Paradoxical low severity of COVID-19 in Prader-Willi syndrome: data from a French survey on 647 patients

Abstract Background Patients with Prader-Willi syndrome (PWS) often have comorbidities, especially obesity, that may constitute a risk factor for severe forms of COVID-19. We aimed to assess prevalence and medical course of SARS-CoV-2 infection in children and adults with PWS. From November 2020 to January 2021, we performed a detailed medical survey on 342 adults and 305 children with PWS followed in the French reference center. Results We obtained responses from 288 adults (84%) and 239 children (78%). From March 2020 to January 2021, 38 adults (13.2%) and 13 children (5.4%) with PWS had SARS-CoV-2 infection. Mean age of adults was 34.1 ± 11.9 years and mean body mass index was 40.6 ± 12.7 kg/m2; 82% had obesity and 37% had diabetes. Only 3 children (23%) had obesity and none had diabetes. Similar to the general population, the most frequent symptoms of COVID-19 were asthenia, fever, cough, headache and shortness of breath. All patients had a favorable outcome. Conclusion PWS itself is not a risk factor for severe COVID-19 in children and adults. On the contrary, evolution of SARS-CoV-2 infection in adults with PWS seems more favorable than expected, given their comorbidities.

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Faculty Opinions recommendation of Association between body mass index and mortality is similar in the hemodialysis population and the general population at high age and equal duration of follow-up.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1104729.560798 ◽

2008 ◽

Author(s):

Neil Turner

Keyword(s):

Body Mass Index ◽

General Population ◽

Body Mass ◽

Equal Duration ◽

High Age

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Faculty Opinions recommendation of Accuracy of body mass index in diagnosing obesity in the adult general population.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1115468.571496 ◽

2008 ◽

Author(s):

Marleen van Baak

Keyword(s):

Body Mass Index ◽

General Population ◽

Body Mass

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Faculty Opinions recommendation of Body mass index category as a risk factor for colorectal adenomas: a systematic review and meta-analysis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717952215.793457621 ◽

2012 ◽

Author(s):

Ivano Biviano

Keyword(s):

Systematic Review ◽

Body Mass Index ◽

Risk Factor ◽

Body Mass ◽

Meta Analysis ◽

Body Mass Index Category ◽

Colorectal Adenomas

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Body Mass Index, Follicle-Stimulating Hormone and their Predictive Value in vitro Fertilization

Revista de Chimie ◽

10.37358/rc.18.7.6428 ◽

2018 ◽

Vol 69 (7) ◽

pp. 1842-1845

Author(s):

Lavinia Stelea ◽

Izabella Petre ◽

Marius Craina ◽

Brigitha Vlaicu ◽

Alina Sisu ◽

...

Keyword(s):

Body Mass Index ◽

Risk Factor ◽

In Vitro Fertilization ◽

Body Mass ◽

Predictive Value ◽

Follicle Stimulating Hormone ◽

Vitro Fertilization ◽

Weight Problems ◽

Fertility Disorder

The aim of this study was to determine if body mass can be considered a risk factor for infertility, and if we can find any correlations between the age values and the FSH and estradiol values, and between the BMI values and the FSH and estradiol values. Our whole sample contains 100 patients splinted in two groups (pregnant patients N1=57 subjects, 57%, and not � pregnant patients N1=43 subjects,43%). In the first part we conducted our analysis on the whole group and after that we focused the analysis on the two groups and we made some comparisons between the groups. We obtained a medium, extremely significant correlation in all scenarios between the age and the FSH values. This is the best association from all the cases which we tested. In all twelve cases we have a positive correlation (r ] 0). As well, we obtained that a BMI value higher than 25can be considered a risk factor for obtaining a pregnancy (p[0.05, RR ] 1, OR]1) . Our study shows that women who have weight problems have much less chances of conceiving a baby, even if they ovulate normally. The risk of infertility increases proportionally to the extra pounds. Irregular ovulation in women is the most common fertility disorder due to obesity disease.

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Longitudinal Body Mass Index Trajectories and Incident Chronic Kidney Disease in the General Population: Community-Based Cohort Study

SSRN Electronic Journal ◽

10.2139/ssrn.3541109 ◽

2020 ◽

Author(s):

Hae-Ryong Yun ◽

Hyung Woo Kim ◽

Tae Ik Chang ◽

Ea Wha Kang ◽

HyeonSeon Lim ◽

...

Keyword(s):

Body Mass Index ◽

Chronic Kidney Disease ◽

Cohort Study ◽

Kidney Disease ◽

General Population ◽

Body Mass ◽

Community Based ◽

Incident Chronic Kidney Disease ◽

Body Mass Index Trajectories

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Combination of sleep duration, TV time and body mass index is associated with cardiometabolic risk moderated by age in youth

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2020-0399 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Ana P. Sehn ◽

Anelise R. Gaya ◽

Caroline Brand ◽

Arieli F. Dias ◽

Roya Kelishadi ◽

...

Keyword(s):

Body Mass Index ◽

Risk Factor ◽

Sleep Duration ◽

Body Mass ◽

Cardiometabolic Risk ◽

High Systolic Blood Pressure ◽

Television Time ◽

The Relationship ◽

Moderating Role

AbstractObjectivesThe combination of sleep duration, television (TV) time and body mass index (BMI) may be related to the alteration of cardiometabolic risk. However, there are few studies that use these variables grouped, and showing the moderating role of age. This study aimed to verify if the combination of sleep duration, TV time and BMI is associated with cardiometabolic risk and the moderating role of age in this relationship in youth.MethodsCross-sectional study conducted with 1411 adolescents (611 male), aged 10–17 years. Sleep duration, TV time and BMI were assessed and grouped into eight categories. Cardiometabolic risk was assessed by a continuous metabolic risk score, including the following variables: low HDL-cholesterol, elevated triglycerides, dysglycemia, high systolic blood pressure, high waist circumference and low cardiorespiratory fitness. Generalized linear models were used to test moderation of age in the relationship between the eight categories of sleep duration/television time/BMI with cardiometabolic risk.ResultsCardiometabolic risk factor showed association with all overweight or obesity independent of sleep time and TV time. Age moderated the relationship between sleep duration/television time/BMI with cardiometabolic risk. This association was stronger in younger adolescents (11 and 13 years), indicating that individuals with inadequate sleep, prolonged TV time and overweight/obesity present higher cardiometabolic risk values when compared to 15-year-old adolescents.ConclusionOverweight/obesity, independently of sleep duration and TV time, is the main risk factor for cardiometabolic disorders in adolescence. When moderated by age, younger adolescents that presented the combination of risk factors had higher cardiometabolic risk.

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