scholarly journals Correction to: Network analysis of the left anterior descending coronary arteries in swim-trained rats by an in situ video microscopic technique

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Marianna Török ◽  
Petra Merkely ◽  
Anna Monori-Kiss ◽  
Eszter Mária Horváth ◽  
Réka Eszter Sziva ◽  
...  
2019 ◽  
Vol 260 ◽  
pp. 105244 ◽  
Author(s):  
Nicoletta Nappo ◽  
Dario Peduto ◽  
Olga Mavrouli ◽  
Cees J. van Westen ◽  
Giovanni Gullà

2006 ◽  
Vol 291 (5) ◽  
pp. H2354-H2361 ◽  
Author(s):  
X. Guo ◽  
M. J. Oldham ◽  
M. T. Kleinman ◽  
R. F. Phalen ◽  
G. S. Kassab

Cigarette smoking (CS) is a major risk factor for vascular disease. The aim of this study was to quantitatively assess the influence of CS on mouse arteries. We studied the effect of short-term (6 wk) and long-term (16 wk) CS exposure on structural and mechanical properties of coronary arteries compared with that of control mice. We also examined the reversibility of the deleterious effects of CS on structural [e.g., wall thickness (WT)], mechanical (e.g., stiffness), and biochemical [e.g., nitric oxide (NO) by-products] properties with the cessation of CS. The left and right coronary arteries were cannulated in situ and mechanically distended. The stress, strain, elastic modulus, and WT of coronary arteries were determined. Western blot analysis was used to analyze endothelial NO synthase (eNOS) in the femoral and carotid arteries of the same mice, and NO by-products were determined by measuring the levels of nitrite. Our results show that the mean arterial pressure was increased by CS. Furthermore, CS significantly increased the elastic modulus, decreased stress and strain, and increased the WT and WT-to-radius ratio compared with those of control mice. The reduction of eNOS protein expression was found only after long-term CS exposure. Moreover, the NO metabolite was markedly decreased in CS mice after short- and long-term exposure of CS. These findings suggest that 16 wk of CS exposure can cause an irreversible deterioration of structural and elastic properties of mouse coronary arteries. The decrease in endothelium-derived NO in CS mice was seen to significantly correlate with the remodeling of arterial wall.


2003 ◽  
Vol 285 (2) ◽  
pp. H653-H660 ◽  
Author(s):  
Leila H. Hamza ◽  
Quang Dang ◽  
Xiao Lu ◽  
Ayesha Mian ◽  
Sabee Molloi ◽  
...  

The objective of this study was to determine the effect of passive myocardium on the coronary arteries under distension and compression. To simulate distension and compression, we placed a diastolic-arrested heart in a Lucite box, where both the intravascular pressure and external (box) pressure were varied independently and expressed as a pressure difference (ΔP = intravascular pressure – box pressure). The ΔP-cross-sectional area relationship of the first several generations of porcine coronary arteries and the ΔP-volume relationship of the coronary arterial tree (vessels >0.5 mm in diameter) were determined using a video densitometric technique in the range of +150 to –150 mmHg. The vasodilated left anterior descending (LAD) coronary artery of six KCl-arrested hearts were perfused with iodine and 3% Cab-O-Sil. The intravascular pressure was varied in a triangular pattern, whereas the absolute cross-sectional area of each vessel and the total arterial volume were calculated using video densitometry under different box pressures (0, 50, 100, and 150 mmHg). In the range of positive ΔP, we found that the compliance of the proximal LAD artery in situ (4.85 ± 3.8 × 10–3 mm2/mmHg) is smaller than that of the same artery in vitro (16.5 ± 6 × 10–3 mm2/mmHg; P = 0.009). Hence, the myocardium restricts the compliance of the epicardial artery under distension. In the negative ΔP range, the LAD artery does not collapse, whereas the same vessel readily collapses when tested in vitro. Hence, we conclude that myocardial tethering prevents collapse of large blood vessel under compression.


