scholarly journals Clinico- pathologic presentation of hypersensitivity pneumonitis in Egyptian patients: a multidisciplinary study

Author(s):  
Dalia Abd El-Kareem ◽  
Yosri M. Akl ◽  
Gina A. Nakhla ◽  
Ali A. Elhindawi ◽  
Mahmoud A. Eltorky
2017 ◽  
Vol 12 ◽  
Author(s):  
Dalia Abd El-Kareem ◽  
Yosri M. Akl ◽  
Gina A. Nakhla ◽  
Ali A. Elhindawi ◽  
Mahmoud A. Eltorky

Background: Hypersensitivity pneumonitis (HP) is a common diffuse parenchymal lung disease in Egypt which can be difficult to recognize due to the dynamic symptoms & associated environmental factors. Methods: Forty-three Egyptian patients were enrolled in this study, presenting with dyspnea and cough, predominant ground-glass opacity (GGO) in high-resolution computed tomography (HRCT) where lung biopsy was needed to establish the diagnosis. Results: The age range was 15 to 60 years. Females represented 90.7% (39 patients) while 9.3% (4 patients) of our patients were males. History of contact with birds was detected in 9 (20.9%) patients. Most of our patients (60.5%) didn’t have exposure history, and only 8 patients (18.6%) were living in geographic areas in Egypt that are known for the exposure to environmental etiologic factors (cane sugar exhaust fumes). The most common HRCT pattern was GGO with mosaic parenchyma in 18 patients (41.86%), followed by GGO with centrilobular nodules in 9 patients (20.93%), then isolated diffuse GGO in 5 patients (11.62%), GGO with traction bronchiectasis in 4 patients (9.3%), GGO with consolidation in 3 patients (6.97%), GGO with reticulations in 2 patients (4.65%), and GGO with cysts in 2 patients (4.65%). The most common histologic finding was isolated multinucleated giant cells in 38 patients (88.3%) commonly found in airspaces (24 patients) and less commonly in the interstitium (14 patients), followed by interstitial pneumonia and cellular bronchiolitis in 36 patients (83.7% each), interstitial ill-formed non-necrotizing granulomas in 12 patients (27.9%), fibrosis in 10 patients (23.2%), and organizing pneumonia pattern in 4 patients (9.3%). Conclusion: The diagnosis of HP presenting with predominant GGO pattern in HRCT requires a close interaction among clinicians, radiologists, and pathologists. Some environmental and household factors may be underestimated as etiologic factors. Further environmental and genetic studies are needed especially in patients with negative exposure history.


VASA ◽  
2011 ◽  
Vol 40 (3) ◽  
pp. 188-198 ◽  
Author(s):  
Reinhold ◽  
Haage ◽  
Hollenbeck ◽  
Mickley ◽  
Ranft

In February 2008 a multidisciplinary study group was established in Germany to improve the treatment of patients with potential vascular access problems. As one of the first results of their work interdisciplinary recommendations for the management of vascular access were provided, from the creation of the initial access to the treatment of complications. As a rule the wrist arteriovenous fistula (AVF) is the access of choice due to its lower complication rate when compared to other types of access. The AVF should be created 3 months prior to the expected start of haemodialysis to allow for sufficient maturation. Second and third choice accesses are arteriovenous grafts (AVG) and central venous catheters (CVC). Ultrasound is a reliable tool for vessel selection before access creation, and also for the diagnosis of complications in AVF and grafts. Access stenosis and thrombosis can be treated surgically and interventionally. The comparison of both methods reveals advantages and disadvantages for each. The therapeutic decision should be based on the individual patients’ constitution, and also on the availability and experience of the involved specialists.


2015 ◽  
Vol 35 ◽  
pp. 74-77
Author(s):  
Gianfranco Ciancetti ◽  
Giorgio Pilla ◽  
Patrizio Torrese

1999 ◽  
Author(s):  
G. Gruetzmacher ◽  
J. Fox ◽  
H. Anderson ◽  
T. Moen ◽  
J. Lupo ◽  
...  

1970 ◽  
Vol 8 (1) ◽  
pp. 1-19
Author(s):  
Elya Munfarida

Discourse analysis has been a study that attracts many intelectuals of various disciplines to discuss about, generating the emergence of theories of their own perspectives. Many criticisms for the theories also show that intelectuals are more interested in this field leading to make discourse analysis as a multidisciplinary study. Based on this ground, Norman Fairclough seeks to reconstruct discourse theory as a criticism to the existing theories, which tends to be side-emphasis and partial on the basis of their own discipline. Combining three traditions, i.e. linguistic, interpretative, and sociological traditions, he offers a discourse model integrating three dimensions: text, discourse practice, and social practice. Each dimension has its area, process, and analysis model, in which all of them dialectically connect to one another. In addition, Fairclough also formulates another important concept, namely intertextuality, which affirms the interrelation of various texts and discourses to a text. This concept will also create ideological effect of structuration and restructuration of the prevalent discourse order. When power and ideology embed in a discourse, intertextuality will function as a mechanism for maintaining and changing the domination relation.


Author(s):  
Maan Alharbi ◽  
Amal Shilash ◽  
Zubair Ahmed ◽  
Donya Alhassan ◽  
Khaled Abdallah ◽  
...  

Medic ro ◽  
2017 ◽  
Vol 3 (117) ◽  
Author(s):  
Andreea Ioana Popescu

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