0708 Cognitive impairment in the metabolic syndrome: a case-control study in the Spanish population

ObjectiveCentral obesity predisposes to various cardiometabolic diseases and is a key component of the metabolic syndrome (MetS). We have previously demonstrated that three obesity-susceptible single nucleotide polymorphisms (SNPs), rs10938397 (GNPDA2), rs8050136 (FTO) and rs17782313 (MC4R), were associated with obesity and waist circumference in cross-sectional studies in the Chinese population. In this study, we investigate whether these SNPs could also predict the persistence of central obesity and MetS in subjects from the Hong Kong Cardiovascular Risk Factors Prevalence Study (CRISPS) cohort.Design and methodsWe genotyped these SNPs in i) 354 subjects with and 994 subjects without central obesity at both baseline and a 12-year follow-up, ii) 2214 subjects (816 cases and 1398 controls) in an MetS cross-sectional case–control study and iii) 225 subjects with and 1221 subjects without MetS at both baseline and the 12-year follow-up.ResultsBoth FTO rs8050136 (Page, sex-adjusted=0.019; odds ratio (OR) (95% confidence intervals (CI)): 1.35 (1.05, 1.73)) and GNPDA2 rs10938397 (Page, sex-adjusted=3×10−3; OR (95% CI): 1.34 (1.11, 1.63)) were significantly associated with persistent central obesity. GNPDA2 rs10938397 was also significantly associated with MetS (Page, sex-adjusted=0.011, OR (95% CI): 1.20 (1.04, 1.38)) in the case–control study. However, none of these SNPs showed an individual association with persistent MetS. In the combined genetic risk analyses for persistent central obesity and persistent MetS, the combined genetic risk score of the three SNPs showed an OR of 1.25 (95% CI: 1.10, 1.42; Page, sex-adjusted=4.92×10−3) and 1.19 (95% CI: 1.03, 1.38; Page, sex-adjusted=0.019) for each additional risk allele respectively.ConclusionThis study demonstrated that FTO and GNPDA2 variants predicted persistent central obesity in the Chinese population, further supporting their importance as obesity-susceptible genes.

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Metabolic Syndrome Components and Acute pancreatitis: A Case-Control Study in China

10.21203/rs.3.rs-45027/v1 ◽

2020 ◽

Author(s):

zhemin Shen ◽

Xueqiao Wang ◽

Zili Zhen ◽

Yao Wang ◽

Peilong Sun

Keyword(s):

Metabolic Syndrome ◽

Acute Pancreatitis ◽

Incidence Rate ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Inflammatory Disorder ◽

The Metabolic Syndrome ◽

Metabolic Syndrome Components ◽

Control Study

Abstract Background: Acute pancreatitis (AP) is a common inflammatory disorder of pancreas. Recent evidence has shown that metabolic syndrome was positively correlated with the severity of AP. However, only few studies have revealed the relationship between metabolic syndrome and the occurrence of AP. We therefore elucidated the association between the metabolic syndrome components and the incidence rate of AP. Methods: A hospital-based case-control study was conducted. 705 patients admitted to our hospital from January 2016 to December 2018 were included in the study. Subjects were divided into case and control group according to their diagnosis: (1) According to the revised Atlanta classification from 2012, patients diagnosed as AP were enrolled into case group. (2) Patients without history of AP or any disease related to metabolic syndrome were allocated into control group. Controls were matched to cases individually by sex and age (control/case ratio=1). Risk factors were determined by univariate and multivariate logistic regression analyses. Results: The incidence rate of metabolic syndrome with AP patients was 30.9%, which was more frequent than controls (13.2%) (OR=2.975; 95%CI 1.947-4.548, p<0.001). In multivariate regression analysis, histories of smoking or alcohol drinking, biliary stone were important predictors of AP. Besides, occurrence of AP was significantly associated with total cholesterol (TC) (OR=1.831; 95%CI 1.137-2.948, p=0.013), triglyceride (TG) (OR=2.058; 95%CI 1.332-3.179, p=0.001), fasting plasma glucose (FPG) (OR =2.345; 95%CI 1.395-3.940, p=0.001), as well as low values of apolipoprotein A (Apo A) (OR =0.247; 95%CI 0.146-0.416, p<0.001). Conclusion: Metabolic syndrome and its components portend high risks of occurrence of AP.

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Case–Control Study of the Metabolic Syndrome and Metabolic Risk Factors for Endometrial Cancer

Cancer Epidemiology Biomarkers & Prevention ◽

10.1158/1055-9965.epi-11-0715 ◽

2011 ◽

Vol 20 (11) ◽

pp. 2384-2395 ◽

Cited By ~ 57

Author(s):

Christine M. Friedenreich ◽

Rita K. Biel ◽

David C.W. Lau ◽

Ilona Csizmadi ◽

Kerry S. Courneya ◽

...

