Liraglutide attenuates high glucose-induced abnormal cell migration, proliferation, and apoptosis of vascular smooth muscle cells by activating the GLP-1 receptor, and inhibiting ERK1/2 and PI3K/Akt signaling pathways

Lili Shi; Ye Ji; Xiaoyan Jiang; Lihong Zhou; Ying Xu; Yanbo Li; Wei Jiang; Ping Meng; Xiaomin Liu

doi:10.1186/s12933-015-0177-4

Liraglutide attenuates high glucose-induced abnormal cell migration, proliferation, and apoptosis of vascular smooth muscle cells by activating the GLP-1 receptor, and inhibiting ERK1/2 and PI3K/Akt signaling pathways

Cardiovascular Diabetology ◽

10.1186/s12933-015-0177-4 ◽

2015 ◽

Vol 14 (1) ◽

pp. 18 ◽

Cited By ~ 31

Author(s):

Lili Shi ◽

Ye Ji ◽

Xiaoyan Jiang ◽

Lihong Zhou ◽

Ying Xu ◽

...

Keyword(s):

Smooth Muscle ◽

Cell Migration ◽

Vascular Smooth Muscle ◽

Smooth Muscle Cells ◽

Signaling Pathways ◽

Vascular Smooth Muscle Cells ◽

High Glucose ◽

Muscle Cells ◽

Akt Signaling ◽

Proliferation And Apoptosis

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Apelin suppresses apoptosis of human vascular smooth muscle cells via APJ/PI3-K/Akt signaling pathways

Amino Acids ◽

10.1007/s00726-010-0555-x ◽

2010 ◽

Vol 39 (5) ◽

pp. 1193-1200 ◽

Cited By ~ 57

Author(s):

Rong-Rong Cui ◽

Ding-An Mao ◽

Lu Yi ◽

Cheng Wang ◽

Xing-Xing Zhang ◽

...

Keyword(s):

Smooth Muscle ◽

Vascular Smooth Muscle ◽

Smooth Muscle Cells ◽

Signaling Pathways ◽

Vascular Smooth Muscle Cells ◽

Muscle Cells ◽

Akt Signaling

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ERK and Akt signaling pathways are involved in advanced glycation end product-induced autophagy in rat vascular smooth muscle cells

International Journal of Molecular Medicine ◽

10.3892/ijmm.2012.891 ◽

2012 ◽

Vol 29 (4) ◽

pp. 613-618 ◽

Cited By ~ 72

Author(s):

PENGFEI HU ◽

DONGWU LAI ◽

PEILIN LU ◽

JING GAO ◽

HONG HE

Keyword(s):

Smooth Muscle ◽

Vascular Smooth Muscle ◽

Smooth Muscle Cells ◽

Signaling Pathways ◽

Vascular Smooth Muscle Cells ◽

Muscle Cells ◽

Akt Signaling ◽

Advanced Glycation ◽

Advanced Glycation End Product

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Vaspin attenuates high glucose-induced vascular smooth muscle cells proliferation and chemokinesis by inhibiting the MAPK, PI3K/Akt, and NF-κB signaling pathways

Atherosclerosis ◽

10.1016/j.atherosclerosis.2013.02.013 ◽

2013 ◽

Vol 228 (1) ◽

pp. 61-68 ◽

Cited By ~ 52

Author(s):

Hailing Li ◽

Wenhui Peng ◽

Jianhui Zhuang ◽

Yuyan Lu ◽

Weixia Jian ◽

...

Keyword(s):

Smooth Muscle ◽

Vascular Smooth Muscle ◽

Smooth Muscle Cells ◽

Signaling Pathways ◽

Vascular Smooth Muscle Cells ◽

High Glucose ◽

Muscle Cells

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Tyrosine Kinase Signaling Pathways Modulate Angiotensin II–Induced Calcium ([Ca2+]i) Transients in Vascular Smooth Muscle Cells

Hypertension ◽

10.1161/01.hyp.27.5.1097 ◽

1996 ◽

Vol 27 (5) ◽

pp. 1097-1103 ◽

Cited By ~ 29

Author(s):

R.M. Touyz ◽

E.L. Schiffrin

Keyword(s):

Smooth Muscle ◽

Angiotensin Ii ◽

Vascular Smooth Muscle ◽

Tyrosine Kinase ◽

Smooth Muscle Cells ◽

Signaling Pathways ◽

Vascular Smooth Muscle Cells ◽

Muscle Cells ◽

Kinase Signaling ◽

Tyrosine Kinase Signaling

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Resveratrol exerts antiproliferative effects on high-glucose-cultured vascular smooth muscle cells via inhibition of STAT3 and upregulation of mitochondrial gene GRIM-19 which is responsible for STAT3 activation

International Journal of Diabetes in Developing Countries ◽

10.1007/s13410-021-00963-3 ◽

2021 ◽

Author(s):

Yongguang Li ◽

Lijie Zhao ◽

Huixuan Zhou ◽

Beibei Han ◽

Haojun Yu ◽

...

