scholarly journals Early soft tissue response to zirconium oxide and titanium healing abutments in vivo: a study in dogs

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Min Wang ◽  
Shuang Zhang ◽  
Longjie Chen ◽  
Haixiao Zou ◽  
Yining Wang ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Zirconium Oxide ◽  
Soft Tissues ◽  
Inflammatory Cells ◽  
Tissue Response ◽  
Tnf Α ◽  
Clinical Indices ◽  
Soft Tissue Response ◽  
Crevicular Fluid

Abstract Background This study aimed to investigate the clinical characteristics and early soft tissue response to zirconium oxide (Zr) and titanium (Ti) healing abutments in dogs. Methods Eight implants (four at each hemi-mandible) were inserted after bilateral mandibular third and fourth premolars and first molar extraction in dogs. Then, two Zr and two Ti healing abutments were connected to each unilateral mandible eight weeks later. The ligation method was used to create a peri-implant mucositis model and the 24 abutments were divided into four groups: Zr or Ti healing abutments with ligation (ZrL, TiL) or non-ligation (ZrN, TiN). The clinical indices, peri-implant crevicular fluid (PICF), and inflammatory cytokines (TNF-α and IL-1β) were measured and analyzed on days 0 and 28. The dogs were then sacrificed on day 28, soft tissues around the implants were harvested, and inflammation infiltration was tested by immunohistochemistry. Normal distribution test and two-way analysis of variance was used to analyze the data. Results The results showed that the clinical indices were similar for Zr and Ti healing abutments. There was significantly more PICF in the ZrL and TiL groups compared to in the ZrN and TiN groups. The TNF-α levels in PICF were significantly different between ZrL and ZrN groups on day 28. And the TNF-α levels in PICF were significantly higher in TiL group on day 28 than that on day 0. However, the number of inflammatory cells was not significantly different between the groups as measured by immunohistochemistry. Conclusions These data indicate that soft tissue responses to Zr healing abutments with peri-implant mucositis were comparable to those of Ti healing abutments in vivo, providing a theoretical foundation for the clinical application of Zr abutments.

scholarly journals Early Soft Tissue Response to Zirconium Oxide and Titanium Healing Abutments in Vivo: A Dog Study

2021 ◽  
Author(s):  
Min Wang ◽  
Shuang Zhang ◽  
Longjie Chen ◽  
Haixiao Zou ◽  
Yining Wang ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Zirconium Oxide ◽  
Soft Tissues ◽  
Inflammatory Cells ◽  
Tissue Response ◽  
Clinical Index ◽  
Tissue Responses ◽  
Soft Tissue Response ◽  
Crevicular Fluid

Abstract Background: This study aimed to investigate clinical characteristics and early soft tissues response to zirconium oxide (Zr) and titanium (Ti) abutments in dogs. Methods: Eight implants-four at each hemi-mandible were inserted after bilateral mandibular third and fourth premolars and first molars extraction. Two Zr and two Ti healing abutments were connected in each unilateral mandible 8 weeks later. The ligation method was used to make peri-implant mucositis model. The twenty-four abutments were divided into four groups, Zr and Ti healing abutments with ligation (ZrL, TiL) and non-ligation (ZrN, TiN) groups. Clinical index, peri-implant crevicular fluid (PICF) and inflammatory cytokines (TNF-α and IL-1β), soft tissue responses were tested. Two-way analysis of variance was used to analyze the data. Results: The results showed that the clinical index were similar around Zr and Ti healing abutments. PICF in ZrL and TiL groups were significantly higher than those in ZrN and TiN groups. Immunohistochemistry demonstrated inflammatory cells were non-significant differences. Conclusion: These data indicate soft tissue responses to Zr healing abutments with peri-implant mucositis was comparable to those to Ti healing abutments in vivo, and can provide theoretical foundation for Zr’s clinical application.

