The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: a case control study

Abstract Background Sudden sensorineural hearing loss (SSNHL) is a disease with an unknown etiology; damage to the auditory nerve from inflammation due to viral infection or vascular incidents has been implicated. According to several studies, cytokines, including interleukins, are associated with SSNHL in terms of serum expression and genetic polymorphisms. Interleukin-1 (IL-1) plays a key role in inflammation and may be associated with SSNHL. This study analyzed the association of single nucleotide polymorphisms (SNPs) of IL-1 receptor (IL-1R) genes with SSNHL in Taiwan. Methods We conducted a case–control study involving 401 patients with SSNHL and 730 healthy controls. Four SNPs (IL-1R type 1 gene [IL1R1] [rs3917225 and rs2234650] and IL-1R type 2 gene [IL1R2] [rs4141134 and rs2071008]) were selected. The genotypes were determined using the TaqMan assay. The Hardy–Weinberg equilibrium (HWE) was tested for each SNP, and genetic effects were evaluated. Results The TT genotype of rs2234650 had an adjusted odds ratio (OR) of 2.988 (95% confidence interval [95% CI] 1.27–6.82) (P = 0.012) compared with the CC genotype in patients with SSNHL. The SNP rs2234650 was associated with SSNHL in the recessive model (TT vs. CC + CT, P = 0.0206, OR = 2.681). The CT genotype of rs4141134 had an adjusted OR of 3.860 (95% CI 2.01–7.44; P < 0.0001) compared with the TT genotype, in patients with SSNHL. The SNP rs4141134 was associated with SSNHL under the dominant model (CC + CT vs. TT, P < 0.0001, OR = 4.087). Conclusion These findings suggest that IL1R1 and IL1R2 gene polymorphisms may contribute to an increased risk of SSNHL in Taiwan.

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The Association of Arsenic Exposure and Metabolism With Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study

Diabetes Care ◽

10.2337/dc16-0810 ◽

2016 ◽

Vol 40 (1) ◽

pp. 46-53 ◽

Cited By ~ 30

Author(s):

Maria Grau-Pérez ◽

Chin-Chi Kuo ◽

Miranda Spratlen ◽

Kristina A. Thayer ◽

Michelle A. Mendez ◽

...

Keyword(s):

Type 2 Diabetes ◽

Case Control Study ◽

Arsenic Exposure ◽

Case Control ◽

Control Study ◽

Diabetes In Youth

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HbA 1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study

Journal of Diabetes and its Complications ◽

10.1016/j.jdiacomp.2017.10.008 ◽

2018 ◽

Vol 32 (2) ◽

pp. 203-209 ◽

Cited By ~ 11

Author(s):

Victor W. Zhong ◽

Juhaeri Juhaeri ◽

Stephen R. Cole ◽

Christina M. Shay ◽

Penny Gordon-Larsen ◽

...

Keyword(s):

Type 2 Diabetes ◽

Case Control Study ◽

Case Control ◽

Nested Case Control ◽

Control Study

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Alexithymia impact on type 1 and type 2 diabetes: A case-control study

Annales d Endocrinologie ◽

10.1016/j.ando.2014.06.001 ◽

2014 ◽

Vol 75 (4) ◽

pp. 213-219 ◽

Cited By ~ 3

Author(s):

Leila Mnif ◽

Rahma Damak ◽

Fatma Mnif ◽

Sami Ouanes ◽

Mohamed Abid ◽

...

Keyword(s):

Type 2 Diabetes ◽

Case Control Study ◽

Case Control ◽

Control Study

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The Interleukin 1 Receptor Type 1 Variant rs2234651 is a Risk Factor for Coronary Artery Disease in a Chinese Han Population: A Case Control Study

10.21203/rs.2.18857/v2 ◽

2020 ◽

Author(s):

Jiayi Gu ◽

Ping Zhou ◽

Yongyue Wei ◽

Wei Gao ◽

Yujiao Yang ◽

...

