scholarly journals F-BAR family proteins, emerging regulators for cell membrane dynamic changes—from structure to human diseases

2015 ◽  
Vol 8 (1) ◽  
Author(s):  
Suxuan Liu ◽  
Xinyu Xiong ◽  
Xianxian Zhao ◽  
Xiaofeng Yang ◽  
Hong Wang
Keyword(s):  
Cell Membrane ◽  
Human Diseases ◽  
Dynamic Changes ◽  
Membrane Dynamic

Flotillin-mediated endocytosis and ALIX–syntenin-1–mediated exocytosis protect the cell membrane from damage caused by necroptosis

2019 ◽  
Vol 12 (583) ◽  
pp. eaaw3423 ◽  
Author(s):  
Weiliang Fan ◽  
Jia Guo ◽  
Beichen Gao ◽  
Wenbin Zhang ◽  
Liucong Ling ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Cell Membrane ◽  
Lipid Raft ◽  
Affinity Purification ◽  
Human Diseases ◽  
Membrane Disruption ◽  
Cross Linking ◽  
Lysosomal Degradation ◽  
Regulated Necrosis ◽  
Associated Proteins

Necroptosis is a form of regulated necrosis that is implicated in various human diseases including Alzheimer’s disease. Necroptosis requires the translocation of the pseudokinase MLKL from the cytosol to the plasma membrane after its phosphorylation by the kinase RIPK3. Using protein cross-linking followed by affinity purification, we detected the lipid raft–associated proteins flotillin-1 and flotillin-2 and the ESCRT-associated proteins ALIX and syntenin-1 in membrane-localized MLKL immunoprecipitates. Phosphorylated MLKL was removed from membranes through either flotillin-mediated endocytosis followed by lysosomal degradation or ALIX–syntenin-1–mediated exocytosis. Thus, cells undergoing necroptosis need to overcome these independent suppressive mechanisms before plasma membrane disruption can occur.

Dynamic changes of red cell membrane thiol groups followed by bimane fluorescent labeling

1981 ◽  
Vol 640 (3) ◽  
pp. 748-759 ◽  
Author(s):  
Nechama S. Kosower ◽  
Edward M. Kosower ◽  
Yehudit Zipser ◽  
Zehava Faltin ◽  
Ruth Shomrat
Keyword(s):  
Cell Membrane ◽  
Fluorescent Labeling ◽  
Red Cell ◽  
Thiol Groups ◽  
Dynamic Changes ◽  
Red Cell Membrane

scholarly journals Quantitative phase evaluation of dynamic changes on cell membrane during laser microsurgery

2008 ◽  
Vol 13 (5) ◽  
pp. 050508 ◽  
Author(s):  
Lingfeng Yu ◽  
Samarendra Mohanty ◽  
Gangjun Liu ◽  
Suzanne Genc ◽  
Zhongping Chen ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Laser Microsurgery ◽  
Dynamic Changes ◽  
Quantitative Phase ◽  
Phase Evaluation

Quantitative phase evaluation of dynamic changes on the cell membrane during laser microsurgery

2009 ◽  
Author(s):  
Lingfeng Yu ◽  
Samarendra Mohanty ◽  
Gangjun Liu ◽  
Suzanne Genc ◽  
Myung K. Kim ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Laser Microsurgery ◽  
Dynamic Changes ◽  
Quantitative Phase ◽  
Phase Evaluation

scholarly journals Simulation of nanoparticles interacting with a cell membrane: probing the structural basis and potential biomedical application

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Xiao Zhang ◽  
Guanghui Ma ◽  
Wei Wei
Keyword(s):  
Cell Membrane ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Atomic Level ◽  
Structural Basis ◽  
Physiological Effects ◽  
Dynamic Changes ◽  
Potential Applications ◽  
A Cell ◽  
Theoretical Analyses

AbstractNanoparticles (NPs), owing to their ultrasmall size, have been extensively researched for potential applications in biomedicine. During their delivery and functionalization within the organism, they frequently interact with cells. The resulting nano-bio interfaces between the NPs and cell membrane play an important role in dominating the physiological effects of NPs. Therefore, understanding how the properties of NPs affect their nano-bio interface interactions with the cell membrane is important. Compared to experimental and theoretical analyses, simulations can provide atomic-level accuracy regarding dynamic changes in structure, which can reveal the mechanisms of nano-bio interface interactions for feasible modulation. Thus, we reviewed the current advances in nano-bio interfaces from the perspective of simulations. This study will determine how the properties of NPs affect their interactions with cell membranes to provide insights for the design of NPs and summarize their corresponding biomedical applications.

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