scholarly journals Association of pericardial adipose tissue with left ventricular structure and function: a region‐specific effect?

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Jin-Seok Kim ◽  
Seon Won Kim ◽  
Jong Seok Lee ◽  
Seung Ku Lee ◽  
Robert Abbott ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Specific Effect ◽  
Left Atrial Volume ◽  
Left Ventricular ◽  
Structure And Function ◽  
Doppler Imaging ◽  
Volume Index ◽  
2D Echocardiography ◽  
Pericardial Adipose Tissue ◽  
And Function

Abstract Background The independent role of pericardial adipose tissue (PAT) as an ectopic fat associated with cardiovascular disease (CVD) remains controversial. This study aimed to determine whether PAT is associated with left ventricular (LV) structure and function independent of other markers of general obesity. Methods We studied 2471 participants (50.9 % women) without known CVD from the Korean Genome Epidemiology Study, who underwent 2D-echocardiography with tissue Doppler imaging (TDI) and computed tomography measurement for PAT. Results Study participants with more PAT were more likely to be men and had higher cardiometabolic indices, including blood pressure, glucose, and cholesterol levels (all P < 0.001). Greater pericardial fat levels across quartiles of PAT were associated with increased LV mass index and left atrial volume index (all P < 0.001) and decreased systolic (P = 0.015) and early diastolic (P < 0.001) TDI velocities, except for LV ejection fraction. These associations remained after a multivariable-adjusted model for traditional CV risk factors and persisted even after additional adjustment for general adiposity measures, such as waist circumference and body mass index. PAT was also the only obesity index independently associated with systolic TDI velocity (P < 0.001). Conclusions PAT was associated with subclinical LV structural and functional deterioration, and these associations were independent of and stronger than with general and abdominal obesity measures.

scholarly journals Association of Pericardial Adipose Tissue With Left Ventricular Structure and Function: A Region-specific Effect?

2020 ◽  
Author(s):  
Jin-Seok Kim ◽  
Seon Won Kim ◽  
Jong Seok Lee ◽  
Seung Ku Lee ◽  
Robert Abbott ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Specific Effect ◽  
Left Atrial Volume ◽  
Left Ventricular ◽  
Structure And Function ◽  
Doppler Imaging ◽  
Volume Index ◽  
Functional Changes ◽  
Pericardial Adipose Tissue ◽  
And Function

Abstract Background: The independent role of pericardial adipose tissue (PAT) as an ectopic fat associated with cardiovascular disease (CVD) remains controversial. This study aimed to determine whether PAT is associated with left ventricular (LV) structure and function independent of other markers of general obesity.Methods: We studied 2,471 participants (50.9% women) without known CVD from the Korean Genome Epidemiology Study, who underwent 2D-echocardiography with tissue Doppler imaging (TDI) and computed tomography measurement for PAT.Results: Study participants with more PAT were more likely to be men and had higher cardiometabolic indices, including blood pressure, glucose, and cholesterol levels (all P <0.001). Greater pericardial fat levels across quartiles of PAT were associated with increased LV mass index and left atrial volume index (all P <0.001) and decreased systolic (P = 0.015) and early diastolic (P <0.001) TDI velocities, except for LV ejection fraction. These associations remained after a multivariable-adjusted model for traditional CV risk factors and persisted after additional adjustment for general adiposity measures, such as waist circumference and body mass index. PAT was the only obesity index independently associated with systolic TDI velocity (P <0.001).Conclusions: PAT was associated with subclinical LV structural and functional changes, and these associations were independent of and stronger than with general and abdominal obesity measures.

Abstract 31: Impact of Acculturation on Cardiac Structure and Function Among Latinos in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): The ECHO-SOL Ancillary Study

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Lenny Lopez ◽  
Katrina Sweet ◽  
Fátima Rodríguez ◽  
Jorge R Kizer ◽  
Frank J Penedo ◽  
...  
Keyword(s):  
Diastolic Dysfunction ◽  
Left Atrial Volume ◽  
Left Ventricular ◽  
Structure And Function ◽  
Volume Index ◽  
Cardiac Structure ◽  
Length Of Residence ◽  
The Us ◽  
Cardiac Structure And Function ◽  
And Function

