scholarly journals Parachute mitral valve associated with reticular chordae tendineae in an adult: case report

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Qun-Jun Duan ◽  
Cui-Ting Duan ◽  
Ai-Qiang Dong ◽  
Hai-Feng Cheng
Keyword(s):  
Mitral Valve ◽  
Fibrous Tissue ◽  
Mechanical Valve ◽  
Functional Communication ◽  
Adult Case ◽  
Chordae Tendineae ◽  
Unique Case ◽  
Case Presentation ◽  
Parachute Mitral Valve ◽  
Reasonable Choice

Abstract Background Parachute mitral valve with reticular chordae tendineae is an extremely rare anomaly. Case presentation We present a case of parachute mitral valve associated with distinctive reticular chordae tendineae in an adult. It was diagnosed from the echocardiogram. The patient was referred for surgery. Valve analysis showed thickened mitral valve leaflets and commissures. The chordae tendinae were lengthy and thick. All the chordae tendinae merged into a solitary papillary muscle. A distinctive reticular fibrous tissue was found on mitral valve apparatus as the chordae tendinae intermixed each other. The only functional communication between the left atrium and the left ventricle was through the reticular spaces. This anomaly was considered to be unrepairable and was replaced with a mechanical valve. Conclusions An extremely rare and unique case of parachute mitral valve associated with reticular chordae tendineae was reported. Mitral valve replacement is a reasonable choice in patients with parachute mitral valve with reticular chordae tendineae.

A Unique Case of Parachute Mitral Valve in an Adult: An Abnormally Long Chorda Tendinea

2012 ◽  
Vol 29 (9) ◽  
pp. E245-E246 ◽  
Author(s):  
Zafer Isılak ◽  
Onur Sinan Deveci ◽  
Murat Yalcın ◽  
Omer Uz ◽  
Mehmet Dogan ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Unique Case ◽  
Parachute Mitral Valve

scholarly journals Parachute mitral valve with late presentation: rare case reports

2018 ◽  
Vol 6 (8) ◽  
pp. 2850 ◽  
Author(s):  
Arun Shivajirao Bade ◽  
Vishal Patil ◽  
Shakil Shaikh ◽  
Hemant Khemani ◽  
Gurkirat Singh ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Mitral Stenosis ◽  
Rare Case ◽  
Case Reports ◽  
Specific Treatment ◽  
Late Presentation ◽  
Severe Pulmonary Hypertension ◽  
Chordae Tendineae ◽  
Parachute Mitral Valve ◽  
Congenital Mitral Stenosis

Congenital mitral stenosis involves the annulus, the zone immediately above and contiguous with the annulus, the leaflets, the chordae tendineae, and the papillary muscles. In a parachute mitral valve (PMV), all chordae tendineae which are usually shorter and thicker than normal type, inserted into this single papillary muscle. This condition restricts the motion of leaflets and obstructs the blood flow into the left ventricle during diastole. Here we present two cases of severe congenital mitral stenosis with severe pulmonary hypertension due to parachute mitral valve that allowed survival into adulthood without any specific treatment.

scholarly journals Biomechanical-Structural Correlation of Chordae tendineae in Animal Models: A Pilot Study

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1678
Author(s):  
Justyn Gach ◽  
Izabela Janus ◽  
Agnieszka Mackiewicz ◽  
Tomasz Klekiel ◽  
Agnieszka Noszczyk-Nowak
Keyword(s):  
Mitral Valve ◽  
Complex Structure ◽  
Future Research ◽  
Uniaxial Tensile ◽  
Uniaxial Tensile Test ◽  
Histopathological Analysis ◽  
Papillary Muscles ◽  
Chordae Tendineae ◽  
Structural Correlation ◽  
Ring Valve

The mitral valve apparatus is a complex structure consisting of the mitral ring, valve leaflets, papillary muscles and chordae tendineae (CT). The latter are mainly responsible for the mechanical functions of the valve. Our study included investigations of the biomechanical and structural properties of CT collected from canine and porcine hearts, as there are no studies about these properties of canine CT. We performed a static uniaxial tensile test on CT samples and a histopathological analysis in order to examine their microstructure. The results were analyzed to clarify whether the changes in mechanical persistence of chordae tendineae are combined with the alterations in their structure. This study offers clinical insight for future research, allowing for an understanding of the process of chordae tendineae rupture that happens during degenerative mitral valve disease—the most common heart disease in dogs.

