The clinicopathological parameters and prognostic significance of HER2 expression in gastric cancer patients: a meta-analysis of literature

Abstract Tumour-stroma ratio (TSR) is a novel potential prognostic factor in cancers and based on the proportions of stroma and tumour area. The prognostic value of TSR in gastric cancer is incompletely known. The aim of this study was to estimate prognostic significance of TSR in gastric adenocarcinoma. A search of PubMed (MEDLINE), Web of Science, EMBASE, Cochrane and Scopus databases was performed. A meta-analysis was conducted on five-year survival in gastric cancer patients using inverse variance random-effects methods. The literature search yielded 5329 potential titles, of which a total of seven studies were eligible. Results of six studies including a total of 1779 patients were pooled in the meta-analysis. Only 23 (1.3%) of the patients received neoadjuvant therapy. All six studies had a cut-off of 50% for the proportion of stroma when dividing the patients into low- and high stroma groups. Low TSR (high amount of stroma) was strongly associated with increased five-year mortality (hazard ratio 2.19, 95% CI 1.69–2.85). In conclusion, TSR is a strong prognostic factor in gastric cancer. It could be used to estimate prognosis of gastric cancer patients not receiving neoadjuvant chemotherapy. Further studies including patients receiving neoadjuvant therapy are recommended.

Download Full-text

A systematic review and meta-analysis protocol of clinical characteristics and prognostic significance of mammalian target of rapamycin for gastric cancer patients

Medicine ◽

10.1097/md.0000000000021138 ◽

2020 ◽

Vol 99 (32) ◽

pp. e21138

Author(s):

Hua Wang ◽

Juan Li

Keyword(s):

Gastric Cancer ◽

Systematic Review ◽

Cancer Patients ◽

Clinical Characteristics ◽

Meta Analysis ◽

Mammalian Target Of Rapamycin ◽

Prognostic Significance ◽

Target Of Rapamycin ◽

Gastric Cancer Patients ◽

Analysis Protocol

Download Full-text

Clinicopathological and Prognostic Value of S100A4 Expression in Gastric Cancer: A Meta-Analysis

The International Journal of Biological Markers ◽

10.5301/jbm.5000054 ◽

2014 ◽

Vol 29 (2) ◽

pp. 99-111 ◽

Cited By ~ 14

Author(s):

Zhian Ling ◽

Ruolin Li

Keyword(s):

Gastric Cancer ◽

Cancer Patients ◽

Prognostic Value ◽

Meta Analysis ◽

Tumor Grade ◽

Pooled Analysis ◽

Cochrane Library ◽

Clinicopathological Parameters ◽

S100a4 Expression ◽

Gastric Cancer Patients

Purposes For several years S100A4 has been implicated in tumor progression and prognosis. However, the prognostic value of S100A4 overexpression in patients with gastric cancer remains unknown. Therefore, we performed a meta-analysis to assess the relationship between S100A4 overexpression and clinical outcome of gastric cancer. Methods and Results Candidate studies were searched from PubMed, Embase, Cochrane Library, and ISI Web of Science. We included studies that evaluated the prognostic value of S100A4 expression in gastric cancer patients with regard to survival and a series of clinicopathological parameters. The pooled hazard ratios (HR) and odds ratios (OR) with 95% confidence intervals (CI) were used to estimate the effects. Ten studies, all from Asia, were included in the meta-analysis. The pooled analysis showed that S100A4 overexpression was significantly associated with worse overall survival (OS) (HR=1.86, 95% CI: 1.45-2.38, p<0.00001) without heterogeneity in the data (I2=43.6%, p=0.131). Furthermore, our results showed that S100A4 overexpression was significantly correlated with some clinicopathological parameters such as tumor grade, stage, metastasis, invasion, and relapse. Conclusions The results of our meta-analysis indicate that S100A4 overexpression correlates with more adverse clinical features and a poor prognosis of gastric cancer patients in Asia, thus suggesting that S100A4 could be a useful marker to evaluate progression and prognosis of Asian gastric cancer patients. More studies from Western countries with a larger number of tumors and standardized methods are required before significant conclusions can be drawn.

Download Full-text

Different prognostic significance of signet ring cell histology for early and advanced gastric cancer patients: a systematic review and meta-analysis

Expert Review of Gastroenterology & Hepatology ◽

10.1080/17474124.2020.1769476 ◽

2020 ◽

Vol 14 (6) ◽

pp. 499-509

Author(s):

Bochao Zhao ◽

Wu Lv ◽

Jingting Zhang ◽

Jiale Zhang ◽

Baojun Huang ◽

...

Keyword(s):

Gastric Cancer ◽

Systematic Review ◽

Advanced Gastric Cancer ◽

Cancer Patients ◽

Meta Analysis ◽

Prognostic Significance ◽

Signet Ring Cell ◽

Signet Ring ◽

Ring Cell ◽

Gastric Cancer Patients

Download Full-text

Clinicopathological and prognostic significance of metastasis-associated in colon cancer-1 in gastric cancer: A meta-analysis

The International Journal of Biological Markers ◽

10.1177/1724600818813634 ◽

2019 ◽

Vol 34 (1) ◽

pp. 27-32 ◽

Cited By ~ 1

Author(s):

Yan Jin ◽

Kun Zhou ◽

Wenjing Zhao ◽

Rongbo Han ◽

Xinying Huo ◽

...