Background: Abnormalities of cardiac structure and function are part of the spectrum of heart failure risk and progression. Acculturation is the process whereby an individual adopts the beliefs and practices of a host culture. Increasing acculturation has been associated with increased psychosocial stress and the adoption of deleterious health behaviors. The extent to which acculturation contributes to cardiovascular disease among Latinos is not well defined, and its association with cardiac structure and function in particular has not been studied among Latinos. Hypothesis: We hypothesized that higher acculturation is associated with worse left ventricular structure and function. Methods: The HCHS/SOL cohort included 16,415 Latino adults age 18-74 years from Cuban, Dominican, Mexican, Puerto Rican, Central American, and South American backgrounds. A random subsample of 1350 also underwent detailed echocardiographic assessment for the following primary outcome measures: left atrial volume index (LAVI), left ventricular mass index (LVMI) and LV ejection fraction (LVEF), LV end diastolic volume (LVEDV) and diastolic dysfunction (Grade 0 vs. Grade 1-3). Acculturation was measured by length of residence in the US categorized as (< 5 years, 5-10 years, >10 years). Chi-square and ANOVA were used to assess differences across acculturation level and dependent variables. Separate linear and logistic regression analyses were used with sequential modeling for age and sex followed by models including diabetes, hypertension, body mass index, tobacco use, and estimated glomerular filtration rate. Results: The mean age of the Echocardiographic Cohort was 56 years (S.D. ±0.5). Length of residence among first generation immigrants (n=1239) was as follows: 9.7% ≤ 5 years; 14.8% 5-10 years; and 75.5% ≥10 years. Fully adjusted models demonstrated abnormal cardiac structure was significantly higher with increasing years of US residence: increasing LAVI (1.6 ml/m 2 higher ≥10 years vs. ≤ 5 years), increasing LVEDV (5.6 ml higher ≥10 years vs. ≤ 5 years), and LVMI (4.9g/m 2 higher ≥10 years vs. ≤ 5 years) (p<0.01 each). Increasing length of residence in the US was also associated with higher prevalence of diastolic dysfunction in models adjusted for age and gender (54.2% ≤ 5 years vs. 63.7% ≥10 years; p=0.04), though this became marginally non-significant in our fully adjustment models (p=0.07). There were no significant differences in systolic cardiac function as measured by LVEF. Conclusions: Among a diverse Latino population, higher acculturation defined as greater length of residence in the US, a proxy measure for acculturation, was associated with larger LA volume, larger LV cavity, higher LV mass and a tendency to higher prevalence of diastolic dysfunction independent of traditional risk factors. Acculturation may be a significant process that impacts cardiac structure and function among Latinos.

scholarly journals Obstructive and restrictive ventilatory patterns are differentially associated with cardiac structure and function in late-life

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
S Ramalho ◽  
B.L Claggett ◽  
D.W Kitzman ◽  
P.P Chang ◽  
G Cipriano Junior ◽  
...  
Keyword(s):  
Left Atrial Volume ◽  
Late Life ◽  
Left Ventricular ◽  
Structure And Function ◽  
Public Institution ◽  
Volume Index ◽  
Funding Source ◽  
Cardiac Structure ◽  
Cardiac Structure And Function ◽  
And Function

Abstract Background Pulmonary and cardiac function both decline with age. However, few data exist regarding the associations of obstructive and restrictive spirometric patterns with cardiac structure and function in late-life. Purpose Determine the associations of reduced percent predicted forced vital capacity (ppFVC) and forced expired volume in 1 second (FEV1)/FVC with cardiac structure and function in late life. Methods In the Atherosclerosis Risk in Communities longitudinal cohort study, 3,854 heart failure free participants underwent echocardiography and spirometry at the fifth study visit (2011–2013). Relationships were examined using multivariable linear regression. Models adjusted for demographics and clinical risk factors (Table legend). Results Mean age was 75±5 years, 40% were male, 19% black, and 6% current smokers. Mean FEV1/FVC was 72±8, and ppFVC was 98±17%. In adjusted analyses, lower FEV1/FVC was associated with higher pulmonary arterial pressure (PASP) but not with measures of left ventricular (LV) structure or function (Table). In contrast, lower ppFVC, was associated with greater LV mass, worse LV strain, higher E/e' ratio, greater left atrial volume index, and higher PASP (all p&lt;0.01; Table). Conclusion In late life, reductions in both FEV1/FVC and ppFVC are associated with higher pulmonary pressure, but only ppFVC was associated with worse LV structure and function. Funding Acknowledgement Type of funding source: Public Institution(s). Main funding source(s): National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services