Controlled implant/soft tissue interaction by nanoscale surface modifications of 3D porous titanium implants

Nanoscale ◽  
2015 ◽  
Vol 7 (21) ◽  
pp. 9908-9918 ◽  
Author(s):  
Elisabeth Rieger ◽  
Agnès Dupret-Bories ◽  
Laetitia Salou ◽  
Marie-Helene Metz-Boutigue ◽  
Pierre Layrolle ◽  
...  
Keyword(s):  
Surface Modification ◽  
Soft Tissue ◽  
Surface Modifications ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Tissue Response ◽  
Soft Tissue Response ◽  
Modification Of Titanium

Nanoscale surface modification of titanium microbeads can control the soft tissue response in vitro and in vivo.

Soft tissue response to zirconia and titanium implant abutments: an in vivo within-subject comparison

2012 ◽  
Vol 39 (10) ◽  
pp. 995-1001 ◽  
Author(s):  
Ralph van Brakel ◽  
Gert J. Meijer ◽  
Jan Willem Verhoeven ◽  
John Jansen ◽  
Cornelis de Putter ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Titanium Implant ◽  
Tissue Response ◽  
Implant Abutments ◽  
Soft Tissue Response ◽  
Subject Comparison

scholarly journals In Vivo Investigation of Soft Tissue Response of Novel Silver/Poly(Vinyl Alcohol)/ Graphene and Silver/Poly(Vinyl Alcohol)/Chitosan/Graphene Hydrogels Aimed for Medical Applications – The First Experience

2018 ◽  
Vol 68 (3) ◽  
pp. 321-339 ◽  
Author(s):  
Tijana Lužajić Božinovski ◽  
Danica Marković ◽  
Vera Todorović ◽  
Bogomir Prokić Bolka ◽  
Ivan Milošević ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Vinyl Alcohol ◽  
Subcutaneous Tissue ◽  
Tissue Response ◽  
Surrounding Tissue ◽  
Poly Vinyl Alcohol ◽  
Medical Applications ◽  
Capsule Thickness ◽  
Soft Tissue Response

Abstract In this paper, we have shown for the fi rst time the soft tissue response of novel silver/ poly(vinyl alcohol)/graphene (Ag/PVA/Gr) and silver/poly(vinyl alcohol)/chitosan/ graphene (Ag/PVA/CHI/Gr) nanocomposite hydrogels aimed for medical applications. These novel hydrogels were produced by in situ electrochemical synthesis of silver nanoparticles in the polymer matrices as described in our previously published works. Both Ag/PVA/Gr and Ag/PVA/CHI/Gr, as well as controls Ag/PVA, Ag/PVA/CHI and commercial Suprasorb©hydrogel discs, were implanted in the subcutaneous tissue of rats. Implants with the surrounding tissue were dissected after post-implantation on days 7, 15, 30 and 60, and then processed for histological examination. The tissue irritation index (TIrI) score, according to ISO 10993-6, 2007, as well as the number of leukocytes in the peri-implant zone and connective tissue capsule thickness were examined. The results show that each TIrI score, the leukocyte number around the implanted materials and capsule thickness gradually decreased during the observation period. At the endpoint of follow-up, the Ag/PVA/CHI/Gr implant was surrounded with a thinner capsule, while both the TIrI score and the number of leukocytes of the peri-implant zone were greater compared to the Ag/PVA/Gr implant. Despite the observed differences, we can conclude that our in vivo experiment suggested that both novel hydrogels were biocompatible and suitable for medical use.

scholarly journals Is it Necessary to Accurately Know the Response of Facial Soft Tissues to Bone Movement in Orthognatic/Orthofacial Surgery?

