scholarly journals The effectiveness and safety of treatments used for polycystic ovarian syndrome management in adolescents: a systematic review and network meta-analysis protocol

2015 ◽  
Vol 4 (1) ◽  
Author(s):  
Reem A. Al Khalifah ◽  
Iván D. Flórez ◽  
Brittany Dennis ◽  
Binod Neupane ◽  
Lehana Thabane ◽  
...  
Keyword(s):  
Systematic Review ◽  
Polycystic Ovarian Syndrome ◽  
Meta Analysis ◽  
Ovarian Syndrome ◽  
Analysis Protocol

scholarly journals Association between melatonin receptor gene polymorphisms and polycystic ovarian syndrome: a systematic review and meta-analysis

2020 ◽  
Vol 40 (6) ◽  
Author(s):  
Shiqi Yi ◽  
Jiawei Xu ◽  
Hao Shi ◽  
Wenbo Li ◽  
Qian Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Single Nucleotide Polymorphisms ◽  
Polycystic Ovarian Syndrome ◽  
Meta Analysis ◽  
Genetic Models ◽  
Cochrane Library ◽  
Nucleotide Polymorphisms ◽  
Melatonin Receptor ◽  
Single Nucleotide ◽  
Ovarian Syndrome

Abstract Background: Polycystic ovarian syndrome (PCOS) is a kind of common gynecological endocrine disorder. And the mutations of melatonin receptor (MTNR) genes are related to the occurrence of PCOS. But previous researches have shown opposite results. So, the object of our systematic review and meta-analysis is to investigate the relationship between MTNR 1A/B polymorphisms and PCOS. Methods: PubMed, Embase, Ovid, the Cochrane Library, Web of Science and three Chinese databases (VIP, CNKI and Wanfang) were used to retrieve eligible articles published between January 1980 and February 2020. And we used the odds ratio (OR) and its 95% confidence interval (CI) to investigate the strength of the association by six genetic models, allelic, codominant (homozygous and heterozygous), dominant, recessive and superdominant models. Review Manager 5.3, IBM SPSS statistics 25 and Stata MP 16.0 software were used to do this meta-analysis. Results: Our meta-analysis involved 2553 PCOS patients and 3152 controls, for two single nucleotide polymorphisms (rs10830963 C> G in MTNR1B and rs2119882 T> C in MTNR1A) and significant associations were found in some genetic models of these single nucleotide polymorphisms (SNPs). For rs10830963, strongly significant was found in the heterozygote model (GC vs. CC, P=0.02). Additionally, a slight trend was detected in the allelic (G vs. C), homozygote (GG vs. CC) and dominant (GG+GC vs. CC) model of rs10830963 (P=0.05). And after further sensitivity analysis, a study with high heterogeneity was removed. In the allelic (P=0.000), homozygote (P=0.001), dominant (P=0.000) and recessive (GG vs. GC+CC, P=0.001) model, strong associations between rs10830963 and PCOS were found. Moreover, for rs2119882, five genetic models, allelic (C vs. T, P=0.000), codominant (the homozygote (CC vs. TT, P=0.000) and heterozygote model (CT vs. TT, P=0.02), dominant (CC + CT vs. TT, P=0.03) and recessive model (CC vs. CT + TT, P=0.000) showed significant statistical associations with PCOS. Conclusion: MTNR1B rs10830963 and MTNR1B rs2119882 polymorphisms are associated with PCOS risk. However, the above conclusions still require being confirmed by much larger multi-ethnic studies.

Maternal polycystic ovarian syndrome in autism spectrum disorder: a systematic review and meta-analysis

2019 ◽  
Vol 24 (12) ◽  
pp. 1787-1797 ◽  
Author(s):  
Maria Katsigianni ◽  
Vasilios Karageorgiou ◽  
Irene Lambrinoudaki ◽  
Charalampos Siristatidis
Keyword(s):  
Systematic Review ◽  
Autism Spectrum Disorder ◽  
Polycystic Ovarian Syndrome ◽  
Meta Analysis ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Ovarian Syndrome

The Effect of Lifestyle Intervention on Body Composition, Glycemic Control, and Cardiorespiratory Fitness in Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis

2015 ◽  
Vol 25 (6) ◽  
pp. 533-540 ◽  
Author(s):  
Liza Haqq ◽  
James McFarlane ◽  
Gudrun Dieberg ◽  
Neil Smart
Keyword(s):  
Systematic Review ◽  
Body Composition ◽  
Lifestyle Intervention ◽  
Body Mass ◽  
Cardiorespiratory Fitness ◽  
Polycystic Ovarian Syndrome ◽  
Meta Analysis ◽  
Reproductive Age ◽  
Dietary Interventions ◽  
Ovarian Syndrome