Genetic Influence on Left Ventricular Structure and Function: A Korean Twin and Family Study

2015 ◽  
Vol 18 (3) ◽  
pp. 281-289 ◽  
Author(s):  
Hye-Mi Noh ◽  
Sang Cheol Lee ◽  
Seung Woo Park ◽  
Joohon Sung ◽  
Yun-Mi Song
Keyword(s):  
Left Atrial Volume ◽  
Left Ventricular ◽  
Structure And Function ◽  
Volume Index ◽  
Atrial Volume ◽  
Left Atrial Volume Index ◽  
Mitral Inflow ◽  
Diastolic Velocity ◽  
Lv Mass ◽  
And Function

Genetic factors have been suggested to be one of the determinants of the variation of left ventricular (LV) structure and function. However, the heritability range of LV structure varies across studies and the influence of genetics on LV function is not well established, especially in Asian populations. Study subjects were 1,642 healthy Korean adults from 426 families, consisting of 298 pairs of monozygotic twins, 62 pairs of dizygotic twins, one set of triplets, 567 siblings, and 354 parents. LV structure and function were measured by M-mode and 2D echocardiography, and conventional and tissue Doppler imaging (TDI). Pairwise intra-class correlations for various familial relationships and heritability were estimated for LV structure and function. The heritability of LV mass, LV ejection fraction (LVEF), left atrial volume index, the ratio between early and late diastolic velocity of mitral inflow (E/A ratio), and the ratio between early diastolic velocity of mitral inflow and early diastolic mitral annular velocities (E/Ea ratio) was 0.44, 0.27, 0.44, 0.25, and 0.33, respectively. Bivariate genetic analysis showed that LV structural and functional traits had significant genetic correlations with cardiovascular risk factors. Additive genetic correlation (ρG) of LV mass with body mass index, systolic blood pressure, and high density lipoprotein cholesterol were 0.49, 0.42, and -0.15 respectively. LVEF (ρG = 0.33) and left atrial volume index (ρG = 0.24) also had a significant genetic correlation with systolic blood pressure. These findings support the theory that genetic factors have significant influence on these traits and necessitate further work to identify the specific genes involved.

scholarly journals 3D Echocardiography – A Useful Method for Cardiovascular Risk Assessment in End-Stage Renal Disease Patients

2021 ◽  
pp. S109-S120
Author(s):  
M. Kovářová ◽  
Z. Žilinská ◽  
J. Páleš ◽  
Z. Kužmová ◽  
A. Gažová ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
End Stage Renal Disease ◽  
Left Ventricular ◽  
Structure And Function ◽  
2D Echocardiography ◽  
Diastolic Velocity ◽  
Stage Renal Disease ◽  
End Stage ◽  
And Function ◽  
Esrd Patients

Patients with chronic kidney disease (CKD) have an increased risk of premature mortality, mainly due to cardiovascular causes. The association between hemodialysis and accelerated atherosclerosis has long been described. The ankle-brachial index (ABI) is a surrogate marker of atherosclerosis and recent studies indicate its utility as a predictor of future cardiovascular disease and all-cause mortality. The clinical implications of ABI cut-points are not well defined in patients with CKD. Echocardiography is the most widely used imaging method for cardiac evaluation. Structural and functional myocardial abnormalities are common in patients with CKD due to pressure and volume overload as well as non-hemodynamic factors associated with CKD. Our study aimed to identify markers of subclinical cardiovascular risk assessed using ABI and 2D and 3D echocardiographic parameters evaluating left ventricular (LV) structure and function in patients with end-stage renal disease (ESRD) (patients undergoing dialysis), patients after kidney transplantation and non-ESRD patients (control). In ESRD, particularly in hemodialysis patients, changes in cardiac structure, rather than function, seems to be more pronounced. 3D echocardiography appears to be more sensitive than 2D echocardiography in the assessment of myocardial structure and function in CKD patients. Particularly 3D derived end-diastolic volume and 3D derived LV mass indexed for body surface appears to deteriorate in dialyzed and transplanted patients. In 2D echocardiography, myocardial mass represented by left ventricular mass/body surface area index (LVMI) appears to be a more sensitive marker of cardiac structural changes, compared to relative wall thickness (RWT), left ventricle and diastolic diameter index (LVEDDI) and left atrial volume index (LAVI). We observed a generally favorable impact of kidney transplantation on cardiac structure and function; however, the differences were non-significant. The improvement seems to be more pronounced in cardiac function parameters, peak early diastolic velocity/average peak early diastolic velocity of mitral valve annulus (E/e´), 3D left ventricle ejection fraction (LV EF) and global longitudinal strain (GLS). We conclude that ABI is not an appropriate screening test to determine the cardiovascular risk in patients with ESRD.

