scholarly journals Malignant Transformation of Oral Lichen Planus: A Retrospective Study of 565 Japanese Patients

2021 ◽  
Author(s):  
Fumihiko Tsushima ◽  
Jinkyo Sakurai ◽  
Atsushi Uesugi ◽  
Yu Oikawa ◽  
Toshimitsu Ohsako ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Japanese Patients ◽  
Histopathological Diagnosis ◽  
Oral Epithelial Dysplasia ◽  
Oral Lichenoid Lesions ◽  
Potentially Malignant ◽  
Clear Differentiation ◽  
Oral Lichen

Abstract Objective Oral lichen planus (OLP) is a chronic inflammatory oral mucosa disease that is recognized as an oral potentially malignant disorder. However, the potentially malignant nature of OLP remains unclear.Materials and Methods We designed this study to examine the demographic and clinical characteristics of OLP and evaluate its malignant potential. A total of 565 patients with a clinical and histopathological diagnosis of OLP who presented at our department between 2001 and 2017 were retrospectively studied. Patients who had clinical and histopathological features of oral lichenoid lesions (OLLs) classified as oral lichenoid contact lesions (OLCLs), oral lichenoid drug reactions (OLDRs) and oral lichenoid lesions of graft-versus-host disease (OLL-GVHD) were excluded.Results The study population included 123 men and 442 women aged 21-93 years (median, 62 years). The 565 patients were followed up for an average duration of 55.9 months, during which 4 (0.7%) patients developed squamous cell carcinoma (SCC). In three of these 4 patients who developed SCC, the clinical type of OLP was the red type.Conclusions Our results suggested that OLP was associated with a low risk of malignant transformation. Further investigation of the clinical risk factors associated with malignant transformation is necessary.Clinical relevance We recommend regular follow-up for OLP patients and clear differentiation of oral epithelial dysplasia (OED) and OLLs to enable early detection of malignant transformation.

scholarly journals Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Fumihiko Tsushima ◽  
Jinkyo Sakurai ◽  
Atsushi Uesugi ◽  
Yu Oikawa ◽  
Toshimitsu Ohsako ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Japanese Patients ◽  
Histopathological Diagnosis ◽  
Transformation Rate ◽  
Oral Epithelial Dysplasia ◽  
Oral Lichenoid Lesions ◽  
Potentially Malignant ◽  
Oral Lichen

Abstract Background Oral lichen planus (OLP) is a chronic inflammatory oral mucosa disease that is recognized as an oral potentially malignant disorder. However, the potentially malignant nature of OLP remains unclear. Methods We designed this study to examine the demographic and clinical characteristics of patients with OLP and evaluate the associated malignant transformation rate. A total of 565 patients with a clinical and histopathological diagnosis of OLP who presented at our department between 2001 and 2017 were retrospectively studied. Patients who had clinical and histopathological features of oral lichenoid lesions (OLLs) classified as oral lichenoid contact lesions, oral lichenoid drug reactions and oral lichenoid lesions of graft-versus-host disease were excluded. Results The study population included 123 men and 442 women aged 21–93 years (mean ± standard deviation, 60.5 ± 11.8). The 565 patients were followed up for a duration of 55.9 ± 45.3 months, during which 4 (0.7%) patients developed squamous cell carcinoma (SCC). In three of these 4 patients who developed SCC, the clinical type of OLP was the red type. Conclusions Our results suggested that OLP was associated with a low risk of malignant transformation. We recommend regular follow-up for OLP patients and clear differentiation of oral epithelial dysplasia and OLLs to enable early detection of malignant transformation. Further investigation of the clinical risk factors associated with malignant transformation is necessary.

