scholarly journals Depression in young adults

2004 ◽  
Vol 10 (1) ◽  
pp. 4-12 ◽  
Author(s):  
Daniel J. Smith ◽  
Douglas H. R. Blackwood
Keyword(s):  
Young Adults ◽  
Age At Onset ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Bipolar Spectrum Disorders ◽  
Spectrum Disorders ◽  
Atypical Presentations ◽  
Genetic Loading ◽  
First Time

Depression, as a heterogeneous collection of disorders, is likely to include subgroups that are more genetic in origin. In common with other neuropsychiatric disorders such as schizophrenia, Alzheimer's disease and Huntington's disease, earlier age at onset in depression is associated with higher genetic loading and poorer long-term outcome. Adolescents and young adults with depression are also at high risk of developing a bipolar illness. This article reviews depressive illnesses that occur for the first time in adolescence and young adulthood. Case studies are used to discuss atypical presentations and the evolving concept of bipolar-spectrum disorders.

Clinical Characteristics, Short- and Long-term Outcome of Acute Coronary Syndrome in Young Adults

2013 ◽  
Vol 111 (7) ◽  
pp. 80B
Author(s):  
Keiji Yamada ◽  
Satoru Sakuragi ◽  
Kota Okabe ◽  
Takashi Fuziwara ◽  
Takashi Miki ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Young Adults ◽  
Clinical Characteristics ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Coronary Syndrome ◽  
Short And Long Term

Very Long-Term Outcome of Community-Dwelling Patients With Schizophrenia Spectrum Disorders in Rural Greece

2019 ◽  
Vol 207 (12) ◽  
pp. 1012-1018 ◽  
Author(s):  
Vaios Peritogiannis ◽  
Aikaterini Grammeniati ◽  
Afroditi Gogou ◽  
Panagiota Gioti ◽  
Venetsanos Mavreas
Keyword(s):  
Community Dwelling ◽  
Schizophrenia Spectrum Disorders ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders

scholarly journals A Revised Surgical Strategy for the Distal Tibiofibular Interosseous Osteochondroma

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Huarui Yang ◽  
Kangquan Shou ◽  
Shijun Wei ◽  
Zhi Fang ◽  
Qiwen Hu ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Ankle Joint ◽  
Tibial Osteotomy ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Potential Damage ◽  
The Stability ◽  
And Function ◽  
First Time

Osteochondroma is one of the most common benign bone tumor; however, the surgical treatment still remains a challenge for those that occur at the distal tibiofibular interosseous location. Previously, the transfibular approach has been successfully described, but the potential damage of the syndesmosis would give rise to the instability of the ankle joint and thus may result in the unfavorable long-term outcome. Here, a revised strategy which can protect the syndesmotic complex is introduced. From 2010 to 2017, eleven patients with the distal tibiofibular interosseous osteochondroma who underwent the revised surgery were collected. The distal fibular osteotomy and posterior tibial osteotomy were performed to keep the inferior syndesmosis intact for better stability of the ankle joint. Both the anterior tibiofibular ligaments (AITFL) and posterior tibiofibular ligaments (PITFL) have been preserved successfully, and thus, the stability of the ankle joint has been maintained due to our strategy. The VAS and AOFAS scores were utilized to assess the clinical outcome and function. Postoperatively, all the patients were pain-free and were able to wear the appropriate shoes at the last follow-up. Preoperative and postoperative AOFAS scores were 93.63±6.91 and 47.27±5.27 (P<0.05), respectively. Moreover, the average VAS score was 1.73±0.27 (compared with preoperative as 7.45±2.15, P<0.05), demonstrating obvious improvement after the operation. To our best knowledge, this is the first time to perform the resection of the distal tibial interosseous osteochondroma involving the fibula without interrupting the inferior syndesmotic complex especially the AITFL and PITFL. We believe that this strategy may pave a new way for optimized clinical outcome for these patients with distal tibiofibular interosseous osteochondroma. This clinical trial study is registered with number ChiCTR1900024690.

scholarly journals The Impact of the Course of Disease before Botulinum Toxin Therapy on the Course of Treatment and Long-Term Outcome in Cervical Dystonia