scholarly journals Improved Left Ventricular Diastolic Function with Exercise Training in Hypertension: A Doppler Imaging Study

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Huan Zheng ◽  
Ming Luo ◽  
Yi Shen ◽  
Hong Fang
Keyword(s):  
Exercise Training ◽  
Diastolic Function ◽  
Anaerobic Threshold ◽  
Interventricular Septum ◽  
Left Atrial Volume ◽  
Exercise Group ◽  
Left Ventricular ◽  
Doppler Imaging ◽  
Volume Index ◽  
Hypertensive Patients

Objective.To study the effects of 6 months’ exercise training on ventricular function in hypertensive patients.Methods.Both groups received routine anti-hypertensive pharmacological therapy and one received a 6 months’ exercise program in addition. All patients underwent incremental cardiopulmonary exercise test and echocardiography in baseline and after 6 months.Results.(1) In 6 months’ follow-up, PeakVO2, Powermax(max workload), AT (anaerobic threshold), VO2AT(VO2at anaerobic threshold), tAT(time from beginning to anaerobic threshold) (), were increased in the exercise group. HRrest(Heart rate at rest) was decreased (). LAVI (left atrial volume index), peak mitral filling velocities during early (E) and late (A) diastole E/A ratio, DT(deceleration time of the mitral E wave), IVST(Interventricular septum thickness in diastole), tissue Doppler indice Mean Ea/Aa ratio () were also improved. (2) Correlation analysis: 4 variates had significant effect on change of PeakVO2in the exercise group: age (), change of HRrest(), change of E/A (), change of Mean Ea/Aa (); Through analyzing 2 groups patients’ baseline values, their age (), VO2AT(), HRrest(), LAVI (), E/A () were found to be independent predictors of MeanEa/Aa. -value under .05 was considered statistically significant.Conclusion.6 months’ exercise could enhance hypertensive patients’ aerobic exercise level and diastolic function to a certain extent.

scholarly journals Low birth weight predicts impaired cardiac structure and function in mid-adulthood

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
Q Huynh ◽  
C Magnussen ◽  
A Venn ◽  
T Marwick
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Left Ventricular ◽  
Structure And Function ◽  
Volume Index ◽  
Cardiac Structure ◽  
Weight Category ◽  
Causal Pathways ◽  
Cardiac Structure And Function ◽  
And Function

Abstract Aims We sought to determine the relationship of low birth weight (LBW) with adult cardiac structure and function and investigate potential causal pathways. Methods We followed 925 Australians (41.3% male) from childhood (7–15 years) to young- (26–36 years) and mid-adulthood (36–50 years). Left ventricular (LV) global longitudinal strain (GLS, %), LV mass index (LVMi, g/m2.7), LV filling pressure (E/e') and left atrial volume index (LAVi, g/m2) were measured by echocardiography in mid-adulthood. Birth weight category was self-reported in adulthood and classified as low (≤5 pounds or ≤2270 g), normal (5–8 pounds or 2271–3630 g) and high (&gt;8 pounds or &gt;3630 g). Results 7.5% (69/925) reported LBW. Compared with participants with normal birth weight, those with LBW had a 2.01-fold (1.19–3.41, p=0.009) higher risk of impaired GLS (GLS &gt;−18%) and 2.63-fold (0.89–7.81, p=0.08) higher risk of LV hypertrophy (LVMi &gt;48 g/m2.7 in men or &gt;44 g/m2.7 in women) in adulthood independent of age, sex and any measures of socioeconomic status. Participants with LBW significantly increased body fat from childhood to adulthood relative to their peers, which was associated with greater levels of triglycerides, fasting blood glucose and arterial stiffness in adulthood. These factors were the strongest mediators in the association of LBW with impaired GLS in adulthood and together, explained half of the LBW effect size. The remaining half of this association was independent of any measured factors. Conclusions LBW was associated with impaired cardiac structure and function in mid-adulthood. This association was only partially explained by known risk factors. FUNDunding Acknowledgement Type of funding sources: None.