Micron (1969) ◽  
1979 ◽  
Vol 10 (3) ◽  
pp. 163-164
Author(s):  
Mark J. Ottenbreit ◽  
Robert O. Bollinger ◽  
Fred A. Uchwat ◽  
Susumu Inoue

1991 ◽  
Vol 17 (2) ◽  
pp. A73 ◽  
Author(s):  
Guy Leelerc ◽  
Lawrence Weir ◽  
Michael Simons ◽  
Robert D. Safian ◽  
Marianne Kearney ◽  
...  

2021 ◽  
pp. 1-11
Author(s):  
Xiao Lin ◽  
Jianchun Li ◽  
Ruizhi Tan ◽  
Xia Zhong ◽  
Jieke Yang ◽  
...  

<b><i>Background:</i></b> Acute kidney injury (AKI) is a severe clinical syndrome, causing a profound medical and socioeconomic burden worldwide. This study aimed to explore underlying molecular targets related to the progression of AKI. <b><i>Methods:</i></b> A public database originated from the NCBI GEO database (serial number: GSE121190) and a well-established and unbiased method of weighted gene co-expression network analysis (WGCNA) to identify hub genes and potential pathways were used. Furthermore, the unbiased hub genes were validated in 2 classic models of AKI in a rodent model: chemically established AKI by cisplatin- and ischemia reperfusion-induced AKI. <b><i>Results:</i></b> A total of 17 modules were finally obtained by the unbiased method of WGCNA, where the genes in turquoise module displayed strong correlation with the development of AKI. In addition, the results of gene ontology revealed that the genes in turquoise module were involved in renal injury and renal fibrosis. Thus, the hub genes were further validated by experimental methods and primarily obtained Rplp1 and Lgals1 as key candidate genes related to the progression of AKI by the advantage of quantitative PCR, Western blotting, and in situ tissue fluorescence. Importantly, the expression of Rplp1 and Lgals1 at the protein level showed positive correlation with renal function, including serum Cr and BUN. <b><i>Conclusions:</i></b> By the advantage of unbiased bioinformatic method and consequent experimental verification, this study lays the foundation basis for the pathogenesis and therapeutic agent development of AKI.


Pharmacology ◽  
1988 ◽  
Vol 37 (2) ◽  
pp. 85-93 ◽  
Author(s):  
Takashi Saito ◽  
Maythem Saeed ◽  
Richard J. Bing

2017 ◽  
Author(s):  
William K. Carroll ◽  
Jean Philippe Sapinski

Since the 1970s, transnational alternative policy groups (TAPGs) have emerged as a component of global civil society, generating visions and strategies for a ‘globalization from below’ that points toward post-capitalist alternatives. This study proceeds from a neo-Gramscian understanding that hegemonic think tanks and TAPGs are embedded in opposing historical blocs, as they develop and deploy knowledge with the intent to make their respective blocs more coherent and effective. Here, we map the global network of TAPGs and kindred international groups – alternative media, social movement organizations, and international NGOs – in order to discern more specifically how TAPGs are embedded in a larger formation. In this era of capitalist globalization, are TAPGs, like their hegemonic counterparts, positioned as ‘brokers’, bridging across geographic spaces (e.g. North-South) and movement domains to foster the convergence across difference that is taken as a criterial attribute of a counter-hegemonic historical bloc? Our network analysis suggests that transnational alternative policy groups are well placed to participate in the transformation of the democratic globalization network from a gelatinous and unselfconscious state, into an historical bloc capable of collective action toward an alternative global order. However, this general finding must be qualified in two respects. On the one hand, there are gaps in the bloc, having to do with the representation and integration of regions and movement domains, and with the salience of post-capitalism as a unifying social vision. On the other hand, our architectonic network analysis does not reveal what the various relations and mediations in which TAPGs are active agents actually mean in concrete practice. There is a need both for closer analysis of the specific kinds of relations that link transnational alternative policy groups to other international actors, including intergovernmental organizations and funding foundations, and for field work that explores the actual practices of these groups, in situ.


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