Toxins ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 493
Author(s):  
Harald Hefter ◽  
Isabelle Schomaecker ◽  
Max Schomaecker ◽  
Dietmar Rosenthal ◽  
Sara Samadzadeh
Keyword(s):  
Botulinum Toxin ◽  
Cervical Dystonia ◽  
Age At Onset ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Course Of Disease ◽  
Related Data ◽  
Botulinum Toxin Therapy ◽  
The Impact

This study analyses the influence of the course of the disease of idiopathic cervical dystonia (CD) before botulinum toxin (BoNT) therapy on long-term outcomes. 74 CD-patients who were treated on a regular basis in the botulinum toxin outpatient department of the University of Düsseldorf and had received at least 3 injections were consecutively recruited after written informed consent. Patients were asked to rate the amount of change of CD in relation to the severity of CD at begin of BoNT therapy (IMPQ). Then they had to draw the course of disease of CD from onset of symptoms until initiation of BoNT therapy (CoDB-graph) on a sheet of paper into a square of 10 × 10 cm2 size. Remaining severity of CD was estimated by the treating physician using the TSUI-score. Demographical and treatment related data were extracted from the charts of the patients. Depending on the curvature four different types of CoDB-graphs could be distinguished. Time to BoNT therapy, increase of dose and improvement during BoNT treatment were significantly (p < 0.05) different when patients were split up according to CoDB-graph types. The lower the age at onset of symptoms, the shorter was the time to therapy (p < 0.02). Initial dose (p < 0.04) and actual dose (p < 0.009) were negatively correlated with the age of the patients at recruitment. The course of disease of CD before BoNT therapy has influence on long-term outcome. This has implications on patient management and information on the efficacy of BoNT treatment.

scholarly journals Use of antihypertensive medication after ischemic stroke in young adults and its association with long-term outcome

2019 ◽  
Vol 51 (1) ◽  
pp. 68-77 ◽  
Author(s):  
Myrna M. E. van Dongen ◽  
Karoliina Aarnio ◽  
Nicolas Martinez-Majander ◽  
Jani Pirinen ◽  
Juha Sinisalo ◽  
...  
Keyword(s):  
Young Adults ◽  
Ischemic Stroke ◽  
Antihypertensive Medication ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Stroke In Young Adults ◽  
Stroke In Young

scholarly journals Physical and Neurological Development of a Girl Born to a Mother with Methylmalonic Acidemia and Kidney Transplantation and Review of the Literature

Children ◽  
2021 ◽  
Vol 8 (11) ◽  
pp. 1013
Author(s):  
Alessia Marcellino ◽  
Cristiana Alessia Guido ◽  
Silvia Bloise ◽  
Saverio Mallardo ◽  
Sara Isoldi ◽  
...  
Keyword(s):  
Transplant Recipient ◽  
Methylmalonic Acid ◽  
Kidney Transplant Recipient ◽  
Methylmalonic Acidemia ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Neurological Effects ◽  
First Time ◽  
Significant Weakness

Background: actual literature suggests that children of methylmalonic acidemia patients are mostly healthy, but data are only partial, especially regarding long-term outcome. Therefore, our aim was to evaluate the possible long-term neurological effects of fetal exposure to high levels of methylmalonic acid in a child of a renal transplant recipient. Methods: we retrospectively evaluated the clinical and neurological records of a girl whose mother is a kidney transplant recipient affected by methylmalonic acidemia. Subsequently, we compared our results with the ones already published. Results: the girl’s weight and stature were within the normal range in the first years of life but, starting from 4 years of age, she became progressively overweight. Regarding the neurodevelopment aspects, for the first time we performed a complete and seriated neuropsychological evaluation, highlighting a mild but significant weakness in the verbal domain, with a worsening trend at three-year revaluation. Conclusions: since children of MMA patients are exposed to methylmalonic acid, the efforts of the physicians caring for these children should be directed on careful evaluation of growth, prevention of obesity and regular neurological examination together with structured neuropsychological tests to achieve a better insight in possible complications of pregnancy in patients suffering from this condition.

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