scholarly journals Chemotherapy is not necessary for early-stage serous and endometrioid ovarian cancer after undergoing comprehensive staging surgery

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Shuqing Li ◽  
Zhiling Zhu
Keyword(s):  
Ovarian Cancer ◽  
Early Stage ◽  
Staging Surgery ◽  
Endometrioid Ovarian Cancer

scholarly journals Chemotherapy is not necessary for early-stage serous and endometrioid ovarian cancer after undergoing comprehensive staging surgery

2020 ◽  
Author(s):  
Shuqing Li ◽  
Zhiling Zhu
Keyword(s):  
Ovarian Cancer ◽  
Overall Survival ◽  
Adjuvant Chemotherapy ◽  
Propensity Score ◽  
Propensity Score Matching ◽  
Early Stage ◽  
Platinum Based Chemotherapy ◽  
Number Of Patients ◽  
Staging Surgery ◽  
Endometrioid Ovarian Cancer

Abstract In order to investigate whether adjuvant chemotherapy is essential for patients with early-stage serous and endometrioid epithelial ovarian cancer, the present study collected data from the US Surveillance, Epidemiology and End Results database between 2004 and 2015. All subjects underwent comprehensive staging surgery and were diagnosed as stages IA-IIA, grade 1-2. A total of 2,644 patients were enrolled in the present study, among which 1,589 patients received platinum-based chemotherapy. Comparisons of categorical data were performed via χ2 tests. Variables with P<0.05 in univariate analyses were further analyzed using multiple logistic regression. Selection bias from the heterogeneity of demographic and clinical characteristics was avoided using propensity score matching. Cox proportional hazards models were applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), investigating the association between variables and 5-year overall survival. After the propensity score matching, there was an equal number of patients with or without chemotherapy (n=925). The results of the present study indicated that those aged ≥65 years were at an increased risk of ovarian cancer, and the age was associated with poor prognosis (HR, 1.486; CI, 1.208-1.827; P<0.001). Endometrioid carcinoma was associated with improved 5-year overall survival compared with serous cystadenocarcinoma (HR, 0.697; CI, 0.584-0.833; P<0.001). Chemotherapy could not prolong the 5-year overall survival of patients with early-stage serous and endometrioid ovarian cancer (HR, 1.092; CI, 0.954-1.249; P=0.201). These results demonstrated that adjuvant chemotherapy was unnecessary for patients with early-stage serous and endometrioid ovarian cancer after they underwent comprehensive staging surgery.

scholarly journals Chemotherapy is not Necessary for Early-Stage Serous and Endometrioid Ovarian Cancer After Undergoing Comprehensive Staging Surgery

2020 ◽  
Author(s):  
Shuqing Li ◽  
Zhiling Zhu
Keyword(s):  
Ovarian Cancer ◽  
Overall Survival ◽  
Adjuvant Chemotherapy ◽  
Propensity Score ◽  
Propensity Score Matching ◽  
Early Stage ◽  
Univariate Analysis ◽  
Platinum Based Chemotherapy ◽  
Staging Surgery ◽  
Endometrioid Ovarian Cancer

Abstract Background: To investigate whether adjuvant chemotherapy was essential for patients with early-stage serous and endometrioid epithelial ovarian cancer，we collected data from the US Surveillance, Epidemiology, and End Results database between 2004 and 2015. All subjects underwent comprehensive staging surgery and their pathological diagnoses were stage IA-IIA, grade 1-2. Ultimately, a total of 2,644 patients were enrolled in the study, among which 1,589 patients received platinum-based chemotherapy. Comparisons of categorical data were done by chi-square tests. Variables with P < 0.05 in univariate analysis were further analyzed using multiple logistic regression. Selection bias from the heterogeneity of demographic and clinical characteristics were avoided by propensity score matching. Cox proportional hazards models were applied to estimate hazard ratios (HR) and 95% confidence intervals (CI), exploring the relationship between variables and 5-year overall survival.Results: After propensity score matching, patients with or without chemotherapy were equal number (n=925). Our results indicated that 65 years of age or older increased the hazard and was related to poor prognostic (HR = 1.486, CI = 1.208- 1.827, P < 0.001). Endometrioid carcinoma was associated with better 5-year overall survival than serous cystadenocarcinoma (HR = 0.697, CI = 0.584-0.833, P < 0.001). Chemotherapy could not prolong 5-year overall survival of early-stage serous and endometrioid ovarian cancer patients (HR = 1.092, CI = 0.954-1.249, P = 0.201).Conclusions: These results demonstrated that adjuvant chemotherapy was unnecessary for patients with early-stage serous and endometrioid ovarian cancer after they underwent comprehensive staging surgery.

scholarly journals Genital endometriosis: pathogenesis, diagnosis, and association with malignancies

2021 ◽  
Vol 4 (4) ◽  
pp. 339-345
Author(s):  
I.Yu. Il’ina ◽  
◽  
D.V. Burdin ◽  
M.R. Narimanova ◽  
D.M. Ibragimova ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Early Stage ◽  
Treatment Modalities ◽  
Apoptosis Resistance ◽  
Eutopic Endometrium ◽  
Keywords Endometriosis ◽  
Strong Focus ◽  
Endometrioid Ovarian Cancer ◽  
Further Development ◽  
And Child Health

