scholarly journals The relationship between neck circumference and gestational diabetes mellitus in Iranian women

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Tahoora Sedighi Barforoush ◽  
Reza Ghadimi ◽  
Zaynab Pahlevan ◽  
Niloufar Ahmadi ◽  
Mouloud Agajani Delavar
Keyword(s):  
Diabetes Mellitus ◽  
Logistic Regression ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Roc Analysis ◽  
American Diabetes Association ◽  
Neck Circumference ◽  
Adjusted Logistic Regression ◽  
The Relationship

Abstract Background The aim of the present study was to assess the relationship between neck circumference and gestational diabetes. Methods This prospective study was conducted on 372 Iranian pregnant women. The criteria set by the American Diabetes Association through 2 h was used to classify subjects with regard to their gestational diabetes. At the 14–16th weeks of pregnancy, the neck circumference was measured. The maternal and fetal outcomes were measured as well. Results The adjusted logistic regression revealed that neck circumference was a predictor for gestational diabetes mellitus (OR = 1.20; 95% CI = 1.06, 1.34; P = 0.002). The ROC analysis depicted that the cut-off for neck circumference in indicating gestational diabetes was 34.3 cm, with the sensitivity of 53% and the specificity of 66%. Conclusion The findings of the present study revealed that the neck circumference of ≥34.3 cm can be deemed as a predictor of gestational diabetes in the case of Iranian pregnant women.

The Relationship Between Neck Circumference and Gestational Diabetes Mellitus in Iranian Pregnant Women

2020 ◽  
Author(s):  
Tahoora Sedighi Barforoush ◽  
Reza Ghadimi ◽  
Zaynab Pahlevan ◽  
Niloufar Ahmadi ◽  
Mouloud Agajani Delavar
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Roc Analysis ◽  
Neck Circumference ◽  
Adjusted Logistic Regression ◽  
Pregnancy Weight ◽  
The Relationship ◽  
Weight Gain During Pregnancy

Abstract Background It is widely assumed that gestational diabetes is one of the most important causes of fetal and maternal and complications, and the predictive factors for this observation are not fully understood. Neck circumference could be deemed as a predictive factor for gestational diabetes. Thus, the aim of present study was to assess the relationship between neck circumference and gestational diabetes.Methods The study was conducted on 372 Iranian pregnant women. The criteria set by the American Diabetes Association through a 2-hour was used to classify subjects with regard to gestational diabetes. At 14–16 weeks of pregnancy, neck circumference was measured. The maternal and fetal outcomes were measured, too.Results Gestational diabetes mellitus was developed in 74 women in 24–28 weeks of pregnancy. Neck circumference at 14–16 of pregnancy age was found to be positively correlated with age (r = 0.18, P = ≤ 0.0001), pre-pregnancy weight (r = 0.45, P = ≤ 0.0001), body mass index (r = 0.46, P = ≤ 0.0001), and weight gain during pregnancy (r = 0.11, P = 0.031). The adjusted logistic regression revealed that neck circumference was a predictor for gestational diabetes mellitus (OR = 1.20; 95% CI = 1.06, 1.34; P = 0.002). The ROC analysis depicted that cut-off of neck circumference in indicating gestational diabetes was 34.3 cm, with the sensitivity of 53% and the specificity of 66%.Conclusion The finding of the present study indicated that a neck circumference ≥ 34.3 cm in Iranian pregnant women can provide as a predictor of gestational diabetes.

scholarly journals Lifestyle intervention to prevent gestational diabetes mellitus and adverse maternal outcomes among pregnant women at high risk for gestational diabetes mellitus

2020 ◽  
Vol 48 (12) ◽  
pp. 030006052097913
Author(s):  
Xueyan Lin ◽  
Ting Yang ◽  
Xueqin Zhang ◽  
Wei Wei
Keyword(s):  
Diabetes Mellitus ◽  
Logistic Regression ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Lifestyle Intervention ◽  
Intervention Group ◽  
Control Group ◽  
Maternal Outcomes ◽  
Multivariate Logistic Regression

