Assessing brain volume changes in older women with breast cancer receiving adjuvant chemotherapy: a brain magnetic resonance imaging pilot study

Purpose Preoperative magnetic resonance imaging (MRI) detects occult contralateral breast cancers (CBCs) in women with breast cancer, but the impact of detection on long-term CBC events is unclear. We examined whether MRI use decreases the occurrence of CBCs and the detection of stages II to IV disease among women who develop a CBC. Patients and Methods Analyzing the SEER-Medicare database, we assessed overall, synchronous (< 6 months after primary cancer diagnosis), and subsequent (ie, metachronous) stage-specific CBC occurrences in women who were diagnosed with stages I and II breast cancer during 2004-2009 and who were observed through 2011. Results Among 38,971 women with breast cancer, 6,377 (16.4%) received preoperative MRI. After propensity score matching, and compared with women who did not undergo MRI, preoperative MRI use was significantly associated with a higher synchronous CBC detection rate (126.4 v 42.9 per 1,000 person-years, respectively; hazard ratio, 2.85; P < .001) but a lower subsequent CBC detection rate (3.3 v 4.5 per 1,000 person-years, respectively; hazard ratio, 0.68; P = .002). However, the 5-year cumulative incidence of CBC remained significantly higher among women undergoing MRI compared with those not undergoing MRI (7.2% v 4.0%, respectively; P < .001). The analyses of projected CBC events for 10,000 patients who receive MRI indicated that, after a 5-year follow-up, MRI use would detect an additional 192 in situ CBCs (95% CI, 125 to 279) and 120 stage I CBCs (95% CI, 62 to 193) but would not have a significant impact on stages II to IV CBC occurrences (∼ 6; 95% CI, −21 to 47). Conclusion An increased synchronous CBC detection rate, attributable to MRI, was not offset by a decrease of subsequent CBC occurrence among older women with early-stage breast cancer, suggesting that preoperative MRI in women with breast cancer may lead to overdiagnosis.

Download Full-text

Abstract P1-13-05: A prospective study to evaluate joint changes by ultrasound and magnetic resonance imaging induced by adjuvant chemotherapy followed by aromatase inhibitors in postmenopausal early breast cancer patients developing G3 arthralgia

10.1158/0008-5472.sabcs13-p1-13-05 ◽

2013 ◽

Author(s):

C Fontaine ◽

M Shahabpour ◽

L Decoster ◽

S Hanssens ◽

D Schallier ◽

...

Keyword(s):

Breast Cancer ◽

Magnetic Resonance Imaging ◽

Adjuvant Chemotherapy ◽

Magnetic Resonance ◽

Prospective Study ◽

Cancer Patients ◽

Aromatase Inhibitors ◽

Breast Cancer Patients ◽

Resonance Imaging ◽

A Prospective Study

Download Full-text

Measurement of residual tumour size after neo-adjuvant chemotherapy for locally advanced breast cancer: accuracy of clinical examination, mammography, ultrasound and magnetic resonance imaging

European Journal of Cancer Supplements ◽

10.1016/s1359-6349(06)80399-x ◽

2006 ◽

Vol 4 (2) ◽

pp. 159

Author(s):

W. Hung ◽

Chan ◽

L. Chan ◽

K. Mak ◽

A. Fung ◽

...

Keyword(s):

Breast Cancer ◽

Magnetic Resonance Imaging ◽

Adjuvant Chemotherapy ◽

Magnetic Resonance ◽

Locally Advanced Breast Cancer ◽

Tumour Size ◽

Locally Advanced ◽

Residual Tumour ◽

Resonance Imaging ◽

Neo Adjuvant Chemotherapy

Download Full-text

The Effects of a Serious Game on Depressive Symptoms and Anxiety in Breast Cancer Patients with Depression: A Pilot Study Using Functional Magnetic Resonance Imaging

Games for Health Journal ◽

10.1089/g4h.2017.0183 ◽

2018 ◽

Vol 7 (6) ◽

pp. 409-417 ◽

Cited By ~ 3

Author(s):

Sun Mi Kim ◽

Hee-Jun Kim ◽

Hyun Chan Hwang ◽

Ji Sun Hong ◽

Sujin Bae ◽

...

Keyword(s):

Breast Cancer ◽

Magnetic Resonance Imaging ◽

Depressive Symptoms ◽

Pilot Study ◽

Magnetic Resonance ◽

Functional Magnetic Resonance Imaging ◽

Cancer Patients ◽

Breast Cancer Patients ◽

Functional Magnetic Resonance ◽

Resonance Imaging

Download Full-text

Brain Magnetic Resonance Imaging Reveals Different Courses of Disease in Pediatric and Adult Cerebral Malaria

Clinical Infectious Diseases ◽

10.1093/cid/ciaa1647 ◽

2020 ◽

Author(s):

Praveen K Sahu ◽

Angelika Hoffmann ◽

Megharay Majhi ◽

Rajyabardhan Pattnaik ◽

Catriona Patterson ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Cerebral Malaria ◽

Brain Volume ◽

Fatal Outcome ◽

Brain Magnetic Resonance Imaging ◽

Quantitative Mri ◽

Resonance Imaging ◽

Brain Swelling ◽

Brain Volumes

Abstract Background Cerebral malaria is a common presentation of severe Plasmodium falciparum infection and remains an important cause of death in the tropics. Key aspects of its pathogenesis are still incompletely understood, but severe brain swelling identified by magnetic resonance imaging (MRI) was associated with a fatal outcome in African children. In contrast, neuroimaging investigations failed to identify cerebral features associated with fatality in Asian adults. Methods Quantitative MRI with brain volume assessment and apparent diffusion coefficient (ADC) histogram analyses were performed for the first time in 65 patients with cerebral malaria to compare disease signatures between children and adults from the same cohort, as well as between fatal and nonfatal cases. Results We found an age-dependent decrease in brain swelling during acute cerebral malaria, and brain volumes did not differ between fatal and nonfatal cases across both age groups. In nonfatal disease, reversible, hypoxia-induced cytotoxic edema occurred predominantly in the white matter in children, and in the basal ganglia in adults. In fatal cases, quantitative ADC histogram analyses also demonstrated different end-stage patterns between adults and children: Severe hypoxia, evidenced by global ADC decrease and elevated plasma levels of lipocalin-2 and microRNA-150, was associated with a fatal outcome in adults. In fatal pediatric disease, our results corroborate an increase in brain volume, leading to augmented cerebral pressure, brainstem herniation, and death. Conclusions Our findings suggest distinct pathogenic patterns in pediatric and adult cerebral malaria with a stronger cytotoxic component in adults, supporting the development of age-specific adjunct therapies.

Download Full-text