scholarly journals Combination therapy of BCR-ABL-positive B cell acute lymphoblastic leukemia by tyrosine kinase inhibitor dasatinib and c-JUN N-terminal kinase inhibition

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Xinhua Xiao ◽  
Ping Liu ◽  
Donghe Li ◽  
Zhizhou Xia ◽  
Peihong Wang ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Combination Therapy ◽  
Tyrosine Kinase ◽  
B Cell ◽  
Tyrosine Kinase Inhibitor ◽  
Kinase Inhibitor ◽  
Lymphoblastic Leukemia ◽  
Kinase Inhibition ◽  
Cell Acute Lymphoblastic Leukemia

scholarly journals Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia

Blood ◽  
2019 ◽  
Vol 134 (15) ◽  
pp. 1257-1268 ◽  
Author(s):  
Yinghui Zhu ◽  
Xin He ◽  
Yi-Chun Lin ◽  
Haojie Dong ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Tyrosine Kinase ◽  
Cell Survival ◽  
Tyrosine Kinase Inhibitor ◽  
Kinase Inhibitor ◽  
Lymphoblastic Leukemia ◽  
Key Points ◽  
Survival And Growth ◽  
Inhibitor Treatment

Key Points High PRMT1 expression maintains MLL-r ALL cell survival and growth by regulating FLT3 methylation at R972/973. PRMT1 inhibition enhances ablation of MLL-r ALL by tyrosine kinase inhibitor treatment.

scholarly journals Tyrosine kinase inhibitor prophylaxis after transplant for Philadelphia chromosome‐positive acute lymphoblastic leukemia

2019 ◽  
Vol 110 (10) ◽  
pp. 3255-3266 ◽  
Author(s):  
Yu Akahoshi ◽  
Satoshi Nishiwaki ◽  
Shuichi Mizuta ◽  
Kazuteru Ohashi ◽  
Naoyuki Uchida ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Kinase Inhibitor ◽  
Lymphoblastic Leukemia ◽  
Philadelphia Chromosome ◽  
Philadelphia Chromosome Positive

scholarly journals Phosphatidylinositol 3-kinase inhibition potentiates glucocorticoid response in B-cell acute lymphoblastic leukemia

2017 ◽  
Vol 233 (3) ◽  
pp. 1796-1811 ◽  
Author(s):  
Cecilia Evangelisti ◽  
Alessandra Cappellini ◽  
Mariana Oliveira ◽  
Rita Fragoso ◽  
João T. Barata ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Lymphoblastic Leukemia ◽  
Phosphatidylinositol 3 Kinase ◽  
Kinase Inhibition ◽  
Glucocorticoid Response ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Phosphatidylinositol 3
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