Objective We assessed the effects of a lifestyle intervention on gestational diabetes mellitus (GDM) incidence and risk of adverse maternal outcomes among pregnant women at high risk for GDM. Methods From July to December 2018, we enrolled 1822 eligible pregnant women; of these, 304 had at least one risk factor for GDM. Participants were randomly allocated to the intervention or control group. Usual prenatal care was offered to both groups; the intervention group also received individually modified education on diet, physical activity, and weight control. The GDM diagnosis was based on an oral glucose tolerance test at 24–28 gestational weeks. Multivariate logistic regression was used to evaluate the effects of the lifestyle intervention on risk of GDM and adverse maternal outcomes. Results A total of 281 women (139 in the intervention group and 142 controls) were included. Incidences of GDM and adverse maternal outcomes were all significantly lower in the intervention than in the control group. Multivariate logistic regression indicated that women in the intervention group had a lower risk of GDM and adverse maternal outcomes, after adjusting potential confounding factors. Conclusion The present lifestyle intervention was associated with lower risks of GDM and adverse maternal outcomes.

scholarly journals Establishment of a nomogram model to predict macrosomia in pregnant women with gestational diabetes mellitus

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yujiao Zou ◽  
Yan Zhang ◽  
Zhenhua Yin ◽  
Lili Wei ◽  
Bohan Lv ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Logistic Regression ◽  
Gestational Diabetes ◽  
Confidence Interval ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
External Validation ◽  
Amniotic Fluid Index ◽  
Independent Risk Factors

Abstract Aim To establish a nomogram model to predict the risk of macrosomia in pregnant women with gestational diabetes mellitus in China. Methods We retrospectively collected the medical records of 783 pregnant women with gestational diabetes who underwent prenatal examinations and delivered at the Affiliated Hospital of Qingdao University from October 2019 to October 2020. The pregnant women were randomly divided into two groups in a 4:1 ratio to generate and validate the model. The independent risk factors for macrosomia in pregnant women with gestational diabetes mellitus were analyzed by multivariate logistic regression, and the nomogram model to predict the risk of macrosomia in pregnant women with gestational diabetes mellitus was established and verified by R software. Results Logistic regression analysis showed that prepregnancy body mass index, weight gain during pregnancy, fasting plasma glucose, triglycerides, biparietal diameter and amniotic fluid index were independent risk factors for macrosomia (P < 0.05). The areas under the ROC curve for internal and external validation of the model were 0.813 (95 % confidence interval 0.754–0.862) and 0.903 (95 % confidence interval 0.588–0.967), respectively. The calibration curve was a straight line with a slope close to 1. Conclusions In this study, we constructed a nomogram model to predict the risk of macrosomia in pregnant women with gestational diabetes mellitus. The model has good discrimination and calibration abilities, which can help clinical healthcare staff accurately predict macrosomia in pregnant women with gestational diabetes mellitus.

scholarly journals The Relationship Between Hypertriglyceridemic Waist Circumference Phenotype and Gestational Diabetes Mellitus

2020 ◽  
Author(s):  
Xiao-jiao Jia ◽  
Jia-xin Wang ◽  
Li-wei Bai ◽  
Tian-shu Hua ◽  
Zhong-hou Han ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Waist Circumference ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Logistic Regression Analysis ◽  
Hypertriglyceridemic Waist ◽  
Group A ◽  
The Relationship

Abstract Background: To investigate the correlation between hypertriglyceridemic waist circumference (HTWC) phenotype and gestational diabetes mellitus (GDM).Methods: A total of 1083 patients with gestational age ≤8 weeks were divided into four groups: normal triglyceride and waist circumference group (group A, n=575), simple abdominal obesity group (group B, n=317), simple high triglyceride group (group C, n=125), and HTWC group (group D, n=66). General information and serum biochemical indicators were measured and recorded. Analysis of variance (ANOVA) and logistic regression analysis were used to evaluate the relationship between HTWC with GDM.Results: The prevalence of GDM in the HTWC group was significantly greater than in the other three groups. After adjustment by multivariate logistic regression analysis, the proportion of GDM in the HTWC group was 1.753 times higher than in group A.Conclusion: These findings suggest that there is a significant correlation between HTWC phenotype and GDM, indicating that the HTWC phenotype could be applied as a simple marker for identifying GDM risk factors.

scholarly journals First Trimester Combined Test (FTCT) as a Predictor of Gestational Diabetes Mellitus

2019 ◽  
Vol 16 (19) ◽  
pp. 3654 ◽  
Author(s):  
Federica Visconti ◽  
Paola Quaresima ◽  
Eusebio Chiefari ◽  
Patrizia Caroleo ◽  
Biagio Arcidiacono ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Logistic Regression ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
First Trimester ◽  
Maternal Serum ◽  
Fetal Aneuploidy ◽  
Combined Test ◽  
Β Hcg

