577-nm high-power optically pumped semiconductor laser is safe and effective in the treatment of inflammatory acne: a prospective, single-center, split-face comparative study

Abstract Objective This study aimed to appraise the efficacy of a 577-nm high-power optically pumped semiconductor laser (HOPSL) for the treatment of inflammatory acne. Methods The study included 50 patients with acne vulgaris (inflammatory type), 14 men, and 36 women; patient ages ranged from 16 to 35 years. The left side of the face was treated with a single pass of a 577-nm high-power optically pumped semiconductor laser (HOPSL) every 2 weeks for 3 sessions. The severity of acne examined prior to the first session and 4 weeks after the last session (Investigator's Global Assessment of acne severity, IGA; single lesion count). Results At baseline, no statistically significant difference in the severity of inflammatory acne lesions between both sides was observed. One month after the final session, a significant improvement (IGA reduction of > 50%) of the overall severity of acne was observed in 49 patients (98%) on the laser-treated side versus 41 (82%) the control side of the face (P < .05). Hence, we found a significant reduction in the mean percentage of inflammatory papules, pustules, and nodules on the laser-treated versus the control side (79.33 vs 56.92, 78.04 vs 43.33, 64.85 vs 21.93%, respectively) (P < 0.05). Side effects in the form of erythema and irritation during sessions were transient and tolerated by the patients. Conclusion The 577-nm high-power optically pumped semiconductor laser is effective and safe for the treatment of inflammatory lesions (papules, pustules, and nodules) in acne patients.

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577-nm High-Power Optically Pumped Semiconductor Laser is Safe and Effective in The Treatment of Inflammatory Acne: A Prospective, Single-Center, Split-Face Comparative Study

10.21203/rs.3.rs-141449/v1 ◽

2021 ◽

Author(s):

Mohamed EEM ◽

KM Tawfik ◽

Elsayed IB ◽

Edwin Boelke ◽

Gerber PA

Keyword(s):

Semiconductor Laser ◽

High Power ◽

Acne Vulgaris ◽

Lesion Count ◽

Optically Pumped ◽

Significant Difference ◽

The Face ◽

The Mean ◽

Split Face ◽

Single Lesion

Abstract Objective: This study aimed to appraise the efficacy of a 577 nm high-power optically pumped semiconductor laser (HOPSL) for the treatment of inflammatory acne.Methods: The study included 50 patients with acne vulgaris (inflammatory type), 14 men, and 36 females; patient ages ranged from 16 to 35 years. The left side of the face was treated with a single pass of a 577 nm high-power optically pumped semiconductor laser every 2 weeks for 3 sessions. Patients were examined prior to the first session and 4 weeks after the last session (Investigator's Global Assessment of acne severity, IGA; single lesion count).Results: At baseline, no statistically significant difference in the severity of inflammatory acne lesions between both sides was observed. One month after the final session, a significant improvement (IGA reduction of >50 percent) of the over-all severity of the acne was observed in 49 patients (98 percent) on laser-treated side versus 41 (82 percent) the control side of the face (P < .05). Accordingly, we found a significant reduction in the mean percentage of inflammatory papules, pustules, and nodules (79.33 vs 56.92, 78.04 vs 43.33, 64.85 vs 21.93 percent, respectively) (P<0.05). Side effects in the form of erythema and irritation during sessions were transient and tolerated by the patients.Conclusion: The 577 nm high-power optically pumped semiconductor laser is effective and safe for the treatment of inflammatory lesions (papules, pustules, and nodules) in acne patients.Running title: 577 nm high-power optically pumped semiconductor laser (HOPSL) for the treatment of inflammatory acne

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Is There Pathological Uniformity between the Periphery and Center of a Gastrointestinal Stromal Tumor?

Journal of Clinical Medicine ◽

10.3390/jcm10040687 ◽

2021 ◽

Vol 10 (4) ◽

pp. 687

Author(s):

Seong Ji Choi ◽

Kwan Hong Lee ◽

Chan Kyoo Yoo ◽

Jai Hoon Yoon ◽

Ki Seok Jang ◽

...

Keyword(s):

Risk Stratification ◽

Mitotic Index ◽

High Power ◽

Malignant Potential ◽

Mitotic Count ◽

Pathological Diagnosis ◽

High Power Field ◽

Gastric Gists ◽

Significant Difference ◽

The Mean

Background: Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors and have some malignant potential. Mitotic count is important for predicting the malignant potential of GISTs. Proper treatment of GISTs requires accurate pathological diagnosis. In general, endoscopic ultrasound-guided fine-needle aspiration and deep biopsy are used for pathological diagnosis of GIST before making decisions about surgery. This study sought to evaluate the pathological uniformity of gastric GISTs for mitotic index of the center and periphery of the GIST. Methods: We retrospectively reviewed the data of 37 gastric GIST patients who underwent wedge resection at Hanyang University Hospital. We used Armed Forces Institute of Pathology criteria to classify gastric GISTs. To determine the pathological uniformity of gastric GISTs, we compared GIST risk stratification between the center and periphery of GISTs. Results: The mean size of GISTs was 3.56 ± 2.10 cm. Three lesions were located in the antrum, 11 in the fundus, 9 in the cardia, and 14 in the body. The mean age of patients was 58.65 ± 9.44 years; 18 patients were male and 19 were female. Thirty-five patients (94.6%) showed the same level of risk stratification between the center and periphery of gastric GISTs, while two patients (5.4%) presented different levels of risk between the two sites. No significant difference in mitotic count was observed between the two sites (kappa value = 0.863; p = 0.001). Conclusions: Mitotic index category (either more than five mitoses per high-power field or five or fewer mitoses per high-power field) of GISTs showed good concurrence between the center and periphery.

