scholarly journals Factors associated with mammographic breast density among women in Karachi Pakistan

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Uzma Shamsi ◽  
Shaista Afzal ◽  
Azra Shamsi ◽  
Iqbal Azam ◽  
David Callen
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Breast Density ◽  
Benign Breast Disease ◽  
Serum Vitamin ◽  
Breast Disease ◽  
Mammographic Breast Density ◽  
Serum Vitamin D ◽  
Dense Breasts ◽  
Younger Age

Abstract Background There are no studies done to evaluate the distribution of mammographic breast density and factors associated with it among Pakistani women. Methods Participants included 477 women, who had received either diagnostic or screening mammography at two hospitals in Karachi Pakistan. Mammographic breast density was assessed using the Breast Imaging Reporting and Data System. In person interviews were conducted using a detailed questionnaire, to assess risk factors of interest, and venous blood was collected to measure serum vitamin D level at the end of the interview. To determine the association of potential factors with mammographic breast density, multivariable polytomous logistic regression was used. Results High-density mammographic breast density (heterogeneously and dense categories) was high and found in 62.4% of women. There was a significant association of both heterogeneously dense and dense breasts with women of a younger age group < 45 years (OR 2.68, 95% CI 1.60–4.49) and (OR 4.83, 95% CI 2.54–9.16) respectively. Women with heterogeneously dense and dense breasts versus fatty and fibroglandular breasts had a higher history of benign breast disease (OR 1.90, 95% CI 1.14–3.17) and (OR 3.61, 95% CI 1.90–6.86) respectively. There was an inverse relationship between breast density and body mass index. Women with dense breasts and heterogeneously dense breasts had lower body mass index (OR 0.94 95% CI 0.90–0.99) and (OR 0.81, 95% CI 0.76–0.87) respectively. There was no association of mammographic breast density with serum vitamin D levels, diet, and breast cancer. Conclusions The findings of a positive association of higher mammographic density with younger age and benign breast disease and a negative association between body mass index and breast density are important findings that need to be considered in developing screening guidelines for the Pakistani population.

scholarly journals Factors Associated with Mammographic Breast Density among Premenopausal and Menopausal Women in Karachi Pakistan

2021 ◽  
Author(s):  
Uzma Shamsi ◽  
Shaista Afzal ◽  
Azra Shamsi ◽  
Iqbal Azam ◽  
David Callen
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Breast Density ◽  
Benign Breast Disease ◽  
Serum Vitamin ◽  
Breast Disease ◽  
Mammographic Breast Density ◽  
Serum Vitamin D ◽  
Dense Breasts ◽  
Younger Age

Abstract Background: There are no studies done to evaluate the distribution of mammographic breast density and factors associated with it among Pakistani women. Methods: Participants included 477 women, who had received either diagnostic or screening mammography at two hospitals in Karachi Pakistan. Mammographic breast density was assessed using the Breast Imaging Reporting and Data System. In person interviews were conducted using a detailed questionnaire, to assess risk factors of interest, and venous blood was collected to measure serum vitamin D level at the end of the interview. To determine the association of potential factors with mammographic breast density, multivariable polytomous logistic regression was used. Results: High-density mammographic breast density (heterogeneously and dense categories) was found in 62.4 % of women. There was a significant association of both heterogeneously dense and dense breasts with women of a younger age group < 45 years (OR= 2.68, 95% CI= 1.60-4.49) and (OR= 4.83, 95% CI= 2.54-9.16) respectively. Women with heterogeneously dense and dense breasts vs. fatty and fibroglandular breasts had a higher history of benign breast disease (OR = 1.90, 95% CI= 1.14–3.17) and (OR= 3.61, 95%CI= 1.90-6.86) respectively. There was an inverse relationship between breast density and body mass index. Women with dense breasts and heterogeneously dense breasts had lower body mass index (OR= 0.94 95% CI= 0.90-0.99) & (OR= 0.81, 95%CI= 0.76-0.87) respectively. There was no association of mammographic breast density with serum vitamin D levels, diet, and breast cancer. Conclusion: The findings of a positive association of higher mammographic density with younger age and benign breast disease and a negative association between body mass index and breast density are important findings that need to be considered in developing screening guidelines for the Pakistani population.

scholarly journals Benign Breast Disease, Mammographic Breast Density, and the Risk of Breast Cancer

