scholarly journals Correlation between left ventricular diastolic dysfunction and dyslipidaemia in asymptomatic patients with new-onset type 2 diabetes mellitus

2021 ◽  
Vol 33 (1) ◽  
Author(s):  
K. M. Hassan Ayman ◽  
A. Abdallah Mahmoud ◽  
A. Abdel-Mageed Eman ◽  
Sayed Marwa ◽  
M. Soliman Mona ◽  
...  
Keyword(s):  
Diastolic Dysfunction ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
Newly Diagnosed ◽  
Type 2 Dm ◽  
Asymptomatic Patients ◽  
Ventricular Diastolic Dysfunction ◽  
New Onset

Abstract Background Poor glycaemic control is associated with a greater risk of development of heart failure in diabetic patients. We aimed to study the prevalence of left ventricular (LV) systolic and diastolic dysfunction in asymptomatic patients with new-onset type 2 DM. We conducted a cross-sectional study including patients with newly diagnosed (within 1 year) type 2 DM; all patients were between the ages of 30 and 60 years, normotensive and clinically asymptomatic and attended the outpatient clinic of the endocrinology unit at a university hospital between March 2016 and June 2017. Demographic characteristics, clinical risk factors and waist-hip ratio (WHR) were assessed. Blood samples for laboratory analysis were obtained. Detailed echocardiography was performed to evaluate systolic and diastolic function. Results A total of 100 patients were included. Sixty-one percent had diastolic dysfunction with preserved ejection fraction. Left ventricular diastolic dysfunction (LVDD) was more prevalent in diabetic patients with HbA1c ≥ 8.1 (75%) Patients with LVDD had significant dyslipidaemia in comparison to those without LVDD. Multivariate logistic regression analysis showed that WHR and HbA1c levels are the only predictors of impaired diastolic function in patients with new-onset DM. Kaplan-Meier survival curves showed a significant correlation between the incidence of diastolic dysfunction and the duration of DM, with higher incidence with HbA1c ≥ 8.1. Conclusions Diastolic dysfunction is highly prevalent in patients with newly diagnosed DM and is positively correlated with HbA1c level, obesity, dyslipidaemia and the duration of diabetes.

scholarly journals Prevalence of left ventricular diastolic dysfunction by echocardiography in type II diabetes mellitus patients

2019 ◽  
Vol 6 (4) ◽  
pp. 1334
Author(s):  
Ansari Mohammed Shoeb Himayun Kabeer ◽  
Shaikh Ambreen Fatema Abdul Hafiz
Keyword(s):  
Diastolic Dysfunction ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
Type Ii ◽  
Type 2 Dm ◽  
Ventricular Diastolic Dysfunction

Background: Epidemiological data indicates a greater risk of cardiovascular morbidity and mortality, particularly congestive heart failure in diabetic patients, compared with nondiabetic patients. Heart failure in many patients is due to left Ventricular Diastolic Dysfunction (LVDD), but its prevalence among diabetic adults is still not known, especially in the primary health care settings. Present study aims to evaluate the prevalence of LVDD by Echocardiography in Type II Diabetes Mellitus (DM).Methods: Authors did a prospective study, from May 2012 to August 2014, in Department of Medicine, Dr. D. Y. Patil Hospital, Kolhapur which included 100 randomly selected patients of Type II DM. The diagnosis of Type II DM was done according to the criteria laid down by American Diabetes Association 2012. A detailed clinical history was taken using a structured questionnaire prepared by us and all patients were evaluated for left ventricular function by Echocardiography. Equipment used for echocardiography-Mind ray DC USG, Doppler machine Probe used-7.5MHz.Results: On Echocardiography, Diastolic Dysfunction was found to be prevalent among individuals with Type 2 DM. Duration of DM and increasing age were found to be significantly associated with presence of Diastolic Dysfunction among individuals with Type 2 DM. Maximum number of patients were observed in the age group 51-60 years in our institute. 45% of the patients were asymptomatic, rest of the patients had predominantly cardiac symptoms.Conclusions: It is essential to screen diabetic patients with Echocardiography at an early stage to prevent future cardiovascular complications.

scholarly journals Echocardiographic evaluation of left ventricular diastolic dysfunction in recently diagnosed type 2 diabetes mellitus

2018 ◽  
Vol 6 (5) ◽  
pp. 1691
Author(s):  
Swapnil Jain ◽  
C. L. Nawal ◽  
Amandeep Singh ◽  
Radhey Shyam Chejara ◽  
Sagar Barasara ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diastolic Dysfunction ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
P Value ◽  
Diabetic Patients ◽  
Ventricular Diastolic Dysfunction

