scholarly journals Application of data-intelligence algorithms for modeling the compaction performance of new pharmaceutical excipients

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Garba M. Khalid ◽  
Abdullahi G. Usman

Abstract Background Pharmaceutical excipient development is an extensive process requiring a series of pre-formulation studies to evaluate their performance. The present study compares the conventional compaction and compression pre-formulation studies with artificial intelligence (AI) modeling to predict the performances of thermally and chemically modified starches obtained from Livingstone potato. Results The native starch was modified by three methods, and we obtained the following starches; pregelatinized starch (PS), ethanol dehydrated pregelatinized starch (ES), and acid hydrolyzed starch (AS). Microcrystalline cellulose (Avicel® PH101) was employed as a reference since its use in tablet direct compression has been established. The role of compaction pressure on the degree of volume reduction of the tablets was studied using Kawakita and Heckel models which highlighted that when the starch is modified by pregelatinization followed by ethanol dehydration, and/and or acid hydrolysis modification, a directly compressible starch can be obtained that can plastically deform. The data-intelligence results indicated the reliability of the AI-based models over the linear models. Hence, the comparative results demonstrated that the Adaptive neuro-fuzzy inference system (ANFIS) outperformed the other two models in modeling the performance of all of the four excipients with considerable performance accuracy. Conclusion The compressibility indices have shown matching characteristics of AS and ES to Avicel® PH101 in terms of direct compressibility potential than PS. Moreover, the data intelligence modeling demonstrates the reliability and satisfactory of ANFIS as a hybrid model over the other two models with increased performance skills in modeling the compaction properties of these novel pharmaceutical excipients.

Author(s):  
Supriya Raheja

Background: The extension of CPU schedulers with fuzzy has been ascertained better because of its unique capability of handling imprecise information. Though, other generalized forms of fuzzy can be used which can further extend the performance of the scheduler. Objectives: This paper introduces a novel approach to design an intuitionistic fuzzy inference system for CPU scheduler. Methods: The proposed inference system is implemented with a priority scheduler. The proposed scheduler has the ability to dynamically handle the impreciseness of both priority and estimated execution time. It also makes the system adaptive based on the continuous feedback. The proposed scheduler is also capable enough to schedule the tasks according to dynamically generated priority. To demonstrate the performance of proposed scheduler, a simulation environment has been implemented and the performance of proposed scheduler is compared with the other three baseline schedulers (conventional priority scheduler, fuzzy based priority scheduler and vague based priority scheduler). Results: Proposed scheduler is also compared with the shortest job first CPU scheduler as it is known to be an optimized solution for the schedulers. Conclusion: Simulation results prove the effectiveness and efficiency of intuitionistic fuzzy based priority scheduler. Moreover, it provides optimised results as its results are comparable to the results of shortest job first.


2016 ◽  
Vol 73 (8) ◽  
pp. 1937-1953 ◽  
Author(s):  
Mehdi Komasi ◽  
Soroush Sharghi

Because of the importance of water resources management, the need for accurate modeling of the rainfall–runoff process has rapidly grown in the past decades. Recently, the support vector machine (SVM) approach has been used by hydrologists for rainfall–runoff modeling and the other fields of hydrology. Similar to the other artificial intelligence models, such as artificial neural network (ANN) and adaptive neural fuzzy inference system, the SVM model is based on the autoregressive properties. In this paper, the wavelet analysis was linked to the SVM model concept for modeling the rainfall–runoff process of Aghchai and Eel River watersheds. In this way, the main time series of two variables, rainfall and runoff, were decomposed to multiple frequent time series by wavelet theory; then, these time series were imposed as input data on the SVM model in order to predict the runoff discharge one day ahead. The obtained results show that the wavelet SVM model can predict both short- and long-term runoff discharges by considering the seasonality effects. Also, the proposed hybrid model is relatively more appropriate than classical autoregressive ones such as ANN and SVM because it uses the multi-scale time series of rainfall and runoff data in the modeling process.


2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Rahib H. Abiyev

Frequently the reliabilities of the linguistic values of the variables in the rule base are becoming important in the modeling of fuzzy systems. Taking into consideration the reliability degree of the fuzzy values of variables of the rules the design of inference mechanism acquires importance. For this purpose, Z number based fuzzy rules that include constraint and reliability degrees of information are constructed. Fuzzy rule interpolation is presented for designing of an inference engine of fuzzy rule-based system. The mathematical background of the fuzzy inference system based on interpolative mechanism is developed. Based on interpolative inference process Z number based fuzzy controller for control of dynamic plant has been designed. The transient response characteristic of designed controller is compared with the transient response characteristic of the conventional fuzzy controller. The obtained comparative results demonstrate the suitability of designed system in control of dynamic plants.