Endometriosis is a hormone-dependent genetic disease that develops in impaired immune homeostasis. However, its pathogenesis remains an enigma. It is known that eutopic endometrium in women with endometriosis is different from that in healthy women. Morphologic examination of eutopic endometrium sample allows diagnosing endometriosis at an early stage. To date, the association between endometriosis and the risk of malignancies is in strong focus. Endometriosis is a benign disorder but shares similarities with malignancies, e.g., apoptosis resistance and stimulation of angiogenesis. Recent findings suggest that endometriosis is a precursor of clear cell and endometrioid ovarian cancer. Further studies are needed to identify novel markers of endometriosis for its timely diagnosis. Timely and adequate therapy reduces the prevalence of ovarian tumors. Further development of molecular studies on endometriosis and ovarian cancer predictors will uncover pathogenic mechanisms and find potential preventive and treatment modalities. KEYWORDS: endometriosis, ovarian cancer, eutopic endometrium, ectopic endometrium, apoptosis, angiogenesis. FOR CITATION: Il’ina I.Yu., Burdin D.V., Narimanova M.R., Ibragimova D.M. Genital endometriosis: pathogenesis, diagnosis, and association with malignancies. Russian Journal of Woman and Child Health. 2021;4(4):339–345 (in Russ.). DOI: 10.32364/2618-8430- 2021-4-4-339-345.

scholarly journals A large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Masato Yoshihara ◽  
Ryo Emoto ◽  
Kazuhisa Kitami ◽  
Shohei Iyoshi ◽  
Kaname Uno ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Large Scale ◽  
Negative Impact ◽  
Early Stage ◽  
Stage Iv ◽  
Therapeutic Interventions ◽  
Limited Information ◽  
Mucinous Histology ◽  
Staging Surgery ◽  
The Impact

AbstractPositive ascites cytology is a strong prognostic factor in patients with early-stage ovarian cancer (OvCa). However, limited information is currently available on the impact of positive ascites cytology on patient prognoses under each clinical background. We herein investigated the comprehensive impact of positive ascites cytology on patients with epithelial OvCa and the effectiveness of additional therapeutic interventions, including complete staging surgery and chemotherapy. Among 4730 patients with malignant ovarian neoplasms, retrospectively identified in multiple institutions, 1906 with epithelial OvCa were included. In the investigation of its effects on clinical factors using a multivariate analysis, positive ascites cytology correlated with a poor prognosis. Positive ascites cytology had a significantly worse prognosis than those with negative cytology in all subgroups except for patients with stage IV tumors and a mucinous histology. Chemotherapy may be effective in reducing the negative impact of positive ascites cytology on the prognosis of patients in terms of progression-free and overall survivals, while complete staging surgery did not improve the prognosis of patients with positive ascites cytology. Collectively, our findings suggested that positive ascites cytology had a negative impact on the prognosis of patients with epithelial OvCa, but not those with stage IV tumors or a mucinous histology.

scholarly journals Prognostic Aspects of Positive Ascites Cytology and Effects of Therapeutic Interventions in Epithelial Ovarian Cancer: a Large-scale Multi-institutional Study

2021 ◽  
Author(s):  
Masato Yoshihara ◽  
Ryo Emoto ◽  
Kazuhisa Kitami ◽  
Shohei Iyoshi ◽  
Kaname Uno ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Large Scale ◽  
Negative Impact ◽  
Early Stage ◽  
Stage Iv ◽  
Therapeutic Interventions ◽  
Limited Information ◽  
Mucinous Histology ◽  
Staging Surgery ◽  
The Impact

Abstract Positive ascites cytology is a strong prognostic factor in patients with early-stage ovarian cancer (OvCa). However, limited information is currently available on the impact of positive ascites cytology on patient prognoses under each clinical background. We herein investigated the comprehensive impact of positive ascites cytology on patients with epithelial OvCa and the effectiveness of additional therapeutic interventions, including complete staging surgery and chemotherapy. Among 4,730 patients with malignant ovarian neoplasms, retrospectively identified in multiple institutions, 1,906 with epithelial OvCa were included. In the investigation of its effects on clinical factors using a multivariate analysis, positive ascitic cytology correlated with a poor prognosis. Positive ascites cytology had a significantly worse prognosis than those with negative cytology in all subgroups except for patients with stage IV tumors and a mucinous histology. Chemotherapy may be effective in reducing the negative impact of positive ascites cytology on the prognosis of patients in terms of progression-free and overall survivals, while complete staging surgery did not improve the prognosis of patients with positive ascites cytology. Collectively, our findings suggested that positive ascites cytology had a negative impact on the prognosis of patients with epithelial OvCa, but not those with stage IV tumors or a mucinous histology.

scholarly journals Comparison of Left Lower Entrance and Traditional Laparoscopic Greater Omentum Resection for Stage I Ovarian Cancer

2021 ◽  
Author(s):  
Aiwen Le ◽  
Fan Yang ◽  
Kai Kang ◽  
Guna He
Keyword(s):  
Ovarian Cancer ◽  
Early Stage ◽  
Operation Time ◽  
Stage I ◽  
Greater Omentum ◽  
Control Group ◽  
Observation Group ◽  
Effective Technique ◽  
Significant Difference ◽  
Staging Surgery

Abstract Objective : To describe the surgical method, safety and convenience of " lower left entrance laparoscopic greater omentum resection" and evaluate its clinical application value for stage I ovarian cancer. Methods: 31 patients with early stage I ovarian cancer underwent with laparoscopic staging surgery adopted " lower left entrance laparoscopic omentum resection " as the observation group, and 29 cases underwent by conventional laparoscopy as control group. The intraoperative and postoperative indexes were compared. Results: During the greater omentum resection, there was no significant difference between two groups in the blood loss, but the operation time in observation group was significantly shorter than the control group. There was no difference in postoperative hospital stay、gastrointestinal exhaust time and postoperative severe complications.Conclusion: " lower left entrance laparoscopic greater omentum resection " may be a safe and effective technique in stage I ovarian cancer.

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