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Endometrial Cancer ◽

Case Control Study ◽

Case Control ◽

Metabolic Risk Factors ◽

Metabolic Risk ◽

The Metabolic Syndrome ◽

Control Study

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Case Control Study for the Evaluation of Beneficial Effect(s) of Pistachio Nut Intake on Cardiovascular Risk Factors in Asian Indians with the Metabolic Syndrome

The FASEB Journal ◽

10.1096/fasebj.25.1_supplement.971.15 ◽

2011 ◽

Vol 25 (S1) ◽

Author(s):

Seema Gulati ◽

Anoop Misra

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Cardiovascular Risk ◽

Asian Indians ◽

Case Control Study ◽

Case Control ◽

The Metabolic Syndrome ◽

Pistachio Nut ◽

Nut Intake ◽

Control Study

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Modified metabolic syndrome and second cancers in women: A case control study

South Asian Journal of Cancer ◽

10.4103/2278-330x.195341 ◽

2016 ◽

Vol 05 (04) ◽

pp. 189-191

Author(s):

Carlos-Manuel Ortiz-Mendoza ◽

Ernesto Pérez-Chávez ◽

Tania-Angélica De-la Fuente-Vera

Keyword(s):

Diabetes Mellitus ◽

Metabolic Syndrome ◽

Case Control Study ◽

Serum Levels ◽

Case Control ◽

Fasting Serum ◽

Second Cancers ◽

The Metabolic Syndrome ◽

Anthropometric Features ◽

Control Study

Abstract Background: According to some studies, the metabolic syndrome causes diverse primary cancers; however, there is no evidence about metabolic syndrome impact on second cancers development in women. Aim: To find out the implication of the modified metabolic syndrome in women with second cancers. Materials and Methods: This was a case-control study, at a general hospital in Mexico City, in women with second cancers (cases) and age-matched women with only one neoplasm (controls). The analysis comprised: Tumor (s), anthropometric features, and body mass index (BMI); moreover, presence of diabetes mellitus, hypertension, and fasting serum levels of total cholesterol, triglycerides and glucose. Results: The sample was of nine cases and 27 controls. In cases, the metabolic syndrome (diabetes mellitus or glucose > 99 mg/dL + hypertension or blood pressure ≥ 135/85 mm Hg + triglycerides > 149 mg/dL or BMI ≥ 30 kg/m 2 ) was more frequent (odds ratio 20.8, 95% confidence interval: 1.9-227.1). Conclusion: Our results suggest that in women, the modified metabolic syndrome may be a risk factor for second cancers.

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Plasma Alkylresorcinol Metabolite, A Biomarker of Whole-Grain Wheat and Rye Intake, and Risk of Metabolic Syndrome: A Case-Control Study

10.21203/rs.3.rs-35930/v1 ◽

2020 ◽

Author(s):

Li Zhou ◽

Xiaoxing Mo ◽

Qiang Wang ◽

Hongjie Liu ◽

Yang Liu ◽

...

Keyword(s):

Metabolic Syndrome ◽

High Performance ◽

Case Control Study ◽

Smoking Status ◽

Epidemiological Studies ◽

Case Control ◽

Whole Grain ◽

The Metabolic Syndrome ◽

Drinking Status ◽

Control Study

Abstract Background: Whole-grain intake assessed through dietary recording methods has been suggested to be inversely associated with the metabolic syndrome (MetS) risk in several epidemiological studies. However, limited studies have evaluated the association between whole-grain intake and MetS risk when using objective biomarkers of whole-grain intake. The aim of this study was to examine the association between plasma 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), a biomarker of whole-grain wheat and rye intake, and MetS risk in a Chinese population.Methods: A case-control study of 667 MetS cases and 667 matched controls was conducted based on baseline data of the Tongji-Ezhou Cohort study. Plasma DHPPA concentrations were assessed by high-performance liquid chromatography-tandem mass spectrometry. MetS was determined using definition of the Joint Interim Statement.Results: Plasma DHPPA was inversely associated with MetS risk. After adjustment for age, sex, body mass index, smoking status, alcohol drinking status, physical activity and education level, the odds ratios (ORs) for MetS across increasing quartiles of plasma DHPPA concentrations were 1 (referent), 0.86 (0.58-1.26), 0.77 (0.52-1.15), and 0.59 (0.39-0.89), respectively. The inverse relation between plasma DHPPA and MetS persisted in stratified analyses according to confounding factors. In addition, the cubic spline analysis revealed a potential nonlinear association between plasma DHPPA and MetS, with a steep reduction in the risk at the lower range of plasma DHPPA concentration.Conclusions: Our study revealed that higher plasma DHPPA concentrations were associated with lower odds of MetS. Our findings provided further evidence to support health benefits of whole grain consumption.

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