Association of BUD13 polymorphisms with metabolic syndrome in Chinese population: a case-control study

Metabolic syndrome (MetS) is a significant health care problem worldwide and is characterized by increased fasting glucose and obesity. Resistin is a protein hormone produced both by adipocytes and immunocompetent cells, including those residing in adipose tissue, and is believed to modulate glucose tolerance and insulin action. This study examined the association of resistin gene polymorphisms, rs1862513 and rs3745368, and related haplotypes with the development of metabolic syndrome in a Han Chinese population. This case-control study was performed on 3792 subjects, including 1771 MetS cases and 2021 healthy controls from the Jilin province of China. Metabolic syndrome was defined according to the criteria of the International Diabetes Federation (IDF). Logistic regression analysis was used to estimate the relationship between gene polymorphism and MetS. Our results showed that there were no significant associations between MetS and the genotype distributions in four kinds of inheritance models, allele frequencies, and related haplotypes of resistin gene polymorphisms rs1862513 and rs3745368 (allpvalues > 0.05). Based on our study findings, we concluded that mutations in resistin genes are not associated with the presence of MetS in a Han Chinese population from Jilin province in China.

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Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study

Acta Endocrinologica ◽

10.1530/eje-10-0902 ◽

2011 ◽

Vol 164 (3) ◽

pp. 381-388 ◽

Cited By ~ 23

Author(s):

Chloe Y Y Cheung ◽

Annette W K Tso ◽

Bernard M Y Cheung ◽

Aimin Xu ◽

K L Ong ◽

...

Keyword(s):

Metabolic Syndrome ◽

Genetic Risk ◽

Chinese Population ◽

Central Obesity ◽

Case Control Study ◽

Case Control ◽

Cross Sectional ◽

The Metabolic Syndrome ◽

Control Study

ObjectiveCentral obesity predisposes to various cardiometabolic diseases and is a key component of the metabolic syndrome (MetS). We have previously demonstrated that three obesity-susceptible single nucleotide polymorphisms (SNPs), rs10938397 (GNPDA2), rs8050136 (FTO) and rs17782313 (MC4R), were associated with obesity and waist circumference in cross-sectional studies in the Chinese population. In this study, we investigate whether these SNPs could also predict the persistence of central obesity and MetS in subjects from the Hong Kong Cardiovascular Risk Factors Prevalence Study (CRISPS) cohort.Design and methodsWe genotyped these SNPs in i) 354 subjects with and 994 subjects without central obesity at both baseline and a 12-year follow-up, ii) 2214 subjects (816 cases and 1398 controls) in an MetS cross-sectional case–control study and iii) 225 subjects with and 1221 subjects without MetS at both baseline and the 12-year follow-up.ResultsBoth FTO rs8050136 (Page, sex-adjusted=0.019; odds ratio (OR) (95% confidence intervals (CI)): 1.35 (1.05, 1.73)) and GNPDA2 rs10938397 (Page, sex-adjusted=3×10−3; OR (95% CI): 1.34 (1.11, 1.63)) were significantly associated with persistent central obesity. GNPDA2 rs10938397 was also significantly associated with MetS (Page, sex-adjusted=0.011, OR (95% CI): 1.20 (1.04, 1.38)) in the case–control study. However, none of these SNPs showed an individual association with persistent MetS. In the combined genetic risk analyses for persistent central obesity and persistent MetS, the combined genetic risk score of the three SNPs showed an OR of 1.25 (95% CI: 1.10, 1.42; Page, sex-adjusted=4.92×10−3) and 1.19 (95% CI: 1.03, 1.38; Page, sex-adjusted=0.019) for each additional risk allele respectively.ConclusionThis study demonstrated that FTO and GNPDA2 variants predicted persistent central obesity in the Chinese population, further supporting their importance as obesity-susceptible genes.

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Association of Genetic Variants in the Adiponectin Gene with Metabolic Syndrome: A Case-Control Study and a Systematic Meta-Analysis in the Chinese Population

PLoS ONE ◽

10.1371/journal.pone.0058412 ◽

2013 ◽

Vol 8 (4) ◽

pp. e58412 ◽

Cited By ~ 15

Author(s):

Meng Gao ◽

Daxia Ding ◽

Jinghua Huang ◽

Yali Qu ◽

Yu Wang ◽

...

Keyword(s):

Metabolic Syndrome ◽

Genetic Variants ◽

Chinese Population ◽

Case Control Study ◽

Meta Analysis ◽

Case Control ◽

Adiponectin Gene ◽

Control Study

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Higher Levels of Magnesium and Lower Levels of Calcium in Whole Blood Are Positively Correlated with the Metabolic Syndrome in a Chinese Population: A Case-Control Study

Annals of Nutrition and Metabolism ◽

10.1159/000450761 ◽

2016 ◽

Vol 69 (2) ◽

pp. 125-134 ◽

Cited By ~ 5

Author(s):

Zheping Yuan ◽

Chengguo Liu ◽

Yiping Tian ◽

Xuhui Zhang ◽

Huaizhuang Ye ◽

...

Keyword(s):

Metabolic Syndrome ◽

Whole Blood ◽

Chinese Population ◽

Case Control Study ◽

Absorption Spectrometry ◽

Case Control ◽

Control Group ◽

The Metabolic Syndrome ◽

Flame Atomic Absorption ◽

Control Study

Magnesium (Mg) and calcium (Ca) are essential for numerous kinds of metabolisms in human body. To investigate the associations between Mg and Ca and the ratio of Ca to Mg (Ca/Mg) in whole blood with metabolic syndrome (MetS) in a Chinese population, a matched case-control study including 204 MetS patients and 204 healthy controls (aged 48-89) was carried out in 2011. MetS were diagnosed according to the criteria of Chinese Diabetes Society. Controls had no abnormal metabolic components and were matched with cases by age, gender and region. Blood samples were collected in the morning after an overnight fast. Whole blood Mg and Ca were determined by flame atomic absorption spectrometry. Subjects who were male constituted 44.1% of the part of this study. The average age was 64.0 ± 7.18, and the average body mass index was 24.3 ± 3.75. The MetS group showed significantly higher Mg and lower Ca and Ca/Mg as compared with the control group. Comparing with the bottom tertile (T1) of Mg, increased ORs for MetS were found in median tertile (T2) and top tertile (T3) of Mg. For Ca, T2 and T3 were negatively associated with MetS. Inverse relationship was also found between Ca/Mg ratio and MetS. Our findings suggested that increased Mg and decreased Ca and Ca/Mg in whole blood were correlated with MetS in Chinese adults.

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