scholarly journals Associations between physical activity, sedentary behaviour and left ventricular structure and function from the Echocardiographic Study of Latinos (ECHO-SOL)

Open Heart ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. e001647
Author(s):  
Andrew E Berdy ◽  
Bharathi Upadhya ◽  
Sonia Ponce ◽  
Katrina Swett ◽  
Richard B Stacey ◽  
...  
Keyword(s):  
Physical Activity ◽  
Sedentary Behaviour ◽  
Left Ventricular ◽  
Structure And Function ◽  
Volume Index ◽  
Cardiac Structure ◽  
Echocardiographic Study ◽  
Modifiable Factors ◽  
Cardiac Structure And Function ◽  
And Function

ObjectiveThe cross-sectional association between accelerometer-measured physical activity (PA), sedentary behaviour (SB) and cardiac structure and function is less well described. This study’s primary aim was to compare echocardiographic measures of cardiac structure and function with accelerometer measured PA and SB.MethodsParticipants included 1206 self-identified Hispanic/Latino men and women, age 45–74 years, from the Echocardiographic Study of Latinos. Standard echocardiographic measures included M-mode, two-dimensional, spectral, tissue Doppler and myocardial strain. Participants wore an Actical accelerometer at the hip for 1 week.ResultsThe mean±SE age for the cohort was 56±0.4 years, 57% were women. Average moderate to vigorous PA (MVPA) was 21±1.1 min/day, light PA was 217±4.2 min/day and SB was 737±8.1 min/day. Both higher levels of light PA and MVPA (min/day) were associated with lower left ventricular (LV) mass index (LVMI)/end-diastolic volume and a lower E/e′ ratio. Higher levels of MVPA (min/day) were associated with better right ventricular systolic function. Higher levels of SB were associated with increased LVMI. In a multivariable linear regression model adjusted for demographics and cardiovascular disease modifiable factors, every 10 additional min/day of light PA was associated with a 0.03 mL/m2 increase in left atrial volume index (LAVI) (p<0.01) and a 0.004 cm increase in tricuspid annular plane systolic excursion (p<0.01); every 10 additional min/day of MVPA was associated with a 0.18 mL/m2 increase in LAVI (p<0.01) and a 0.24% improvement in global circumferential strain (p<0.01).ConclusionsOur findings highlight the potential positive association between the MVPA and light PA on cardiac structure and function.

P2443Diagnostic performance of 2d-echocardiography versus cardiac catheterization in assessing left ventricular end-diastolic pressure: a meta-analysis

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
K Acosta ◽  
J Cano ◽  
E Esposo ◽  
L Shiu ◽  
A Masbang
Keyword(s):  
Cardiac Catheterization ◽  
Diagnostic Performance ◽  
Diastolic Pressure ◽  
Meta Analysis ◽  
Left Atrial Volume ◽  
Public Health Problem ◽  
Left Ventricular ◽  
Volume Index ◽  
Major Public Health Problem ◽  
2D Echocardiography

