensin System ◽

Renin Angiotensin ◽

Type 2 Diabetic

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Effect of propolis on glycemic control in patients with type 2 diabetes: an updated systematic review and meta-analysis of randomized controlled trials

Nutrition & Food Science ◽

10.1108/nfs-01-2021-0026 ◽

2021 ◽

Vol ahead-of-print (ahead-of-print) ◽

Author(s):

Zahra Mosallanezhad ◽

Cain Clark ◽

Fatemeh Bahreini ◽

Zahra Motamed ◽

Abdolhamid Mosallanezhad ◽

...

Keyword(s):

Systematic Review ◽

Serum Insulin ◽

Meta Analysis ◽

Diabetic Patients ◽

Controlled Trials ◽

Type 2 Diabetic Patients ◽

Content Type ◽

Randomized Controlled ◽

Type 2 Diabetic

Purpose The purpose of this systematic review and meta-analysis was to investigate the efficacy of propolis on glycemic indices in type 2 diabetic patients. Design/methodology/approach Web of science (ISI), Embase, Scopus and PubMed were systematically searched to find randomized controlled trials (RCTs) assessing the effects of propolis intake on glycemic controls in type 2 diabetic patients, from inception up to September 1, 2020. A random-effects model was used to pool weighted mean difference (WMD). Meta-regression was performed to detect the potential sources of inter-study heterogeneity. Findings Seven trials were included in the meta-analysis. Compared to controls, propolis intake significantly improved serum fasting blood sugar (FBS) (WMD = −13.62 mg/dl, 95% CI = [−23.04, −4.20], P = 0.005, I2 = 58.5%) and hemoglobin A1C (HbA1c) (WMD = −0.52%, 95% CI = [−0.86, −0.18], P = 0.002, I2 = 64.0%). In contrast, receiving propolis did not change serum insulin (WMD = −1.46 (uIU/ml), 95% CI = [−2.94, 0.02], P = 0.05, I2 = 75.0%) and homeostatic model assessment for insulin resistance (HOMA-IR) (WMD = −0.98 (%), 95% CI = [−2.00, 0.04], P = 0.06, I2 = 82.3%) compared to controls. Originality/value The present meta-analysis demonstrated that propolis intake significantly reduces serum FBS and HbA1c in diabetic patients but does not alter serum insulin and HOMA-IR. Further large-scale RCT’s are needed to approve these effects.

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