Keyword(s):

Gastric Cancer ◽

Colon Cancer ◽

Overall Survival ◽

Cancer Patients ◽

Meta Analysis ◽

Prognostic Significance ◽

Clinicopathological Features ◽

Poor Overall Survival ◽

Expression Levels ◽

Gastric Cancer Patients

Background: The gene metastasis-associated in colon cancer-1 (MACC1) has been reported to be overexpressed in diverse human malignancies, and an increasing amount of evidence suggests that its overexpression is associated with the development and progression of many human tumors. However, the prognostic and clinicopathological value of MACC1 in gastric cancer remains inconclusive. Therefore, we conducted this meta-analysis to investigate the effect of positive MACC1 expression on clinicopathological features and survival outcomes in gastric cancer. Methods: Medline, Web of Science, and EMBASE databases were searched for relevant articles published up to 10 April 2018. The correlation of MACC1 expression levels with overall survival and clinicopathological features was analyzed. Results: In this meta-analysis, nine studies with a total of 2103 gastric cancer patients were included. Our results showed that high expression of MACC1 was significantly related to a poor overall survival. Moreover, our meta-analysis showed that MACC1 overexpression was significantly linked to distant metastasis and vascular invasion. There were no significant correlations between positive MACC1 expression and gender, localization, tumor-node-metastasis (TNM) stage, tumor extent (T stage) and lymph node involvement (N stage) Conclusions: MACC1 expression levels can serve as a novel prognostic factor in gastric cancer patients.

Download Full-text

Prognostic significance of malignant ascites in gastric cancer patients with peritoneal metastasis: A systemic review and meta-analysis

World Journal of Clinical Cases ◽

10.12998/wjcc.v7.i20.3247 ◽

2019 ◽

Vol 7 (20) ◽

pp. 3247-3258 ◽

Cited By ~ 2

Author(s):

Ling-Nan Zheng ◽

Feng Wen ◽

Ping Xu ◽

Shuang Zhang

Keyword(s):

Gastric Cancer ◽

Cancer Patients ◽

Peritoneal Metastasis ◽

Meta Analysis ◽

Prognostic Significance ◽

Malignant Ascites ◽

Systemic Review ◽

Gastric Cancer Patients

Download Full-text

The roles of E2Fs in gastric cancer: the transcription factors E2F1/2/3/4/5 as potential therapeutic targets and E2F6/7/8 as new prognostic biomarkers in gastric cancer

10.21203/rs.3.rs-31173/v1 ◽

2020 ◽

Author(s):

Hui Li ◽

Shufen Zhao ◽

Liwei Shen ◽

Peige Wang ◽

Shihai Liu ◽

...

Keyword(s):

Gastric Cancer ◽

Cancer Patients ◽

Expression Patterns ◽

Prognostic Significance ◽

Therapeutic Targets ◽

Tumor Grade ◽

Clinicopathological Parameters ◽

Gastric Cancer Cells ◽

Prognostic Accuracy ◽

Gastric Cancer Patients

Abstract Background E2F is a family of transcription factor proteins with multiple functions; E2F proteins are involved in cell cycle regulation, cell differentiation, the DNA damage response and cell death. Studies have shown that E2Fs have prognostic significance in many cancers, but the expression patterns and prognostic values of E2Fs in gastric cancer have not been systematically elucidated. Methods In this study, we used the ONCOMINE database and UALCAN online analysis website to compare the transcriptional levels and expression of eight E2F family members between gastric cancer and normal samples. UALCAN was also used to analyze the relationship between the expression of 8 E2F members and clinicopathological parameters. The prognostic value of the E2Fs were determined by Kaplan-Meier Plotter. A protein-protein interaction (PPI) network was constructed using the STRING database. The functions and pathways of E2F family and its neighboring 50 frequently changed genes were analyzed using the Database for Annotation, Visualization, and Integrated Discovery (DAVID) software. Finally, quantitative PCR was used to verify the expression of E2Fs in gastric cancer cells. Results The expression patterns of 8 E2F members were significantly related to the clinical cancer stage and tumor grade of gastric cancer patients. High mRNA expression of E2F1/2/3/4/5 was a prognostic factor for poor OS in gastric cancer patients, while high expression of E2F6/7/8 was associated with better OS. In addition, a high mutation rate (46%) for E2Fs was observed in patients with gastric cancer. The expression levels of E2F1/2/3/5/8 in AGS and HGC27 cell lines were higher than those in normal cells, while E2F7 showed the opposite trend. Conclusions In summary, these results indicate that E2F1/2/3/4/5 can be used as potential therapeutic targets in gastric cancer, and E2F6/7/8 can be used as new prognostic markers to improve the survival rate and prognostic accuracy in gastric cancer.

Download Full-text