2018 ◽  
Vol 1 (4) ◽  
pp. 327-330
Author(s):  
Sergio Olate ◽  
Márcio De Moraes ◽  
Celso Palmieri
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Clinical Situation ◽  
Tissue Response ◽  
Bone Level ◽  
Orthognatic Surgery ◽  
New Methodologies ◽  
The Aesthetic ◽  
Soft Tissue Response ◽  
Facial Soft Tissues

Orthognatic and orthofacial surgery contains procedures designed to correct skeletal facial anomalies, presenting clear aesthetic and functional orientations. Outcomes have demonstrated that the technique is efficient in the short and long terms; nowadays, orthognatic surgery is common in facial surgical practice. Nevertheless, the aesthetic aspects of the indication and results of the surgery make accurate planning a challenge, raising doubts in terms of recognizing the real soft tissue response to the movement produced at bone level. A prospective, multicenter study will be necessary to define this clinical situation? This brief review is an example of how necessary to study new methodologies about the response of soft tissue to bone movements.

In vivo bone and soft tissue response to injectable, biodegradable oligo(poly(ethylene glycol) fumarate) hydrogels

Biomaterials ◽  
2003 ◽  
Vol 24 (19) ◽  
pp. 3201-3211 ◽  
Author(s):  
Heungsoo Shin ◽  
P. Quinten Ruhé ◽  
Antonios G. Mikos ◽  
John A. Jansen
Keyword(s):  
Soft Tissue ◽  
Ethylene Glycol ◽  
Tissue Response ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Soft Tissue Response

scholarly journals Analysis of the Peri-implant Soft Tissues in Contact with Zirconia Abutments: An Evidence-based Literature Review

2013 ◽  
Vol 14 (3) ◽  
pp. 567-572 ◽  
Author(s):  
José Vitor Quinelli Mazaro ◽  
Marcelo Coelho Goiato ◽  
Daniela Micheline dos Santos ◽  
Rodrigo Antonio de Medeiros ◽  
Aljomar José Vechiato-Filho
Keyword(s):  
Soft Tissue ◽  
Literature Review ◽  
Soft Tissues ◽  
Case Reports ◽  
Biological Response ◽  
Tissue Response ◽  
Biological Behavior ◽  
Evidence Based ◽  
Pubmed Database ◽  
Soft Tissue Response

ABSTRACT Aim The aim of this study is to evaluate through a literature review, the soft tissue response in contact with zirconia abutments, including case reports comparing prosthetics rehabilitations with zirconia and titanium abutments upto 3 years of follow-up as well as the factors that should be considered on implant's abutment selection. Background Metallic abutments can provide grayish color when in contact with thin soft tissues which may lead the implant prosthetic treatment to failure. In this context, the abutments of zirconia stand out because there is an excellent linking between esthetics and the health of peri-implant soft tissues. Materials and methods A consult of the published researches was made on the PubMed database from 2000 to September 2012. The including criteria were: literature reviews, clinical studies and case reports in English that focused on the response of the soft tissue in contact with zirconia implant abutments. The studies that were not in English and did not match the tackled issue were excluded. Results A total of 32 articles were found. According to the search strategy, just 16 articles were selected for this review. Three studies affirmed that zirconia abutments have an excellent soft tissue response; one study showed increased gingival recession with zirconia abutments and nine studies do not stand out any difference on biological behavior between titanium and zirconia abutments. Three studies affirmed that zirconia abutments provide natural gingival appearance, anatomic contour and greater esthetics. Conclusion The use of zirconia abutments is recommended for anterior regions because of their greater optical properties and esthetic results and more studies should be performed and analyzed longitudinally regarding their biological response. Clinical significance The zirconia abutments have been established to be essential in order to achieve great esthetic results in cases of thin peri-implant soft tissues and in regions where the three-dimensional placement of implants is more superficial. How to cite this article de Medeiros RA, Vechiato-Filho AJ, Pellizzer EP, Mazaro JVQ, dos Santos DM, Goiato MC. Analysis of the Peri-implant Soft Tissues in Contact with Zirconia Abutments: An Evidence-based Literature Review. J Contemp Dent Pract 2013;14(3):567-572.

scholarly journals Establishing predictive indicators for the status of loaded soft tissues