Sensors ◽  
2021 ◽  
Vol 22 (1) ◽  
pp. 143
Author(s):  
Babu R. Dawadi ◽  
Danda B. Rawat ◽  
Shashidhar R. Joshi ◽  
Pietro Manzoni

Internet and telecom service providers worldwide are facing financial sustainability issues in migrating their existing legacy IPv4 networking system due to backward compatibility issues with the latest generation networking paradigms viz. Internet protocol version 6 (IPv6) and software-defined networking (SDN). Bench marking of existing networking devices is required to identify their status whether the existing running devices are upgradable or need replacement to make them operable with SDN and IPv6 networking so that internet and telecom service providers can properly plan their network migration to optimize capital and operational expenditures for future sustainability. In this paper, we implement “adaptive neuro fuzzy inference system (ANFIS)”, a well-known intelligent approach for network device status identification to classify whether a network device is upgradable or requires replacement. Similarly, we establish a knowledge base (KB) system to store the information of device internetwork operating system (IoS)/firmware version, its SDN, and IPv6 support with end-of-life and end-of-support. For input to ANFIS, device performance metrics such as average CPU utilization, throughput, and memory capacity are retrieved and mapped with data from KB. We run the experiment with other well-known classification methods, for example, support vector machine (SVM), fine tree, and liner regression to compare performance results with ANFIS. The comparative results show that the ANFIS-based classification approach is more accurate and optimal than other methods. For service providers with a large number of network devices, this approach assists them to properly classify the device and make a decision for the smooth transitioning to SDN-enabled IPv6 networks.


Author(s):  
Khalid Mahmoud ◽  
Hatice Bebiş ◽  
A. G. Usman ◽  
A. N. Salihu ◽  
M. S. Gaya ◽  
...  

<p>The need for elucidating the effects of environmental factors in the determination of the novel corona virus (COVID-19) is very vital. This study is a methodological study to compare three different test models (1. Artificial neural networks (ANN), 2. Adaptive neuro fuzzy inference system (ANFIS), 3. A linear classical model (MLR)) used to determine the relationship between COVID-19 spread and environmental factors (temperature, humidity and wind). These data were obtained from the studies (Pirouz, Haghshenas, Haghshenas, &amp; Piro, 2020) with confirmed COVID-19 patients in Wuhan, China, using temperature, humidity and wind as the independent variables. The measured and the predicted results were checked based on three different performance indices; Root mean square error (RMSE), determination coefficient (R2) and correlation coefficient (R). The results showed that ANFIS and ANN are more promising over the classical MLR models having an average R-values of 0.90 in both calibration and verification stages. The findings indicated that ANFIS outperformed MLR and ANN. In addition, their performance skills boosted up to 25% and 9% respectively based on the determination coefficient for the prediction of confirmed COVID-19 cases in Wuhan city of China. Overall, the results depict the reliability and ability of AI-based models (ANFIS and ANN) for the simulation of COVID-19 using the effects of various environmental variables. </p>


2017 ◽  
Vol 3 (1) ◽  
pp. 36-48
Author(s):  
Erwan Ahmad Ardiansyah ◽  
Rina Mardiati ◽  
Afaf Fadhil

Prakiraan atau peramalan beban listrik dibutuhkan dalam menentukan jumlah listrik yang dihasilkan. Ini menentukan  agar tidak terjadi beban berlebih yang menyebabkan pemborosan atau kekurangan beban listrik yang mengakibatkan krisis listrik di konsumen. Oleh karena itu di butuhkan prakiraan atau peramalan yang tepat untuk menghasilkan energi listrik. Teknologi softcomputing dapat digunakan  sebagai metode alternatif untuk prediksi beban litrik jangka pendek salah satunya dengan metode  Adaptive Neuro Fuzzy Inference System pada penelitian tugas akhir ini. Data yang di dapat untuk mendukung penelitian ini adalah data dari APD PLN JAWA BARAT yang berisikan laporan data beban puncak bulanan penyulang area gardu induk majalaya dari januari 2011 sampai desember 2014 sebagai data acuan dan data aktual januari-desember 2015. Data kemudian dilatih menggunakan metode ANFIS pada software MATLAB versi b2010. Dari data hasil pelatihan data ANFIS kemudian dilakukan perbandingan dengan data aktual dan data metode regresi meliputi perbandingan anfis-aktual, regresi-aktual dan perbandingan anfis-regresi-aktual. Dari perbandingan disimpulkan bahwa data metode anfis lebih mendekati data aktual dengan rata-rata 1,4%, menunjukan prediksi ANFIS dapat menjadi referensi untuk peramalan beban listrik dimasa depan.


2009 ◽  
Vol 8 (3) ◽  
pp. 887-897
Author(s):  
Vishal Paika ◽  
Er. Pankaj Bhambri

The face is the feature which distinguishes a person. Facial appearance is vital for human recognition. It has certain features like forehead, skin, eyes, ears, nose, cheeks, mouth, lip, teeth etc which helps us, humans, to recognize a particular face from millions of faces even after a large span of time and despite large changes in their appearance due to ageing, expression, viewing conditions and distractions such as disfigurement of face, scars, beard or hair style. A face is not merely a set of facial features but is rather but is rather something meaningful in its form.In this paper, depending on the various facial features, a system is designed to recognize them. To reveal the outline of the face, eyes, ears, nose, teeth etc different edge detection techniques have been used. These features are extracted in the term of distance between important feature points. The feature set obtained is then normalized and are feed to artificial neural networks so as to train them for reorganization of facial images.


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