2013 ◽  
Vol 105 (14) ◽  
pp. 1043-1049 ◽  
Author(s):  
Jeffrey A. Tice ◽  
Ellen S. O’Meara ◽  
Donald L. Weaver ◽  
Celine Vachon ◽  
Rachel Ballard-Barbash ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Density ◽  
Benign Breast Disease ◽  
Breast Disease ◽  
Mammographic Breast Density

scholarly journals Benign breast disease and changes in mammographic breast density

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Laura L. Reimers ◽  
Mandy Goldberg ◽  
Parisa Tehranifar ◽  
Karin B. Michels ◽  
Barbara A. Cohn ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Density ◽  
Benign Breast Disease ◽  
Breast Disease ◽  
Mammographic Breast Density ◽  
Computer Assisted ◽  
First Birth ◽  
Dense Area ◽  
Nulliparous Women ◽  
Using Data

Abstract Background Mammographic breast density (MBD) and benign breast disease (BBD) are two of the strongest risk factors for breast cancer. Understanding trends in MBD by age and parity in women with BBD is essential to the clinical management and prevention of breast cancer. Methods Using data from the Early Determinants of Mammographic Density (EDMD) study, a prospective follow-up study of women born in 1959–1967, we evaluated MBD in 676 women. We used linear regression with generalized estimating equations to examine associations between self-reported BBD and MBD (percent density, dense area, and non-dense area), assessed through a computer-assisted method. Results A prior BBD diagnosis (median age at diagnosis 32 years) was reported by 18% of our cohort. The median time from BBD diagnosis to first available study mammogram was 9.4 years (range 1.1–27.6 years). Women with BBD had a 3.44% higher percent MBD (standard error (SE) = 1.56, p-value = 0.03) on their first available mammogram than women without BBD. Compared with parous women without BBD, nulliparous women with BBD and women with a BBD diagnosis prior to first birth had 7–8% higher percent MBD (β = 7.25, SE = 2.43, p-value< 0.01 and β = 7.84, SE = 2.98, p-value = 0.01, respectively), while there was no difference in MBD in women with a BBD diagnosis after the first birth (β = −0.22, SE = 2.40, p-value = 0.93). Conclusion Women with self-reported BBD had higher mammographic breast density than women without BBD; the association was limited to women with BBD diagnosed before their first birth.

scholarly journals Comparison of Vitamin D Level among Vaccinated and Non Vaccinated Pregnant Women with Covid-19

2021 ◽  
Vol 15 (10) ◽  
pp. 3500-3502
Author(s):  
Saeeda Safi ◽  
Umme habiba ◽  
Shandana Mustafa Jadoon ◽  
Umbreen Idrees ◽  
Ayesha Aftab ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Body Mass ◽  
Gestational Age ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Group I ◽  
Group Ii

Objective: The aim of this study is to compare the vitamin D level among vaccinated and non-vaccinated pregnant women with COVID-19. Study Design: Observational/comparative study Place and Duration: The study was conducted at the department of Gynae and Obs Quaid-e-Azam International Hospital, Islamabad and Qazi Hussain Ahmad Medical Complex, Nowshera for Duration of six months from October 2020 to March 2021. Methods: Total 120pregnant women had coronavirus disease were presented. Informed written consent was taken for details demographics age, gestational age, parity and body mass index. 18-45years was the women ages. Patients were categorized into 2-groups. Group I had 60 vaccinated patients and in group II 60 non-vaccinated pregnant women. Blood sample of all the patients were taken for the level of serum 25-hydroxy vitaminD3 [25 (OH) D3]. Vitamin D deficiency was calculated and compared among both groups. Sufficient serum vitamin D level was considered >30ng/ml. SPSS 23.0 version was used to analyze complete data. Results: In group I age was 28.4±8.55 years with mean BMI 24.08±1.18 kg/m2 and in group II age was 27.41±6.37 years with mean body mass index 23.12±4.42 kg/m2. Mean gestation age in group I was 33.12±9.42 weeks and in group II mean gestational age was 34.07±5.63 weeks. Mean parity in group I was 3.88±7.27 and in group II 4.01±4.14 was mean parity. We found 28 (46.7%) primigravida cases in I-group and 30 (50%) primigravida females in II-group. In group I 51(85%) patients had vitamin D deficiency and in group II 54 (90%) had deficiency of vitamin D. Among 51 deficient women of group I, number of severe deficiency (<10ng/ml) women were 8 (13.3%), deficiency (10-20ng/ml) were 13 (21.7%) and not-sufficient (20-30ng/ml) were 30 (50%) and in group II prevalence of severity (<10ng/ml) patients were 10 (16.7%), deficient cases (10-20ng/ml) were 15 (25%) and not-sufficient cases (20-30ng/ml) were 29 (48.3%). Deficient vitamin D serum levels were 15.01±1.22 in group I and 14.34±4.12 in group II. Conclusion: In this study we concluded that prevalence of vitamin D deficiency was highly among pregnant women and most probably in non-vaccinated pregnant patients but did not find any significantly difference among both groups. Keywords: Pregnancy, COVID-19, Vitamin D, Vaccination

scholarly journals Body Mass Index, Vitamin D, and Type 2 Diabetes: A Systematic Review and Meta-Analysis

