e18303 Background: Traditional diagnostic model for cancer heavily relies on physicians and their teams’ knowledge. However, under this diagnostic model, patients’ source of information is quite limited. Cancer patients usually fill with negative emotion. Lack of knowledge to the disease and treatment options further leads to less confidence to their treatment outcome. Methods: In order to improve their faith in getting proper treatment and the hope for surviving the deadly disease, we has introduced an artificial intelligence based clinical decision-support system, the Watson for Oncology (WFO), since May-2018. WFO is developed by IBM, it assesses information from a patient’s medical record, evaluates medical evidence, and displays potential treatment options. Our oncologist can then apply their own expertise to identify the most appropriate treatment options. We have generated a new 7-step consultation system with the help of WFO. That include 1: introduce the WFO to patients, 2: patients express their demands and expectations, 3: the oncologist presents patient’s medical condition, 4: discussion with other members in the consultation team, 5: input patients’ information into WFO system and review treatment options, 6: discuss and finalize treatment options with patients, 7: feedbacks form patients after consultation. 70 patients who were hospitalized from May-2018 to Dec-2018 were divided into two groups, 50 patients volunteered to be assigned to the new 7-step consultation system and 20 patients stayed with the traditional diagnostic method to find them treatment options. All patients were followed up by questionnaire. Results: The results showed that patients in the 7-step consultation group presented significantly higher satisfaction rate towards treatment options, confidence level to their health care workers, and willingness to follow the treatment option when compared to patients in the traditional diagnostic group. Conclusions: The WFO assisted 7-step consultation system not only provides a more efficient way to find treatment options, but also improves patients’ understanding to their disease and possible side effects towards the treatment. Most importantly, patients build stronger confidence with their health care team and are willing to believe they will benefit from the treatment plans.