scholarly journals R-spondin 2 mediates neutrophil egress into the alveolar space through increased lung permeability

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
S. R. Jackson ◽  
M. F. D. M. Costa ◽  
C. F. Pastore ◽  
G. Zhao ◽  
A. I. Weiner ◽  
...  
Keyword(s):  
Alveolar Space ◽  
Lung Permeability

Effects of fetal corticosteroid treatments on postnatal surfactant function in preterm lambs

1995 ◽  
Vol 79 (3) ◽  
pp. 846-851 ◽  
Author(s):  
T. Ueda ◽  
M. Ikegami ◽  
D. Polk ◽  
K. Mizuno ◽  
A. Jobe
Keyword(s):  
Surface Area ◽  
Dynamic Compliance ◽  
Alveolar Space ◽  
Prenatal Treatment ◽  
Ultrasound Guided ◽  
Functional Characteristics ◽  
Arterial Pco2 ◽  
Alveolar Surfactant ◽  
Pool Sizes

Effects of prenatal corticosteroid on the properties of surfactant have not previously been evaluated. A single ultrasound-guided fetal injection with 0.5 mg/kg betamethasone 48 h before delivery of preterm lambs at 134- to 135-days gestation improved oxygenation, lowered the ventilatory pressures required to maintain arterial PCO2 between 30 and 40 Torr and decreased the protein leak of albumin from the intravascular to the alveolar space. This dose of glucocorticoid did not alter surfactant-saturated phosphatidylcholine pool sizes in the airspaces of preterm lambs. However, the treatment changed the characteristics of the surfactant recovered from the ventilated preterm lambs. The in vitro conversion from heavy to light subtype surfactant decreased from 59% for the saline-treated lambs to 37% for the corticosteroid-treated lambs after 180 min of surface area cycling (P < 0.02). Surfactant from the corticosteroid-treated lambs also increased the dynamic compliance of preterm surfactant-deficient rabbits more than did surfactant from the saline-treated lambs (P < 0.05). Prenatal treatment of preterm lambs with betamethasone improved the functional characteristics of surfactant without significant effects on the alveolar surfactant pool sizes.

Reproducibility of lung clearance of 99mTC-DTPA aerosols for measuring an index of lung permeability

1983 ◽  
Vol 14 (3) ◽  
pp. 205-207
Author(s):  
Gunter Oberdörster ◽  
Mark J. Utell ◽  
David A. Weber ◽  
Mariana Ivanovich ◽  
Richard W. Hyde ◽  
...  
Keyword(s):  
Lung Clearance ◽  
Lung Permeability

Lung permeability in adult obliterative bronchiolitis

1989 ◽  
Vol 83 (4) ◽  
pp. 323-327 ◽  
Author(s):  
M.C. Sweatman ◽  
C.F.A. Pantin ◽  
R. Lawrence ◽  
M. Turner-Warwick
Keyword(s):  
Obliterative Bronchiolitis ◽  
Lung Permeability

Lung permeability and hemodynamics during endotoxemia: Effect of aprotinin

1986 ◽  
Vol 41 (6) ◽  
pp. 620-626 ◽  
Author(s):  
R. Winn ◽  
J. Gleisner ◽  
R. Maunder ◽  
J. Harlan ◽  
J. Hildebrant
Keyword(s):  
Lung Permeability

scholarly journals Comparison of Reversal of Rat Pulmonary Fibrosis of Nintedanib, Pirfenidone and Human Umbilical Mesenchymal Stem Cells from Wharton’s Jelly

2020 ◽  
Author(s):  
Kuo-An Chu ◽  
Chang-Ching Yeh ◽  
Fu-Hsien Kuo ◽  
Wen-Ren Lin ◽  
Chien-Wei Hsu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Pulmonary Fibrosis ◽  
Oxygen Saturation ◽  
Cell Number ◽  
Blood Oxygen ◽  
Collagen Deposition ◽  
Alveolar Space ◽  
Blood Oxygen Saturation ◽  
Umbilical Mesenchymal Stem Cells

Abstract Background:The present study compared the effects of antifibrotic medications, pirfenidone and nintedanib, with transplantation of human umbilical mesenchymal stem cells (HUMSCs) in restoring rat pulmonary fibrosis (PF).Methods:A stable animal model was established via an intratracheal injection of 5 mg bleomycin (BLM). One single transplantation of 2.5 × 107 HUMSCs or initiation of daily oral nintedanib/pirfenidone administration was performed on Day 21 following BLM damage.Results:Pulmonary function examination revealed that BLM rats exhibited a significant decrease in blood oxygen saturation and an increase in respiratory rates. While no significant improvements were found in BLM rats receiving nintedanib or pirfenidone, those who transplanted with HUMSCs showed statistical amelioration in blood oxygen saturation and significant alleviation in respiratory rates. Quantification results revealed that a significant reduction in alveolar space and marked increases in substantial cell infiltration and collagen deposition in the left lungs of BLM rats. No significant alteration was observed in BLM rats administered nintedanib or pirfenidone. However, BLM rats transplanted with HUMSCs had a significant recovery in alveolar space and noticeable decreases in cell infiltration and collagen deposition. The inflammatory cell numbers in the bronchoalveolar lavage was increased in the BLM group. While the rats treated with nintedanib or pirfenidone had a lower cell number than the BLM group, a higher cell number was found as compared with the Normal group. In rats transplanted with HUMSCs, the cell number did not differ from the Normal group.Conclusions:Transplantation of HUMSCs could effectively treat PF as opposed to the administration of anti-fibrotic drugs with nintedanib or pirfenidone with significant better result in lung volume, pathological changes, lung function and blood oxygen saturation.

scholarly journals Seropathological Diagnosis of Toxoplasma gondii in Stray Cats in Baghdad Province

2014 ◽  
Vol 38 (1) ◽  
pp. 92-98
Author(s):  
Mohammed J. Alwan
Keyword(s):  
Toxoplasma Gondii ◽  
Alveolar Space ◽  
Internal Organs ◽  
Blood Samples ◽  
Pathological Lesions ◽  
Stray Cats ◽  
Significant Difference ◽  
Adult Cat ◽  
The Brain ◽  
Local Necrosis

The current study was performed an investigation in seropositive stray cats with Toxoplasma gondii and to correlate the results of pathological lesions with seropositive results of the cats. To achieve these goals, fifty blood samples and specimens from internal organs (liver, spleen, brain, kidney, intestine and lung) of stray cats were collected from different area of Baghdad Province during the period 1.10.2011-1.10.2012. Seropositive ELISA-IgG was demonstrated that 66 % of stray cats while female expressed (75 %) of seropositive ELISA-IgG were higher than male (30% ) and animals with average age 2months showed high percentage of seropositive ELISA-IgG (100%) as compared with age (adult cat) that expressed( 63.82 %) of seropositive. There was a significant difference (P≤0.01) among positive cases to anti-Toxoplasma ELISA-IgG. Severe pathological lesions were noticed in the lungs ,livers and intestines of animals that expressed high (optical density) (OD) of anti-Toxoplasma IgG ,in addition ,tachyzoits intracytoplasm of alveolar macrophages and hepatocytes as well as free zoites in alveolar space of the lung, were reported. Local necrosis with tachyzoites was seen in the brain of the cats, in addition to mineralization. On bases of the presence of pathological lesions in cats that expressed seropositive anti-Toxoplasma antibodies, it can be conclude that T.gondii is responsible for the appearance of inflammatory reaction in the internal organs of cats and there is a correlation between seropositive and pathological lesions of T.gondii infection and this parasite is highly distributed in Baghdad stray cats and it may be an important cause of abortion in the women.

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