The role of family history of Cancer in Oral Cavity Cancer

Abstract Objectives Oral and oropharyngeal squamous cell carcinoma (SCC) is the 10th most common cancer in the United States (8th in males, 13th in females), with an estimated 54,010 new cases expected in 2021, and is primarily associated with smoked tobacco, heavy alcohol consumption, areca nut use and persistent high-risk human papillomavirus (HPV). Family history of cancer (FHC) and family history of head and neck cancer (FHHNC) have been reported to play an important role in the development of OSCC. We aimed to investigate the role of FHC, FHHNC and personal history of cancer in first/second degree-relatives as co-risk factors for oral cancer. Methods This was a retrospective study of patients diagnosed with OSCC at the Division of Oral Medicine and Dentistry at Brigham and Women’s Hospital and at the Division of Head and Neck Oncology at Dana Farber Cancer Institute. Conditional logistic regressions were performed to examine whether OSCC was associated with FHC and FHHNC of FDRs and SDRs, personal history of cancer and secondary risk factors. Results Overall, we did not find an association between FHC, FHHNC and OSCC risk, whereas patients with a cancer history in one of their siblings were 1.6-times more likely to present with an OSCC. When secondary risk factors were considered, patients with a history of oral leukoplakia and dysplasia had a 16-times higher risk of having an OSCC. Conclusions Our study confirmed that a previous history of oral leukoplakia or dysplasia was an independent risk factor for OSCC. A positive family history of cancer in one or more siblings may be an additional risk factor for OSCC.

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202 Diabetes, Alcohol Consumption, Family History of Cancer and Obesity as Risk Factors for the Occurrence of Sporadic Pancreatic Neuroendocrine Tumours: A Multicenter European Study (EPINET)

Gastroenterology ◽

10.1016/s0016-5085(16)30303-1 ◽

2016 ◽

Vol 150 (4) ◽

pp. S53

Author(s):

Roberto Valente ◽

Alastair Hayes ◽

Sven-Petter Haugvik ◽

Per Hedenström ◽

Darko Siuka ◽

...

Keyword(s):

Risk Factors ◽

Family History ◽

Alcohol Consumption ◽

Neuroendocrine Tumours ◽

European Study ◽

Family History Of Cancer ◽

History Of ◽

Pancreatic Neuroendocrine Tumours ◽

History Of Cancer

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Hospital visitors as controls in case-control studies

Revista de Saúde Pública ◽

10.1590/s0034-89102001000500005 ◽

2001 ◽

Vol 35 (5) ◽

pp. 436-442 ◽

Cited By ~ 5

Author(s):

Gulnar Azevedo S Mendonça ◽

José Eluf-Neto

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Family History ◽

Case Control ◽

Breast Size ◽

Case Control Studies ◽

Family History Of Cancer ◽

History Of ◽

Incident Cases ◽

History Of Cancer

OBJECTIVE: Selecting controls is one of the most difficult tasks in the design of case-control studies. Hospital controls may be inadequate and random controls drawn from the base population may be unavailable. The aim was to assess the use of hospital visitors as controls in a case-control study on the association of organochlorinated compounds and other risk factors for breast cancer conducted in the main hospital of the "Instituto Nacional de Câncer" -- INCA (National Cancer Institute) in Rio de Janeiro (Brazil). METHODS: The study included 177 incident cases and 377 controls recruited among female visitors. Three different models of control group composition were compared: Model 1, with all selected visitors; Model 2, excluding women visiting relatives with breast cancer; and Model 3, excluding all women visiting relatives with any type of cancer. Odds ratios (OR) and 95% confidence intervals were calculated to test the associations. RESULTS: Age-adjusted OR for breast cancer associated with risk factors other than family history of cancer, except smoking and breast size, were similar in the three models. Regarding family history of all cancers, except for breast cancer, there was a decreased risk in Models 1 and 2, while in Model 3 there was an increased risk, but not statistically significant. Family history of breast cancer was a risk factor in Models 2 and 3, but no association was found in Model 1. In multivariate analysis a significant risk of breast cancer was found when there was a family history of breast cancer in Models 2 and 3 but not in Model 1. CONCLUSIONS: These results indicate that while investigating risk factors unrelated to family history of cancer, the use of hospital visitors as controls may be a valid and feasible alternative.

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