Keyword(s):

Case Control Study ◽

Interleukin 1 ◽

Case Control ◽

Chinese Han Population ◽

Chinese Han ◽

Han Population ◽

Artery Disease ◽

Cad Risk ◽

Control Study

Abstract Background While increased expression of soluble CD121a (Interleukin 1 Receptor Type 1, IL-1R1) has been shown to be significantly correlated with the severity of coronary artery disease (CAD), it is not yet clear whether IL-1R1 gene variants impact CAD pathogenesis. Methods The present study evaluated the effects of IL-1R1 variants on CAD in a Chinese-Han population; A two-stage case-control study assessed 928 Chinese-Han patients via coronary arteriography for coronary atherosclerosis. The allele and genotype frequencies of the analyzed IL-1R1 polymorphisms were determined via a polymerase chain reaction assay and directly sequenced. Results The IL-1R1 variant rs2234651 was found to be associated with both CAD risk and severity (the degree of exhibited vascular stenosis/number of affected vessels, P = 0.034; Gensini scoring, P = 0.006). Furthermore, significant increase of IL-8 and IL-11 in patients carrying the CT+TT genotype was observed. Finally, serum CD121a levels significantly increased in patients with CAD that harbored the CT+TT genotype ( P <0.05). Conclusions These results demonstrate that the IL-1R1 variant rs2234651 is significantly associated with CAD risk and severity in the analyzed Chinese-Han population and rs2234651 may be a valuable target for CAD prevention and/or treatment.

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Perinatal Risk Factors in Young Adult-Onset Type 1 and Type 2 Diabetes—A Population-Based Case-Control Study

Obstetrical & Gynecological Survey ◽

10.1097/01.ogx.0000356748.26298.56 ◽

2009 ◽

Vol 64 (8) ◽

pp. 511-512

Author(s):

Niina Lammi ◽

Paul A. Blomstedt ◽

Elena Moltchanova ◽

Johan G. Eriksson ◽

Jaakko Tuomilehto ◽

...

Keyword(s):

Risk Factors ◽

Type 2 Diabetes ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Adult Onset ◽

Perinatal Risk Factors ◽

Control Study

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The association between thiazolidinediones and hospitalisation for fracture in type 2 diabetic patients: a Taiwanese population-based nested case–control study

Diabetologia ◽

10.1007/s00125-009-1609-z ◽

2009 ◽

Vol 53 (3) ◽

pp. 489-496 ◽

Cited By ~ 16

Author(s):

F.-Y. Hsiao ◽

C. D. Mullins

Keyword(s):

Case Control Study ◽

Population Based ◽

Case Control ◽

Diabetic Patients ◽

Taiwanese Population ◽

Type 2 Diabetic Patients ◽

Nested Case Control ◽

Type 2 Diabetic ◽

Control Study

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Characteristics of the Gut Microbiota and Metabolism in Patients With Latent Autoimmune Diabetes in Adults: A Case-Control Study

10.2337/figshare.16441407 ◽

2021 ◽

Author(s):

Yuanyuan Fang ◽

Chenhong Zhang ◽

Hongcai Shi ◽

Wei Wei ◽

Jing Shang ◽

...

Keyword(s):

Type 2 Diabetes ◽

Type 1 Diabetes ◽

Gut Microbiota ◽

Case Control Study ◽

Autoimmune Diabetes ◽

Case Control ◽

Latent Autoimmune Diabetes ◽

Control Study

OBJECTIVE Type 1 and type 2 diabetes are associated with gut dysbiosis. However, the relationship between the gut microbiota and latent autoimmune diabetes in adults (LADA), sharing clinical and metabolic features with classic type 1 and type 2 diabetes, remains unclear. Here, we identified the characteristics of the gut microbiota and metabolic profiles in patients with LADA using a multi-omics approach. RESEARCH DESIGN AND METHODS This age- and sex-matched case-control study included 30 patients with LADA, 31 patients with classic type 1 diabetes, 30 patients with type 2 diabetes, and 29 healthy individuals. The gut microbiota profiles were identified via the 16S rRNA gene, and fecal and serum metabolites were measured via untargeted liquid chromatography-mass spectrometry. RESULTS LADA patients had a significantly different structure and composition of the gut microbiota and their metabolites as well as a severe deficiency of short-chain fatty acid-producing bacteria. The gut microbiota structure of the LADA patients was more similar to that of patients with type 1 diabetes who were positive for GAD antibody. We identified seven serum metabolite modules and eight fecal metabolite modules that differed between the LADA group and the other groups. CONCLUSIONS <a>The characteristic gut microbiota and related metabolites of patients with LADA are associated with autoantibodies, glucose metabolism, islet function, and inflammatory factors, which may contribute to the pathogenesis of LADA. </a>Future longitudinal studies should explore whether modulating the gut microbiota and related metabolites can alter the natural course of autoimmune diabetes, in the quest for new therapeutic.

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