Background: Diastolic dysfunction in patients suffering from diabetes mellitus represents an earlier stage in the natural history of cardiomyopathy. This study was done to assess the left ventricular diastolic dysfunction in recently diagnosed (<5yr) Type 2 Diabetes Mellitus by Echocardiography and also to determine association of glycemic status (by HBA1c levels) with left ventricular diastolic dysfunction (LVDD).Methods: An observational descriptive study involving 100 diabetic patients, taken on first come first serve basis after applying inclusion and exclusion criteria. In all the subjects, other than routine investigations, HbA1c was estimated and echocardiography was done to evaluate LVDD.Results: Mean value of HbA1c in the study was 8.31+ 1.408 %. 63 out of 100 subjects had LVDD. There was significant positive correlation between HbA1c and LVDD (p value <0.001). As HbA1c increased, severity of LVDD increased. In this study, as BMI increased, HbA1c and LVDD increased & both findings were statistically significant (p value =0.001).Conclusion: Our study indicates that myocardial damage in patients with diabetes affects diastolic function before systolic function &higher HbA1C level is strongly associated with presence of LVDD. Patients should be advised strict control of diabetes in order to reduce the risk for developing LVDD which is a precursor for more advanced disease.Keywords: Diabetes mellitus, Diastolic dysfunction, BMI, HbA1c

scholarly journals Prevalence of left ventricular diastolic dysfunction among patients with asymptomatic diabetes mellitus type 2

2019 ◽  
Vol 6 (4) ◽  
pp. 1032
Author(s):  
D. Sai Vittal ◽  
M. V. Ram Babu
Keyword(s):  
Diastolic Dysfunction ◽  
Diastolic Heart Failure ◽  
Strong Association ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
Ventricular Diastolic Dysfunction ◽  
Patients With Diabetes ◽  
Onset Of Diabetes

Background: Diastolic heart failure occurs due to impaired myocardial relaxation and compliance. Of late, it has been suggested that the changes in the diastolic function occurs before the onset of diabetes, and present in the prediabetic patients. It is also said to be associated with insulin resistance.Methods: This observational study was performed on 50 diabetic patients, with asymptomatic type 2 diabetes. who came in for 2 D echocardiogram with suspected diastolic dysfunction.Results: The mean age among the 50 patients in the study was 54.1±10.99 years and in controls it was 49.56±10.63 years. The fasting sugar among the patients was 179.43±41.57 mg/dl and the post prandial was 236.72±76.24, and it was in the normal range in the controls. The HbA1c was 9.93±1.2 among the patients and 6.09 ± 0.34 in the controls. In the patients, the E/A ratio was 0.83±0.09 compared to 1.22±0.31 of the controls, which was highly significant as the E/e ratio which was 15.1±3.4 and 7.3±0.08 respectively.Conclusions: There was a higher prevalence of diastolic dysfunction among the patients with diabetes in our study. There was no relation of age or gender among the diabetic and the controls, while a strong association and indicators seem to be FBS, PLBS and HbA1c.

scholarly journals Left Ventricular Diastolic Dysfunction in Type 2 Diabetes—Progress and Perspectives

Diagnostics ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 121 ◽  
Author(s):  
Elena-Daniela Grigorescu ◽  
Cristina-Mihaela Lacatusu ◽  
Mariana Floria ◽  
Bogdan-Mircea Mihai ◽  
Ioana Cretu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diastolic Dysfunction ◽  
Diabetic Cardiomyopathy ◽  
Cardiovascular Events ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
Screening Programs ◽  
Ventricular Diastolic Dysfunction

In-depth understanding of early cardiovascular manifestations in diabetes is high on international research and prevention agendas given that cardiovascular events are the leading cause of death for diabetic patients. Our aim was to review recent developments in the echocardiographic assessment of left ventricular diastolic dysfunction (LVDD) as a telltale pre-clinical disturbance preceding diabetic cardiomyopathy. We analyzed papers in which patients had been comprehensively assessed echocardiographically according to the latest LVDD guidelines (2016), and those affording comparisons with previous, widely used recommendations (2009). We found that the updated algorithm for LVDD is more effective in predicting adverse cardiovascular events in patients with established LVDD, and less specific in grading other patients (labelled “indeterminate”). This may prove instrumental for recruiting “indeterminate” LVDD cases among patients with type 2 diabetes mellitus (T2DM) in future screening programs. As an interesting consideration, the elevated values of the index E/e’ can point to early diastolic impairment, foretelling diabetic cardiomyopathy. Identifying subclinical signs early makes clinical sense, but the complex nature of T2DM calls for further research. Specifically, longitudinal studies on rigorously selected cohorts of diabetic patients are needed to better understand and predict the subtle, slow onset of cardiac manifestations with T2DM as a complicating backdrop.