The angiographic features of a case of parachute mitral valve

1969 ◽  
Vol 77 (6) ◽  
pp. 809-813 ◽  
Author(s):  
Allan L. Simon ◽  
William F. Friedman ◽  
William C. Roberts
Keyword(s):  
Mitral Valve ◽  
Parachute Mitral Valve

scholarly journals Use of mitral homograft to support a mechanical valve prosthesis: A feasible solution for recurrent mitral valve dysfunction

2009 ◽  
Vol 137 (3) ◽  
pp. 762-763 ◽  
Author(s):  
José M. Bernal ◽  
Francisco Gutiérrez ◽  
M. Carmen Fariñas ◽  
Elena Arnaiz ◽  
Carmen Diago ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Feasible Solution ◽  
Mechanical Valve ◽  
Valve Prosthesis ◽  
Valve Dysfunction

Blindness paving the path to the diagnosis of metastatic prostate carcinoma: A unique case presentation

2021 ◽  
pp. 205141582110537
Author(s):  
Aadhar Jain ◽  
Anveshi Nayan ◽  
Sujata Patwardhan
Keyword(s):  
Vision Loss ◽  
Specific Antigen ◽  
Primary Source ◽  
Metastatic Lesion ◽  
Unique Case ◽  
Case Presentation ◽  
Intracranial Metastases ◽  
Appropriate Therapy ◽  
Brain Involvement ◽  
Metastatic Prostate Carcinoma

Background: Intracranial metastases from prostate adenocarcinoma are very unusual and typically occur late in the course of the disease, and initial presentation with symptomatic brain involvement, especially vision loss is very rare (with this being only the sixth such reported case to the best of our knowledge). The present case elucidates how a diagnosis was reached in such a scenario and the management provided. Case presentation: A 66-year-old gentleman presented with loss of vision and headache with no other ocular or neurological complaint. Computed tomography (CT) of his head revealed a destructive lesion involving the clivus and a space-occupying lesion (SOL) in occipito-parietal region. Detailed inquiry regarding the possible primary source of suspected the metastatic lesion revealed an increased frequency of urination, nocturia, and significant weight loss. His serum prostate-specific antigen (PSA) levels were raised. He was treated by surgical hormonal therapy and his visual symptoms improved. Conclusion: Awareness of such a presentation can lead to an accurate diagnosis. Initiation of appropriate therapy can successfully alleviate the neurologic deficits.

Abstract 14338: Prevalence, Associations and Outcomes of Double Orifice and Parachute Mitral Valve

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
uzoma obiaka ◽  
Anna Chow ◽  
Jen Lie Yau ◽  
Valeria Matto Morina ◽  
Shubhika Srivastava
Keyword(s):  
Mitral Valve ◽  
Age At Diagnosis ◽  
Text Search ◽  
Associated Lesions ◽  
Significant Difference ◽  
Parachute Mitral Valve ◽  
Valve Function ◽  
Echocardiographic Images ◽  
Double Orifice

Background: The incidence of congenital mitral valve disease is 0.4%; Double Orifice Mitral Valve (DOMV) and Parachute Mitral Valve (PMV) are two morphologic pathologies that may result in mitral valve dysfunction. The objectives of this study are 1) To describe valve function and progression and 2) To define factors contributing to disease progression. Methods: Retrospective database review. Fyler codes for DOMV, PMV and text search was performed. Echocardiographic images, echo reports, and chart review were used to identify mitral regurgitation (MR), mitral stenosis (MS), morphology, and associated lesions. Results: 39 patients with DOMV and 76 patients with PMV were identified. In the DOMV cohort, 51% were male, median age at diagnosis was 0.17 years (IQR 0.01, 3.88); median follow-up of 5.92 years (IQR 0.46, 10.22). In the PMV cohort, 44% were male, median age at diagnosis at was 0.01 years (IQR 0, 0.34); median follow-up of 2.56 years (IQR 0.25, 9.55). 41% of DOMV and 23% of patients with PMV had normal valve function at initial visit. DOMV was associated with MR (p=0.04), and PMV with MS (p<0.0001). 23% of patients in the PMV cohort had progressive MS compared to 5% of patients in the DOMV cohort (p<0.0001). There was no significant difference in MR progression between both groups (p=0.02). Papillary muscle (PM) morphology was evaluated in 37 (excluding canals) of 76 patients in the PMV cohort. 5 had true PMV (single PM), 32 had variant PMV with two PM groups of which 62.5% had dominant posterior medial PM. 67% of those with posterior medial PM dominance had progressive MS irrespective of association with Shone’s complex. The anterolateral PM muscle group dominant PMV were not associated with Shone’s complex and progressive MS. Conclusion: DOMV are more likely to have MR while PMV are more likely to have MS. DOMV has non progressive MR and MS. Posterior medial PM dominance in PMV is more likely to have progressive MS.