Keyword(s):

Smooth Muscle ◽

Vascular Smooth Muscle ◽

Smooth Muscle Cells ◽

Vascular Smooth Muscle Cells ◽

High Glucose ◽

Mitochondrial Gene ◽

Muscle Cells ◽

Antiproliferative Effects

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Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis

Cardiovascular Diabetology ◽

10.1186/s12933-016-0477-3 ◽

2016 ◽

Vol 15 (1) ◽

Cited By ~ 16

Author(s):

N. Beneit ◽

C. E. Fernández-García ◽

J. L. Martín-Ventura ◽

L. Perdomo ◽

Ó. Escribano ◽

...

Keyword(s):

Smooth Muscle ◽

Cell Migration ◽

Vascular Smooth Muscle ◽

Smooth Muscle Cells ◽

Insulin Receptor ◽

Vascular Smooth Muscle Cells ◽

Muscle Cells

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Oxidative Stress Produced with Cell Migration Increases Synthetic Phenotype of Vascular Smooth Muscle Cells

Annals of Biomedical Engineering ◽

10.1007/s10439-005-7545-2 ◽

2005 ◽

Vol 33 (11) ◽

pp. 1546-1554 ◽

Cited By ~ 39

Author(s):

Hak-Joon Sung ◽

Suzanne G. Eskin ◽

Yumiko Sakurai ◽

Andrew Yee ◽

Noriyuki Kataoka ◽

...

Keyword(s):

Oxidative Stress ◽

Smooth Muscle ◽

Cell Migration ◽

Vascular Smooth Muscle ◽

Smooth Muscle Cells ◽

Vascular Smooth Muscle Cells ◽

Muscle Cells ◽

Synthetic Phenotype

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Inhibition of NF-κB prevents high glucose-induced proliferation and plasminogen activator inhibitor-1 expression in vascular smooth muscle cells

Experimental & Molecular Medicine ◽

10.3858/emm.2011.43.12.079 ◽

2011 ◽

Vol 43 (12) ◽

pp. 684 ◽

Cited By ~ 29

Author(s):

In-Kyung Jeong ◽

Da Hee Oh ◽

Seung-Joon Park ◽

Ja-Heon Kang ◽

Sunshin Kim ◽

...

Keyword(s):

Smooth Muscle ◽

Vascular Smooth Muscle ◽

Smooth Muscle Cells ◽

Plasminogen Activator ◽

Vascular Smooth Muscle Cells ◽

High Glucose ◽

Plasminogen Activator Inhibitor ◽

Muscle Cells ◽

Plasminogen Activator Inhibitor 1 ◽

Activator Inhibitor

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Chalcone flavokawain A attenuates TGF ‐β1‐induced fibrotic pathology via inhibition of ROS /Smad3 signaling pathways and induction of Nrf2/ ARE ‐mediated antioxidant genes in vascular smooth muscle cells

Journal of Cellular and Molecular Medicine ◽

10.1111/jcmm.13973 ◽

2018 ◽

Vol 23 (2) ◽

pp. 775-788 ◽

Cited By ~ 4

Author(s):

You‐Cheng Hseu ◽

Ting‐Yu Yang ◽

Mei‐Ling Li ◽

Peramaiyan Rajendran ◽

Dony Chacko Mathew ◽

...

Keyword(s):

Smooth Muscle ◽

Vascular Smooth Muscle ◽

Smooth Muscle Cells ◽

Signaling Pathways ◽

Vascular Smooth Muscle Cells ◽

Muscle Cells ◽

Antioxidant Genes ◽

Tgf Β1

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PDGF-β receptor and PKC have no effect on angiotensin II-induced JAK2 and STAT1 phosphorylation in vascular smooth muscle cells under high glucose condition

Journal of Receptors and Signal Transduction ◽

10.3109/10799893.2011.592535 ◽

2011 ◽

Vol 31 (5) ◽

pp. 340-349

Author(s):

Oktay Hasan Öztürk ◽

Arzu Çetin ◽

Alper Tokay ◽

Fatih Uzuner ◽

Gamze Tanrıöver ◽

...

Keyword(s):

Smooth Muscle ◽

Angiotensin Ii ◽

Vascular Smooth Muscle ◽

Smooth Muscle Cells ◽

Vascular Smooth Muscle Cells ◽

High Glucose ◽

Muscle Cells ◽

High Glucose Condition ◽

Β Receptor ◽

Glucose Condition

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