Selective suppression of chemokine receptor CXCR3 expression by interferon-b1a in multiple sclerosis
2002 ◽
Vol 8
(2)
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pp. 104-107
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Keyword(s):
T Cells
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We studied the expression of chemokine receptors CCR1, CCR2, CCR3, CCR5, and CXCR3 on CD4 and CD8 positive T cells, and on CD14 positive monocytes in blood from 10 patients with relapsing-remitting multiple sclerosis (MS) at initiation of interferon (IFN)- βtreatment, after 1 month and after 3 months of treatment. It was found that the expression of CXCR3 on CD4+ and CD8+ T cells was significantly reduced after 3 months of treatment. The expression of other receptors was unaltered. Since CXCR3 cells are enriched in cerebrospinal fluid (CSF), and are detected in lesion material in MS this may represent an important mode of action of interferon- βin MS.
2002 ◽
Vol 131
(1-2)
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pp. 186-190
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2019 ◽
Vol 116
(21)
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pp. 10488-10493
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2013 ◽
Vol 19
(14)
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pp. 1867-1877
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2002 ◽
Vol 133
(1-2)
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pp. 184-192
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2001 ◽
Vol 114
(1-2)
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pp. 207-212
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2012 ◽
Vol 70
(8)
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pp. 574-577
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