Assessment and Comparison of Salivary Survivin Biomarker in Oral Leukoplakia, Oral Lichen Planus, and Oral Cancer: A Comparative Study

2017 ◽  
Vol 8 (2) ◽  
pp. 73-76 ◽  
Author(s):  
Ruchika Garg ◽  
Arvind V Shetti ◽  
Anjana S Bagewadi
Keyword(s):  
Oral Cancer ◽  
Comparative Study ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Leukoplakia ◽  
Control Group ◽  
Significant Difference ◽  
Potentially Malignant ◽  
Oral Lichen

ABSTRACT Introduction Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral cavity. It is preceded by various potentially malignant conditions like oral leukoplakia and oral lichen planus. Survivin is an inhibitor of apoptosis whose levels have been found increased in oral cancer as well as various potentially malignant conditions. Thus survivin can act as a biomarker and help in early detection of potentially malignant conditions which can prevent its transformation into malignancy. Aim To assess and compare the level of total human salivary survivin in oral leukoplakia, oral lichen planus, oral cancer, and control group. Materials and methods A total of 96 subjects were included in the study, which were further grouped into 24 in each group. The saliva was analyzed for survivin level among all the four groups. Survivin concentration (pg/mL) was studied in relation to clinical data. The results were analyzed using Mann—Whitney U test to derive the statistical difference. Results The average of levels of survivin in control group was 0.199 pg/mL, in oral leukoplakia group 0.312 pg/mL, in oral lichen planus group 0.380 pg/mL, and in oral cancer group 0.430 pg/mL. A comparison of all these groups revealed statistically significant difference among the groups. Conclusion Survivin may not be considered as an independent predictor of the malignant transformation for premalignant lesions but it can be an indicator for an increased risk of malignant transformation. How to cite this article Garg R, Shetti AV, Bagewadi AS. Assessment and Comparison of Salivary Survivin Biomarker in Oral Leukoplakia, Oral Lichen Planus, and Oral Cancer: A Comparative Study. World J Dent 2017;8(2):73-76.

scholarly journals Clinicopathologic Correlation of Oral Lichen Planus and Oral Lichenoid Lesions: A Preliminary Study

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Marinka Mravak-Stipetić ◽  
Božana Lončar-Brzak ◽  
Iva Bakale-Hodak ◽  
Ivan Sabol ◽  
Sven Seiwerth ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Plasma Cells ◽  
Clinical Feature ◽  
Histopathological Diagnosis ◽  
Oral Lichenoid Lesions ◽  
Number Of Patients ◽  
Preliminary Study ◽  
Mononuclear Infiltrate ◽  
Oral Lichen

Oral lichen planus (OLP) and oral lichenoid lesions (OLL) are clinically and histologically similar lesions but their treatment planning and prognosis are different. The review of the literature indicates numerous criteria to distinguish these two lesions; however there is a lot of inconsistency. Thus, the aim of this study was to determine the correlation of histopathology and clinical OLP and OLL diagnosis and to clarify which histopathologic criteria could best distinguish these two diagnoses. A retrospective study showed that clinically diagnosed 92 OLPs and 14 OLLs have been confirmed histopathologically in 52.2% and 42.9% of cases, respectively. In addition, histopathology showed statistically significant more eosinophils (P<0.0005), plasma cells (P<0.0005), and granulocytes (P<0.05) in OLL than OLP. To establish histopathological diagnosis of OLP and OLL it should be mandatory to define the type of cells in mononuclear infiltrate, which can be associated more accurately with clinical feature and patient history. Therefore, currently accepted diagnostic criteria for OLP and OLL should be modified and validated on a larger number of patients taking into account particular distinguishing histopathological features.

Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data

Oral Oncology ◽  
2017 ◽  
Vol 68 ◽  
pp. 92-102 ◽  
Author(s):  
Sana Maher Hasan Aghbari ◽  
Abdelrahman Ibrahim Abushouk ◽  
Attia Attia ◽  
Ahmed Elmaraezy ◽  
Amr Menshawy ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Patient Data ◽  
Oral Lichenoid Lesions ◽  
Oral Lichen

P233 Lichenoid dysplasia and malignant transformation of oral lichen planus and oral lichenoid lesions

2007 ◽  
Vol 2 (1) ◽  
pp. 201
Author(s):  
P. Vescovi ◽  
M. Meleti ◽  
M. Manfredi ◽  
E. Merigo ◽  
R. Guidotti ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Lichenoid Lesions ◽  
Oral Lichen

scholarly journals Risk of Malignant Transformation in 3173 Subjects with Histopathologically Confirmed Oral Lichen Planus: A 33-Year Cohort Study in Northern Italy