Abstract Introduction Heart failure (HF) is a major public health problem that affects 23 million people worldwide. The global incidence and prevalence rates of HF are approaching epidemiologic proportions, as evidenced by the relentless increase in the number of HF hospitalizations, the growing number of HF deaths, and the spiraling costs associated with the care of HF patients. Its diagnosis may be challenging because symptoms are nonspecific. Determination of left ventricular filling pressure (LVFP) is important to interpret equivocal symptoms so as to optimize therapy. Catheterization remains to be the gold standard; however, it is not practical to submit many patients with clinical suspicion of HF to invasive studies. Although echocardiographic indices are recommended by recent guidelines (Level IIIB), studies have shown conflicting results on its diagnostic performance. Purpose This study aims to identify the diagnostic performance of 2D-echocardiography compared with cardiac catheterization in assessing LV end-diastolic pressure (LVEDP) among adult patients with suspected HF using a meta-analysis of observational studies. Methods Eight studies with a total of 1,153 patients with suspected HF who underwent simultaneous evaluation of echocardiographic estimates of LVFP and invasive measurement of LVEDP by cardiac catheterization were included in the final analysis after extensive searching. Review Manager 5.3 was used to the assess the sensitivity and specificity of E/e' lateral, septal and average, and left atrial volume index (LAVI). Meta-Disc was applied to obtain pooled estimates, receiver operating characteristic curve (ROC) and area under curve (AUC) using a 95% confidence interval. Results Overall, pooled estimates for E/e' septal >15, E/e' lateral >12, E/e' average >13 and LAVI >34 have significant diagnostic values with pooled sensitivity of 62% (95% CI 0.54 to 0.69), 39% (95% CI 0.33 to 0.45), 81% (95% CI 0.73 to 0.87) and 53% (95% CI 0.46 to 0.61) respectively; pooled specificity of 59% (95% CI 0.53 to 0.65), 87% (95% CI 0.81 to 0.91), 72% (95% CI 0.65 to 0.78) and 69% (95% CI 0.57 to 0.79) respectively; and pooled AUC of 0.624, 0.8486, 0.8190 and 0.69 respectively. Conclusion 2D echocardiography have significant diagnostic performance compared with cardiac catheterization in assessing LVEDP among adults with suspected HF. Guidelines may be updated using this meta-analysis.

scholarly journals 0550 Insomnia is Associated with Greater Arterial Stiffness and Cardiac Dysfunction

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A210-A211
Author(s):  
M E Petrov ◽  
S D Youngstedt ◽  
F Mookadam ◽  
N Jiao ◽  
L M Lim ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Global Longitudinal Strain ◽  
Left Atrial Volume ◽  
Severity Index ◽  
Aortic Pressure ◽  
Left Ventricular ◽  
Volume Index ◽  
Left Atrial Volume Index ◽  
Normal Ranges ◽  
2D Echocardiography

Abstract Introduction Insomnia is a novel and modifiable risk factor for incident cardiovascular disease (CVD). However, identification of early markers of subclinical CVD in diagnosed insomnia is understudied. Our aim for this ongoing study is to contrast markers of cardiovascular structure and function between people with insomnia and good-sleeping controls. Methods Persons with insomnia (met ICSD-III criteria) and good sleeping controls (&lt;8 Insomnia Severity Index, mean 8-night SOL and WASO&lt;31min) were recruited from the community. Twenty-two adults (21-39y; 55% women) with no history of CVD, diabetes, inflammatory conditions, significant hypertension, or current sleep-disordered breathing (WatchPat200, Itamar Medical) were enrolled and underwent fasting cardiovascular testing. Testing included: Central augmented aortic pressure (AP) and carotid-femoral pulse wave velocity (cfPWV) for vascular stiffness; brachial artery flow mediated dilation (FMD) to assess endothelial function; and 2D echocardiography to assess ejection fraction (EF%), left ventricular global longitudinal strain (LVGLS), left atrial volume index (LAVI), mitral valve E/e’ ratio (E/e’), and lateral e’. ANCOVA models, adjusting for age, comparing persons with insomnia (n=6) to good sleeping controls (n=16) on each cardiovascular measure were conducted. Results AP (range:-5,10mmHg), cfPWV (range: 4.8-7.6m/s), EF% (range:55.0-72.0%), LVGLS (range:-26,-19%) LAVI (range:14.1-26.7mL/m2), E/e’ (range:3.2-7.8), and lateral e’ (range:0.09-0.22cm/sec) were all within normal ranges according to age and sex normative standards. Mean FMD was 8.8% (SD=4.3, range:4.3-19.8%). Age adjusted ANCOVA models indicated that the insomnia group had significantly worse cardiovascular function than good sleeping controls on cfPWV (M=6.8±0.3 vs. M=5.7±0.2; p=0.004), EF% (M=60.0±1.7 vs. M=65.2±1.0; p=0.017), LVGLS (M=-21.6±0.6 vs. M=-24.3±0.4; p=0.001), and lateral e’ (M=0.12±0.01 vs. M=0.18±0.01; p=0.003). No group differences were found for AP, FMD, LAVI, and E/e’. Conclusion Among relatively healthy young adults, people with insomnia had greater arterial stiffness and worse left ventricular systolic and diastolic functioning. Support American Academy of Sleep Medicine Foundation Focused Projects Award for Junior Investigators 179-FP-18

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