scholarly journals MicroRNAs in Valvular Heart Diseases: Biological Regulators, Prognostic Markers and Therapeutical Targets

2021 ◽  
Vol 22 (22) ◽  
pp. 12132
Author(s):  
Francesco Nappi ◽  
Adelaide Iervolino ◽  
Sanjeet Singh Avtaar Singh ◽  
Massimo Chello
Keyword(s):  
Mitral Valve ◽  
Mitral Valve Prolapse ◽  
Heart Diseases ◽  
Osteoblastic Differentiation ◽  
New Drugs ◽  
Expression Vectors ◽  
Chordae Tendineae ◽  
Valvular Heart Diseases

miRNAs have recently attracted investigators’ interest as regulators of valvular diseases pathogenesis, diagnostic biomarkers, and therapeutical targets. Evidence from in-vivo and in-vitro studies demonstrated stimulatory or inhibitory roles in mitral valve prolapse development, aortic leaflet fusion, and calcification pathways, specifically osteoblastic differentiation and transcription factors modulation. Tissue expression assessment and comparison between physiological and pathological phenotypes of different disease entities, including mitral valve prolapse and mitral chordae tendineae rupture, emerged as the best strategies to address miRNAs over or under-representation and thus, their impact on pathogeneses. In this review, we discuss the fundamental intra- and intercellular signals regulated by miRNAs leading to defects in mitral and aortic valves, congenital heart diseases, and the possible therapeutic strategies targeting them. These miRNAs inhibitors are comprised of antisense oligonucleotides and sponge vectors. The miRNA mimics, miRNA expression vectors, and small molecules are instead possible practical strategies to increase specific miRNA activity. Advantages and technical limitations of these new drugs, including instability and complex pharmacokinetics, are also presented. Novel delivery strategies, such as nanoparticles and liposomes, are described to improve knowledge on future personalized treatment directions.

scholarly journals Malakoplakia in a colonic tubular adenoma: a unique case presentation

2018 ◽  
Vol 67 (6) ◽  
pp. 365-369
Author(s):  
Akash Gupta ◽  
Abdalla Saad Abdalla Al-Zawi ◽  
Asghar Naqvi ◽  
Samih Salama ◽  
Salem Alawami ◽  
...  
Keyword(s):  
Tubular Adenoma ◽  
Unique Case ◽  
Case Presentation

scholarly journals Optimizing P2 Neochordal Length and Stability in Mitral Valve Repair With Use of a Polypropylene Loop

2020 ◽  
Vol 47 (3) ◽  
pp. 207-209
Author(s):  
Anil Ozen ◽  
Ertekin Utku Unal ◽  
Hamdi Mehmet Ozbek ◽  
Gorkem Yigit ◽  
Hakki Zafer Iscan
Keyword(s):  
Mitral Valve ◽  
Mitral Regurgitation ◽  
Mitral Valve Repair ◽  
Severe Mitral Regurgitation ◽  
Posterior Leaflet ◽  
Valve Repair ◽  
Chordae Tendineae ◽  
Optimal Length ◽  
Precise Method ◽  
Artificial Chordae

Determining the optimal length of artificial chordae tendineae and then effectively securing them is a major challenge in mitral valve repair. Our technique for measuring and stabilizing neochordae involves tying a polypropylene suture loop onto the annuloplasty ring. We used this method in 4 patients who had moderate-to-severe mitral regurgitation from degenerative posterior leaflet (P2) prolapse and flail chordae. Results of intraoperative saline tests and postoperative transesophageal echocardiography revealed only mild insufficiency. One month postoperatively, echocardiograms showed trivial regurgitation in all 4 patients. We think that this simple, precise method for adjusting and stabilizing artificial chordae will be advantageous in mitral valve repair.

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