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Evaluation of leptin, adiponectin, and ghrelin levels in patients with acne vulgaris

Human & Experimental Toxicology ◽

10.1177/0960327116630355 ◽

2016 ◽

Vol 36 (1) ◽

pp. 3-7 ◽

Cited By ~ 2

Author(s):

P Ozuguz ◽

SD Kacar ◽

G Asik ◽

U Ozuguz ◽

S Karatas

Keyword(s):

Insulin Resistance ◽

Body Mass Index ◽

Acne Vulgaris ◽

Significance Level ◽

Severe Acne ◽

Significant Difference ◽

Grading Scale ◽

The Mean ◽

High Glycemic Index ◽

Nonobese Patients

Background: The research evaluating adipokines are very few in patients with acne vulgaris. The hypothesis that hyperinsulinemic and high glycemic index diet plays a role in the pathogenesis of acne is still controversial. In this study, we aimed to evaluate adipokines such as leptin (L), adiponectin (A), ghrelin and A levels, and A/L rates that indicate insulin resistance in nonobese patients with severe acne vulgaris. Material and Method: Thirty patients who are nonobese with moderate acne vulgaris, aged 18 to 25 years, and 15 age–sex compatible controls were included in our study. The acne lesions were assessed using the Global Acne Grading Scale (GAGS). All participants were evaluated for the parameters that may affect the metabolism of serum L, A, and ghrelin levels in blood, and their body mass index were calculated. The significance level was determined as p ≤ 0.05. Results: Of the 30 patients, 17 were women and 13 were men. The mean age was 20.60 years and the mean duration of the disease were 2.8 years. All of patients had moderate acne vulgaris (GAGS 19–30). Of the 15 controls, 11 were women and 4 were men. The mean age was 21.20 years. There were not a statistically significant difference in L, ghrelin, A levels, and A/L ratio between the two groups. Conclusions: Adipokines may have a role in the pathogenesis of acne vulgaris. L, A, ghrelin, and insulin resistance may not participate in the responsible mechanisms in nonobese patients with moderate acne vulgaris.

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Doppler-free spectroscopy of mercury at 2537 nm using a high-power, frequency-quadrupled, optically pumped external-cavity semiconductor laser

Optics Letters ◽

10.1364/ol.36.000061 ◽

2010 ◽

Vol 36 (1) ◽

pp. 61 ◽

Cited By ~ 33

Author(s):

Justin Paul ◽

Yushi Kaneda ◽

Tsuei-Lian Wang ◽

Christian Lytle ◽

Jerome V. Moloney ◽

...

Keyword(s):

Semiconductor Laser ◽

High Power ◽

External Cavity ◽

Optically Pumped ◽

Power Frequency

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Filtration efficiency of face masks and veils as protective measures during COVID-19 pandemic

Kuwait Journal of Science ◽

10.48129/kjs.splcov.13629 ◽

2021 ◽

Author(s):

Khaled S. Al-Hadyan ◽

◽

Ghazi A. Alsbeih Alsbeih ◽

Najla M. Al-Harbi ◽

Sara S. Bin Judia ◽

...

Keyword(s):

Particle Size ◽

Control Measure ◽

Filtration Efficiency ◽

Experimental Conditions ◽

Surgical Masks ◽

Significant Difference ◽

Comparable Performance ◽

The Face ◽

3D Printed ◽

The Mean

Wearing face masks have been implemented as a public and personal health control measure against the spread of coronavirus disease (COVID-19). However, the protection level of nonmedical face masks, such as women face veils, is still uncertain. This study aimed to assess the filtration efficiency (FE; percentage of particles retained by a mask) of different types of medical masks (either as sealed or unsealed, single or doubled), non-medical masks (cloth masks) and face veils. FE of face masks was evaluated using an in-house 3D-printed air duct connected to the Aerotrak particle counter with a capability of counting particle sizes of 0.3, 0.5, 0.7, 1, 2 and 5 μm. A set of 10 earloop surgical masks,10 tie-on surgical masks, 3 triple-layers reusable cloth masks and 3 types (short, medium and long) of traditional face veils were included in the study. The unsealed surgical masks showed intermediate FE (36.54-80.58%), with no observed differences between tie-on and earloop or single and doubled masks. For each mask type, the mean FE values of sealed surgical masks (FE≥99.16%) was significantly higher (P<0.001) than the unsealed ones (FE≤80.58%). No significant difference was observed in the mean FE values between unsealed surgical masks and either cloth masks (FE=23.19-75.35%, P=0.26) or face veils (FE=19.10- 70.68%, P=0.14). However, a mockup experiment showed that wearing a surgical mask under the face veil significantly improve the FE (33.73-79.18%; P<0.001). We conclude that besides sealed surgical masks that ensure optimal filtration under the experimental conditions, the unsealed surgical and cloth masks and face veils showed comparable performance and acceptable protection at 5 μm particle size, which is the most relevant particle size associated with COVID-19 infectious droplets. Wearing a surgical mask under the face veil significantly improves the FE compared to wearing a face veil alone.