scholarly journals Plasma B-type Natriuretic Peptide (BNP) as a marker of left ventricular diastolic dysfunction in diabetic patients

2015 ◽  
Vol 8 (1) ◽  
pp. 1-5
Author(s):  
MM Zahurul Alam Khan ◽  
AKM Mohibullah ◽  
Md Zahid Alam ◽  
AMB Safdar ◽  
Shabnam Jahan Hoque ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diastolic Dysfunction ◽  
Natriuretic Peptide ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
Color Flow ◽  
Ventricular Diastolic Dysfunction ◽  
Study Participants

The first stage of diabetic cardiomyopathy is represented by left ventricular diastolic dysfunction (LVDD) with preserved systolic function, in an asymptomatic patient. B-type Natriuretic Peptide (BNP) is a cardiac neurohormone predominantly released from the cardiac ventricles in response to left ventricular volume expansion and pressure overload. The diagnostic role of BNP for detecting LVDD in asymptomatic diabetic patients is still debated and this study was undertaken to find out this relationship of plasma BNP level with LVDD in asymptomatic diabetic patients. First 100 patients who had type 2 diabetes for more than 5 years and had no known cardiac disease other than LVDD (grade-1 & 2), admitted in BIRDEM Hospital were recruited. Plasma BNP was measured by fluorescence polarization immunoassay (FPIA) method using AXSYM auto analyzer. Twodimensional, M-mode, spectral, and color flow Doppler echocardiograms was repeated on the same day of blood collection for plasma BNP measurement. After processing of all available data, statistical analysis of their significance was done with the help of computer based SPSS (Statistical Program for Social Science) program. Male female distribution of the study participants was 46% and 54% respectively. Mean plasma BNP level in all participants was 150 pg/ml. In male and female participants the values were 168 and 135 pg/ml respectively. The distribution did not show any significant association (p=0.491). Of the 100 study participants 89% had E/A ratio <1. Distribution of participants with abnormal E/A and E/e did not show any significant association (p=0.955 and 0.844 respectively). Study participants with varying level of plasma BNP level were analyzed in terms of E/A and E/e ratio. Distribution of participants between BNP Groups and E/A and E/e groups did not show statistically significant association (p=0.529). We concluded that plasma BNP has no relation with LVDD (grade- 1 and 2) in patients with type 2 diabetes mellitus (T2DM) who had no known cardiac disease.Ibrahim Med. Coll. J. 2014; 8(1): 1-5

The Association between Left Ventricle Diastolic Dysfunction and Endothelial Dysfunction and the Results of Stress Myocardial SPECT in Asymptomatic Patients with Type 2 Diabetes

2005 ◽  
Vol 33 (5) ◽  
pp. 473-482 ◽  
Author(s):  
J Charvát ◽  
K Michalova ◽  
J Chlumský ◽  
Z Valenta ◽  
M Kvapil
Keyword(s):  
Type 2 Diabetes ◽  
Left Ventricular Hypertrophy ◽  
Diastolic Dysfunction ◽  
Ventricular Hypertrophy ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Myocardial Spect ◽  
Asymptomatic Patients ◽  
Ventricular Diastolic Dysfunction

Diabetes mellitus is associated with a poor cardiovascular prognosis. Stress myocardial single-photon emission computed tomography (SPECT) reliably detects coronary ischaemia in asymptomatic patients. Our study aimed to evaluate the association between systolic and diastolic left ventricular function, left ventricular hypertrophy, endothelial function and the results of stress myocardial SPECT in 126 patients with type 2 diabetic patients with no cardiovascular symptoms. Thirty-three patients (26%) had abnormal SPECT results, 33 patients (26%) had intermediate (equivocal) results, and 60 patients (48%) had normal results. We found a significant association between an abnormal SPECT result, left ventricular diastolic dysfunction and impaired post-ischaemic dilatation of the brachial artery. No association was found between the SPECT result and systolic function and left ventricular hypertrophy, however. An abnormal SPECT result was significantly associated with left ventricular diastolic dysfunction and the deterioration of post-ischaemic dilatation of the brachial artery in asymptomatic patients with type 2 diabetes.

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