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5740
Author(s):  
Paolo G. Arduino ◽  
Alessandro Magliano ◽  
Alessio Gambino ◽  
Alessandra Macciotta ◽  
Mario Carbone ◽  
...  
Keyword(s):  
Cohort Study ◽  
Oral Cancer ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Northern Italy ◽  
Elderly Subjects ◽  
Histopathological Diagnosis ◽  
Oral Lichen

Background: Oral lichen planus (OLP) is considered an oral potentially malignant disorder. The aim of our study was to estimate the risk for oral cancer in patients diagnosed with OLP. Methods: A population-based cohort study between January 1988 and December 2020 at one hospital in Northern Italy was performed. The primary endpoint of the study was that of the histopathological diagnosis of oral cancer during the follow-up period. Results: The study population comprised 3173 patients. During the follow-up period, 32 men and 50 women developed an oral squamous cell carcinoma (2.58%), with a mean time of 103.61 months after the initial diagnosis of OLP, and 21 patients died because of oral cancer. Almost half of the deceased patients had the last follow-up visit before cancer diagnosis in a period of more than 12 months. Older age, having a red form of OLP and fewer sites of involvement, increased the risk of having cancer, while age and no treatment increased the risk of death. Conclusion: This is the largest group of OLP patients with such a long follow up ever reported. Due to the increased risk of having a malignant transformation, especially in elderly subjects, OLP patients should be regularly followed up, particularly in the Northern Italian population.

scholarly journals Descoberta de carcinoma de células escamosas em lesão previamente diagnosticada como líquen plano oral: malignização ou erro de diagnóstico inicial?

2019 ◽  
Vol 8 (4) ◽  
Author(s):  
Adriana Caroline Leite ◽  
Nathalia Torres Assay ◽  
Fabio Augusto Ito ◽  
Heliton Gustavo de Lima ◽  
Ademar Takahama Junior
Keyword(s):  
Systematic Review ◽  
Retrospective Study ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Clinical Management ◽  
Oral Lichen Planus ◽  
Oxidative Dna Damage ◽  
Malignant Potential ◽  
Oral Lichenoid Lesions ◽  
Oral Lichen

