Determination of GP88 (progranulin) expression in breast tumor biopsies improves the risk predictive value of the Nottingham Prognostic Index

Background and Objectives: Different types of food introduced gradually in the diet will expose children to different food allergens, increasing the chance of developing allergic diseases. The aim of our study was to determine if allergen-specific IgE values can influence, depending on the diet, the prediction of remission of urticaria in children. Materials and Methods: This prospective study was conducted in 132 patients diagnosed over two years with urticaria, admitted to “Sf. Maria” Clinical Pediatric Hospital Iaşi. Total IgE assay was performed by ELISA, and determination of specific serum IgE by the CLA System Quanti Scan method (Innogenetics, Heiden, Germany). Data were gathered and statistical analysis was performed using statistical software SPSS, using descriptive and inferential statistics. Results: The determination of specific IgE to food allergens was performed on a total of 132 cases. The values of specific IgE were positive for one or more food allergens in 84 patients (63.64%). The most common allergens involved were: cow’s milk in 33.3% cases, egg white in 22.6% cases, and hazelnuts in 11.9% cases. The specific IgE values for the different types of food included in our study had a predictive value for disease remission. Conclusions: The determination of specific IgE confirms the presence of a particular food allergen and may have predictive value for the future development of an allergic manifestation.

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The Nottingham prognostic index in primary breast cancer

Breast Cancer Research and Treatment ◽

10.1007/bf01840834 ◽

1992 ◽

Vol 22 (3) ◽

pp. 207-219 ◽

Cited By ~ 658

Author(s):

Marcus H. Galea ◽

Roger W. Blamey ◽

Christopher E. Elston ◽

Ian O. Ellis

Keyword(s):

Breast Cancer ◽

Primary Breast Cancer ◽

Prognostic Index ◽

Nottingham Prognostic Index

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24 Prognostic and predictive value of the determination of tumour angiogenesis in primary solid tumours

European Journal of Cancer ◽

10.1016/0959-8049(95)95276-c ◽

1995 ◽

Vol 31 ◽

pp. S6

Author(s):

G. Gasparini

Keyword(s):

Predictive Value ◽

Solid Tumours ◽

Tumour Angiogenesis

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Nottingham Prognostic Index Plus (NPI+): a modern clinical decision making tool in breast cancer

British Journal of Cancer ◽

10.1038/bjc.2014.120 ◽

2014 ◽

Vol 110 (7) ◽

pp. 1688-1697 ◽

Cited By ~ 53

Author(s):

E A Rakha ◽

D Soria ◽

A R Green ◽

C Lemetre ◽

D G Powe ◽

...

Keyword(s):

Breast Cancer ◽

Decision Making ◽

Clinical Decision Making ◽

Prognostic Index ◽

Clinical Decision ◽

Nottingham Prognostic Index ◽

Decision Making Tool

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IMPORTANCE OF ANTIBODIES TO 21-HYDROXYLASE FOR THE DIAGNOSIS, DIFFERENTIAL DIAGNOSIS AND PROGNOSIS OF AUTOIMMUNE CHRONIC PRIMARY ADRENAL INSUFFICIENCY

PEDIATRIA Journal named after G N SPERANSKY ◽

10.24110/0031-403x-2021-100-2-78-86 ◽

2021 ◽

Vol 100 (2) ◽

pp. 78-86

Author(s):

L.S. Sozaeva ◽

◽

N.V. Makazan ◽

L.V. Nikankina ◽

N.M. Malysheva ◽

...