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1182 ◽  
Author(s):  
Shamaila Rafiq ◽  
Per Jeppesen
Keyword(s):  
Systematic Review ◽  
Body Mass Index ◽  
Vitamin D ◽  
Body Mass ◽  
Observational Studies ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Serum Vitamin D ◽  
Vitamin D Levels

The deficiency of vitamin D is prevalent all over the world. Studies have shown that vitamin D may play an important role in the development of obesity. The current study was conducted to quantitatively evaluate the association between serum 25-(OH) vitamin D levels and the risk of obesity in both diabetic and non-diabetic subjects. A systematic review and meta-analysis of observational studies was carried out for that purpose. We searched the Medline, PubMed, and Embase databases throughout all of March 2018. A total of fifty five observational studies for both diabetic and non-diabetic subjects were finally included in the meta-analysis. The data were analyzed by comprehensive meta-analysis software version 3 and the random effects model was used to analyze the data. The meta-analysis showed an overall inverse relationship between serum vitamin D status and body mass index (BMI) in studies of both diabetic (r = −0.173, 95% = −0.241 to −0.103, p = 0.000) and non-diabetic (r = −0.152, 95% = −0.187 to −0.116, p = 0.000) subjects. The evidence of publication bias was not found in this meta-analysis. In conclusion, the deficiency of vitamin D is associated with an increased level of BMI in the studies of both diabetic and non-diabetic subjects. Reliable evidence from well-designed future randomized controlled trials is required to confirm the findings from observational studies and to find out the potential regulatory effects of vitamin D supplementation to lower BMI.

Abstract P6-10-14: Association between mammographic breast density and histologic features of benign breast disease

2015 ◽  
Author(s):  
Karthik Ghosh ◽  
Robert A Vierkant ◽  
Ryan D Frank ◽  
Daniel W Visscher ◽  
Vernon S Pankratz ◽  
...  
Keyword(s):  
Breast Density ◽  
Benign Breast Disease ◽  
Breast Disease ◽  
Mammographic Breast Density

scholarly journals Mammographic density in asymptomatic menopausal women: correlation with clinical and sonographic findings

2012 ◽  
Vol 45 (3) ◽  
pp. 149-154 ◽  
Author(s):  
Beatriz Regina Alvares ◽  
Christian Henrique de Andrade Freitas ◽  
Rodrigo Menezes Jales ◽  
Orlando José de Almeida ◽  
Emílio Francisco Marussi
Keyword(s):  
Body Mass Index ◽  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Body Mass ◽  
Mammographic Density ◽  
Breast Density ◽  
Hormone Replacement ◽  
Mammographic Breast Density ◽  
Asymptomatic Patients ◽  
Menopausal Women

OBJECTIVE: To evaluate mammographic breast density in asymptomatic menopausal women in correlation with clinical and sonographic findings. MATERIALS AND METHODS: Mammograms and clinical and sonographic findings of 238 asymptomatic patients were retrospectively reviewed in the period from February/2022 to June/2006. The following variables were analyzed: mammographic density patterns, sonographic findings, patients' age, parity, body mass index and use of hormone replacement therapy. RESULTS: Age, parity and body mass index showed a negative correlation with breast density pattern, while use of hormone replacement therapy showed a positive correlation. Supplementary breast ultrasonography was performed in 103 (43.2%) patients. Alterations which could not be visualized at mammography were found in 34 (33%) of them, most frequently in women with breast density patterns 3 and 4. CONCLUSION: The authors concluded that breast density patterns were influenced by age, parity, body mass index and time of hormone replacement therapy. Despite not having found any malignant abnormality in the studied cases, the authors have observed a predominance of benign sonographic abnormalities in women with high breast density patterns and without mammographic abnormalities, proving the relevance of supplementary ultrasonography to identify breast lesions in such patients.

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