O Líquen Plano Oral (LPO) é uma doença crônica imunologicamente mediada com potencial de malignização incerto. O objetivo desse artigo é relatar um caso de Carcinoma de Células Escamosas (CCE) diagnosticado em paciente com diagnóstico prévio de LPO. Paciente do sexo feminino, 69 anos, foi atendida durante uma campanha de diagnóstico precoce de câncer de boca realizada na cidade de Londrina/PR, sendo detectada uma lesão eritroplásica em língua e encaminhada para uma melhor avaliação. Na anamnese a paciente relatou que há 2 anos atrás foi diagnosticada com LPO através de biópsia em língua, não sendo proposto nenhum tratamento. Ao exame físico, observamos uma mancha eritematosa em borda lateral de língua do lado esquerdo, não apresentando nenhuma outra lesão na cavidade oral. Com a hipótese diagnóstica de eritroplasia, foi requisitada a lâmina da biópsia anterior para análise, que revelou características microscópicas incompatíveis com o diagnóstico de LPO. Optamos então por realizar uma nova biópsia e a análise histopatológica revelou ilhas de células epiteliais malignas invadindo o tecido conjuntivo, estabelecendo o diagnóstico de CCE. A paciente foi encaminhada para tratamento, sendo realizada glossectomia parcial. Em acompanhamento de 6 meses a paciente encontra-se bem e sem sinais de recidiva. A transformação maligna do LPO ainda é discutida na literatura e muitos casos relatados podem se tratar de erro no diagnóstico inicial, como no caso apresentado. O erro de diagnóstico pode levar a morbidades importantes e comprometer o prognóstico do caso.Descritores: Diagnóstico; Líquen Plano; Carcinoma de Células Escamosas.ReferênciasGiuliani M, Troiano G, Cordaro M, Corsalini M, Gioco G, Lo Muzio L et al. Rate of malignant transformation of Oral Lichen Planus: a systematic review. Oral Dis. 2019; 25(3):693-709.Bardellini E, Amadori F, Flocchini P, Bonadeo S, Majorana A. Clinicopathological features and malignant transformation of oral lichen planus: a 12-years retrospective study. Acta Odontologica Scandinavica 2013;71(3/4):834-40.Eisen D. The clinical features, malignant potential, and systemic associations of oral lichen planus: a study of 723 patients. J Am Acad Dermatol. 2002;46(2):207-14.Farhi D, Dupin N. Pathophysiology, etiologic factors, and clinical management of oral lichen planus, part I: facts and controversies. Clin Dermatol. 2010;28(1):100-8.Roopashree MR, Gondhalekar RV, Shashikanth MC, George J, Thippeswamy SH, Shukla A. Pathogenesis of oral lichen planus – a review. J Oral Pathol Med. 2010;39(10):729-34.van der Meij EH, van der Waal I. Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications. J Oral Pathol Med. 2003;32(9):507-12.Kramer IR, Lucas RB, Pindborg JJ, Sobin LH. Definition of leukoplakia and related lesions: an aid to studies on oral precancer. Oral Surg Oral Med Oral Pathol. 1978;46(4):518-39.Aghbari SMH, Abushouk AI, Attia A, Elmaraezy A, Menshawy A, Ahmed MS et al. Malignant transformation of oral lichen planus and oral lichenoid lesions: a meta-analysis of 20095 patient data. Oral Oncology. 2017;68:92-102.Eisenberg E. Oral lichen planus:a benign lesion. J Oral Maxillofac Surg. 2000;58(11):1278-85. Alrashdan MS, Cirillo N, McCullough M. Oral lichen planus: a literature review and update. Arch Dermatol Res. 2016;308(8):539-51.Lodi G, Scully C, Carrozzo M, Griffiths M, Sugerman PB, Thongprasom K. Current controversies in oral lichen planus: report of an international consensus meeting. Part 2. Clinical management and malignant transformation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100(2):164-78.Sousa FACG, Paradella TC, Brandão AAH, Rosa LEB. Líquen plano bucal versus displasia epitelial: dificuldades diagnósticas. Braz J Otorhinolaryngol. 2009;75(5):716-20.Rode M, Kogoj-Rode M. Malignant potential of the reticular form of oral lichen planus over a 25-year observation period in 55 patients from Slovenia. J Oral Sci. 2002;44(2):109-11.Van der Meij EH, Mast H, Van der Waal I. The possible premalignant character of oral lichen planus and oral lichenoid lesions: a prospective five-year followup study of 192 patients. Oral Oncol. 2007;43(8):742-48.Oliveira Alves MG, Almeida JD, Balducci I, Guimarães Cabral LA. Oral lichen planus: a retrospective study of 110 Brazilian patients. BMC Res Notes. 2010;3:157.Radochová V, Drˇízhal I, Slezák R. A retrospective study of 171 patients with oral lichen planus in the East Bohemia-Czech Republic–single center experience. J Clin Exp Dent. 2014;6(5):e556-61.Fitzpatrick S, Hirsch S, Gordon S. The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review. J Am Dent Assoc. 2014;145(1):45-56.Bermejo-Fenoll A, Sánchez-Siles M, López-Jornet P, Camacho-Alonso F,  Salazar-Sánchez N. A retrospective clinicopathological study of 550 patients with oral lichen planus in south-eastern Spain. J Oral Pathol Med. 2010;39(6):491-96.Chaiyarit P, Ma N, Hiraku Y, Pinlaor S, Yongvanit P, Jintakanon D et al. Nitrative and oxidative DNA damage in oral lichen planus in relation to human oral carcinogenesis. Cancer Sci. 2005;96:553-59.Georgakopoulou EA, Achtari MD, Achtaris M, Foukas PG, Kotsinas A. Oral lichen planus as a preneoplastic inflammatory model. J Biomed Biotechnol. 2012;2012:759626.Accurso BT, Warner BM, Knobloch TJ, Weghorst CM, Shumway BS, Allen CM et al. Allelic imbalance in oral lichen planus and assessment of its classification as a premalignant condition. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(3):359-66.

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