Keyword(s):

Differential Diagnosis ◽

Adrenal Insufficiency ◽

Predictive Value ◽

Primary Adrenal Insufficiency ◽

Polyglandular Autoimmune Syndrome ◽

Diagnosis And Prognosis ◽

Specificity And Sensitivity ◽

Enzymelinked Immunosorbent Assay

21-hydroxylase (21-OH) is the main antigen of the adrenal cortex, so the determination of antibodies (Ab) to 21-OH can help in the diagnosis and prognosis of chronic primary adrenal insufficiency (CPAI). Purpose of the study: evaluation of the relevance of Ab to 21-OH for the diagnosis and prediction of autoimmune CPAI. Materials and methods of research: the study consisted of three blocks: 1) assessment of the specificity and sensitivity, as well as the prognostic potential of Ab to 21-OH in patients with polyglandular autoimmune syndrome (APS) – individuals with APS type 1 with and without CPAI (n=106); 2) assessment of the dynamics of the level of Ab to 21-OH – patients with autoimmune CPAI were included (n=41); 3) assessment of the significance of Ab data for the differential diagnosis of various forms of CPAI, including patients with CPAI and APS type 1 exclusion (n=30). The study of Ab to 21-hydroxylase was performed using enzymelinked immunosorbent assay (BioVendor kits, Czech Republic). Results: statistically significant differences were obtained in the frequency of detection of Ab to 21-OH in patients with or without PCNI (p<0,001). The sensitivity of the method was 96%, specificity was 75%, a positive predictive value was 90%, and the negative predictive value was 89%. In 83% of patients, the level of Ab decreased with time (median size decreases – 20,4%/year). An inverse relationship was also found between the level of Ab and the duration of the course of CPAI (R=–0,460, p<0,001). In a group of 30 patients with CPAI and with exclusion of APS type 1, 21 were found to have Ab to 21-OH, only one of them had a monogenic non-autoimmune cause of CPAI (a mutation in the MC2R gene). Monogenic forms of CPAI were found in another 7 patients (mutations were found in the DAX1 and ABCD1 genes), among them an increase in Ab to 21-OH was not detected. Conclusion: determination of Ab to 21-OH is a specific and sensitive method for the diagnosis of autoimmune CPAI. An increase in Ab to 21-OH is a risk marker of autoimmune CPAI development.

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Predictive Value of a Morphometric Prognostic Index in Female Breast Cancer

Oncology ◽

10.1159/000227148 ◽

1993 ◽

Vol 50 (1) ◽

pp. 57-62 ◽

Cited By ~ 11

Author(s):

S. Aaltomaa ◽

P. Lipponen ◽

M. Eskelinen ◽

V.-M. Kosma ◽

S. Marin ◽

...

Keyword(s):

Breast Cancer ◽

Predictive Value ◽

Prognostic Index ◽

Female Breast Cancer ◽

Female Breast

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Grading, staging and Nottingham prognostic index scoring of breast carcinoma

Journal of Pathology of Nepal ◽

10.3126/jpn.v7i1.16951 ◽

2017 ◽

Vol 7 (1) ◽

pp. 1078-1083

Author(s):

A Pradhan ◽

P Paudyal ◽

AK Sinha ◽

CS Agrawal

Keyword(s):

Lymph Node ◽

Breast Carcinoma ◽

Lymph Node Metastasis ◽

Prognostic Index ◽

Nottingham Prognostic Index ◽

Eastern Region ◽

Axillary Lymph ◽

Cross Sectional ◽

Tnm System ◽

Node Metastasis

Background: Breast carcinoma is the most frequent malignant tumor in women accounting for approximately 15% of female cancer deaths. It is the second most common malignancy among women in Nepal. Our objectives were to study the extent and spread of different histological types breast carcinoma in the eastern region of Nepal, to grade and stage the tumors, score the prognosis.Materials and Methods: A cross-sectional descriptive study of mastectomy specimens with axillary lymph node sampling was done for a period of two years. Diagnosis was done using WHO classification. Modified Bloom Richardson score and TNM system was used to grade and stage the tumors. Nottingham Prognostic index was applied to score the prognosis.Results: Out of 31 total cases, the most common histologic type was Invasive Carcinoma of No Special Type (67.74%). The largest tumor size was of 12cm which had poor NPI score. Most tumors were of grade II and T2. Out of 30 cases with lymph nodes, 13 were negative for metastasis pN0, 10 were pN1 and 7 were pN2. Extranodal spread was observed in 6 out of 17 cases with lymph node metastasis and was associated with higher grades and poor prognosis.Conclusion: Higher grade tumors, lymph node metastasis and extranodal extension are associated with higher Nottingham Prognostic Index score.

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