Introduction:Polycystic ovarian syndrome (PCOS) affects 18–22% women of reproductive age. We conducted a systematic review and meta-analysis to quantify expected benefits of lifestyle (exercise and dietary) interventions on various clinical outcomes in PCOS.Methods:Potential studies were identified by conducting systematic search of PubMed, the Cumulative Index to Nursing and Allied Health Literature, and Cochrane controlled trials registry (1966 to April 2013) using key concepts of PCOS, exercise, dietary and lifestyle interventions.Results:Significant improvements were seen in women who received lifestyle intervention vs. usual care, in body composition parameters of body mass index, mean difference (MD) = −0.12 kg.m−2 (95% CI [−0.22, −0.03], p = .009), body mass MD = −3.42 kg (95% CI [−4.86, −1.99], p < .00001), waist circumference MD = −1.64 cm (95% CI [−2.09, −1.19], p < .00001), waist−hip ratio MD = −0.03 (95% CI [−0.05, −0.01], p = .0002), and body fat % MD = −1.71% (95% CI [−3.10, −0.32], p = .02). Insulin did not improve, MD = −1.21 pmol/L (95% CI [−3.06, −0.63], p = .20). Lipid profile did not improve, total cholesterol MD = −0.02 mmol/L (95% CI [−0.25, 0.21], p = .89). C-reactive protein was significantly lower, MD = −0.47 mmol/L (95% CI [−0.80, −0.15], p = .004). Significant improvements were also observed in cardiorespiratory fitness with exercise alone reducing resting heart rate, MD = −1.89 beats.min−1 (95% CI [−2.90, −0.88], p = .0002), and peak VO2, MD = 4.86 ml.kg−1.min−1 (95% CI [2.83, 6.88], p < .00001). Lifestyle therapy also improved, peak VO2 MD = 5.09 ml.kg−1.min−1 (95% CI [3.13, 7.05], p < .00001).Conclusions:Our analyses suggest lifestyle intervention is optimal for improving body composition and cardiorespiratory fitness in women with PCOS.

scholarly journals Effect of lifestyle intervention on the reproductive endocrine profile in women with polycystic ovarian syndrome: a systematic review and meta-analysis

2014 ◽  
Vol 3 (1) ◽  
pp. 36-46 ◽  
Author(s):  
Liza Haqq ◽  
James McFarlane ◽  
Gudrun Dieberg ◽  
Neil Smart
Keyword(s):  
Systematic Review ◽  
Usual Care ◽  
Lifestyle Intervention ◽  
Polycystic Ovarian Syndrome ◽  
Meta Analysis ◽  
Total Testosterone ◽  
Testosterone Levels ◽  
Endocrine Profile ◽  
Reproductive Endocrine ◽  
Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) affects 18–22% of women at reproductive age. We conducted a systematic review and meta-analysis evaluating the expected benefits of lifestyle (exercise plus diet) interventions on the reproductive endocrine profile in women with PCOS. Potential studies were identified by systematically searching PubMed, CINAHL and the Cochrane Controlled Trials Registry (1966–April 30, 2013) systematically using key concepts of PCOS. Significant improvements were seen in women receiving lifestyle intervention vs usual care in follicle-stimulating hormone (FSH) levels, mean difference (MD) 0.39 IU/l (95% CI 0.09 to 0.70, P=0.01), sex hormone-binding globulin (SHBG) levels, MD 2.37 nmol/l (95% CI 1.27 to 3.47, P<0.0001), total testosterone levels, MD −0.13 nmol/l (95% CI −0.22 to −0.03, P=0.008), androstenedione levels, MD −0.09 ng/dl (95% CI −0.15 to −0.03, P=0.005), free androgen index (FAI) levels, MD −1.64 (95% CI −2.94 to −0.35, P=0.01) and Ferriman–Gallwey (FG) score, MD −1.01 (95% CI −1.54 to −0.48, P=0.0002). Significant improvements were also observed in women who received exercise-alone intervention vs usual care in FSH levels, MD 0.42 IU/l (95% CI 0.11 to 0.73, P=0.009), SHBG levels, MD 3.42 nmol/l (95% CI 0.11 to 6.73, P=0.04), total testosterone levels, MD −0.16 nmol/l (95% CI −0.29 to −0.04, P=0.01), androstenedione levels, MD −0.09 ng/dl (95% CI −0.16 to −0.03, P=0.004) and FG score, MD −1.13 (95% CI −1.88 to −0.38, P=0.003). Our analyses suggest that lifestyle (diet and exercise) intervention improves levels of FSH, SHBG, total testosterone, androstenedione and FAI, and FG score in women with PCOS.

