scholarly journals Multifaceted role of one-carbon metabolism on immunometabolic control and growth during pregnancy, lactation and the neonatal period in dairy cattle

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Danielle N. Coleman ◽  
Abdulrahman S. Alharthi ◽  
Yusheng Liang ◽  
Matheus Gomes Lopes ◽  
Vincenzo Lopreiato ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dairy Cattle ◽  
Carbon Metabolism ◽  
Growth And Development ◽  
Immune Dysfunction ◽  
Production Performance ◽  
Methyl Donors ◽  
Methyl Donor ◽  
One Carbon Metabolism ◽  
And Oxidative Stress

AbstractDairy cattle undergo dramatic metabolic, endocrine, physiologic and immune changes during the peripartal period largely due to combined increases in energy requirements for fetal growth and development, milk production, and decreased dry matter intake. The negative nutrient balance that develops results in body fat mobilization, subsequently leading to triacylglycerol (TAG) accumulation in the liver along with reductions in liver function, immune dysfunction and a state of inflammation and oxidative stress. Mobilization of muscle and gluconeogenesis are also enhanced, while intake of vitamins and minerals is decreased, contributing to metabolic and immune dysfunction and oxidative stress. Enhancing post-ruminal supply of methyl donors is one approach that may improve immunometabolism and production synergistically in peripartal cows. At the cellular level, methyl donors (e.g. methionine, choline, betaine and folic acid) interact through one-carbon metabolism to modulate metabolism, immune responses and epigenetic events. By modulating those pathways, methyl donors may help increase the export of very low-density lipoproteins to reduce liver TAG and contribute to antioxidant synthesis to alleviate oxidative stress. Thus, altering one-carbon metabolism through methyl donor supplementation is a viable option to modulate immunometabolism during the peripartal period. This review explores available data on the regulation of one-carbon metabolism pathways in dairy cows in the context of enzyme regulation, cellular sensors and signaling mechanisms that might respond to increased dietary supply of specific methyl donors. Effects of methyl donors beyond the one-carbon metabolism pathways, including production performance, immune cell function, mechanistic target or rapamycin signaling, and fatty acid oxidation will also be highlighted. Furthermore, the effects of body condition and feeding system (total mixed ration vs. pasture) on one-carbon metabolism pathways are explored. Potential effects of methyl donor supply during the pepartum period on dairy calf growth and development also are discussed. Lastly, practical nutritional recommendations related to methyl donor metabolism during the peripartal period are presented. Nutritional management during the peripartal period is a fertile area of research, hence, underscoring the importance for developing a systems understanding of the potential immunometabolic role that dietary methyl donors play during this period to promote health and performance.

scholarly journals Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases-1, -2 in placentas from preterm pregnancies and their association with one-carbon metabolites

Reproduction ◽  
2013 ◽  
Vol 145 (4) ◽  
pp. 401-410 ◽  
Author(s):  
Deepali Sundrani ◽  
Preeti Chavan-Gautam ◽  
Hemlata Pisal ◽  
Savita Mehendale ◽  
Sadhana Joshi
Keyword(s):  
Oxidative Stress ◽  
Matrix Metalloproteinases ◽  
Carbon Metabolism ◽  
Preterm Labor ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Vitamin B ◽  
Tissue Inhibitors ◽  
One Carbon Metabolism ◽  
The One ◽  
And Oxidative Stress

Maternal nutrition is an important determinant of one-carbon metabolism and defects in the one-carbon metabolism may lead to poor obstetric outcomes. This study was designed to test the hypothesis that altered intake/metabolism of micronutrients (folic acid and vitamin B12) and docosahexaenoic acid (DHA) contributes to increased homocysteine and oxidative stress leading to altered levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in women delivering preterm. We have earlier reported increased vitamin B12, homocysteine, and oxidative stress along with reduced placental DHA in women delivering preterm. In this study, we further examine the placental levels of MMP2, MMP3, TIMP1, and TIMP2 in 75 women delivering at term and 73 women delivering preterm. Placental levels of MMPs and TIMPs were determined by ELISA. Placental MMP2 and MMP3 levels were higher (P<0.01) in women delivering preterm as compared with term. There was no difference in the placental TIMP1 and TIMP2 levels in women delivering preterm and at term. Further placental MMP2 and MMP3 levels were higher (P<0.01) in women with preterm labor as compared with those in labor at term, suggesting that MMPs may favor degradation of extracellular matrix in the placenta during preterm labor. Our study for the first time suggests a crucial role of micronutrients and MMPs in preterm birth. Future studies need to examine if epigenetic modifications through the one-carbon cycle contribute to increased levels of MMPs leading to preterm deliveries.

Genetic Variation: Impact on Folate (and Choline) Bioefficacy

2010 ◽  
Vol 80 (45) ◽  
pp. 319-329 ◽  
Author(s):  
Allyson A. West ◽  
Marie A. Caudill
Keyword(s):  
Carbon Metabolism ◽  
Genetic Variants ◽  
Plasma Homocysteine ◽  
Water Soluble ◽  
Gene Interactions ◽  
Dietary Folate ◽  
Methyl Donors ◽  
Common Genetic Variants ◽  
One Carbon Metabolism ◽  
The Impact

Folate and choline are water-soluble micronutrients that serve as methyl donors in the conversion of homocysteine to methionine. Inadequacy of these nutrients can disturb one-carbon metabolism as evidenced by alterations in circulating folate and/or plasma homocysteine. Among common genetic variants that reside in genes regulating folate absorptive and metabolic processes, homozygosity for the MTHFR 677C > T variant has consistently been shown to have robust effects on status markers. This paper will review the impact of genetic variants in folate-metabolizing genes on folate and choline bioefficacy. Nutrient-gene and gene-gene interactions will be considered along with the need to account for these genetic variants when updating dietary folate and choline recommendations.