Background—The first trimester combined test (FTCT) is an effective screening tool to estimate the risk of fetal aneuploidy. It is obtained by the combination of maternal age, ultrasound fetal nuchal translucency (NT) measurement, and the maternal serum markers free β-human chorionic gonadotropin (β-hCG) and pregnancy-associated plasma protein A (PAPP-A). However, conflicting data have been reported about the association of FTCT, β-hCG, or PAPP-A with the subsequent diagnosis of gestational diabetes mellitus (GDM). Research design and methods—2410 consecutive singleton pregnant women were retrospectively enrolled in Calabria, Southern Italy. All participants underwent examinations for FTCT at 11–13 weeks (plus 6 days) of gestation, and screening for GDM at 16–18 and/or 24–28 weeks of gestation, in accordance with current Italian guidelines and the International Association Diabetes Pregnancy Study Groups (IADPSG) glycemic cut-offs. Data were examined by univariate and logistic regression analyses. Results—1814 (75.3%) pregnant women were normal glucose tolerant, while 596 (24.7%) were diagnosed with GDM. Spearman univariate analysis demonstrated a correlation between FTCT values and subsequent GDM diagnosis (ρ = 0.048, p = 0.018). The logistic regression analysis showed that women with a FTCT <1:10000 had a major GDM risk (p = 0.016), similar to women with a PAPP-A <1 multiple of the expected normal median (MoM, p = 0.014). Conversely, women with β-hCG ≥2.0 MoM had a reduced risk of GDM (p = 0.014). Conclusions—Our findings indicate that GDM susceptibility increases with fetal aneuploidy risk, and that FTCT and its related maternal serum parameters can be used as early predictors of GDM.

scholarly journals Sufficience serum vitamin D before 20 weeks of pregnancy reduces the risk of gestational diabetes mellitus

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Chao-Yan Yue ◽  
Chun-Mei Ying
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Protective Factor ◽  
Serum Vitamin ◽  
Confounding Factors ◽  
Serum Vitamin D ◽  
The Relationship

Abstract Objective Our aim was to evaluate the relationship between serum vitamin D levels before 20 weeks of pregnancy and the risk of gestational diabetes mellitus. Methods This study is a retrospective study. We analyzed the relationship between serum 25 (OH) D level before 20 weeks of pregnancy (first antenatal examination) and the risk of gestational diabetes mellitus. Age, parity and pre-pregnancy body mass index were used as confounding factors. 8468 pregnant women were enrolled in this study between January 2018 and March 2020 at the Obstetrics and Gynecology Hospital of Fudan University. Adjusted smoothing splinespline plots, subgroup analysis and multivariate logistic regression analysis was conducted to estimate the relative risk between 25(OH)D and gestational diabetes mellitus. Results After fully adjusting the confounding factors, serum vitamin D is a protective factor in gestational diabetes mellitus (OR = 0.90). Compared with vitamin D deficiency, vitamin D insufficiency (OR = 0.78), sufficience (OR = 0.82) are a protective factor for gestational diabetes mellitus. Conclusion Sufficience vitamin D before 20 weeks of pregnancy is a protective factor for gestational diabetes mellitus. Vitamin D > 20 ng/mL can reduce the risk of GDM, which is not much different from the effect of > 30 ng/mL. The protective effect of vitamin D is more significant in obese pregnant women.

scholarly journals The Relationship between Acceptance of Illness and Quality of Life in Mothers with Gestational Diabetes Mellitus

2019 ◽  
pp. 1-10
Author(s):  
Tahereh Alidoost Balas Baneh ◽  
Homa Mosaffay Khomami ◽  
Leila Mirhadian ◽  
Zahra Atrkarroushan
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Significant Relationship ◽  
Two Dimensions ◽  
Acceptance Of Illness ◽  
The Relationship