scholarly journals Coagulation Biomarkers in Women with Recurrent Miscarriage and Polycystic Ovarian Syndrome: Systematic Review and Meta-Analysis

2019 ◽  
Vol 79 (07) ◽  
pp. 697-704 ◽  
Author(s):  
Marcelo Borges Cavalcante ◽  
Manoel Sarno ◽  
Candice Torres de Melo Bezerra Cavalcante ◽  
Edward Araujo Júnior ◽  
Ricardo Barini
Keyword(s):  
Systematic Review ◽  
High Risk ◽  
Polycystic Ovarian Syndrome ◽  
Recurrent Miscarriage ◽  
Meta Analysis ◽  
Factor V Leiden ◽  
Coagulation Disorders ◽  
Mthfr Polymorphism ◽  
Search Terms ◽  
Ovarian Syndrome

Abstract Introduction Pregnant women with polycystic ovarian syndrome (PCOS) have high risk of pregnancy loss. Pathophysiological mechanisms appear to be associated with obesity, hormonal factors, or blood clotting disorders. Our aim is to perform a systematic review and meta-analysis on the relationship between coagulation disorders and risk of recurrent miscarriage (RM) in patients with PCOS and to identify coagulation biomarkers for this condition. Material and Methods PubMed and MEDLINE databases were searched for publications in English language. The search terms used included “RM”, “polycystic ovary syndrome”, “coagulation disorders”, and “thrombophilia”. Odds ratios (ORs) and 95% confidence intervals (CIs) for miscarriage in different RM groups (with and without PCOS). Results A total of 575 publications including the search terms were identified. Six studies were included for qualitative analysis, and five were included for quantitative analysis (meta-analysis). We found no association between RM and inherited thrombophilias in patients with PCOS: (1) Factor V Leiden (OR, 0.74; 95% CI, 0.38 – 1.45; p = 0.38); (2) C677T methylenetetrahydrofolate reductase polymorphism (MTHFR) (OR, 1.01; 95% CI, 0.64 – 1.59; p = 0.97); and (3) A1297C MTHFR polymorphism (OR, 1.08; 95% CI, 0.62 – 1.89; p = 0.77). Other potential biomarkers were identified, with emphasis on plasminogen activator inhibitor type 1. Conclusion Data available in the current literature revealed that there was no association between RM and inherited thrombophilias in patients with PCOS. RM patients with PCOS have a high risk of thromboembolic events.

scholarly journals The prevalence of polycystic ovary syndrome in adolescents: A systematic review and meta-analysis

2019 ◽  
Author(s):  
Marzieh Saei Ghare Naz ◽  
Fahimeh Ramezani Tehrani ◽  
Hamid Alavi Majd ◽  
Fazlollah Ahmadi ◽  
Giti Ozgoli ◽  
...  
Keyword(s):  
Systematic Review ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Meta Analysis ◽  
Qualitative Assessment ◽  
Ovary Syndrome ◽  
The World ◽  
Ovarian Syndrome ◽  
Different Parts

Background: Polycystic ovarian syndrome is an endocrine disorder with many complications. This syndrome is a growing concern among adolescents around the world, with varying reports of its prevalence in different parts of the world. Objective: This study aimed to determine the prevalence of polycystic ovary syndrome in adolescents by a systematic review and meta-analysis. Materials and Methods: In this study, a search for published articles with an English language limitation and without a time limit was done in different databases (Scopus, PubMed, and Web of Science, Emabse and Cochrane) in January 2019. The 12 studies that met the criteria for entering a qualitative assessment scale of 5 and higher were subjected to systematic review and meta-analysis. Egger and Begg’s tests were used to check the publication bias. Data were analyzed with STATA software, version 11.1. Results: Twelve studies were included for meta-analysis. The total number of participants in the study was 149,477. The average quality score of all studies was 8.67 (range: 5–10). The prevalence of polycystic ovarian syndrome in adolescents based on the Rotterdam criteria was 11.04% (95% CI: 6.84–16.09%), based on the National Institute of Health criteria, it was 3.39% (95% CI: 0.28–9.54%), and based on Androgen Excess and Polycystic Ovary Syndrome Society, it was 8.03% (95% CI: 6.24–10.01%). Conclusion: The result of this study showed that there is a variation in the prevalence of PCOS in adolescents based on different criteria; we suggest more community-based studies among adolescences in different parts of the world.

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