scholarly journals Functional Study of the Hap4-Like Genes Suggests That the Key Regulators of Carbon Metabolism HAP4 and Oxidative Stress Response YAP1 in Yeast Diverged from a Common Ancestor

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e112263 ◽  
Author(s):  
Nataliya Petryk ◽  
You-Fang Zhou ◽  
Kateryna Sybirna ◽  
Marie-Hélène Mucchielli ◽  
Bernard Guiard ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Carbon Metabolism ◽  
Common Ancestor ◽  
Oxidative Stress Response ◽  
Functional Study ◽  
And Oxidative Stress

scholarly journals Effects of oxidative stress on fatty acid‐ and one‐carbon‐metabolism in psychiatric and cardiovascular disease comorbidity

2014 ◽  
Vol 130 (3) ◽  
pp. 163-180 ◽  
Author(s):  
J. Assies ◽  
R. J. T. Mocking ◽  
A. Lok ◽  
H. G. Ruhé ◽  
F. Pouwer ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Disease ◽  
Fatty Acid ◽  
Carbon Metabolism ◽  
One Carbon Metabolism

Antiradical function of sulfhydryl residues and oxidative stress markers in dairy cattle plasma

2007 ◽  
Vol 78 (1) ◽  
pp. 61-65 ◽  
Author(s):  
Masahito TANAKA ◽  
Yuko KAMIYA ◽  
Mitsuru KAMIYA ◽  
Shigeru SHIOYA ◽  
Yutaka NAKAI
Keyword(s):  
Oxidative Stress ◽  
Dairy Cattle ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
And Oxidative Stress

scholarly journals Metabolomic Predictors of Non-alcoholic Steatohepatitis and Advanced Fibrosis in Children

2021 ◽  
Vol 12 ◽  
Author(s):  
Kattayoun Kordy ◽  
Fan Li ◽  
David J. Lee ◽  
Jason M. Kinchen ◽  
Michael H. Jew ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Fatty Liver ◽  
Mitochondrial Dysfunction ◽  
Carbon Metabolism ◽  
Fatty Liver Disease ◽  
Plasma Metabolites ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Steatohepatitis ◽  
One Carbon Metabolism

Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in western countries both in children and adults. Metabolic dysregulation associated with gut microbial dysbiosis may influence disease progression from hepatic steatosis to inflammation and subsequent fibrosis. Using a multi-omics approach, we profiled the oral and fecal microbiome and plasma metabolites from 241 predominantly Latino children with non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver (NAFL), and controls. Children with more severe liver pathology were dysbiotic and had increased gene content associated with lipopolysaccharide biosynthesis and lipid, amino acid and carbohydrate metabolism. These changes were driven by increases in Bacteroides and concomitant decreases of Akkermansia, Anaerococcus, Corynebacterium, and Finegoldia. Non-targeted mass spectrometry revealed perturbations in one-carbon metabolism, mitochondrial dysfunction, and increased oxidative stress in children with steatohepatitis and fibrosis. Random forests modeling of plasma metabolites was highly predictive of non-alcoholic steatohepatitis (NASH) (97% accuracy) and hepatic fibrosis, steatosis and lobular inflammation (93.8% accuracy), and can differentiate steatohepatitis from simple steatosis (90.0% accuracy). Multi-omics predictive models for disease and histology findings revealed perturbations in one-carbon metabolism, mitochondrial dysfunction, and increased oxidative stress in children with steatohepatitis and fibrosis. These results highlight the promise of non-invasive biomarkers for the growing epidemic of fatty liver disease.

scholarly journals Maternal One-carbon Metabolism during the Periconceptional Period and Human Foetal Brain Growth: A Systematic Review

Genes ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1634
Author(s):  
Eleonora Rubini ◽  
Inge M. M. Baijens ◽  
Alex Horánszky ◽  
Sam Schoenmakers ◽  
Kevin D. Sinclair ◽  
...  
Keyword(s):  
Carbon Metabolism ◽  
Growth And Development ◽  
Autism Spectrum ◽  
Head Size ◽  
Brain Growth ◽  
Foetal Head ◽  
Foetal Brain ◽  
Head Growth ◽  
Periconceptional Period ◽  
One Carbon Metabolism

The maternal environment during the periconceptional period influences foetal growth and development, in part, via epigenetic mechanisms moderated by one-carbon metabolic pathways. During embryonic development, one-carbon metabolism is involved in brain development and neural programming. Derangements in one-carbon metabolism increase (i) the short-term risk of embryonic neural tube-related defects and (ii) long-term childhood behaviour, cognition, and autism spectrum disorders. Here we investigate the association between maternal one-carbon metabolism and foetal and neonatal brain growth and development. Database searching resulted in 26 articles eligible for inclusion. Maternal vitamin B6, vitamin B12, homocysteine, and choline were not associated with foetal and/or neonatal head growth. First-trimester maternal plasma folate within the normal range (> 17 nmol/L) associated with increased foetal head size and head growth, and high erythrocyte folate (1538–1813 nmol/L) with increased cerebellar growth, whereas folate deficiency (< 7 nmol/L) associated with a reduced foetal brain volume. Preconceptional folic acid supplement use and specific dietary patterns (associated with increased B vitamins and low homocysteine) increased foetal head size. Although early pregnancy maternal folate appears to be the most independent predictor of foetal brain growth, there is insufficient data to confirm the link between maternal folate and offspring risks for neurodevelopmental diseases.

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