Introduction: Study on quality of life and acceptance of the illness plays a significant role in the health of pregnant women, especially pregnant women with gestational diabetes mellitus. The aim of this study was to determine the relationship between the acceptance of illness and quality of life in mothers with gestational diabetes mellitus. Methods: This descriptive-analytical study was performed on 150 mothers with gestational diabetes mellitus referred to Al-Zahra Hospital of Rasht, Iran, using available sampling method. Data were collected by a demographic information checklist and 36-Item Short Form Health Survey questionnaire (SF-36) in two dimensions, physical and mental health. Data were analyzed by SPSS 20 software and using chi-squared, Fisher's exact, and Mantel-Haenszel tests. Results: Among the mothers, 37.3% accepted the illness and 62.7% did not. There was a significant relationship between the quality of life status or score and the gestational age (p = 0.019), surgical history (p = 0.005), number of operations (p = 0.002) and previous history of diabetes in previous pregnancies (p = 0.037). However, with the control of individual and social variables, Mantel-Haenszel test did not show significant relationship between acceptance of illness and the quality of life of the mothers. On the other hand, the relationship between acceptance of illness and quality of life was not significant, based on χ2 test. Conclusion: It is suggested that training classes be held before and during pregnancy for mothers at the reproductive age so that they have the readiness and knowledge to deal with the disease properly.

scholarly journals Relationship Between Insulin Resistance and Mean Platelet Volume in Gestational Diabetes Mellitus

2015 ◽  
Vol 7 (02) ◽  
pp. 112-115 ◽  
Author(s):  
Suleyman Baldane ◽  
Suleyman Hilmi Ipekci ◽  
Aysegul Kebapcilar
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Mean Platelet Volume ◽  
Hypoglycemic Agents ◽  
Platelet Volume ◽  
Positive Correlation ◽  
The Relationship

ABSTRACT Objectives: A few studies have investigated the relationship between mean platelet volume (MPV) and gestational diabetes mellitus (GDM), and in these studies the relationship between MPV and insulin resistance has not been analyzed. Our aim in this study was to compare MPV values of the pregnant women with or without GDM and evaluate the relationship between MPV and homeostasis model assessment insulin resistance index (HOMA-IR) in pregnant women. Materials and Methods: One hundred and fourteen with GDM measurements being obtained before any dietary advice or therapy with insulin or hypoglycemic agents were given, and 76 with healthy pregnant women were included the study. Results: In the group with GDM, MPV value was found to be significantly higher than that of the control group (10.2 fl [8.0–12.2] vs. 9.9 fl [5.81–10.9], P = 0.004). HOMA-IR value was detected to be significantly higher in the group with GDM (2.46 [1.5–5.88] vs. 1.30 [0.17–2.92], P < 0.001). A positive correlation between MPV and HOMA-IR was found (r = 0.30, P = 0.002). Conclusion: We have shown that MPV was significantly elevated in GDM patients when compared to healthy pregnant women. Furthermore, we found that there was a positive correlation between MPV and HOMA-IR.

scholarly journals Hypovitaminosis D Is Associated with Some Metabolic Indices in Gestational Diabetes Mellitus

2020 ◽  
Vol 5 (2) ◽  
pp. 1-14
Author(s):  
Ayobola Abimbola Sonuga ◽  
Oyebola Oluwagbemiga Sonuga
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Glucose Intolerance ◽  
Serum Insulin ◽  
Hypovitaminosis D ◽  
Control Group ◽  
The Relationship

Background: Gestational diabetes mellitus (GDM), a pregnancy complication, is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. Vitamin D deficiency and insufficiency has recently been recognized as a contributing factor to the pathogenesis of GDM, and this link might be associated with hyperglycemia, insulin resistance, and inflammation, which are implicated in GDM. Objectives: This study aims at investigating the relationship between vitamin D, fasting plasma glucose (FPG), insulin, zinc, ferritin, and high-sensitivity C-reactive protein (CRP) in GDM. Method: A case-control study in which 80 women attending the antenatal clinic of University College Hospital (UCH), Ibadan, Nigeria, were recruited; the women were grouped into controls (40 nondiabetic pregnant women) and cases (40 pregnant women with GDM). Blood samples were taken at the second trimester, and metabolites were quantified by standard laboratory methods. Student’s t test and Pearson correlation were used to compare variables and determine the relationship between variables, respectively. Results: Results showed significant (p < 0.05) low levels of serum vitamin D and zinc, and significant (p < 0.05) higher levels of FPG and serum insulin, ferritin, and CRP in the GDM group compared to the control group. In the GDM group, a positive weak relationship was observed between vitamin D and zinc (r = 0.18, p < 0.05), while vitamin D was inversely correlated with FPG, serum insulin, ferritin, and CRP (r = –0.23, –0.21, –0.20, –0.46, respectively, p < 0.05). Conclusion: This study suggests that hypovitaminosis D might be associated with glucose intolerance, insulin insensitivity, and inflammation, which are factors implicated in the development and progression of GDM.

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