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A novel method using 3D CBCT to assess anterior malar prominence among native Bangalore population- A descriptive study

IP Indian Journal of Orthodontics and Dentofacial Research ◽

10.18231/j.ijodr.2021.036 ◽

2021 ◽

Vol 7 (3) ◽

pp. 223-228

Author(s):

Sanda Aamani ◽

Hemanth M ◽

Sharmada B K ◽

Karthik J Kabbur ◽

Goutham Kalladka

Keyword(s):

Descriptive Study ◽

T Test ◽

Linear Measurements ◽

Mean Values ◽

Significant Difference ◽

The Face ◽

Novel Method ◽

Males And Females ◽

The Mean ◽

Paired T Test

There is a lack of accurate three-dimensional studies to locate malar prominence for specified population, this study aims to locate the malar prominence using stable landmarks using CBCT. To derive a novel method to accurately locate the malar prominence and to assess and compare the malar prominence between males and females among Bangalore population using 3D CBCT study. All CBCT scans of study subjects belong to Bangalore population were collected from the pre-existing data available in Radiology imaging Solutions (CBCT centre), Bangalore during the period of September 10th to October 10th 2020. This is a descriptive study. A total of 42 subjects including 21 Males and 21 females were assessed using full skull CBCT scans which were converted to DICOM format and reconstructed into 3D images using NEMOCEPH 3D software. Landmarks used to locate the malar prominence were Fzs, Z, Zm and Ans. The intersection of these landmarks is considered to be as constructed maxillozygion(My). For the accuracy of the constructed Maxillozygion point (My), the distance between the actual Maxillozygion (Mzy) and constructed Maxillozygion (My) is measured and calculated between left and right halves of males and females. Three Orthogonal planes constructed were Midsagittal, Axial and Coronal Planes and the linear measurements with reference to all three reference planes in both the groups are measured. Student paired t- Test, Independent Student t Test, Mann Whitney Test. The mean distance from Mzy and my between right and left half of the face was compared using student paired t- Test. There is no significant difference (p=0.35).The mean values of the constructed anatomical landmark (maxillozygion) coordinated to three orthogonal planes between right and left sides of the face is compared using student paired T test and for both the genders (males and females) was compared using Independent Student t Test, and it is significantly higher in males as compared to females and it is statistically significant at (p=0.01). The location of malar prominence using CBCT by a novel method for Bangalore population is found which can be helpful in diagnosis and treatment planning for malar augmentation, camouflage treatment in subjects with midface deficiencies.

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Role of Adenosine Deaminase in Patients with Erythematotelan-giectatic Rosacea and Demodex folliculorum Positivity

Iranian Journal of Parasitology ◽

10.18502/ijpa.v15i4.4870 ◽

2020 ◽

Author(s):

Serpil SENER ◽

Ulku KARAMAN ◽

Tugba Raika KIRAN ◽

Cemil COLAK ◽

Ali ASLAN ◽

...

Keyword(s):

Adenosine Deaminase ◽

Close Contact ◽

Acne Vulgaris ◽

Skin Surface ◽

Control Group ◽

Purine Nucleotides ◽

Demodex Folliculorum ◽

Significant Difference ◽

The Mean ◽

And Gender

Background: Adenosine deaminase (ADA) is an aminohydrolase involved in the catabolism of purine nucleotides and irreversibly deaminizes adenosine and deoxyadenosine to inosine and deoxyinosine. ADA enzyme deficiency results in the loss of functional properties of B and T lymphocytes. Demodex species have been reported to be transmitted between humans through close contact and to play a role in the pathogenesis of rosacea, acne vulgaris, perioral dermatitis, seborrhoeic dermatitis, micropapillary-pruritic dermatitis and blepharitis. The present study aimed to compare serum ADA levels in D. folliculorum positive patients with the healthy control individuals. Methods: Serum ADA levels were examined for 30 patients diagnosed with erythematotelangiectatic rosacea and 40 healthy individuals in Malatya Inonu University in 2017. Standardized skin surface biopsy (SSSB) method was used to diagnose D. folliculorum. A significant decrease was found in the ADA levels of Demodex-positive rosacea patients when compared to the control group. Results: ADA levels were decreased in the Demodex-positive group. The mean ADA level in patient group was significantly lower than the mean in the control group (P<0.001). There was no significant difference between the patient and control groups in terms of age and gender. Conclusion: During and after treatment of Demodex-positive rosacea patients, determination of ADA levels may give more detailed information on the immune mechanisms.

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