2001 ◽  
Vol 90 (6) ◽  
pp. 2231-2237 ◽  
Author(s):  
Sarah L. Knight ◽  
Richard P. Taylor ◽  
Adrian A. Polliack ◽  
Dan L. Bader
Keyword(s):  
Carbon Dioxide ◽  
Soft Tissue ◽  
Soft Tissues ◽  
Applied Pressure ◽  
Threshold Value ◽  
Tissue Response ◽  
Noninvasive Methods ◽  
The Status ◽  
Complementary Techniques ◽  
Soft Tissue Response

Two complementary techniques were employed to assess the soft tissue response to applied pressure. The noninvasive methods involve the simultaneous measurement of the local tensions of oxygen and carbon dioxide (tcPo 2 and tcPco 2) and the collection and subsequent analysis of sweat collected from the sacrum, a common site for the development of pressure sores. All tests were performed on able-bodied subjects. Results have indicated that oxygen levels (tcPo 2) were lowered in soft tissues subjected to applied pressures of between 40 (5.3 kPa) and 120 mmHg (16.0 kPa). At the higher pressures, this decrease was generally associated with an increase in carbon dioxide levels (tcPco 2) well above the normal basal levels of 45 mmHg (6 kPa). There were also considerable increases, in some cases up to twofold, in the concentrations of both sweat lactate and urea at the loaded site compared with the unloaded control. By comparing selected parameters, a threshold value for loaded tcPo 2 was identified, representing a reduction of ∼60% from unloaded values. Above this threshold, there was a significant relationship between this parameter and the loaded/unloaded concentration ratios for both sweat metabolites. These parameters may prove useful in identifying those subjects whose soft tissue may be compromised during periods of pressure ischemia.

Comparing the Responses of Osseous Versus Soft-Tissue Metastases of Renal Cell Carcinoma to Receptor Tyrosine Kinase Inhibitors and Immunotherapy

Kidney Cancer ◽  
2020 ◽  
Vol 4 (3) ◽  
pp. 151-158
Author(s):  
Katherine Yuxi Tai ◽  
Jad M. El Abiad ◽  
Carol D. Morris ◽  
Mark Christopher Markowski ◽  
Adam S. Levin
Keyword(s):  
Renal Cell Carcinoma ◽  
Soft Tissue ◽  
Cell Carcinoma ◽  
Receptor Tyrosine Kinase ◽  
Renal Cell ◽  
Kinase Inhibitors ◽  
Tissue Response ◽  
Bone Response ◽  
Soft Tissue Response ◽  
Receptor Tyrosine Kinase Inhibitors

BACKGROUND: Checkpoint inhibitors and receptor tyrosine kinase inhibitors (RTKIs) have changed the standard of care for metastatic renal cell carcinoma (mRCC). Anecdotal evidence suggests these therapies may be less effective for treating bone than soft-tissue metastases. PURPOSE: We performed a retrospective review evaluating the relative clinical responses in soft-tissue and bone metastases in patients undergoing therapy using RTKIs and anti-programmed death-1 (PD-1) agents for mRCC. METHODS: Of the 2,212 patients in our institutional cancer registry with renal cell carcinoma (1997–2017), 68 (82 disease courses) were identified with measurable bone and soft-tissue metastases treated with RTKIs and/or PD-1s. Extent of metastasis was quantified at the time of therapy initiation (baseline) and at 3 months, 6 months, and 1 year. Changes in disease status were categorized as complete response, partial response, stable, mixed, or progression of disease according to RECIST v1.1 and MD Anderson criteria. These categories were further organized into “response to treatment” or “evidence of progression” to generate a generalized linear effects model with soft-tissue response as the independent variable and bone response as the dependent variable. Alpha = 0.05. RESULTS: Soft-tissue response correlated with bone response at 3 months (76 disease courses, p = 0.005) and 6 months (48 disease courses, p = 0.017). Of the patients with controlled soft-tissue disease, only 14 (19%) and 15 (32%) had progression in bone at 3 and 6 months, respectively. CONCLUSION: Contrary to anecdotal reports, osseous metastases do not appear to respond worse than soft-tissue metastases to treatment with these agents.

Sign in / Sign up

Export Citation Format

Share Document